cat Application deadline extended for First School Allocation Exercise 2020 for allocation of five new estate kindergarten premises By www.info.gov.hk Published On :: Thu, 30 Jan 2020 17:58:19 Full Article
cat Application arrangements for Scheme for Admission of Hong Kong Students to Mainland Higher Education Institutions for 2020 By www.info.gov.hk Published On :: Tue, 25 Feb 2020 16:46:14 Full Article
cat Award Scheme for Learning Experiences under Qualifications Framework opens for application By www.info.gov.hk Published On :: Fri, 20 Mar 2020 11:13:39 Full Article
cat New notification arrangements on Secondary One discretionary places and distribution of school choice documents for Central Allocation By www.info.gov.hk Published On :: Tue, 24 Mar 2020 15:51:38 Full Article
cat Integration and Application of Knowledge, Experience and Resources Supporting Students with Special Educational Needs in the Epidemic By www.edb.gov.hk Published On :: Tue, 07 Apr 2020 18:09:16 Full Article
cat Appointment of new member to Advisory Committee on Gifted Education By www.info.gov.hk Published On :: Fri, 17 Apr 2020 11:08:29 Full Article
cat Re-appointment of Chairman of Council of Education University of Hong Kong By www.info.gov.hk Published On :: Thu, 23 Apr 2020 11:03:42 Full Article
cat Primary One Central Allocation results to be posted to parents in early June By www.info.gov.hk Published On :: Thu, 23 Apr 2020 14:50:24 Full Article
cat Application for Exemption from the Language Proficiency Requirement is to close on 29 May 2020 By www.edb.gov.hk Published On :: Thu, 30 Apr 2020 00:00:02 Full Article
cat Support schemes applications open By www.news.gov.hk Published On :: Sat, 18 Apr 2020 00:00:00 +0800 The Government today announced that applications are open for several support schemes following the funding approval of the second round of the Anti-epidemic Fund and other relief measures by the Legislative Council Finance Committee. The Club-house Subsidy Scheme, which provides a one-off subsidy of $100,000 to eligible club-houses, is now open for application. The deadline for application is May 18. Upon submission of the completed application form and supporting documents, the disbursement of subsidies could generally be made in around two weeks. The Travel Agents & Practitioners Support Scheme and the Hotel Sector Support Scheme are also open for applications, with the deadlines on June 15 and May 18 respectively. The Subsidy Scheme for the Refuse Transfer Station Account Holders for Transporting Municipal Solid Waste, which offers a one-off subsidy of $8,000 to each of the eligible private municipal solid waste collectors operating in the first quarter, was also endorsed. To ease the application procedures, the Environmental Protection Department will post cheques to recipients of this special subsidy in about a week after the funding endorsement. Meanwhile, the total guarantee commitment of the Special 100% Loan Guarantee under the SME Financing Guarantee Scheme has been increased to $50 billion. The maximum loan amount per enterprise has been increased to $4 million and the principal moratorium arrangement has been extended to the first 12 months. The Special 100% Loan Guarantee will start receiving applications from April 20 and the application period has been extended to one year. Full Article
cat SAS Notes for SAS®9 - 65925: Clicking a URL for a stored process in Excel brings up the SAS Stored Process Web Application Welcome page By feedproxy.google.com Published On :: Tue, 5 May 2020 17:23:17 EST After you submit a stored process from the SAS Stored Process Web Application, the generated URL is placed into a cell in a Microsoft Excel worksheet. When you click this URL, you expect that the stored process is sub Full Article BISRVTIER+BI+Server+Tier
cat SAS Notes for SAS®9 - 65885: The ability to connect to a Google BigQuery database via OAuth Authentication has been added to SAS/ACCESS Interface to Google BigQuery By feedproxy.google.com Published On :: Fri, 1 May 2020 09:59:50 EST The ability to connect to a Google BigQuery database via OAuth is now available with this hot fix. Three new options have been added, REFRESH_TOKEN=, CLIENT_ID=, and CLIENT_SECRET=. You can use these options with Full Article BIGQUERY+SAS/ACCESS+Interface+to+Google+
