All this foreign involvement has failed to prevent the recent coup or stabilize its aftermath. BINUCA has not been able to implement a disarmament, demobilisation and reintegration program, and it failed to convince Bozizé’s regime to reform the security sector or consolidate the peace. ECCAS has been unable to restore order in one of the smallest capitals of Africa, and troop-contributing countries have proved unable to deliver the 600 extra soldiers they committed to provide in April. Paradoxically, France, while securing Bangui’s airport, is also hosting ousted president Bozizé, who declared from exile in Paris his wish to retake power by force with the “support” of private actors.

The crisis that has been occurring in CAR is certainly the most dramatic in its history: more than 600 000 Central Africans are internally displaced or sought refuge in neighbouring countries; according to the United Nations, 1.7 million live in a constant situation of food insecurity and 878 000 need immediate medical assistance; Muslim communities are fleeing Bangui and the western region, subsistence economy no longer exists and the de facto partition of the country, caused by the sectarian violence, is gradually becoming a reality.

Since 2012, single low dose of primaquine (SLDPQ, 0.25mg/kg) has been recommended with artemisinin-based combination therapies, as first-line treatment of acute uncomplicated Plasmodium falciparum malaria, to interrupt its transmission, especially in low transmission settings of multidrug, including artemisinin, resistance. Policy makers in Cambodia have been reluctant to implement this recommendation due to primaquine safety concerns and lack of data on its efficacy.

In this randomized controlled trial, 109 Cambodians with acute uncomplicated P. falciparum malaria received dihydroartemisinin-piperaquine (DP) alone or combined with SLDPQ on the first treatment day. Transmission-blocking efficacy of SLDPQ was evaluated on Days 0, 1, 2, 3, 7, 14, 21, 28 and recrudescence by reverse transcriptase polymerase chain reaction (RT-PCR) (gametocyte prevalence) and membrane-feeding assays with Anopheles minimus mosquitoes (gametocyte infectivity). Without the influence of recrudescent infections, DP+SLDPQ reduced gametocyte carriage 3 fold compared to DP. Of 48 patients tested on Day 0, only three patients were infectious to mosquitoes (~6%). Post-treatment, three patients were infectious: on D14 (3.5%, 1/29), and on the first and seventh day of recrudescence (8.3%, 1/12 for each); this overall low infectivity precluded our ability to assess its transmission blocking efficacy.

Our study confirms effective gametocyte clearance of SLDPQ when combined with DP in multidrug resistant P. falciparum and the negative impact of recrudescent infections due to poor DP efficacy. Artesunate-mefloquine (ASMQ) has replaced DP and ASMQ-SLDPQ has been deployed to treat all P. falciparum symptomatic patients to further support the elimination of multidrug resistant P. falciparum in Cambodia.

Carbapenems are currently the preferred agents for the treatment of serious Acinetobacter infections. However, whether cefepime/cefpirome can be used to treat Acinetobacter bloodstream infection (BSI) if it is active against the causative pathogens is not clear. This study aimed to compare the efficacy of cefepime/cefpirome and carbapenem monotherapy in patients with Acinetobacter BSI. The population included 360 patients with monomicrobial Acinetobacter BSI receiving appropriate antimicrobial therapy admitted to four medical centres in Taiwan in 2012–2017. The predictors of 30-day mortality were determined by Cox regression analysis. The overall 30-day mortality rate in the appropriate antibiotic treatment group was 25.0% (90/360 patients), respectively. The crude 30-day mortality rates for cefepime/cefpirome and carbapenem therapy were 11.5% (7/61 patients) and 26.3% (21/80 patients), respectively. The patients receiving cefepime/cefpirome/carbapenem therapy were infected by Acinetobacter nosocomialis (51.8%), A. baumannii (18.4%) and A. pittii (12.1%). After adjusting for age, Sequential Organ Failure Assessment (SOFA) score, invasive procedures, and underlying diseases, cefepime/cefpirome therapy was not independently associated with a higher or lower 30-day mortality compared to the carbapenem therapy. SOFA score (hazard ratio [HR], 1.324; 95% confidence interval [CI], 1.137–1.543; P < 0.001) and neutropenia (HR, 7.060; 95% CI, 1.607–31.019; P = 0.010) were independent risk factors for 30-day mortality of patients receiving cefepime/cefpirome or carbapenem monotherapy. The incidence density of 30-day mortality for cefepime/cefpirome versus carbapenem therapy was 0.40% versus 1.04%. The therapeutic response of cefepime/cefpirome therapy was comparable to that of carbapenems among patients with Acinetobacter BSI receiving appropriate antimicrobial therapy.

