In various embodiments, safe collaboration between a robot and humans is achieved by operating the robot continuously at or below a first threshold speed at which any collisions with a person's arms do not cause harm, and, upon detection of the person's torso or head within a danger zone around the robot, reducing the speed to or below a second threshold at which any collisions with the person's torso or head do not cause harm.

Provided is a device for wirelessly controlling robots suitable for competition or educational purposes, the device including: an input module configured to receive commands from a human user interface, the human user interface sending signals indicative of inputs by a user to control a robot; a protocol translator configured to translate the received commands into a protocol to which the robot is responsive; a wireless output module configured to wirelessly transmit the translated commands to the robot such that the robot executes the commands.

The presently disclosed subject matter provides compositions that selectively bind cyclooxygenase-2 and comprise a therapeutic and/or diagnostic moiety. Also provided are methods for using the disclosed compositions for diagnosing (i.e., by imaging) a target cell and/or treating a disorder associated with a cyclooxygenase-2 biological activity.

The present invention relates to a 68Ga generator, wherein the 68Ge parent nuclide thereof is attached specifically to a support through a triethoxyphenyl group and continuously disintegrates to 68Ga, the triethoxyphenyl group being covalently bound to a support material through a linker.

A method for cooling a heat source, a method for preventing chemical interaction between a vessel and a cooling composition therein, and a cooling system. The method for cooling employs a containment vessel with an oxidizable interior wall. The interior wall is oxidized to form an oxide barrier layer thereon, the cooling composition is monitored for excess oxidizing agent, and a reducing agent is provided to eliminate excess oxidation. The method for preventing chemical interaction between a vessel and a cooling composition involves introducing a sufficient quantity of a reactant which is reactive with the vessel in order to produce a barrier layer therein that is non-reactive with the cooling composition. The cooling system includes a containment vessel with oxidizing agent and reducing agent delivery conveyances and a monitor of oxidation and reduction states so that proper maintenance of a vessel wall oxidation layer occurs.

Materials and methods of making low-sintering-temperature glass waste forms that sequester radioactive iodine in a strong and durable structure. First, the iodine is captured by an adsorbant, which forms an iodine-loaded material, e.g., AgI, AgI-zeolite, AgI-mordenite, Ag-silica aerogel, ZnI2, CuI, or Bi5O7I. Next, particles of the iodine-loaded material are mixed with powdered frits of low-sintering-temperature glasses (comprising various oxides of Si, B, Bi, Pb, and Zn), and then sintered at a relatively low temperature, ranging from 425° C. to 550° C. The sintering converts the mixed powders into a solid block of a glassy waste form, having low iodine leaching rates. The vitrified glassy waste form can contain as much as 60 wt % AgI. A preferred glass, having a sintering temperature of 500° C. (below the silver iodide sublimation temperature of 500° C.) was identified that contains oxides of boron, bismuth, and zinc, while containing essentially no lead or silicon.

The present invention relates to antibody molecules against anticoagulants, in particular dabigatran, and their use as antidotes of such anticoagulants.

Disclosed herein are compounds that inhibit Hsp90 interactions with IAP proteins, such as Survivin, XIAP, cIAP1, or cIAP2, and methods for identifying and using such compounds.

This disclosure relates to temperature sensitive conjugates, compositions, and uses related thereto. In certain embodiments, the disclosure relates to conjugate polymers comprising a) a temperature sensitive polymer and b) an antibody. Typically the antibody has an epitope to a platelet receptor. The antibody may be a single-chain antibody wherein the platelet receptor is GPIIb/IIIa, such as an anti-GPIIb/IIIa antibody. In certain embodiments, the antibody binds specifically to the activated conformation of GPIIb/IIIa, i.e., an activation-specific GPIIb/IIIa antibody.

A composition having proanthocyanidin compounds having an average degree of polymerization of at least about 6. A method of administering to an immunosuppressed patient or a patient diagnosed with sepsis or septic shock a composition having a proanthocyanidin. A method of administering to a patient diagnosed with a gram negative bacterial infection a composition having proanthocyanidin compounds having an average degree of polymerization of at least about 6.

A system or method for inferring and selective display of visual and sound media content based on a pet(s)'s level of engagement or reactions to content displayed on any number of content display devices including, but not limited to, television screens, computer monitors, tablets, and cell phones and measured by a sensor. A content selection algorithm takes as input the sensor measurements and historical or pre-computed data to infer the pet(s)'s preference for content. A content modification algorithm interposes algorithmically computed shapes and sounds overlaid on top of the existing content to attract the attention of the pet(s) observing the display.

A method includes receiving, at a multimedia device, a data stream representing multimedia content, the data stream comprising first timing information for the multimedia content, and metadata representing interactive event information associated with the multimedia content, the metadata comprising second timing information for the interactive event information. During the playback of the multimedia content, a first user interactive event is identified that is associated with a first time point in the playback of the multimedia content based on the interactive event information, and the first user interactive event is performed concurrent with the first time point in the playback of the multimedia content.