cat Clinical implications of chromatin accessibility in human cancers By www.eurekalert.org Published On :: Tue, 05 May 2020 00:00:00 EDT (Impact Journals LLC) Volume 11, Issue 18 of @Oncotarget Clinical implications of chromatin accessibility assessed by ATAC-seq profiling in human cancers especially in a large patient cohort is largely unknown. Full Article
cat Indicators of cancer may also be markers of heart failure By www.eurekalert.org Published On :: Wed, 06 May 2020 00:00:00 EDT (Wiley) Heart failure and cancer are conditions with a number of shared characteristics. A new study published in the Journal of Internal Medicine found that in patients with heart failure, several known tumor markers can also be indicators of heart failure severity and progression. Full Article
cat Diminished returns of educational attainment on heart disease among black Americans By www.eurekalert.org Published On :: Wed, 06 May 2020 00:00:00 EDT (Bentham Science Publishers) Using a nationally representative sample, the researchers explored racial/ethnic variation in the link between educational attainment and heart disease among American adults. Full Article
cat Free use of Kudos Pro to help researchers keep communicating during pandemic disruption By www.eurekalert.org Published On :: Fri, 01 May 2020 00:00:00 EDT (Kudos Innovations Ltd) Kudos helps researchers maximize reach and visibility of research by opening up Kudos Pro. The platform helps showcase work to a range of target audiences, supporting researchers in fields where conferences have been cancelled -- and those with COVID-19-relevant work that needs rapid communication. Over 2,000 researchers have already signed up. Full Article
cat Archaeologists verify Florida's Mound Key as location of elusive Spanish fort By www.eurekalert.org Published On :: Thu, 23 Apr 2020 00:00:00 EDT (Florida Museum of Natural History) Florida and Georgia archaeologists have discovered the location of Fort San Antón de Carlos, home of one of the first Jesuit missions in North America. The Spanish fort was built in 1566 in the capital of the Calusa, the most powerful Native American tribe in the region, on present-day Mound Key in the center of Estero Bay on Florida's Gulf Coast. Full Article
cat Global trade in soy has major implications for the climate By www.eurekalert.org Published On :: Thu, 07 May 2020 00:00:00 EDT (University of Bonn) The extent to which Brazilian soy production and trade contribute to climate change depends largely on the location where soybeans are grown. This is shown by a recent study conducted by the University of Bonn together with partners from Spain, Belgium and Sweden. In some municipalities, CO2 emissions resulting from the export of soybean and derivatives are more than 200 times higher than in others. Full Article
cat Ocean acidification prediction now possible years in advance By www.eurekalert.org Published On :: Fri, 01 May 2020 00:00:00 EDT (University of Colorado at Boulder) CU Boulder researchers have developed a method that could enable scientists to accurately forecast ocean acidity up to five years in advance. This would enable fisheries and communities that depend on seafood negatively affected by ocean acidification to adapt to changing conditions in real time, improving economic and food security in the next few decades. Full Article
cat A standard for real-time calculation of pollutant emissions allocated to the use of ICT By www.eurekalert.org Published On :: Fri, 08 May 2020 00:00:00 EDT (École de technologie supérieure) The first ever standard for real-time calculation of pollutant emissions allocated to the use of information and communication technologies (ICT) was recently introduced, thanks to the work of the IEEE ICT Emissions Working Group Committe, chaired by Mohamed Cheriet, a Professor in the Systems Engineering Department at École de technologie supérieure. Under the auspices of the IEEE Standards Association, the Working Group Committee is made up of researchers from diverse backgrounds and many different countries. Full Article
cat Tran receives scholarship honoring women in higher education By www.eurekalert.org Published On :: Fri, 08 May 2020 00:00:00 EDT (Medical College of Georgia at Augusta University) Lynn Tran, a student in the University System of Georgia MD/PhD program at the Medical College of Georgia at Augusta University, has received a Louise McBee Scholarship from the Georgia Association for Women in Higher Education. Full Article
