CONGRATULATIONS you survived 2012, Big Whoop.

Princeton President Christopher L. Eisgruber issued a statement to the University community Sunday, Jan. 29, 2017, on the federal immigration executive order.

Princeton President Christopher L. Eisgruber and 47 other American college and university presidents today sent a letter to President Trump urging him to "rectify or rescind the recent executive order closing our country's borders to immigrants and others from seven majority-Muslim countries and to refugees from throughout the world." "If left in place," the letters says, "the order threatens both American higher education and the defining principles of our country."

Princeton University and 16 other universities filed a friend-of-the-court brief Monday supporting a legal challenge to the Trump administration's Jan. 27 executive order on immigration.

A Princeton University-based study could prove significant in answering among the most enduring questions for ecologists: Why do species live where they do, and what are the factors that keep them there? The ranges of animals in the world's temperate mountain areas — often presumed to be determined by competition — may actually be determined more by temperature and habitat, the researchers report. The findings indicate that species living in temperate mountain habitats — particularly in the northern latitudes — could face even greater repercussions from climate change than previously thought.

U.S. VIRGIN ISLANDS – Recently, U.S. Environmental Protection Agency (EPA) Regional Administrator Pete Lopez met with Gov. Albert Bryan Jr. of the U.S.

SAN JUAN, PUERTO RICO – Recently, U.S.

YELLOW SPRINGS, Ohio (October 17, 2019) – The U.S. Environmental Protection Agency (EPA) will present the proposed cleanup options for the Vernay Laboratories Inc. site at a public meeting on Thursday, Oct. 24 in Yellow Springs. The information session will run from 5-7 p.m.

WASHINGTON (April 22, 2019) – Today, U.S.

Metz, France (May 7, 2019) - Yesterday, U.S. Environmental Protection Agency (EPA) Administrator Andrew Wheeler concluded his visit to Metz, France where he attended the annual G7 Environmental Ministers Meeting.

KARUIZAWA, JAPAN – Yesterday, U.S. Environmental Protection Agency (EPA) Administrator Andrew Wheeler concluded his visit to Karuizawa, Japan where he attended the inaugural G20 Energy and Environmental Ministers Meeting.

(MEXICO CITY) – Today, U.S. Environmental Protection Agency Administrator Andrew Wheeler wrapped up trilateral meetings with Canada and Mexico as part of the 25th Anniversary of the Commission for Environmental Cooperation (CEC) Council meetings in Mexico City.

WASHINGTON (May 4, 2020) — This week, as part of the Environmental Protection Agency’s (EPA’s) month-long celebration of our nation’s progress in improving air quality over the last 50 years, we are celebrating the 14t

Jahrelang allein unterwegs? Hier erklären eine Langzeitwanderin, eine Seglerin und eine Radfahrerin, welche Strategien ihnen unterwegs helfen - und jetzt den Corona-Alltag erleichtern.

The C train reached its last stop just after 9 a.m. Saturday at the Euclid Ave. station in East New York when the man insisted he needed five more minutes before he could leave the car.

The C train reached its last stop just after 9 a.m. Saturday at the Euclid Ave. station in East New York when the man insisted he needed five more minutes before he could leave the car.

Metropolitan Police Federation chairman says planned 14-day strategy is unenforceable

A Saskatoon family physician wanted to find a way to help send supplies to the northern community of La Loche and set an initial goal for $15,000 - but within days the donations total over $26,000.

Demonstrators describe an arrest and pepper ball use by IMPD during a protest over the death of Dreasjon Reed near 62nd Street and Michigan Road.

A life on the high seas promised adventure, until a kidnapping turned a young man's life upside down.

The Agricultural Producers Association of Saskatchewan (APAS) is the latest organization to weigh in on the Co-op Refinery labour dispute, saying demonstrations at Co-op facilities could negatively affect farmer’s seeding.

The Duke of Sussex sent a special video message to mark what would have been the opening ceremony of the 2020 Invictus Games.

Run Programs as an Administrator with this Shortcut

While the weather may have looked like mid-November in Brockville Saturday morning, that didn't stop people from donating to the Brockville community food drive.

A polar vortex has blasted into the northeastern US this weekend bringing rare May snowfall and record low temperatures to some areas.

Filed under: Asia, Thailand

Not only are tourists still coming, but they've been arriving in increasing numbers in recent years, according to government data.

Continue reading Demonstrations in Thailand? No Problem, Travelers Say.

Demonstrations in Thailand? No Problem, Travelers Say. originally appeared on Gadling on Mon, 02 Dec 2013 11:26:00 EST. Please see our terms for use of feeds.

Members of the Joint Operational Committee in Tshwane is in self-isolation after one member tested positive for Covid-19, spokesperson Brigadier Vishnu Naidoo has told News24.

Ultimately, there are no easy solutions to reigniting a Covid-19 affected economy. It is evident, however, that addressing the public health crisis is non-negotiable, writes Haroon Bhorat.

Messages to mothers and words of support were front and centre as Edmontonians cruised by MacTaggart Place retirement residence on Saturday afternoon.

