Princeton University has offered admission to 1,890 students, or 6.1 percent of the record 31,056 applicants for the Class of 2021, in what is the University's most selective admission process to date. Last year, the University's admission rate was 6.46 percent. The class size is expected to be 1,308 students for the Class of 2021.

Princeton University has reaffirmed a statement it made in 2015 expressing the hope that the then-upcoming U.N. Climate Negotiations in Paris would “lead to significant progress in promoting clean energy and other positive actions to address the environmental impacts of climate change.”

NEW YORK – Because levels of contamination in groundwater are falling naturally, the U.S. Environmental Protection Agency (EPA) is proposing to amend part of its previous plan to clean up an area of the Lightman Drum Company Superfund site in Winslow Township, New Jersey.

For Immediate Release No. 20-OPA-042

YELLOW SPRINGS, Ohio (October 17, 2019) – The U.S. Environmental Protection Agency (EPA) will present the proposed cleanup options for the Vernay Laboratories Inc. site at a public meeting on Thursday, Oct. 24 in Yellow Springs. The information session will run from 5-7 p.m.

Metz, France (May 7, 2019) - Yesterday, U.S. Environmental Protection Agency (EPA) Administrator Andrew Wheeler concluded his visit to Metz, France where he attended the annual G7 Environmental Ministers Meeting.

KARUIZAWA, JAPAN – Yesterday, U.S. Environmental Protection Agency (EPA) Administrator Andrew Wheeler concluded his visit to Karuizawa, Japan where he attended the inaugural G20 Energy and Environmental Ministers Meeting.

DALLAS – (April 24, 2020) In conjunction with the 50th anniversary of Earth Day, the U.S. Environmental Protection Agency (EPA) awarded $11.5 million to replace 580 older diesel school buses.

NEW YORK - In conjunction with Air Quality Awareness Week, the U.S. Environmental Protection Agency (EPA) Region 2 recently approved several updates to New York and New Jersey’s clean air plans.

Nearly all of the assaults occurred on Thursday along the border of South Williamsburg and Bedford-Stuyvesant between 9:55 and 11:15 a.m., cops said.

Damian Lawlor celebrates the special place Clones has in the GAA and how Cavan-Monaghan this afternoon would have heralded the start of an Irish summer

The Boilermakers open the 2018 ESPN Charleston Classic against Appalachian State, with the winner facing Davidson or Wichita State.

Charlotte Web writes: Since 2001 the TIOBE Index has been ranking top results for the search query +"<language> programming" on the top 25 search engines. "This month, C moved up past Java and entered the number one position," reports JAXenter. "There's a new number one. (Or, should we say an old number one?)" "Java and C were already very close in April, but this month C surpasses Java again," explains Paul Jansen CEO TIOBE Software. He also points out that the last time C was number one was back in 2015, suggesting that today embedded software languages like C and C++ "are gaining popularity because these are used in software for medical devices." "On another note, it is also worth mentioning that Rust is really getting close to the top 20 now (from #27 to #21 within one month)." "Perl, on the other hand, might be on its way off of the charts," argues JAXenter, "if it continues its downward trend. This month it saw a rate of change of -0.51%. It is currently number 18 on the list, but in May 2019 it was number 13." Python also passed C++ to take the #3 spot, while C# overtook Visual Basic for the #5 spot. ("Classic Visual Basic" also lost the #16 spot to PL/SQL). Even PHP rose a notch, pushing past SQL to take the #8 spot, and Scratch also moved up one, overtaking Objective C for the #19 position.

Read more of this story at Slashdot.

The SLGA retail store and the private off sale in La Loche are closed for two weeks, the province announced.

A Welsh MP claims cases include workers with the NHS and in care homes.

In this week's Match of Their Day, former Manchester United and Everton player Phil Neville selects his three favourite Premier League games.

Kingston’s top health officials say that there are no current cases of COVID-19 active in the city.

Justin Gaethje produces the best performance of his career to finish Tony Ferguson and win the UFC interim lightweight title at UFC 249.

In this week's Match of Their Day, former Manchester United and Everton player Phil Neville selects his three favourite Premier League games.

