Customers can now purchase CBD wholesale THC Free broad spectrum oil and private label CBD products with the exact profile of rare cannabinoids of their choice such as CBG, CBN, CBC, and CBDV.
The global automotive aftermarket is rapidly evolving, with demand for starter solenoids being higher than before. T&X Starter Solenoid Manufacturers moved in supply the growing market, and their products have gained popularity the world over.
What a gorgeous embroidery! I would love to learn and have begun collecting just a few things. I really need to just do it!
Chicken Scratch embroidery?? Never heard of it! How cool!!! Glad you are catching up on these different techniques!
Monika Hamori, professor at IE Business School in Madrid and author of the HBR article "Job-Hopping to the Top and Other Career Fallacies."
Amy Gallo, HBR contributing editor, discusses a useful tactic to more effectively deal with conflict in the workplace: understanding whether you generally seek or avoid conflict. Each personality style influences how you approach a particular conflict, as well as how your counterpart does. Gallo talks about how to escape the common pitfalls of conflict seekers and conflict avoiders, so that you can improve your work and your relationships. She’s the author of the “HBR Guide to Dealing with Conflict.”
Nick Morgan, a communications expert and speaking coach, says that while email, texting, and Slack might seem like they make communication easier, they actually make things less efficient. When we are bombarded with too many messages a day, he argues, humans are likely to fill in the gaps with negative information or assume the worst about the intent of a coworker's email. He offers up a few tips and tricks for how we can bring the benefits of face-to-face communication back into the digital workplace. Morgan is the author of the book, "Can You Hear Me?: How to Connect with People in a Virtual World."
Sydney Finkelstein, professor at the Tuck School of Business at Dartmouth College, says that being the most knowledgeable and experienced person on your team isn't always a good thing. Expertise can steer you wrong in two important ways. It can stop you from being curious about new developments in your field. And it can make you overconfident about your ability to solve problems in different areas. He says that, to be effective leaders, we need to be more aware of these traps and seek out ways to become more humble and open-minded. Finkelstein is the author of the HBR article "Don't Be Blinded By Your Own Expertise."
Courtesy of the creators of BAGPATCH, the colorful peel-and-stick woven labels with sassy messages to help travelers ID their luggage.
Last winter i purchased a Polaroid Zip Mobile printer, and decided to give it a first try-out on the road, as it was intended to be used. Here’s my review, and what I learned!
The Commission of Railway Safety, which investigates all serious rail accidents and clears all rail projects, also said that now that such an incident of migrant or other persons walking along the tracks leading to consequent deaths have come to notice, all-out efforts must be made to prevent recurrence of such incidents in future.
The National Weather Service has issued an excessive heat warning for parts of Grand Canyon National Park. The warning is in effect from 10 am Saturday, June 17 to 8 pm Wednesday, June 21 for areas below 5,000 feet in the canyon including Phantom Ranch and Indian Garden. https://www.nps.gov/grca/learn/news/summer-safety.htm
https://thenextweb.com/microsoft/2020/05/08/microsoft-bundled-its-beautiful-bing-wallpapers-into-a-free-android-app/
In today’s Adobe Illustrator tutorial I’m going to take you through the process of creating a colourful embroidered patch, based on the kinds of designs associated with National Parks. The artwork will incorporate a landscape scene at sunset, which helps to keep the design simple with a silhouette graphic and a warm colour palette. Stick […]
The post Video Tutorial: How to Create an Embroidered Patch Design in Illustrator appeared first on Spoon Graphics.
Image from Wikimedia With photography and image-based social media flourishing, there’s no better time to get into this amazing hobby. Although many people do just fine with little or no guidance, there are certain common mistakes which a lot of rookies run into. To give you a better start in the world of photography, you need to keep a keen eye out for these slip-ups. Here are three of the most widespread. If you want to pursue photography as a career, then one of the worst things you can do is neglect to learn the jargon. I’ve met more than a few photographers who have a natural talent. Without playing with any settings or even glancing at the subject, they get shots which make even the blandest scenes look incredible. With some of these protégés, I’ve been totally shocked at how little technical knowledge they have. A good photographer is ... Read more
The post 3 Common Photography Mistakes To Avoid appeared first on Digital Photography Tutorials.