Research Event

Event participants

Dr Maria Ângela Bragança, Secretary of State for Cooperation, Ministry of External Relations, Angola

Invitation Only Research Event

Event participants

Dr Leena Koni Hoffmann, Centre for Population, Poverty and Public Policy Studies; Author, Who Speaks for the North? Politics and Influence in Northern Nigeria; ERANDA Junior Research Fellow, Africa Programme, Chatham House (2013)
Chair: Elizabeth Donnelly, Assistant Head, Africa Programme, Chatham House

Research Event

Event participants

Dr Doyin Okupe, Senior Special Assistant on Public Affairs to the President of Nigeria 

Invitation Only Research Event

12 March 2015 , Volume 91, Number 2

Invitation Only Research Event

Event participants

Professor Philippe Sands QC, Barrister, Matrix Chambers
Chris Whomersley, Deputy Legal Adviser, Foreign and Commonwealth Office (2002-14)
Professor Julia Xue, Academy Senior Fellow, International Law Programme, Chatham House
Chair: Elizabeth Wilmshurst, Distinguished Fellow, International Law Programme, Chatham House

21 July 2016

gali_nette posted a photo:

Sean Hannity reacts on 'Watters' World' to the Obama administration being caught lying about Russia collusion.

Ousted vaccine expert Rick Bright said he is "frustrated at our inability to be heard as scientists."

Antibodies are widely used as cancer therapeutics, but their current use is limited by the low number of antigens restricted to cancer cells. A receptor tyrosine kinase, receptor tyrosine kinase-like orphan receptor 2 (ROR2), is normally expressed only during embryogenesis and is tightly down-regulated in postnatal healthy tissues. However, it is up-regulated in a diverse set of hematologic and solid malignancies, thus ROR2 represents a candidate antigen for antibody-based cancer therapy. Here we describe the affinity maturation and humanization of a rabbit mAb that binds human and mouse ROR2 but not human ROR1 or other human cell-surface antigens. Co-crystallization of the parental rabbit mAb in complex with the human ROR2 kringle domain (hROR2-Kr) guided affinity maturation by heavy-chain complementarity-determining region 3 (HCDR3)-focused mutagenesis and selection. The affinity-matured rabbit mAb was then humanized by complementarity-determining region (CDR) grafting and framework fine tuning and again co-crystallized with hROR2-Kr. We show that the affinity-matured and humanized mAb retains strong affinity and specificity to ROR2 and, following conversion to a T cell–engaging bispecific antibody, has potent cytotoxicity toward ROR2-expressing cells. We anticipate that this humanized affinity-matured mAb will find application for antibody-based cancer therapy of ROR2-expressing neoplasms.

Extracytoplasmic sugar decoration of glycopolymer components of the bacterial cell wall contributes to their structural diversity. Typically, the molecular mechanism that underpins such a decoration process involves a three-component glycosylation system (TGS) represented by an undecaprenyl-phosphate (Und-P) sugar-activating glycosyltransferase (Und-P GT), a flippase, and a polytopic glycosyltransferase (PolM GT) dedicated to attaching sugar residues to a specific glycopolymer. Here, using bioinformatic analyses, CRISPR-assisted recombineering, structural analysis of cell wall–associated polysaccharides (CWPS) through MALDI-TOF MS and methylation analysis, we report on three such systems in the bacterium Lactococcus lactis. On the basis of sequence similarities, we first identified three gene pairs, csdAB, csdCD, and csdEF, each encoding an Und-P GT and a PolM GT, as potential TGS component candidates. Our experimental results show that csdAB and csdCD are involved in Glc side-chain addition on the CWPS components rhamnan and polysaccharide pellicle (PSP), respectively, whereas csdEF plays a role in galactosylation of lipoteichoic acid (LTA). We also identified a potential flippase encoded in the L. lactis genome (llnz_02975, cflA) and confirmed that it participates in the glycosylation of the three cell wall glycopolymers rhamnan, PSP, and LTA, thus indicating that its function is shared by the three TGSs. Finally, we observed that glucosylation of both rhamnan and PSP can increase resistance to bacteriophage predation and that LTA galactosylation alters L. lactis resistance to bacteriocin.

Fucosylation of the innermost GlcNAc of N-glycans by fucosyltransferase 8 (FUT8) is an important step in the maturation of complex and hybrid N-glycans. This simple modification can dramatically affect the activities and half-lives of glycoproteins, effects that are relevant to understanding the invasiveness of some cancers, development of mAb therapeutics, and the etiology of a congenital glycosylation disorder. The acceptor substrate preferences of FUT8 are well-characterized and provide a framework for understanding N-glycan maturation in the Golgi; however, the structural basis of these substrate preferences and the mechanism through which catalysis is achieved remain unknown. Here we describe several structures of mouse and human FUT8 in the apo state and in complex with GDP, a mimic of the donor substrate, and with a glycopeptide acceptor substrate at 1.80–2.50 Å resolution. These structures provide insights into a unique conformational change associated with donor substrate binding, common strategies employed by fucosyltransferases to coordinate GDP, features that define acceptor substrate preferences, and a likely mechanism for enzyme catalysis. Together with molecular dynamics simulations, the structures also revealed how FUT8 dimerization plays an important role in defining the acceptor substrate-binding site. Collectively, this information significantly builds on our understanding of the core fucosylation process.

Immigration is a prominent part of the United States’ DNA, despite concerns about immigrants’ ability to integrate. An examination of recent immigrant inflows shows newcomers to the United States are integrating well, based on language proficiency, socioeconomic attainment, political participation, residential locale, and social interaction indicators.

Drawing on experiences from Asia, Europe, North America, and the Pacific region, this report presents eight strategies that represent best practices developed by immigrant-receiving countries to increase the economic contributions of immigration.

Two competing models for selecting economic-stream immigrants are now prevalent in advanced industrialized economies: points-based and employer-led selection. Increasingly, however, hybrid selection systems are being created, implementing best practices from each selection process.

The report examines U.S. immigration and international development policies, which have unique objectives and respond to distinct political and administrative constraints, and points out that international development has never been a U.S. immigration policy objective; nonetheless, it is an unintended consequence.