Carbapenem-resistant Gram-negative pathogens are a critical public health threat and there is an urgent need for new treatments. Carbapenemases (β-lactamases able to inactivate carbapenems) have been identified in both serine β-lactamase (SBL) and metallo β-lactamase (MBL) families. The recent introduction of SBL carbapenemase-inhibitors has provided alternative therapeutic options. Unfortunately, there are no approved inhibitors of MBL-mediated carbapenem-resistance and treatment options for infections caused by MBL-producing Gram-negatives are limited. Here, we present ZN148, a zinc-chelating MBL-inhibitor capable of restoring the bactericidal effect of meropenem and in vitro clinical susceptibility to carbapenems in >98% of a large international collection of MBL-producing clinical Enterobacterales strains (n=234). Moreover, ZN148 was able to potentiate the effect of meropenem against NDM-1-producing Klebsiella pneumoniae in a murine neutropenic peritonitis model. ZN148 showed no inhibition of the human zinc-containing enzyme glyoxylase II at 500 μM and no acute toxicity was observed in an in vivo mouse model with cumulative dosages up to 128 mg/kg. Biochemical analysis showed a time-dependent inhibition of MBLs by ZN148 and removal of zinc ions from the active site. Addition of exogenous zinc after ZN148 exposure only restored MBL activity by ~30%, suggesting an irreversible mechanism of inhibition. Mass-spectrometry and molecular modelling indicated potential oxidation of the active site Cys221 residue. Overall, these results demonstrate the therapeutic potential of a ZN148-carbapenem combination against MBL-producing Gram-negative pathogens and that ZN148 is a highly promising MBL inhibitor, capable of operating in a functional space not presently filled by any clinically approved compound.

Background: Intensive care unit (ICU) patients may experience ceftriaxone underexposure but clinical outcomes data are lacking. The objective of this study was to determine the impact of ceftriaxone dosing on clinical outcomes amongst ICU patients without central nervous system (CNS) infection.

Methods: A retrospective study of ICU patients receiving intravenous, empiric ceftriaxone for non-CNS infections was conducted. Patients ≥18 years of age who received ≤2 grams of ceftriaxone daily for ≥72 hours were included and categorized as receiving ceftriaxone 1 gram or 2 grams daily. The primary, composite outcome was treatment failure: inpatient mortality and/or antibiotic escalation due to clinical worsening. Propensity score matching was performed based on the probability of receiving ceftriaxone 2 grams daily. Multivariable logistic regression determined the association between ceftriaxone dose and treatment failure in a propensity-matched cohort.

Results: A total of 212 patients were included in the propensity-matched cohort. The most common diagnoses (83.0%) were pneumonia and urinary tract infection. Treatment failure occurred in 17.0% and 5.7% of patients receiving 1 gram and 2 grams daily, respectively (p=0.0156). Overall inpatient mortality was 8.5%. Ceftriaxone 2 gram dosing was associated with a reduced likelihood of treatment failure (adjusted odds ratio=0.190; 95% confidence interval: 0.059 – 0.607). Other independent predictors of treatment failure included sequential organ failure assessment score (aOR 1.440, 95% CI 1.254 – 1.653) and creatinine clearance at 72 hours from ceftriaxone initiation (aOR 0.980, 95% CI (0.971 – 0.999).

Conclusions: Ceftriaxone 2 grams daily when used as appropriate antimicrobial coverage may be appropriate for ICU patients with lower mortality risk.

