Provided herein are mitochondrial-nuclear exchanged cells and animals comprising mitochondrial DNA (mtDNA) from one subject and nuclear DNA (nDNA) from a different subject. Methods for producing a mitochondrial-nuclear exchanged animal and animals made by the methods are provided. Also provided are methods of screening for agents useful for treating a disease or disorder using mitochondrial-nuclear exchanged animals or cells, tissues or organs thereof.

A method of synthesizing a crystalline molecular sieve having an MSE framework type comprises crystallizing a reaction mixture comprising a source of water, a source of an oxide of a tetravalent element, Y, selected from at least one of silicon, tin, titanium, vanadium, and germanium, optionally a source of a trivalent element, X, a source of an alkali or alkaline earth metal, M, and a source of organic dications, Q, such as 3-hydroxy-1-(4-(1-methylpiperidin-1-ium-1-yl)butyl)quinuclidin-1-ium, 3-hydroxy-1-(5-(1-methylpiperidin-1-ium-1-yl)pentyl)quinuclidin-1-ium, 1,1'-(butane-1,4-diyl)bis(1-methylpiperidin-1-ium), 1,1'-(pentane-1,5-diyl)bis(1-methylpiperidin-1-ium), 1,1'-(hexane-1,6-diyl)bis(1-methylpiperidin-1-ium), and 1,1'-((3as,6as)-octahydropentalene-2,5-diyl)bis(1-methylpiperidin-1-ium).

The present invention generally relates to use of compounds and compositions as a chemosensitizers and/or radiosensitizers and/or inhibitors of PNKP phosphatase activity. The present invention provides pharmaceutical combinations and/or a pharmaceutically acceptable salt thereof, kits containing such compounds and/composition and methods of using such compounds and/or compositions.

The present invention relates to compounds of Formula I or II, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which relates to mophinan compounds useful as μ, δ and/or κ receptor opioid compounds and pharmaceuticals containing same that may be useful for mediating analgesia, combating drug addiction, alcohol addiction, drug overdose, mental illness, bladder dysfunctions, neurogenic bladder, interstitial cystitis, urinary incontinence, premature ejaculation, inflammatory pain, peripherally mediated and neuropathic pain, cough, lung edema, diarrhea, cardiac disorders, cardioprotection, depression, and cognitive, respiratory, diarrhea, irritable bowel syndrome and gastro-intestinal disorders, immunomodulation, and anti-tumor agents.

Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.

The present invention relates to electronic devices, in particular organic electroluminescent devices, comprising compounds of the formula (1), and the corresponding compounds.

An electronic device includes, a circuit board including a through hole, a member including a screw hole, a screw including a screw body having an outer diameter smaller than an inner diameter of the through hole and a screw head having an outer diameter larger than the inner diameter of the through hole, wherein the screw body penetrates through the through hole to engage with the screw hole and the screw head is disposed on an opposite side of the circuit board to the member, and a first washer provided between the screw head and the circuit board, the first washer including a first washer body and a plurality of first washer legs extending from the first washer body toward the circuit board, the first washer legs being in contact with the circuit board and having a characteristic of reducing stress on the circuit board upon being heated.

A device for processing welding electrodes with a grinding surface driven by a driving motor with a shaft, which faces the motor and runs in a housing, wherein at least one opening is provided in the housing for guiding a welding electrode for grinding in a defined position relative to the grinding wheel. The housing is releasably fixed to a motor flange for bearing the shaft, and the grinding wheel is arranged on a side of the motor flange which is remote from the motor. The motor flange is formed by a sleeve, which is adapted to be stuck onto the housing in such a way, that at least one opening extends from the circumference of the housing towards the grinding surface facing the motor.

Disclosed is a grinding tool, which includes a first disk having an installation hole in a center portion thereof such that the grinding tool is installed on a grinder, a second disk forming a discharge passage with partitions on a bottom surface of the first disk, wherein air intaken from a central lower portion of the grinding tool is discharged to an outside thereof through the discharge passage, and a ring-shaped shank disposed under the second disk and including grinding tips to grind a target.