Over at All Things Photo, I’ve shared a video detailing a scam targeting photographers selling prints online. Also included in the video are 7 tips to avoid being scammed online. While the video is on the long side it’s worth a listen to protect yourself and learn the limitations of fraud protection with your bank and insurance companies. If you’re driving you can also listen to the podcast recording via the All Things Photo podcast. If you haven’t already I welcome you to follow All Things Photo on YouTube, Twitter and Facebook.
Center for Biological Diversity Press Release WASHINGTON – Four commonly used neonicotinoid pesticides can harm bees and other pollinators, according to a new analysis by California’s Department of Pesticide Regulation. The study found that current approved uses of the “neonics” … Continue reading
We're familiar with awarding prizes for excellence, from the Oscars to The International Design Awards. But what if we started giving prizes to shame bad examples of design? Enter the Procrustes Awards.
Whether you call it a field visit, a contextual inquiry or a customer discovery interview, the goal of early stage research is the same: to uncover users' needs. Here are 5 mistakes I've seen crop up time and again in this kind of research.
We introduce the conormal fan of a matroid M, which is a Lagrangian analog of the Bergman fan of M. We use the conormal fan to give a Lagrangian interpretation of the Chern-Schwartz-MacPherson cycle of M. This allows us to express the h-vector of the broken circuit complex of M in terms of the intersection theory of the conormal fan of M. We also develop general tools for tropical Hodge theory to prove that the conormal fan satisfies Poincar'e duality, the hard Lefschetz theorem, and the Hodge-Riemann relations. The Lagrangian interpretation of the Chern-Schwartz-MacPherson cycle of M, when combined with the Hodge-Riemann relations for the conormal fan of M, implies Brylawski's and Dawson's conjectures that the h-vectors of the broken circuit complex and the independence complex of M are log-concave sequences.
A perfect matroid design (PMD) is a matroid whose flats of the same rank all have the same size. In this paper we introduce the q-analogue of a PMD and its properties. In order to do that, we first establish new cryptomorphic definitions for q-matroids. We show that q-Steiner systems are examples of q-PMD's and we use this matroid structure to construct subspace designs from q-Steiner systems. We apply this construction to S(2, 13, 3; q) Steiner systems and hence establish the existence of subspace designs with previously unknown parameters.
We identify the structure of the lexicographically least word avoiding 5/4-powers on the alphabet of nonnegative integers. Specifically, we show that this word has the form $p au(varphi(z) varphi^2(z) cdots)$ where $p, z$ are finite words, $varphi$ is a 6-uniform morphism, and $ au$ is a coding. This description yields a recurrence for the $i$th letter, which we use to prove that the sequence of letters is 6-regular with rank 188. More generally, we prove $k$-regularity for a sequence satisfying a recurrence of the same type.
The disclosed embodiments describe a method, an apparatus, an application specific integrated circuit, and a server that provides a fast and efficient look up for data analysis. The apparatus and server may be configured to obtain data segments from a plurality of input devices. The data segments may be individual unique subsets of the entire data set obtained by a plurality input devices. A hash function may be applied to an aggregated set of the data segments. A result of the hash function may be stored in a data structure. A codebook may be generated from the hash function results.
Device for forming, on a nanowire made of a semiconductor, an alloy of this semiconductor with a metal or metalloid by bringing this nanowire into contact with electrically conductive metal or metalloid probes and Joule heating the nanowire at the points of contact with the probes so as to form an alloy such as a silicide. Application to the production of controlled-channel-length metal-silicide transistors.
A system, method and computer program product for avoiding a processing flaw in a computer processor triggered by a predetermined sequence of hardware events. The system may include a detecting unit and a power-on reset unit. The detecting unit detects that the predetermined sequence of hardware events is going to occur at the computer processor. The power-on reset unit initializes the computer processor to a state stored in computer memory in response to detecting the sequence of hardware events.
A durable ambient light curable waterproof liquid rubber coating with volatile organic compound (VOC) content of less than 450 grams per liter made from ethylene propylene diene terpolymer (EPDM) in a solvent, a photoinitiator, an additive, pigments, and fillers, and a co-agent and a method for making the formulation, wherein the formulation is devoid of thermally activated accelerators.
The disclosure provides a method for crosslinking a colloid, including: (a) providing a colloid solution; (b) adding a crosslinking agent and solid particles to the colloid solution, wherein the amount of solid particles added is enough to convert the colloid solution into a solid mixture, and wherein a crosslinking reaction proceeds in the solid mixture; and (c) removing the solid particles from the solid mixture.