There is an urgent need for new, potent anti-tuberculosis (TB) drugs with novel mechanisms of action that can be included in new regimens to shorten the treatment period for TB. After screening a library of carbostyrils, we optimized 3, 4-dihydrocarbostyril derivatives and identified OPC-167832 as having potent anti-tuberculosis activity. The minimum inhibitory concentrations of the compound for Mycobacterium tuberculosis ranged from 0.00024 to 0.002 μg/mL. It had bactericidal activity against both growing and intracellular bacilli, and the frequency of spontaneous resistance for Mycobacterium tuberculosis H37Rv was less than 1.91 x 10^-7. It did not show antagonistic effects with other anti-TB agents in an in vitro checkerboard assay. Whole genome and targeted sequencing of resistant isolates to OPC-167832 identified the decaprenylphosphoryl-β-D-ribose 2'-oxidase (DprE1), an essential enzyme for cell wall biosynthesis, as the target of this compound, and further studies demonstrated inhibition of the DprE1 enzymatic activity by OPC-167832. In a mouse model of chronic TB, OPC-167832 showed potent bactericidal activities starting at a dose of 0.625 mg/kg. Further, it exhibited significant combination effects in 2-drug combinations with delamanid, bedaquiline, or levofloxacin. Finally, 3-4 drug regimens comprised of delamanid and OPC-167832 as the core along with bedaquiline, moxifloxacin, or linezolid showed superior efficacy in reducing bacterial burden and preventing relapse compared to the standard treatment regimen. In summary, these results suggest that OPC-167832 is a novel and potent anti-TB agent and regimens containing OPC-167832 and new or repurposed anti-TB drugs may have the potential to shorten the duration of treatment for TB.

Probiotics might provide an alternative approach for the control of oral candidiasis. However, studies on the antifungal activity of probiotics in the oral cavity are based on the consumption of yogurt or other dietary products, and there is a necessary to use appropriate biomaterials and specific strains to obtain probiotic formulations targeting local oral administration. In this study, we impregnated gellan gum, a natural biopolymer used as a food-additive, with a probiotic and investigated its antifungal activity against Candida albicans. Lactobacillus paracasei 28.4, a strain recently isolated from the oral cavity of a caries-free individual, was incorporated in several concentrations of gellan gum (0.6% to 1%). All tested concentrations could incorporate L. paracasei cells while maintaining bacterial viability. Probiotic/gellan formulations were stable for 7 days when stored at room temperature or 4°C. Long-term storage of bacteria-impregnated gellan gum was achieved when L. paracasei 28.4 was lyophilized. The probiotic/gellan formulations provided a release of L. paracasei cells over 24 hours that was sufficient to inhibit the growth of C. albicans with effects dependent on the cell concentrations incorporated into gellan gum. The probiotic/gellan formulations also had inhibitory activity against Candida spp. biofilms by reducing the number of Candida spp. cells (p < 0.0001), decreasing the total biomass (p = 0.0003), and impairing hyphae formation (p = 0.0002), compared to the control group which received no treatment. Interestingly, probiotic formulation of 1% w/v gellan gum provided an oral colonization of L. paracasei in mice with approximately 6 log of CFU/mL after 10 days. This formulation inhibited the C. albicans growth (p < 0.0001), prevented the development of candidiasis lesions (p = 0.0013), and suppressed inflammation (p = 0.0006) when compared to the mice not treated in the microscopic analysis of the tongue dorsum. These results indicate that gellan gum is a promising biomaterial and can be used as a carrier system to promote oral colonization for probiotics that prevent oral candidiasis.

We report the first clinical Escherichia. coli strain EC3000 with concomitant chromosomal colistin and carbapenem resistance. A novel in-frame deletion, 6-11(RPISLR), in pmrB contributing to colistin resistance was verified using recombinant DNA techniques. Although decreased fitness compared to the wild-type (WT) strain or EC3000 revertant (chromosomal replacement of WT pmrB in EC3000), a portion of serially passaged EC3000 strains preserving colistin resistance without selective pressure raises the concern for further spread.

Dihydroartemisinin-piperaquine has shown excellent efficacy and tolerability in malaria treatment. However, concerns have been raised of potentially harmful cardiotoxic effects associated with piperaquine. The population pharmacokinetics and cardiac effects of piperaquine were evaluated in 1,000 patients, mostly children enrolled in a multicentre trial from 10 sites in Africa. A linear relationship described the QTc-prolonging effect of piperaquine, estimating a 5.90ms mean QTc-prolongation per 100ng/mL increase in piperaquine concentration. The effect of piperaquine on absolute QTc-interval estimated a mean maximum QTc-interval of 456ms (EC₅₀=209ng/mL). Simulations from the pharmacokinetic-pharmacodynamic models predicted 1.98-2.46% risk of having QTc-prolongation > 60ms in all treatment settings. Although piperaquine administration resulted in QTc-prolongation, no cardiovascular adverse events were found in these patients. Thus, the use of dihydroartemisinin-piperaquine should not be limited by this concern.