A tool is disclosed for selective honing of the outer diameter of a cylinder using an abrasive belt in semi-circular contact upon the outer-diameter of a cylindrical work-piece to perform a similar function to honing the inner-diameter of a hollow cylinder. The belt is retained within the tool body by U-shaped restraint arms, and a slot in the tool body. A clamp block retains the ends of the belt which exit the slot. Springs on the arms, and contact of the block on the outside of the tool body, force the belt into a triangular shape inside the body. A cylindrical work-piece inserted within the triangular shaped belt causes the belt to deform into three semi-circular areas of contact between the belt and work-piece. When the work-piece is rotated, the belt abrades material from the work-piece.

A dust collecting attachment that is mounted on a sander includes a suction portion mounted on a portion of a front housing where an output shaft projects, a flexible hose having a front end of the flexible hose connected to the suction portion, a discharge portion connected to a rear end of the flexible hose and a changeable member placed on both a motor housing and the discharge portion. The changeable member allows the discharge portion to be mounted at any position around an axis of the motor housing.

The invention relates to a machine part comprising a first physical component, wherein: the first physical component is configured for moving relative to a second physical component; the first physical component has a first surface with a contact area for physical contact with the second physical component; the first physical component is shaped spatially complementarity to the second physical component at the contact area, and a polyelectrolyte layer is present on the first surface at a location of the contact area. The invention further relates to a machine comprising the present machine part and the second physical component. In addition, the invention relates to the use of a polyelectrolyte layer to reduce the friction between the first physical component and the second physical component, and a rolling-elements bearing.

Device for managing the electrodes for electrical discharge machining EDM machine tools comprises at least one magazine (1) that has a series of individual housings (33) designed to accept and hold exchangeable elements (5) consisting of electrodes (6, 22) mounted on an electrode holder (11a, 11b), and a changer device (2) equipped with a gripper (2) intended to move the exchangeable elements (5) from the individual housings (33) towards the machine and vice versa. A first adapter piece (21) is associated with each of the exchangeable elements (5). This adapter piece (21) surrounds the electrode holder (11a, 11b) and is gripped around its periphery by the gripper (9) of the changer (2) so as to guarantee that the exchangeable element (5) is held precisely. The device further comprises a second adapter piece (32) associated with each of the individual housings (33) of the magazine (1) that are likely to be used.

A multi-channel optoelectronic device is configured to establish a redundant status link with a remote device. The optoelectronic device can transmit N transmit optical signals to the remote device over a plurality of transmit channels and receive N receive optical signals from the remote device over a plurality of receive channels. The optoelectronic device includes one or more spare transmit and receive channels. When used with a remote device having spare transmit and receive channels, each device can establish a status link with the other and use the status link to switch out transmit and/or receive channels to identify and permanently switch out the worst transmit and/or receive channels. Alternately, the device can interoperate with a non-status-link enabled remote device by determining that the remote device is not status-link enabled, transitioning to a low transmit power mode, and transmitting and receiving over a plurality of default transmit and receive channels.

A fiber optic data transmission system includes an optical fiber and a data transmitter having a first laser having a first wavelength, a first phase modulator for phase modulating light from the first laser as a function of a first data input stream so as to create a first phase-modulated output data stream, a second laser having a second wavelength different from the first wavelength, and a second phase modulator for phase modulating light from the second laser as a function of a second data input stream so as to create a second phase-modulated output data stream. The transmitter also includes a combiner combining the first and second output data streams into a phase-modulated optical signal for transmission over the optical fiber.

Disclosed herein are various embodiments of a time-domain reflectometer having a transmitter configured to apply, to a system under test (SUT), an intensity-modulated probe signal generated based on a periodic pseudo-random bit sequence. The reflectometer further has a receiver configured to receive, back from the SUT, a reflected signal corresponding to the probe signal. The receiver converts the received reflected signal into a binary bit sequence using a relatively simple slicer circuit, and without the use of complex analog circuits and/or multi-bit analog-to-digital converters. The binary bit sequence is then compared with the original pseudo-random bit sequence to obtain a measure of the impulse response of the SUT. In some embodiments, the reflectometer has a controllable noise generator that can be used, e.g., to optimize the obtained measure for the detection of multiple SUT defects having significantly differing reflection characteristics.