A method for operating an invisible system service on Android platform is disclosed. The method for operating system services on Android platform includes selectively registering a created system service in a context manager according to a type of the created system service, where the type of the system service comprises a first type for permitting access from an outside and a second type for not permitting access from the outside, and the selectively registering comprises registering in the context manager the created system service belonging to the first type and not registering in the context manager the created system service belonging to the second type.
The present invention provides therapeutically active compounds and compositions as receptor antagonists and methods of use thereof. In one aspect, the compounds are useful in modulating pain, inflammation and acute phase reactions by inhibiting the PGE2 receptors including PGE2 EP1, EP2 and EP4 receptors.
An improved process for the N-alkylation of tertiary morphinan alkaloid bases to form the corresponding quaternary morphinan alkaloid derivatives.
Steroid compounds having increased resistance against metabolism and increased water solubility are disclosed, together with methods for their production. These substances are suitable for the manufacture of pharmaceuticals for the treatment of steroid related or steroid induced CNS disorders and for use in methods of prevention, alleviation or treatment of such disorders.
The present invention relates to a process for the preparation of 17α-(3-hydroxypropyl)-17β-hydroxysteroids of the formula I starting from 17-ketosteroids of the formula III via the intermediates of the formula V wherein the radicals R3, R5, R6, R7, R10, R13, R15, R16, R40, R41 and R42 have the meaning indicated in the description.
Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-17 bicyclic amines of triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II and III: These compounds are useful for the treatment of HIV and AIDS.
Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-3 cycloalkenyl triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II, III and IV: wherein X can be a C4-8 cycloalkyl, C4-8 cycloalkenyl, C4-9 spirocycloalkyl, C4-9 spirocycloalkenyl, C4-8 oxacycloalkyl, C4-8 dioxacycloalkyl, C6-8 oxacycloalkenyl, C6-8 dioxacycloalkenyl, C6-9 oxaspirocycloalkyl, or C6-9 oxaspirocycloalkenyl ring. These compounds are useful for the treatment of HIV and AIDS.
Provided are methods for the treatment of a rheumatic disease, such as rheumatoid arthritis, ankylosating spondylitis and/or polymyalgia rheumatic, by administering a delayed-release dosage form of a glucocorticoid to a subject in need thereof wherein the treatment is administered once daily for at least about two weeks. Also provided are methods for the treatment of osteoarthritis by administering a delayed-release dosage form of a glucocorticoid to a subject in need thereof wherein the treatment is administered once daily for at least about two weeks.
The invention relates to nitrooxyderivative of corticosteroids of general formula (I) and pharmaceutically acceptable salts or stereoisomers thereof R—(Z)a—Rx (I) wherein R is the corticosteroid residue of formula (II): wherein: R1 is OH, R2—CH3, or R1 and R2 are taken together to form a group of formula (III) R3 is Cl or F;R4 is H or F; wherein R1, R2, R3 and R4 can be linked to the correspondent carbon atoms of the steroidal structure in position α or β; with the proviso that: when R1 and R2 are the group of formula (III) then R3 is F and R4 is H or F; The compounds are useful in the treatment of respiratory diseases, inflammatory diseases, dermatological diseases and ocular diseases.
The invention relates to compounds of formula (I): wherein R is ethyl, propyl or allyl, and pharmaceutically acceptable salts, solvates or amino acid conjugates thereof. The compounds of formula (I) are useful as FXR agonists.
The invention relates to a process for the preparation of a compound of formula (I): wherein R1 and R2 are as defined in the description, by reaction of a compound of formula (II) with a base. Compound (I) is an intermediate useful in the preparation of gestodene.
This invention is applicable to bicycle non-circular chainrings or ovoid chainrings, attachable to a drive crank arm with a spider, forming a structure with anchorage points distributed in a star like shape; the said ovoid chainring (1) having a major diameter, whose angle with the said crank arm measured in the pedaling direction defines its orientation; whereas, said ovoid chainring has a number of anchorage points to said spider which is a multiple of the number of anchorage points of the spider, constituting multiple anchorage options to this crank arm, separated in such a distance that respective orientation values differ in 3°; and for such a small variation, the proposed constructive solution is equipping the ovoid chainring with consecutive overlapped holes and respective countersinks with different depth, forming stair steps which help supporting tangential loads to the chainring.