Background: MRSA pose significant therapeutic challenges, related to their: frequency in clinical infections; innate virulence properties; and propensity for multi-antibiotic resistance. MRSA are among the most common causes of endovascular infections, including infective endocarditis (IE).

Objective: To employ transthoracic echocardiography (TTE) to evaluate the effect of exebacase, a novel direct lytic agent, in experimental aortic valve MRSA IE.

Study Design: TTE was utilized to evaluate the in vivo effect of exebacase on MRSA-infected vegetation progression when combined with daptomycin (vs daptomycin alone). Primary intravegetation outcomes were: maximum size; weights at sacrifice; and MRSA counts at infection baseline vs after 4 days of daptomycin treatment (alone or in addition to exebacase administered once on treatment Day 1).

Results: A single dose of exebacase in addition to daptomycin cleared significantly more intravegetation MRSA than daptomycin alone. This was associated with a statistical trend toward reduced maximum vegetation size in the exebacase + daptomycin vs the daptomycin-alone therapy groups (p = 0.07). Also, mean vegetation weights in the exebacase-treated group were significantly lower vs daptomycin-alone (p < 0.0001). Maximum vegetation size by TTE correlated with vegetation weight (p = 0.005). In addition, intravegetation MRSA counts in the combination group were significantly lower vs untreated controls (p<0.0001) and the daptomycin-alone group (p<0.0001).

Conclusion: This study suggests that exebacase has a salutary impact on MRSA-infected vegetation progression when combined with daptomycin, especially in terms of vegetation MRSA burden, size and weight. Moreover, TTE appears to be an efficient non-invasive tool to assess therapeutic efficacies in experimental MRSA IE.

Chagas disease, caused by the protozoan Trypanosoma cruzi, is one of the main causes of death due to cardiomyopathy and heart failure in Latin American countries. The treatment of Chagas disease is directed at eliminating the parasite, decreasing the probability of cardiomyopathy, and disrupting the disease transmission cycle. Benznidazole (BZ) and nifurtimox (NFX) are recognized as effective drugs for the treatment of Chagas disease by the World Health Organization, but both have high toxicity and limited efficacy, especially in the chronic disease phase. At low doses, aspirin (ASA) has been reported to protect against T. cruzi infection. We evaluated the effectiveness of BZ in combination with ASA at low doses during the acute disease phase and evaluated cardiovascular aspects and cardiac lesions in the chronic phase. ASA treatment prevented the cardiovascular dysfunction (hypertension and tachycardia) and typical cardiac lesions. Moreover, BZ+ASA-treated mice had a smaller cardiac fibrotic area than that in BZ-treated mice. These results were associated with an increase in the number of eosinophils and reticulocytes and level of nitric oxide in the plasma and cardiac tissue of ASA-treated mice relative to respective controls. These effects of ASA and BZ+ASA in chronically infected mice were inhibited by pretreatment with the LXA₄ receptor antagonist, Boc-2, indicating that the protective effects of ASA are mediated by ASA-triggered lipoxin. These results emphasize the importance of exploring new drug combinations for treatments of acute phase of Chagas disease that are beneficial for chronic patients.

BACKGROUND:

For children who cannot be discharged from the emergency department, definitive care has become less frequent at most hospitals. It is uncertain whether this is true for common conditions that do not require specialty care. We sought to determine how the likelihood of definitive care has changed for 3 common pediatric conditions: asthma, croup, and gastroenteritis.

BACKGROUND AND OBJECTIVES:

Children with medical complexity (CMC) comprise only 6% of the pediatric population, account for ~40% of pediatric health care spending, and provide an important opportunity for cost saving. Savings in this group can have an important impact on pediatric health care costs. The objective of this study was to assess the impact of a multicenter care management program on spending and use in CMC.

BACKGROUND:

Elevated non–high-density lipoprotein cholesterol (HDL-C) levels are used to identify children at increased cardiovascular risk, but the use of non–HDL-C in childhood to predict atherosclerosis is unclear. We examined whether the National Heart, Lung, and Blood Institute classification of youth non–HDL-C status predicts high common carotid artery intima-media thickness in adulthood.