An optical transport network system includes a plurality of NEs, each transmitting wavelength-multiplexed optical signals. Each NE includes a routing information DB that is used to store reachable area information, which contains identifiers of other NEs in a range within which the optical signals can be transmitted from the own NE without using an REG. A FROM NE includes a path candidate searching unit that searches for a plurality of path candidates for transmitting optical signals from the FROM NE to a TO NE. The TO NE includes a path selecting unit that selects a path for transmitting optical signals from among a plurality of path candidates. The path selecting unit obtains the number of times for which the REG is used for each of the plurality of path candidates; and, based on each number of times that is obtained, selects a path for transmitting the optical signals.

This invention relates to provisioning wavelength-selective switches and reconfigurable optical add-drop multiplexers to minimize the bandwidth narrowing effect from the optical filters. Novel architectures and methods are disclosed that can significantly reduce bandwidth-narrowing on channels in a reconfigurable WDM network where a large number of optical filter elements are cascaded. Instead of blocking unused channels as in the prior art, unused channels are selectively provisioned depending on the state of their adjacent channels. Unused adjacent channels of an active channel are provisioned to follow the same path as the active channels. As each channels is deployed, the channel frequency is selected so as to minimize bandwidth narrowing.

An optical transceiver of one embodiment includes a transmitter optical subassembly to transmit an optical signal, a receiver optical subassembly to receive an optical signal, a mother board, a daughter board, and a housing. The mother board mounts electronic circuits that electrically communicate with the optical transmitter optical subassembly and the receiver optical subassembly. The daughter board mounts other electronic circuits that electrically communicate with the optical transmitter optical subassembly and the receiver optical subassembly. The daughter board has an extra area mounting a portion of the other electronic circuits. The housing defines a space for installing the optical transmitter optical subassembly, the receiver optical subassembly, the mother board, and the daughter board. The extra area is disposed outside the space.

Electrode milling cutter for machining spot welding electrodes, said electrode milling cutter having one or more milling edges, wherein at least one of the milling edges is interrupted by one or more cut-outs at one or more points. The invention also relates to a milling device and to an apparatus for subsequently machining spot welding electrodes.

This disclosure is directed to an apparatus, system and method for retrieving a target material from a suspension. A system includes a processing vessel, such as an Eppendorf tube, a syringe or a test tube, and a collector. The collector is sized and shaped to fit into a primary vessel, such as a test tube. The collector funnels the target material from the suspension through a cannula and into the processing vessel. The cannula extends into a cavity at a first end of the collector that holds the processing vessel. The collector includes a funnel at a second end in fluid communication with the cannula. In one implementation, the processing vessel includes at least one displacement fluid to be expelled, such that the at least one displacement fluid pushes the target material into the collector.

The present invention provides molecular biosensors capable of signal amplification, and methods of using the molecular biosensors to detect the presence of a target molecule.

This disclosure describes an optical method of detecting the presence of pressure-sensitive labels, using the reflective properties of their edges. Labels that are removably attached to a liner are moved through a light beam that is directed across their direction of motion so the light impinges on the labels at a predetermined angle of incidence. The light remains in its plane of incidence when it reflects off all parts of the liner and labels except the labels' edges. Due to the angularity of the labels' edges, the light beam is deflected out of the plane of incidence upon reflection off the edges, thus enabling detection of the label edges by light reflected out of the plane of incidence.

A portable, tabletop fluid sampling device simplifies spectral analysis to produce an accurate but inexpensive chromatic fingerprint for fluid samples. In one embodiment, the sampling device uses an array of variable wavelength LED emitters and photodiode detectors to measure Rayleigh scattering of electromagnetic energy from the fluid sample contained in a cuvette. Either the fluid itself, or particles suspended in the fluid can then be identified by performing spectral pattern matching to compare results of a spectral scan against a library of known spectra. A wide range of applications include substance identification, security screening, authentication, quality control, and medical diagnostics.