A Canadian department store chain is calling it quits after more than a century in business.

Two more businesses operating in Calgary have been shut down by health officials for violating the province's rules regarding COVID-19.

A new, squeaky clean business venture is helping Calgary’s most vulnerable during the COVID-19 pandemic.

A man is dead after a single-vehicle motorcycle crash in southeast Calgary.

French tennis chief Bernard Guidicelli admitted that Roland Garros could be staged behind closed doors.

Fear is ripe soil for the unscrupulous. With so much uncertainty and concern over our health and the broader world economy, cybercriminals have been playing on that fear to steal a few extra dollars out of the most scared and vulnerable. The U.S. Secret Service warned that phishing attacks were up significantly and scams over fake COVID-19 treatments have led to seizures and arrests.

From companies and organizations to individuals, it’s never been more important for everyone to have their cybersecurity measures on high alert. And whether you’re looking to protect your own assets or you’ve been tasked with safeguarding a company and all its workers, the vital work of white hat hackers is absolutely essential these days.

The training in The Ultimate 2020 White Hat Hacker Certification Bundle can put you in a position to understand all aspects of maintaining cybersecurity for a communication system of virtually any size, a lucrative career that can earn you a six-figure income.

The four-part Complete Cyber Security Course (taught by cybersecurity expert and noted consultant Nathan House) is a 360-degree starting point for any cybersecurity career. Starting at the beginning, each part of this multi-pronged introduction will help guide you through vital knowledge, from network hacking techniques and vulnerability scanning to all the defense methods that assure every laptop, desktop, smartphone and tablet in your network remain secure.

The hacker training continues with the rest of the courses in the collection, including building security analysis tools using Python and learning how to analyze web app security vulnerabilities and solutions using frameworks like Ruby on Rails and PHP. Read the rest

A department store that served Vancouver's Gastown and Downtown Eastside neighbourhoods for decades is closing, along with four other Army and Navy locations, because of the COVID-19 pandemic.

Police and City of Vancouver park rangers escorted the last person living in Oppenheimer Park out of the tent city Saturday afternoon, moments before crews with excavators moved in to clean up the mountains of trash left behind.

The following article, Witness Tampering? Asst. HHS Secretary Releases Threatening Text Messages From Dem Rep. Eric Swalwell: “In clear violation of House Ethics rules “, was first published on 100PercentFedUp.com.

Now that Michael Caputo, who was previously a target of the Mueller investigation, has been cleared, he has released some pretty damning text messages from the virulently anti-Trump lawmaker from California, Rep. Eric Swalwell (D). The text messages appear to prove that Swalwell, who has spent the last 3 1/2 years calling for Trump’s impeachment, […]

Continue reading: Witness Tampering? Asst. HHS Secretary Releases Threatening Text Messages From Dem Rep. Eric Swalwell: “In clear violation of House Ethics rules “ ...

Research Event

Event participants

Dr Doyin Okupe, Senior Special Assistant on Public Affairs to the President of Nigeria 

12 March 2015 , Volume 91, Number 2

17 May 2016

6 January 2017 , Volume 93, Number 1

ridureyu1 posted a photo:

An innocent party noisemaker...

ridureyu1 posted a photo:

NOT ANOTHER CLOWN AUUUUUGH

Ousted vaccine expert Rick Bright said he is "frustrated at our inability to be heard as scientists."

Elizabeth Spiers wrote about an incident where Jared Kushner used the memorial of an employee to congratulate himself for success.

Some Buckeyes are not comfortable being told by a "woman in power" to quarantine, one expert said.