cat Position statement addresses difficult issue: allocating scare resources in COVID-19 era By www.eurekalert.org Published On :: Wed, 06 May 2020 00:00:00 EDT (American Geriatrics Society) The COVID-19 pandemic has placed unprecedented pressure on societies worldwide, given the pandemic's rapid, often deadly spread. In health care, the pandemic has raised the pressing question of how society should allocate scarce resources during a crisis. This is the question experts addressed today in a new position statement published by the American Geriatrics Society (AGS) in the Journal of the American Geriatrics Society (DOI: 10.1111/jgs.16537). Full Article
cat Drug Interactions of Medications Commonly Used in Diabetes By spectrum.diabetesjournals.org Published On :: 2006-10-01 Curtis TriplittOct 1, 2006; 19:202-211Pharmacy Update Full Article
cat Addressing Health Literacy and Numeracy to Improve Diabetes Education and Care By spectrum.diabetesjournals.org Published On :: 2010-10-01 Richard O. WhiteOct 1, 2010; 23:238-243Articles Full Article
cat Insights From the National Diabetes Education Program National Diabetes Survey: Opportunities for Diabetes Self-Management Education and Support By spectrum.diabetesjournals.org Published On :: 2017-05-01 Linda J. PiccininoMay 1, 2017; 30:95-100From Research to Practice Full Article
cat Iatrogenic Inpatient Hypoglycemia: Risk Factors, Treatment, and Prevention: Analysis of Current Practice at an Academic Medical Center With Implications for Improvement Efforts By spectrum.diabetesjournals.org Published On :: 2008-10-01 Gregory A. MaynardOct 1, 2008; 21:241-247Articles Full Article
cat Educator Experience with the U.S. Diabetes Conversation Map(R) Education Program in the Journey for Control of Diabetes: The IDEA Study By spectrum.diabetesjournals.org Published On :: 2010-07-01 Omar D. FernandesJul 1, 2010; 23:194-198Care Innovations Full Article
cat Diabetes Self-Management Education for Older Adults: General Principles and Practical Application By spectrum.diabetesjournals.org Published On :: 2006-10-01 Emmy SuhlOct 1, 2006; 19:234-240Articles Full Article
cat Making a Difference With Interactive Technology: Considerations in Using and Evaluating Computerized Aids for Diabetes Self-Management Education By spectrum.diabetesjournals.org Published On :: 2001-04-01 Russell E. GlasgowApr 1, 2001; 14:Feature Articles Full Article
cat Associations Between Self-Management Education and Comprehensive Diabetes Clinical Care By spectrum.diabetesjournals.org Published On :: 2010-01-01 Tammie M. JohnsonJan 1, 2010; 23:41-46Feature Articles Full Article
cat Implementing Diabetes Self-Management Education in Primary Care By spectrum.diabetesjournals.org Published On :: 2006-04-01 Sharlene EmersonApr 1, 2006; 19:79-83Articles Full Article
cat Group Education in Diabetes: Effectiveness and Implementation By spectrum.diabetesjournals.org Published On :: 2003-04-01 Carolé R. MensingApr 1, 2003; 16:Articles Full Article
cat Four Theories and a Philosophy: Self-Management Education for Individuals Newly Diagnosed With Type 2 Diabetes By spectrum.diabetesjournals.org Published On :: 2003-04-01 T. Chas SkinnerApr 1, 2003; 16:Lifestyle and Behavior Full Article
cat J’can healthcare worker dies from COVID-19-related complications By jamaica-star.com Published On :: Thu, 07 May 2020 05:01:09 -0500 Antoniette Bryden has fond memories of her mother, Arlene Reid, 51, a healthcare worker originally from Yallahs, St Thomas, who died of COVID-19 in Brampton, Ontario, Canada, on April 27. Reid, a personal support worker (PSW) who worked part-time... Full Article
cat COVID-19: Economic Implications for Japan and the United States By www8.gsb.columbia.edu Published On :: Fri, 01 May 2020 00:00:00 -0400 Exploring the economic implications of COVID-19 on Japan and the US. Full Article