Spectroscopy apparatuses oriented to the critical angle of the sample are described that detecting the spectral characteristics of a sample wherein the apparatus consists of an electromagnetic radiation source adapted to excite a sample with electromagnetic radiation introduced to the sample at a location at an angle of incidence at or near a critical angle of the sample; a transmitting crystal in communication with the electromagnetic radiation source and the sample, the transmitting crystal having a high refractive index adapted to reflect the electromagnetic radiation internally; a reflector adapted to introduce the electromagnetic radiation to the sample at or near an angle of incidence near the critical angle between the transmitting crystal and sample; and a detector for detecting the electromagnetic radiation from the sample. Also, provided herein are methods, systems, and kits incorporating the peri-critical reflection spectroscopy apparatus.

An optical electrical field enhancing device includes: a transparent substrate having a structure of fine protrusions and recesses on the surface thereof; and a metal structure layer of fine protrusions and recesses formed on the surface of the structure of fine protrusions and recesses. The metal structure layer of fine protrusions and recesses has a structure of fine protrusions and recesses, in which the distances among adjacent protrusions are less than the distances among corresponding adjacent protrusions of the structure of fine protrusions and recesses of the transparent substrate.

A reflection type optical sensor that detect a surface condition of a moving body and that is used for an image generation apparatus which forms images on a recording media includes a light-emitting device which has a plurality of light emitter systems including at least two light-emitting members and a light-emitting optical system having a plurality of light-emitting lenses corresponding to a plurality of the light emitter systems and guiding light emitted from the light emitter systems to the moving body and a light-receiving device which has a light receiver system including at least two light-receiving members and a light-receiving optical system having light-receiving lenses corresponding to the at least two light-receiving members and guiding light reflected by the moving body to the light receiver system. The image generation apparatus has further a surface condition judging device in addition to the reflection type optical sensor.

An additional electric power receiving method replacing conventional grounding with a negative voltage source includes the step of transmitting electromagnetic wave or current from a power supply source to a rectifier, wherein a grounding end of the rectifier is in electrical communication with the negative voltage source, and the negative voltage source is selected from a negative potential intrinsic of an organism. A device applicable to the electric power receiving method includes a rectifier having an input end and two output ends, wherein the input end is in electrical communication with a power supply source, and rectified direct current is transmitted from the output ends. With the method and device, not only an increase in additional electric power obtained is achieved, but conversion efficiency and stability of current and electromagnetic wave is enhanced.

A wireless media player and a related system and methodology are disclosed. One aspect of the wireless media player system pertains to a virtual connector system, apparatus, and method for the automatic establishment of wireless connectivity with other electronic devices. In one embodiment, the media player device employs the use of integrated Radio Frequency Identification (RFID) technology to exchange communication settings, media capability, and other parameters with an external device that also has integrated RFID technology. The automatic exchange of settings and other information via a proximity-based RFID data exchange allows a media player to quickly establish a secure communication link with another device via a commonly supported wireless protocol such as Ultra Wideband (UWB) or Bluetooth. Another aspect of the media player system pertains to a method of using the captured media capability of the connecting device to customize certain menu options and software parameters in the media player.

A composite including a metal having oxygen-reducing activity, nitrogen and carbon, the composite comprising polyhedral particles, an electrode catalyst including the composite, a method of preparing the composite, and a fuel cell using the composite.

A composition comprising an extruded inorganic support comprising an oxide of a metal or metalloid, and at least one catalytically active metal, wherein the extruded inorganic support has pores, a total pore volume, and a pore size distribution, wherein the pore size distribution displays at least two peaks of pore diameters, each peak having a maximum, wherein a first peak has a first maximum of pore diameters of equal to or greater than about 120 nm and a second peak has a second maximum of pore diameters of less than about 120 nm, and wherein greater than or equal to about 5% of a total pore volume of the extruded inorganic support is contained within the first peak of pore diameters.