Representative Michael McCaul, who has harshly criticized China in his position as the ranking member on the House Foreign Affairs Committee, disclosed that his family owns stock in a Chinese tech company he described as a threat to national security.An April 20 periodic transaction report showed that McCaul disclosed a February purchase of between $50,000 and $100,000 in shares of the Chinese firm Tencent Holdings, Politico reported.In November, several months before the shares were purchased, the Texas congressman said that Tencent Holdings is among the "Chinese companies that threaten America’s economic and national security."The tech conglomerate is "heavily involved" in the "social credit system, a dystopian system China has implemented to score its citizens’ behavior," McCaul said at the time, as well as an "integral part" of the Chinese Communist Party’s industrial policies and "one of four national champions for artificial intelligence."McCaul's lawyer, Elliot Berke, said that the shares are not owned personally by McCaul but by his wife, and the decision to invest in Tencent was made by a third party.“Congressman McCaul did not purchase any shares in China’s Tencent Holdings or any other Chinese company,” the attorney said. “Congressman McCaul’s wife has assets she solely owns and a third party manager made the purchase without her direction.”Rachel Walker, a spokeswoman for McCaul, emphasized that the revelation of the Tencent shares “highlights that many Americans unwittingly invest their money in Chinese owned companies."Federal employees are often unaware they own such investments because the federal government’s thrift savings plan program creates portfolios that include Tencent and other Chinese companies, Walker said. McCaul has argued that such retirement investment plans should not invest American dollars in such "shady" Chinese companies, often without the knowledge of the investor."Congressman McCaul has been a fierce critic of the brutal behavior of the Chinese Communist Party and will continue to fight to hold them accountable as the Chair of the China Task Force," Walker said. "This should be a wake-up call to us all that the CCP’s involvement in the U.S. economy is far more reaching than many Americans realize and that we need to change the way we do business with China, including our investments."Tencent owns the Chinese social media platform WeChat, which has more than one billion users and is suspected of monitoring the activities of users both inside and outside of China. Tencent is also associated with Chinese tech firm Huawei, which U.S. officials said can secretly access American cellular phone networks, giving it access to sensitive information.McCaul has taken a leading role in criticizing China's handling of the coronavirus pandemic as well, accusing Beijing of launching perhaps the "worst cover-up in human history."He was tapped on Thursday by House Minority Leader Kevin McCarthy as chairman of the China Task Force, the aim of which is to develop "legislative solutions to address the Chinese Communist Party’s malign global agenda."The task force will "develop new and enduring policy solutions that, among others, enhance our economic strength and create jobs, protect our national security, rethink our supply chains and grow our competitive edge in technology," McCaul said in a statement on his appointment.

In a tweet Saturday morning, Tesla's chief executive said it would file a lawsuit against county officials over not being able to run its factory.

(University of Stirling) A new University of Stirling study is seeking to understand how the easing of COVID-19 pandemic restrictions on licensed premises can be effectively managed to protect emergency services.

Lethal infections by strains of the highly-pathogenic avian influenza virus (HPAIV) H5N1 pose serious threats to both the poultry industry and public health worldwide. A lack of confirmed HPAIV epitopes recognized by cytotoxic T lymphocytes (CTLs) has hindered the utilization of CD8+ T-cell–mediated immunity and has precluded the development of effectively diversified epitope-based vaccination approaches. In particular, an HPAIV H5N1 CTL-recognized epitope based on the peptide MHC-I–β2m (pMHC-I) complex has not yet been designed. Here, screening a collection of selected peptides of several HPAIV strains against a specific pathogen-free pMHC-I (pBF2*1501), we identified a highly-conserved HPAIV H5N1 CTL epitope, named HPAIV–PA123–130. We determined the structure of the BF2*1501–PA123–130 complex at 2.1 Å resolution to elucidate the molecular mechanisms of a preferential presentation of the highly-conserved PA123–130 epitope in the chicken B15 lineage. Conformational characteristics of the PA123–130 epitope with a protruding Tyr-7 residue indicated that this epitope has great potential to be recognized by specific TCRs. Moreover, significantly increased numbers of CD8+ T cells specific for the HPAIV–PA123–130 epitope in peptide-immunized chickens indicated that a repertoire of CD8+ T cells can specifically respond to this epitope. We anticipate that the identification and structural characterization of the PA123–130 epitope reported here could enable further studies of CTL immunity against HPAIV H5N1. Such studies may aid in the development of vaccine development strategies using well-conserved internal viral antigens in chickens.