Jose, an Argentinian worker serving in Southeast Asia, tells of how he entered overseas service and what he has seen God do through his not-so-typical ministry.

Penn State Health today resumed construction of Penn State Health Cocoa Outpatient Center, an expansion of medical services at the former CocoaPlex Center location.

Gauteng, the Western Cape and KwaZulu-Natal are the hot spots for card fraud in South Africa, according to a report on global fraud activity.

Credit card fraud increased to 19.47% as at the end of March 2019, compared to 12.2% reported at the beginning of January 2019.

With credit card fraud rising at an alarming rate in the first quarter of the year, the Ombudsman for Banking Services has provided 10 tips to avoid becoming a victim of scammers.

Automated EFT payments enabled by technology from fintech company Ozow may be a secure alternative method to transact than card payments.

Seven goals in Ljubljana made Portugal winger Ricardinho the all-time top UEFA Futsal EURO finals top scorer: we look at the numbers and the skills behind the man that lifted the trophy, 'O Mágico',

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Jose, an Argentinian worker serving in Southeast Asia, tells of how he entered overseas service and what he has seen God do through his not-so-typical ministry.

It is crucial that all children are provided with high-quality and safe health care. Pediatric inpatient needs are unique in regard to policies, equipment, facilities, and personnel. The intent of this clinical report is to provide recommendations for the resources necessary to provide high-quality and safe pediatric inpatient medical care.

If your battery capacity ever drops below 80 percent when you have AppleCare+, you're in luck!

You don't have to fork over a bunch of cash to get a bunch of storage. PNY flash drives, SD cards, and portable drives are on sale at Amazon, with prices starting as low as $5.84.

A sixth resident has died from coronavirus in a care home on Skye.

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CNA Staff, Mar 31, 2020 / 06:01 pm (CNA).- Local media in Nicaragua are reporting that despite the nation’s bishops’ conference suspending Mass and prohibiting large gatherings, the mayor of Granada is going ahead with an annual pilgrimage that the bishops had canceled.

For more than 150 years, Catholics in Nicaragua have venerated an image of Jesus del Rescate (Jesus of the Rescue) in Popoyuapa, near the city of Rivas. The image represents the crowning of thorns and the flogging of Christ.

Normally there is an annual pilgrimage to the image, which pilgrims make by wagon and on foot, during the "Week of Sorrows" that marks "the final stretch" of the time of Lent, according to ACI Prensa, CNA’s Spanish language news partner.

However, the bishops have said that this year it will not be possible to carry it out in the traditional way, given the coronavirus (COVID-19) pandemic.

Nevertheless, Julia Mena, mayor of Granada, has organized and funded a group of pilgrims to do the pilgrimage, providing them with food and personal hygiene supplies, according to the Nicaraguan news website Confidencial. The priest at the shrine told Confidencial that he has “no plans to receive the pilgrimage.”

The Nicaraguan Episcopal Conference has not commented publicly on the matter.

Nicaragua has five confirmed cases of COVID-19. The government has not yet decreed any kind of alert or emergency regarding the pandemic, nor has it ordered a suspension of classes, Confidencial reports.

The country’s Ministry of Health has maintained that the internal movements of travelers arriving from countries with outbreaks of coronavirus would not be restricted, La Prensa reports.

President Daniel Ortega has been president of Nicaragua since 2007, and oversaw the abolition of presidential term limits in 2014.

The Church had suggested that elections, which are not scheduled until 2021, be held this year, but Ortega has ruled this out.

Ortega was a leader in the Sandinista National Liberation Front, which had ousted the Somoza dictatorship in 1979 and fought US-backed right-wing counterrevolutionaries during the 1980s. Ortega was also leader of Nicaragua from 1979 to 1990.

CNA Staff, Apr 2, 2020 / 02:50 pm (CNA).- The statue of the Nazarene of Saint Paul will be processed April 8 through the streets of Caracas to help the faithful observe Holy Week.

It will be atop a popemobile used by St. John Paul II when he visited the country in 1985.

According to local tradition, the striking image was brought to Caracas from Seville in 1674. The wooden sculpture depicts Christ dressed in an ornately embroidered purple robe carrying his cross.

According to accounts, the image was processed in the city with prayers during a plague that broke out in Caracas in 1696, and the devotional act was credited with ending the pestilence.