cat State Cyber Interventions Below the Threshold of the Use of Force: Challenges in the Application of International Law By feedproxy.google.com Published On :: Wed, 17 Apr 2019 10:45:01 +0000 Invitation Only Research Event 30 April 2019 - 10:00am to 4:00pm Chatham House | 10 St James's Square | London | SW1Y 4LE Event participants Chair: Elizabeth Wilmshurst, Distinguished Fellow, International Law Programme, Chatham House Under what circumstances will a state-sponsored cyberattack on another state that falls below the threshold of the use of force be a breach of international law – for example, hacking into another state’s electoral databases, usurping inherently governmental functions such as parliamentary processes or an attack on another state’s financial system? In the dynamic field of state cyber operations, persistent, low-level cyberattacks are increasing, as are multilateral attempts to attribute the attacks to the states responsible. There is general agreement that international law applies to cyberspace but the question is how it applies and with what consequences. This meeting will bring together a small group of academics and practitioners to explore the application of international law to states’ cyber operations that interfere in the internal affairs of another state and which fall below the threshold of the use of force. What is the law on non-intervention in international law and how does it apply to states’ cyber activities? Does the Nicaragua case represent the best expression of the law in this area including the requirement of coercion? And are there any other principles of international law that are relevant? The meeting will also consider processes and procedures for agreeing on the law and best practices. The purpose of the meeting will be to inform a research paper by Chatham House. Attendance at this event is by invitation only. Event attributes Chatham House Rule Department/project International Law Programme Full Article
cat Sovereignty and Non-Intervention: The Application of International Law to State Cyberattacks By feedproxy.google.com Published On :: Fri, 01 Nov 2019 10:55:01 +0000 Research Event 4 December 2019 - 5:30pm to 7:00pm Chatham House | 10 St James's Square | London | SW1Y 4LE Event participants Douglas, Legal Director, GCHQZhixiong Huang, Luojia Chair of International Law, Wuhan UniversityNemanja Malisevic, Director of Digital Diplomacy, MicrosoftHarriet Moynihan, Associate Fellow, International Law Programme, Chatham HouseChair: Elizabeth Wilmshurst, Distinguished Fellow, International Law Programme, Chatham House International law applies to cyber operations – but views differ on exactly how. Does state-sponsored interference in another state's affairs using cyber means – for example, disinformation campaigns in elections, disabling government websites, or disrupting transport systems – breach international law? If so, on what basis and how are the principles of sovereignty and non-intervention relevant? States are increasingly attributing cyber operations to other states and engaging in the debate on how international law applies, including circumstances that would justify countermeasures.As states meet to debate these issues at the UN, the panel will explore how international law regulates cyberoperations by states, consider the prospects of progress at the UN, and assess the value of other initiatives.This event coincides with the launch of a Chatham House research paper which analyses how the principles of sovereignty and intervention apply in the context of cyberoperations, and considers a way forward for agreeing a common understanding of cyber norms.This event will bring together a broad group of actors, including policymakers, the private sector, legal experts and civil society, and will be followed by a drinks reception. Department/project International Law Programme, Cyber, Sovereignty and Human Rights Jacqueline Rowe Programme Assistant, International Law Programme 020 7389 3287 Email Full Article