A fuel cell electrode that contains a support layer and a catalyst layer, wherein the catalyst layer does not contain a noble metal catalyst and is formed of carbon nanotubes, wherein the carbon nanotubes have pores in sidewalls thereof, and have a pore size distribution of 0.1 nm to 30 nm and a BET specific surface area of 100 to 4,000 m2/g, wherein the pores penetrate or do not penetrate the sidewalls.

A polyester resin is a polycondensate obtained by reacting a divalent alcohol, a divalent carboxylic acid, and a mono- or divalent rosin by the use of a zinc compound as a reaction catalyst.

An implantable device having a power source is provided. The power source uses reverse electrowetting technology to generate a charge to power the implantable device. The power source includes a flexible, non-conductive substrate having a first side and a second side opposite the first side with a channel between the first and second sides. Electrodes are arranged about the channel in a predefined pattern. A liquid is contained in the channel. The liquid includes a dielectric liquid and a conductive liquid that do not mix. The electric change is generated by moving the liquid back and forth across the electrodes. The force to pump or move the liquid is provided by organic means, such as, for example, the change in blood pressure between systolic and diastolic, the expansion and contraction of an organ, or the movement of a muscle.

The invention discloses a novel method of controlling the open circuit potential (OCP) of a medical implant by coupling it with small amounts of metals having a lower OCP than the implant. Coupling of Mg to less than 1% of the surface area of a titanium implant is shown to induce cathodic polarization of the titanium that inhibits cell proliferation at the surface of the implant. Mg—Ti coupling in medical devices promises to attenuate or eliminate potential complications of surgery such as peri-implantitis and bacterial infections at the site of implantation.

An azaindenofluorenedione derivative shown by the following formula (I), (IIa) or (IIb):

An in-liquid plasma electrode according to the present invention is an in-liquid plasma electrode for generating plasma in a liquid and has an electrically conductive member having an electric discharge end surface in contact with the liquid, and an electrically insulating member covering an outer periphery of the conductive member at least except the electric discharge end surface. Preferably, d and x satisfy −2d≦x≦2d, where d is a length of a minor axis of the cross section when a conductive end portion of the electrically conductive member having the electric discharge end surface has an approximately circular cross section, or d is a length of a short side of the cross section when the conductive end portion has an approximately rectangular cross section, and x is a distance from a reference plane to a plane containing the electric discharge end surface when the reference plane is an end surface of the electrically insulating member that is approximately parallel with the electric discharge end surface. Owing to this construction, it is possible to provide an in-liquid plasma electrode which can simply generate plasma in a wide variety of liquids including a conductive liquid such as water and alcohol, and furthermore an in-liquid plasma generating apparatus having this electrode, and an in-liquid plasma generating method using this electrode.

The invention relates to a safety device (1) for detecting electrode breakage in an electric arc furnace, wherein an electrode (6) is secured on an electrode support arm (4), and wherein a conduit is filled with a medium under a constant pressure and a pressure drop is produced at an electrode breakage, which is detected as an alarm signal. Here, the conduit (7a-d,3) is integrated in a protective component that is arranged beneath the electrode support arm (4) thereon, wherein in case of an electrode breakage, the conduit (7a-d,3) is damaged by a produce electric arc and the pressure drop takes place.

The invention relates to an electronic circuit and a method for feeding power to at least one electrode of an alternating-current electric-arc furnace, particularly for melting metal. Known circuits of this type typically comprise a series connection with a transformer for providing a supply voltage for the electric-arc furnace from a power grid (1) and a AC power controller (8) connected between the transformer (6) and the electrode (11) for regulating the current through the electrode (11). According to the invention, a further development for such electronic circuits is proposed, which development has a simple design, is inexpensive and prevents overload of the AC power controller (8) even in operating modes of the electric-arc furnaces at high electrode currents. This further development provides to bypass the AC power controller with a bypass switch (9) that is opened or closed with the help of a controller as a function of the amount of current flowing through the electrode (11).