The image was originally kept in a church dedicated to Saint Paul the Hermit, whose intercession was attributed to ending a plague in 1579. The wooden sculpture is now reserved in Saint Teresa Basilica, as Saint Paul’s church was demolished and replaced with a municipal theater by an anticlerical president in 1881.

The procession is held annually on Holy Wednesday.

Cardinal Baltazar Enrique Porras Cardozo, Archbishop of Merida and apostolic administrator of Caracas, said the “route will cover a great part of the city for veneration by its devotees,” and asked for understanding as the route itself has not yet been finalized and will be announced later.

According to local media, the prelate said in a letter that the image should be transported in accordance with safety and hygiene regulations to avoid spreading the coronavirus.

Porras said that the image should not be carried by people but transported by vehicle only and there should be another vehicle for a priest and assistant along with sound equipment for the prayers.

The archdiocese said that parishes can join the initiative and organize such a procession in their own areas as long as they observe the proper health precautions.

Finally, the archdiocese asked the faithful devotees of the Nazarene of Saint Paul to offer their prayers from their homes and to wait for the end of the coronavirus lockdown to visit the image in Saint Teresa Basilica.

CNA Staff, Apr 29, 2020 / 04:30 pm (CNA).- Venezuela’s prolonged social, political and economic crisis has only been compounded by the coronavirus pandemic, the archbishop emeritus of Caracas, Cardinal Jorge Urosa Savino, charged Tuesday.

Even before the coronavirus pandemic, Venezuela has been marred by violence and social upheaval under the socialist administration of Nicolas Maduro, with severe shortages of food and medicine, high unemployment, power outages, and hyperinflation. Some 4.5 million Venezuelans have emigrated since 2015.

In response to the threat of the virus, the government imposed a nationwide stay at home order March 17. According to government statistics, to date there have been 329 cases of COVID-19 with ten deaths. The country is ill prepared to handle the crisis, with chronic shortages of medical supplies, and many doctors have left the country.

“The national reality is terrible,” and the government has no answers, Urosa said in an April 28 statement to ACI Prensa, CNA’s Spanish-language news partner.

While the cardinal acknowledged the lockdown has prevented the spread of the virus, he pointed out that “the quarantine has hurt a great many people because the economic, social and logistical conditions in the country weren’t taken into account,” including “the extremely serious problem of the gasoline shortage for transport, especially for food.”

In some cases, crops are rotting in farmers’ fields due to lack of fuel to transport them to market.

Especially hard hit, the cardinal said, are “informal” workers who are paid off the books,  and who are now  “barely surviving,” and only with “the help of family members, social organizations and the Church.”

On April 25, Venezuelan vice president Delcy Rodríguez announced state intervention and oversight of several food supply companies in order to control the prices of 27 products for 180 days.

Urosa criticized the intervention, calling it “an extremely serious mistake, since it will probably result in greater shortages. Price controls are acceptable, but intervening in efficient businesses is not. The government can’t even manage to supply gasoline.” “The state-run petroleum industry has collapsed, and now Venezuelans’ food is in danger!” 

 “The current government doesn’t have any answers for such elementary things such as the extremely serious problem of the gasoline shortage” and runaway inflation. “In the last 40 days, the dollar has doubled in value, which is undoubtedly the fundamental cause of the spike in prices,” the cardinal said.

Urosa decried political persecution, which “has gotten worse since March because amid the quarantine, the government has ramped up the repression. During these weeks the government has jailed, even without due process, many political activists, especially from the inner circle of Juan Guaidó, president of the National Assembly and leader of the Venezuelan opposition.”

Guaidó declared himself the nation's interim leader Jan. 23 last year following Maduro’s inauguration for a second term. Maduro won a May 2018 presidential election, which was boycotted by the opposition and has been rejected by much of the international community. The United States was swift to recognize Guaidó as interim president, eventually followed by over 60 countries. Both the National Assembly and the Venezuelan bishops' conference declared Maduro's reelection to be invalid.

With the military firmly in support of Maduro, however, opposition protests calling for his resignation have failed to oust the leader.

On March 30, Guaidó charged that the Maduro regime had unleashed a new wave of harassment against his close collaborators. Andrea Bianchi, the wife of close associate Rafael Rico, was kidnapped, beaten and then left naked on a highway. Two others, Rómulo García and Víctor Silio were also picked up and later charged with possession of marijuana and a handgun.