cat The Application of International Law to State Cyberattacks: Sovereignty and Non-Intervention By feedproxy.google.com Published On :: Fri, 29 Nov 2019 16:56:12 +0000 2 December 2019 Hostile cyber operations by one state against another state are increasingly common. This paper analyzes the application of the sovereignty and non-intervention principles in relation to states’ cyber operations in another state below the threshold of the use of force. Read online Download PDF Harriet Moynihan Senior Research Fellow, International Law Programme @HarrietMoyniha9 2019-11-29-Intl-Law-Cyberattacks.jpg A computer hacked by a virus known as Petya. The Petya ransomware cyberattack hit computers of Russian and Ukrainian companies on 27 June 2017. Photo: Getty Images. SummaryThe vast majority of state-to-state cyberattacks consist of persistent, low-level intrusions that take place below the threshold of use of force. International law, including the principle of non-intervention in another state’s internal affairs and the principle of sovereignty, applies to these cyber operations.It is not clear whether any unauthorized cyber intrusion would violate the target state’s sovereignty, or whether there is a threshold in operation. While some would like to set limits by reference to effects of the cyber activity, at this time such limits are not reflected in customary international law. The assessment of whether sovereignty has been violated therefore has to be made on a case by case basis, if no other more specific rules of international law apply.In due course, further state practice and opinio iuris may give rise to an emerging cyber-specific understanding of sovereignty, just as specific rules deriving from the sovereignty principle have crystallized in other areas of international law.Before a principle of due diligence can be invoked in the cyber context, further work is needed by states to agree upon rules as to what might be expected of a state in this context.The principle of non-intervention applies to a state’s cyber operations as it does to other state activities. It consists of coercive behaviour by one state that deprives the target state of its free will in relation to the exercise of its sovereign functions in order to compel an outcome in, or conduct with respect to, a matter reserved to the target state.In practice, activities that contravene the non-intervention principle and activities that violates sovereignty will often overlap.In order to reach agreement on how international law applies to states’ cyber operations below the level of use of force, states should put their views on record, where possible giving examples of when they consider that an obligation may be breached, as states such as the UK, Australia, France and the Netherlands have done.Further discussion between states should focus on how the rules apply to practical examples of state-sponsored cyber operations. There is likely to be more commonality about specific applications of the law than there is about abstract principles.The prospects of a general treaty in this area are still far off. In due course, there may be benefit in considering limited rules, for example on due diligence and a prohibition on attacking critical infrastructure, before tackling broad principles. Department/project International Law Programme, Cyber, Sovereignty and Human Rights Full Article
cat 12-LOX catalyzes the oxidation of 2-arachidonoyl-lysolipids in platelets generating eicosanoid-lysolipids that are attenuated by iPLA2{gamma} knockout [Signal Transduction] By feedproxy.google.com Published On :: 2020-04-17T00:06:05-07:00 The canonical pathway of eicosanoid production in most mammalian cells is initiated by phospholipase A2-mediated release of arachidonic acid, followed by its enzymatic oxidation resulting in a vast array of eicosanoid products. However, recent work has demonstrated that the major phospholipase in mitochondria, iPLA2γ (patatin-like phospholipase domain containing 8 (PNPLA8)), possesses sn-1 specificity, with polyunsaturated fatty acids at the sn-2 position generating polyunsaturated sn-2-acyl lysophospholipids. Through strategic chemical derivatization, chiral chromatographic separation, and multistage tandem MS, here we first demonstrate that human platelet-type 12-lipoxygenase (12-LOX) can directly catalyze the regioselective and stereospecific oxidation of 2-arachidonoyl-lysophosphatidylcholine (2-AA-LPC) and 2-arachidonoyl-lysophosphatidylethanolamine (2-AA-LPE). Next, we identified these two eicosanoid-lysophospholipids in murine myocardium and in isolated platelets. Moreover, we observed robust increases in 2-AA-LPC, 2-AA-LPE, and their downstream 12-LOX oxidation products, 12(S)-HETE-LPC and 12(S)-HETE-LPE, in calcium ionophore (A23187)-stimulated murine platelets. Mechanistically, genetic ablation