Antibodies are widely used as cancer therapeutics, but their current use is limited by the low number of antigens restricted to cancer cells. A receptor tyrosine kinase, receptor tyrosine kinase-like orphan receptor 2 (ROR2), is normally expressed only during embryogenesis and is tightly down-regulated in postnatal healthy tissues. However, it is up-regulated in a diverse set of hematologic and solid malignancies, thus ROR2 represents a candidate antigen for antibody-based cancer therapy. Here we describe the affinity maturation and humanization of a rabbit mAb that binds human and mouse ROR2 but not human ROR1 or other human cell-surface antigens. Co-crystallization of the parental rabbit mAb in complex with the human ROR2 kringle domain (hROR2-Kr) guided affinity maturation by heavy-chain complementarity-determining region 3 (HCDR3)-focused mutagenesis and selection. The affinity-matured rabbit mAb was then humanized by complementarity-determining region (CDR) grafting and framework fine tuning and again co-crystallized with hROR2-Kr. We show that the affinity-matured and humanized mAb retains strong affinity and specificity to ROR2 and, following conversion to a T cell–engaging bispecific antibody, has potent cytotoxicity toward ROR2-expressing cells. We anticipate that this humanized affinity-matured mAb will find application for antibody-based cancer therapy of ROR2-expressing neoplasms.

Lens proteins become increasingly cross-linked through nondisulfide linkages during aging and cataract formation. One mechanism that has been implicated in this cross-linking is glycation through formation of advanced glycation end products (AGEs). Here, we found an age-associated increase in stiffness in human lenses that was directly correlated with levels of protein–cross-linking AGEs. α-Crystallin in the lens binds to other proteins and prevents their denaturation and aggregation through its chaperone-like activity. Using a FRET-based assay, we examined the stability of the αA-crystallin–γD-crystallin complex for up to 12 days and observed that this complex is stable in PBS and upon incubation with human lens–epithelial cell lysate or lens homogenate. Addition of 2 mm ATP to the lysate or homogenate did not decrease the stability of the complex. We also generated complexes of human αA-crystallin or αB-crystallin with alcohol dehydrogenase or citrate synthase by applying thermal stress. Upon glycation under physiological conditions, the chaperone–client complexes underwent greater extents of cross-linking than did uncomplexed protein mixtures. LC-MS/MS analyses revealed that the levels of cross-linking AGEs were significantly higher in the glycated chaperone–client complexes than in glycated but uncomplexed protein mixtures. Mouse lenses subjected to thermal stress followed by glycation lost resilience more extensively than lenses subjected to thermal stress or glycation alone, and this loss was accompanied by higher protein cross-linking and higher cross-linking AGE levels. These results uncover a protein cross-linking mechanism in the lens and suggest that AGE-mediated cross-linking of α-crystallin–client complexes could contribute to lens aging and presbyopia.

Contact between inflammatory cells and endothelial cells (ECs) is a crucial step in vascular inflammation. Recently, we demonstrated that the cell-surface level of endomucin (EMCN), a heavily O-glycosylated single-transmembrane sialomucin, interferes with the interactions between inflammatory cells and ECs. We have also shown that, in response to an inflammatory stimulus, EMCN is cleared from the cell surface by an unknown mechanism. In this study, using adenovirus-mediated overexpression of a tagged EMCN in human umbilical vein ECs, we found that treatment with tumor necrosis factor α (TNF-α) or the strong oxidant pervanadate leads to loss of cell-surface EMCN and increases the levels of the C-terminal fragment of EMCN 3- to 4-fold. Furthermore, treatment with the broad-spectrum matrix metalloproteinase inhibitor batimastat (BB94) or inhibition of ADAM metallopeptidase domain 10 (ADAM10) and ADAM17 with two small-molecule inhibitors, GW280264X and GI254023X, or with siRNA significantly reduced basal and TNFα-induced cell-surface EMCN cleavage. Release of the C-terminal fragment of EMCN by TNF-α treatment was blocked by chemical inhibition of ADAM10 alone or in combination with ADAM17. These results indicate that cell-surface EMCN undergoes constitutive cleavage and that TNF-α treatment dramatically increases this cleavage, which is mediated predominantly by ADAM10 and ADAM17. As endothelial cell-surface EMCN attenuates leukocyte–EC interactions during inflammation, we propose that EMCN is a potential therapeutic target to manage vascular inflammation.