A bicycle gear shift control system capable of avoiding frequent gear shifting includes: a power module; a microcomputer electrically connected to the power module for allowing a cyclist to switch between the automatic gear shifting mode and a manual gear shifting mode; a gear shifting driver electrically connected to the microcomputer, substantially connected to a derailleur, and instructed by the microcomputer to drive the derailleur to perform gear shift control; and a manual shifting controller electrically connected to the microcomputer. The microcomputer has an automatic gear shifting logic whereby the microcomputer determines the timing of automatic gear shifting and performs gear shifting. The microcomputer further has a gear shifting delay logic that involves delaying for a delay time interval from commencement of gear shifting according to a gear shifting criterion and ruling out all other gear shifting commands during the delay time interval.
The present invention relates to compounds of Formula I or II, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which relates to mophinan compounds useful as μ, δ and/or κ receptor opioid compounds and pharmaceuticals containing same that may be useful for mediating analgesia, combating drug addiction, alcohol addiction, drug overdose, mental illness, bladder dysfunctions, neurogenic bladder, interstitial cystitis, urinary incontinence, premature ejaculation, inflammatory pain, peripherally mediated and neuropathic pain, cough, lung edema, diarrhea, cardiac disorders, cardioprotection, depression, and cognitive, respiratory, diarrhea, irritable bowel syndrome and gastro-intestinal disorders, immunomodulation, and anti-tumor agents.
A hot-melt formulation useful as a wound dressing comprises a chemically crosslinked polymer matrix obtainable from prepolymers crosslinkable by means of photopolymerization. Hydrocolloids are embedded in the chemically crosslinked polymer, matrix. The formulation is obtainable by combining the prepolymers and hydrocolloids, and heating and processing the mixture through a slot die, wherein the mixture has a viscosity of less than 100 Pa*s and a processing temperature of less than 150° C. The prepolymers are crosslinked by means of photopolymerization by irradiation with UV light.
An accommodating intraocular lens (AIOL) includes an optic adapted to produce a trapezoidal phase shift and a plurality of haptics. Each haptic extends from a haptic-optic junction to at least one transverse arm contacting a capsular bag of the eye, and each haptic has sufficient length and rigidity to stretch a capsular bag of the eye to contact ciliary muscles of the eye. The haptic-optic junctions vault the optic forward relative to the haptics and compression of the haptics by the ciliary muscles moves the anterior optic forward. A combined accommodative power produced by the motion of the anterior optic and the trapezoidal phase shift is at least 0.5 Diopters.
A ligand design allows compact nanoparticle materials, such as quantum dots (QDs), with excellent colloidal stability over a wide range of pH and under high salt concentrations. Self-assembled biomolecular conjugates with QDs can be obtained which are stable in biological environments. Energy transfer with these ligands is maximized by minimizing distances between QDs/nanoparticles and donors/acceptors directly attached to the ligands or assembled on their surfaces.
A method for treating spheroidal graphite iron includes the step: pouring molten spheroidal graphite iron into a pouring electrical furnace (1); covering the molten spheroidal graphite iron (5) with alkali slag (6) which is melted at high temperature and rich in alkali earth metal ion, rare earth metal ion, or mixture of them; connecting the molten spheroidal graphite iron (5) with the negative pole of the direct current source by one pole (7); connecting the alkali slag (6) with the positive pole of the direct current source by another pole (4), treating the molten spheroidal graphite iron (5) with the alkali slag (6) which is used as electrolyte. The method can prevent the spheroidized fading velocity of the spheroidal graphite iron. The pouring electrical furnace can be used for treating the molten spheroidal graphite iron.
The present invention relates to compounds suitable as modulators of protein misfolding and/or protein aggregation. The compounds are particularly suitable as inhibitors of amyloid aggregate formation and/or modulators of amyloid surface properties, and/or as activators of degradation or reduction of amyloid aggregates.
The present invention relates to fusion proteins comprising an antibody, functional fragment or functional derivative thereof having specific binding affinity to either the extracellular domain of oncofetal fibronectin (ED-B) or at least one of the extracellular domains of oncofetal tenascin fused to a cytokine selected from the group consisting of IL-10, IL15, IL-24 and GM-CSF, functional fragments and functional derivatives thereof. The invention is also directed to the use of at least one of said fusion proteins for the manufacture of a medicament. In particular, the invention concerns the use of said medicament for the treatment of tumors or chronic inflammatory diseases such as atherosclerosis, arthritis and psoriasis.