The NGO Venezuelan Program for Education-Action in Human Rights reported that during the state of emergency, 34 people have been arbitrarily arrested and attacks against politicians, journalists and healthcare workers have increased.

“The bishops have always strongly criticized the political repression by the government and once again I call for the release of all political prisoners. They are even in greater physical danger because of the pandemic situation we’re going through,” Urosa stressed.

On March 26, “the Trump administration unsealed sweeping indictments against Venezuelan President Nicolás Maduro and members of his inner circle on narcoterrorism charges, a dramatic escalation in the U.S. campaign to force the authoritarian socialist from power,” even offering “a $15 million reward for information leading to his capture or conviction,” the Washington Post reported.

In response, the Maduro regime activated a plan against the Venezuelan opposition called “Operation Bolivarian Fury.”

The archbishop emeritus denounced these recent “threats of violence by the government against Venezuelans. Maduro himself has spoken of a supposed ‘Bolivarian fury’ as a threat against members of the Venezuelan opposition in case of international problems. That’s illegal, unconstitutional and unacceptable from every point of view. That threat of violence is intolerable.” 

The cardinal said the government has used the quarantine simply as an opportunity to strengthen its social and political control.

On April 25, the Maduro regime placed shipping containers on the Caracas-La Guaira highway to prevent demonstrators from other cities who have been protesting the shortages of food, water and electricity in other cities from getting to the capital.

“Why restrict the right to free transit?” the cardinal asked.

The Maduro regime also blocked the highway in February 2019 to prevent humanitarian aid from entering the country from Colombia.

Guaidó charged April 24 on Twitter that “a dictatorship of corrupt and incapable people has brought us to a crisis where farmers are losing their crops while families are starving to death in the barrios. They turned the richest country in the region into a hell. They’ll leave here, the sacrifice has been enough already.”

As signs of hope, Urosa pointed to ongoing work of Caritas Venezuela and the creative ways the clergy has reached out to the faithful through social media. “Our message is one of encouragement, trust in God, solidarity and hope in this dark hour,” he said.

 Catholics “have an unshakeable faith in God who is love,” who had died and risen and “has shown us the merciful face of God.” “We’ll come out of this,” the archbishop said, “the suffering we are experiencing has united us closer to God and opens to us the gates of heaven.”

The archbishop encouraged Venezuelans to always stand in solidarity with each other and “to be the face of God to those in need. God is love and is with us. Let us join ourselves to him and the Blessed Virgin Mary, Mother of Mercy in this painful hour.”

 

A version of this story was first published by ACI Prensa, CNA's Spanish-language news partner. It has been adapted by CNA.

Microsoft originally sought to become a 'carbon neutral' company, meaning it could generate carbon emissions as long as it offset them through other means, but "in short, neutral is not enough to address the world's needs," says Microsoft President Brad Smith.

Penn State Behrend faculty member Michael Campbell has been named distinguished professor of biology. Campbell, who joined the college in 1994, also directs the Lake Erie Regional Grape Research and Extension Center.

The experiences that Chris Eggerman, a 2017 graduate, had while at Penn State gave him a glimpse of the challenges and rewards he would enjoy in a career, and, paired with his education in the College of Information Sciences and Technology, equipped him with the skills he uses in his current profession as a security adviser at Liberty Mutual.

CARO RAMSAY, AUTHOR

Penn State Health St. Joseph has moved swiftly to tackle the COVID-19 crisis, converting portions of its hospital as COVID-19 clinics, applying tried-and-true methods and learning on the fly.

The Association for Clinical and Translational Science recently recognized Steven Hicks for his achievements. Hicks received the Early (Faculty) Career Development Award.

Nurses act as caregiver, adviser, confidante, educator, advocate – often all at once – and for multiple patients. Nurses also shape policies at the national level as representatives of professional organizations. During National Nurses Week, we’re celebrating the important role nurses play, now and every day of the year.

North Carolina officials' switch in reading-test vendors just weeks before the new school year got underway is spotlighting the often murky process of contracts and procurements for K-12 services.

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The Penn State Wilkes-Barre Alumni Society provided lunch for local, hardworking medical professionals as a way to thank them for their efforts during the ongoing coronavirus outbreak and working to keep local residents safe.