A sensor system for monitoring and controlling the performance of the bottom electrode and the deflection of an electric arc in an electric steel making furnace includes an organized matrix of anode pins interspersed with refractory material and extending toward an electrically conductive plate secured to distal ends of the anode pins. A sensing device includes two temperature sensors at spaced apart locations along each of a distributed select group of anode pins for providing corresponding electrical signals and a current sensor responsive to electrical current flowing through the anode pins of the distributed select group of anode pins for providing a corresponding electrical signal. A controller responsive to the electrical signals derived at the anode pins of the select group operates the power supply and a display for monitoring the electrical performance of the elongated anode pins for heating by the electric arc in the furnace.

Metallurgical reactors having cooling capability and electrode feed capability are disclosed. The reactors may include a shell having a sidewall and a bottom, where the shell is adapted to contain a molten material. The reactors may include at least one consumable electrode protruding through an opening of the shell and into the molten material. The reactors may include a current contact clamp configured to conduct operating current to the electrode, where the current clamp is in contact with the electrode, and where the current clamp comprises at least one internal channel, wherein the internal channel is configured to circulate a cooling medium. The reactors may include an electric isolation ring disposed between the electrode and the opening of the shell, wherein the electric isolation ring is configured to sealingly engage the electrode and the opening so as to restrict flow of the molten material out of the shell.

Apparatus and method are provided for electric induction heating and/or stirring of a molten electrically conductive composition in a containment vessel with the apparatus being removably insertable in the molten composition. An induction coil embedded in refractory or a coating is submerged in the composition and used to heat and/or stir the molten composition either externally or internally to the refractory or coating.

In various embodiments, an electrode has a shaft extending from an electrode head and a cooling passage extending from an open end disposed at an attachment end of the shaft to a closed end disposed within the electrode head.

A roof system for an electric arc furnace includes a skew removably attached to the electric arc furnace, a lining of refractory material affixed to the skew, and a delta composed of a refractory material. The delta has at least one aperture capable of receiving an electrode. The delta fits onto and is supported by the refractory lining that is affixed to the skew.

A device (10) for adjusting the locking point of the electrode of a smelting furnace includes a vice (120) for supporting said electrode and supplying it with power. A structure (13) is coupled with the vice (120), supports the electrode and moves the electrode vertically.

A movable device for injecting oxygen and other technical materials into an electric arc furnace includes a housing situated above a portion of a step of a crucible and equipped with a cooling coil, an injection lance of oxygen and other technical materials, a supporting and moving system of the lance between minimum and maximum range points of the liquid bath level contained therein, positioned in the housing, an opening situated in the housing and facing the inside of the crucible in which the lance is transferably guided, and a scraping member disposed between the opening and the lance.

A support arm for a water-cooled, current-conducting electrode includes wall elements, wherein each wall element is a flat conductive metal with a hollowed out recess on its outer surface extending over its length. The support arm further includes a cover extending over each recess to define a closed cooling channel within each wall element when the cover is welded to the wall element. The cover includes with an inlet port and an outlet port for cooling water.

An integrated process control installation is provided for electric induction metal melting furnaces with variable furnace states. The integrated process control installation can include supporting charge delivery and slag removal installations, and furnace process operations for process control of melting metal in the furnaces. The variable furnace states, supporting installations, and furnace process operations are controlled by a supporting processing installation, while a robotic apparatus performs the furnace process operations.

The present invention relates to an electric channel inductor assembly and method of forming an electric channel inductor assembly. A nonremovable, hollow, nonmagnetic channel mold is used to form the one or more flow channels of the assembly. A heated fluid medium is circulated in the hollow interior of the mold after the mold is situated in the assembly to heat treat the refractory surrounding the exterior walls of the mold. After heat treatment a liquid is supplied to the hollow interior of the mold to chemically dissolve the mold.

Apparatus and process for heating and melting a material in a susceptor vessel are provided wherein phase synchronized ac voltage is supplied from a separate power source to each one of at least two induction coils in separate zones around the vessel. Power magnitude from each source to an induction coil is controlled by pulse width control of the source's output voltage. Output frequency from each source is either fixed or variable based upon the electrically conductive state of the material. Optional electromagnetic stirring is achieved by establishing a phase shift between the voltage outputs of the power supplies after the material in the susceptor vessel has melted.