of iPLA2γ markedly decreased the calcium-stimulated production of 2-AA-LPC, 2-AA-LPE, and 12-HETE-lysophospholipids in mouse platelets. Importantly, a potent and selective 12-LOX inhibitor, ML355, significantly inhibited the production of 12-HETE-LPC and 12-HETE-LPE in activated platelets. Furthermore, we found that aging is accompanied by significant changes in 12-HETE-LPC in murine serum that were also markedly attenuated by iPLA2γ genetic ablation. Collectively, these results identify previously unknown iPLA2γ-initiated signaling pathways mediated by direct 12-LOX oxidation of 2-AA-LPC and 2-AA-LPE. This oxidation generates previously unrecognized eicosanoid-lysophospholipids that may serve as biomarkers for age-related diseases and could potentially be used as targets in therapeutic interventions. Full Article
cat Glucocerebrosidases catalyze a transgalactosylation reaction that yields a newly-identified brain sterol metabolite, galactosylated cholesterol [Glycobiology and Extracellular Matrices] By feedproxy.google.com Published On :: 2020-04-17T00:06:05-07:00 β-Glucocerebrosidase (GBA) hydrolyzes glucosylceramide (GlcCer) to generate ceramide. Previously, we demonstrated that lysosomal GBA1 and nonlysosomal GBA2 possess not only GlcCer hydrolase activity, but also transglucosylation activity to transfer the glucose residue from GlcCer to cholesterol to form β-cholesterylglucoside (β-GlcChol) in vitro. β-GlcChol is a member of sterylglycosides present in diverse species. How GBA1 and GBA2 mediate β-GlcChol metabolism in the brain is unknown. Here, we purified and characterized sterylglycosides from rodent and fish brains. Although glucose is thought to be the sole carbohydrate component of sterylglycosides in vertebrates, structural analysis of rat brain sterylglycosides revealed the presence of galactosylated cholesterol (β-GalChol), in addition to β-GlcChol. Analyses of brain tissues from GBA2-deficient mice and GBA1- and/or GBA2-deficient Japanese rice fish (Oryzias latipes) revealed that GBA1 and GBA2 are responsible for β-GlcChol degradation and formation, respectively, and that both GBA1 and GBA2 are responsible for β-GalChol formation. Liquid chromatography–tandem MS revealed that β-GlcChol and β-GalChol are present throughout development from embryo to adult in the mouse brain. We found that β-GalChol expression depends on galactosylceramide (GalCer), and developmental onset of β-GalChol biosynthesis appeared to be during myelination. We also found that β-GlcChol and β-GalChol are secreted from neurons and glial cells in association with exosomes. In vitro enzyme assays confirmed that GBA1 and GBA2 have transgalactosylation activity to transfer the galactose residue from GalCer to cholesterol to form β-GalChol. This is the first report of the existence of β-GalChol in vertebrates and how β-GlcChol and β-GalChol are formed in the brain. Full Article
cat Genetic Profile and Functional Proteomics of Anal Squamous Cell Carcinoma: Proposal for a Molecular Classification By feedproxy.google.com Published On :: 2020-04-01 Lucía Trilla-FuertesApr 1, 2020; 19:690-700Research Full Article
cat The DNA sensor cGAS is decorated by acetylation and phosphorylation modifications in the context of immune signaling By feedproxy.google.com Published On :: 2020-04-28 Bokai SongApr 28, 2020; 0:RA120.001981v1-mcp.RA120.001981Research Full Article
cat Seminal Plasma Proteome as an Indicator of Sperm Dysfunction and Low Sperm Motility By feedproxy.google.com Published On :: 2020-04-20 Yunlei LiApr 20, 2020; 0:RA120.002017v1-mcp.RA120.002017Research Full Article
cat Robust summarization and inference in proteome-wide label-free quantification By feedproxy.google.com Published On :: 2020-04-22 Adriaan StickerApr 22, 2020; 0:RA119.001624v1-mcp.RA119.001624Research Full Article
cat Developments and Applications of Functional Protein Microarrays By feedproxy.google.com Published On :: 2020-04-17 Guan-Da SyuApr 17, 2020; 0:R120.001936v1-mcp.R120.001936Review Full Article
cat Identification of an Unconventional Subpeptidome Bound to the Behcet's Disease-associated HLA-B*51:01 that is Regulated by Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) By feedproxy.google.com Published On :: 2020-05-01 Liye ChenMay 1, 2020; 19:871-883Research Full Article
