With scarce resources that are quickly dwindling, developing nations could soon be buried by debt.

The sports industry is harnessing digital engagement to enhance fan experiences and cope with threats to its traditional business model

Hazy CEO Harry Keen explains why artificially produced data is gaining favour over information generated by real-world events

Researchers from the venture capital firm Octopus Ventures gave much of the credit to QUBIS, the university's dedicated commercialisation arm

David Murray-Hundley, our resident Grumpy Entrepreneur, on the eight things for startups to consider if the bubble bursts

The new chancellor Rishi Sunak announced his first budget today, with coronavirus naturally top of the agenda but also pledges to reduce Entrepreneurs’ Relief and invest in technology, research and development

George C. Linderman and Stefan Steinerberger
Math. Comp. 89 (2020), 1933-1952.
Abstract, references and article information

Startups moving to the scale-up phase will naturally experience growing pains, here's how to manage your team through that period with as little disruption as possible

Health startups are being corralled by the NHS and the government to point their talents at the COVID-19 pandemic, while others are volunteering services to help stymie the spread of the infectious new disease

The relationship wellness app is seeing a significant uptick in interest as couples are locked down together during the COVID-19 pandemic

Invoicing is a vital business practice, and for organisations starting out it's just one more thing to get to grips with. To help, we've created a best practice guide for writing professional invoices

How to optimise your website, increase conversions and monetise your online offering

You don't need a backer to start a business. Here's how to start a business from scratch.

Asian Ethnic Cultural Performances 2019 will be staged on Sunday to demonstrate the diversity of Asia’s cultures.

The event will feature ethnic performances and activities with representatives from 19 Asian countries and places taking part.

Korean traditional Nongak and Taepyeongmu dances, a Japanese Tokushima Awa dance, Indian classical and Bollywood dances, and folk dance performances of countries such as Bangladesh, Laos, Vietnam, the Philippines and Sri Lanka will be showcased.

Hong Kong and Macau arts groups will stage a hip hop lion dance and a cheerleading performance.

Other activities include traditional arts and crafts, costume and food displays, as well as a bamboo musical instrument workshop.

A CIBS mobile studio supported by Radio Television Hong Kong will also be set up to let members of the public learn about broadcasting.

The event will be held from 2pm to 6pm at the Cultural Centre Piazza. Admission is free.

Click here for details.

The Leisure & Cultural Services Department’s Community Oral History Theatre Project will be launched in Kowloon City District on January 15.

An oral history theatre performance and a sharing session will kick off the project.

The performance will feature an excerpt from the production of Sai Kung, Therefore I Live.

It will be held at Hung Hom Community Hall.

Admission is free with tickets.

Click here for details.

The Science Museum is presenting the special Unlocking the Secrets - The Science of Conservation at The Palace Museum exhibition to tie in with the 600th anniversary of the Forbidden City in 2020.

More than 100 artefacts from the Palace Museum collection are being showcased to highlight the application of science and technology in conservation.

They include bronzes, clocks, textiles, thangkas, wood furniture, lacquerware and inlaid works along with ceramics, calligraphy and hand-painted copies of ancient paintings.

The show also presents the Conservation Office’s work by showcasing intriguing restoration cases so that visitors can learn more about the work and skills of conservators as well as their mission to preserve Hong Kong’s heritage assets.

The Science Museum will launch a series of interactive family activities, including demonstrations and workshops conducted by Palace Museum conservators, guided tours featuring theatrical plays and storytelling, and visits to conservation laboratories.

Jointly presented by the Leisure & Cultural Services Department and the Palace Museum, the exhibition will run until March 18 next year.

Call 2732 3232 for enquiries.

The Space Museum will present Turtle Odyssey 3D between January 1 and April 30 where audiences can join sea turtle Bunji for a remarkable adventure and meet an astonishing range of strange and fascinating creatures, including breaching whales, manta rays and clownfish.

Bunji's journey starts from the moment her fragile egg cracks open below the warm sand of an Australian beach.

Having traversed thousands of kilometres of open oceans, she returns after decades with mysterious precision back to the very beach where she was born to lay eggs and start the next generation.

Her journey reminds the audience of how interconnected all creatures are, moving them to cherish these beautiful and vulnerable sea turtles even more.

The 41-minute show will be screened daily at 2.40pm and 6.10pm. An additional show at 11.10am will be available on Sundays and public holidays.

Tickets are available at the Space Museum Box Office and URBTIX. The museum is closed on Tuesdays except public holidays.

Click here for details.

Janet L. Kelly
Aug 1, 2014; 27:218-223
Pharmacy and Therapeutics

The UK-based digital identity specialist managed to raise a bumper round during the peak of the COVID-19 pandemic, and is looking at ways to apply its technology to help combat the global crisis

"Driverless cars, robot butlers and reusable rockets--if the big inventions of the past decade and the artificial intelligence developed to create them have taught us anything, it's that maths is undeniably cool. And if you’re still not convinced, chances are you’ve never had it explained to you via a live experiment with a pigeon before. Temporary pigeon handler and queen of making numbers fun is Dr Hannah Fry, the host of this year's annual Royal Institution Christmas Lectures." Learn more in "Christmas Lectures presenter Dr Hannah Fry on pigeons, AI and the awesome power of maths," by Rachael Pells, inews, December 23, 2019.

Pyruvate kinase muscle isoform 2 (PKM2) is a key glycolytic enzyme involved in ATP generation and critical for cancer metabolism. PKM2 is expressed in many human cancers and is regulated by complex mechanisms that promote tumor growth and proliferation. Therefore, it is considered an attractive therapeutic target for modulating tumor metabolism. Various stimuli allosterically regulate PKM2 by cycling it between highly active and less active states. Several small molecules activate PKM2 by binding to its intersubunit interface. Serine and cysteine serve as an activator and inhibitor of PKM2, respectively, by binding to its amino acid (AA)-binding pocket, which therefore represents a potential druggable site. Despite binding similarly to PKM2, how cysteine and serine differentially regulate this enzyme remains elusive. Using kinetic analyses, fluorescence binding, X-ray crystallography, and gel filtration experiments with asparagine, aspartate, and valine as PKM2 ligands, we examined whether the differences in the side-chain polarity of these AAs trigger distinct allosteric responses in PKM2. We found that Asn (polar) and Asp (charged) activate PKM2 and that Val (hydrophobic) inhibits it. The results also indicate that both Asn and Asp can restore the activity of Val-inhibited PKM2. AA-bound crystal structures of PKM2 displayed distinctive interactions within the binding pocket, causing unique allosteric effects in the enzyme. These structure-function analyses of AA-mediated PKM2 regulation shed light on the chemical requirements in the development of mechanism-based small-molecule modulators targeting the AA-binding pocket of PKM2 and provide broader insights into the regulatory mechanisms of complex allosteric enzymes.

(Michigan Medicine - University of Michigan) They know it's addictive. They know it's linked to dangerous lung diseases. And they know it delivers more nicotine than the cigarettes it's supposed to replace. But the social aspects of vaping drives young people to use Juul and other e-cigarettes, according to nearly two-thirds of teens and young adults in a new study. Less than 5% say the availability of fruity flavors drives use of e-cigarettes by members of their generation, and only 10% say addiction does.

(Elsevier) Children looking for health information online could end up more prone to obesity. A new study in the Journal of Nutrition Education and Behavior, published by Elsevier, shows a lack of digital health literacy can lead children to misinterpret portions, adopt recommendations intended for adults, or take guidance from noncredible sources.