An interactive television program guide system with program series reminder and recording capabilities is provided. The system allows a user to set a reminder or schedule a recording for a single episode or for each episode of a program series. In addition, other options may be provided that allow the user to determine, for example, whether to schedule reminders/recordings for episodes on all channels on which the program airs or only on a selected channels, whether to schedule reminders/recordings for all episodes including reruns or only new episodes, whether to schedule reminders/recordings for network or syndicated episodes, and whether to schedule reminders/recordings for episodes on all days or only on selected days of the week. Before the scheduled broadcast time of each episode of each selected program series, the system sends a reminder message to the user that reminds the user of the program episode or sends a record command to a videocassette recorder to initiate recording of the episode. The system allows a user to view a list of all currently requested program reminders and scheduled program recordings. The user may update, change, or cancel any entry in either list or the system may automatically update the lists to match new broadcast schedule information. If the user sets a reminder or schedules a recording that conflicts with an existing reminder or recording, the system may inform the user of the conflict and allow the user to resolve the conflict or the system may resolve the conflict.

System and method for providing a probabilistic order of tiles relative to a current section of a video that a user is viewing. A cache implementation uses this ordering to decide what tiles to evict from the cache, i.e. which tiles will probably not be accessed within a particular timeframe, but not when to evict (this is up to the cache implementation). A cache implementation can also use the prioritized list of the present embodiment to pre-fetch tiles.

Thumbnail images representative of recorded TV programs are generated and presented to aid a user in browsing the recorded TV programs. In one implementation, a temporary thumbnail image is generated when a TV program first starts recording. The temporary thumbnail is used to populate any user interface (UI) screens that reference the recoded TV program. Once the TV program has reached a threshold amount of recording (e.g., a prescribed duration of recording, or completion of the recording), a permanent thumbnail image is generated and associated with the TV program. The permanent thumbnail is then presented in any subsequent UI screens, replacing the temporary thumbnail. In another implementation, display of the thumbnail images in the UI screens may be further controlled by setting preferences, such as parental controls.

A video-on-demand (VOD) content delivery system has a VOD Application Server which manages a database of templates ordered in a hierarchy for presentation of video content elements of different selected types categorized in hierarchical order. The templates include those for higher-order displays which have one or more links to lower-order displays of specific content. The VOD Application Server, in response to viewer request, displays a high-order templatized display, and in response to viewer selection of a link, displays the lower-order display of specific content. The hierarchical templatized displays enable viewers to navigate to an end subject of interest while having a unique visual experience of moving through a series of displays to the end subject of interest.

A belt drive arrangement for an auxiliary unit of a motor vehicle includes, but is not limited to a belt pulley for receiving a drive belt, a shaft of the auxiliary unit that can be driven with the torque of the belt pulley, and a clutch device for the releasable torque transmission between the belt pulley and the shaft of the auxiliary unit. The clutch device includes, but is not limited to an electromagnet and a spring element. The spring element is preloaded in such a manner that the clutch in a currentless state of the electromagnet is closed.

A method for operating a brake system for a work machine that includes at least one operating brake acting directly or indirectly on at least one ground engagement element of the work machine and at least one operating brake actuator which is movable between a fully engaged position and a fully released position and an accelerator actuator for activating propulsion of the work machine. In an activated state of the brake system the operating brake actuator is moved automatically to its fully engaged position when the accelerator actuator is released.

A transmission assembly in a vehicle includes a transmission configured to receive a transmission fluid. A controller operatively connected to the transmission and configured to store a first look-up table defining respective warm-up calibration factors (Fw) for a respective first set of ambient temperatures. The controller has a processor and tangible, non-transitory memory on which is recorded instructions for executing a method for determining a current temperature (TTF) of the transmission fluid. The vehicle is keyed off and then keyed on after a key-off time duration (te), the controller being deactivated when the vehicle is keyed off and activated when the vehicle is keyed on. The controller is configured to determine the current temperature of the transmission fluid (TTF) based at least partially on the first look-up table and a key-on temperature (TTFkey-on) of the transmission fluid.

The invention relates to a method for operating a drive device (1) of a motor vehicle, said drive device (1) comprising at least one combustion engine (3) and at least one electric machine (9), as well as a dual clutch transmission (4) which can be functionally connected to the combustion engine (3) and which comprises a first sub-transmission (5), a first clutch (6) being associated therewith, and a second sub-transmission (7), a second clutch (8) and the electric machine (9) being associated therewith. In a purely electrical driving operation, the electric machine (9) is operated in a motorized manner, a driving gear is engaged in the second sub-transmission (7), and both clutches (6, 8) are disengaged. According to the invention, in order to start the combustion engine (3) during the electric driving operation, the second clutch (8) is engaged so as to drive the combustion engine (3) by means of the electric machine (9), a gear is engaged in the first sub-transmission (5), said gear having a lower gear ratio than the engaged driving gear of the second sub-transmission (7), the first clutch (6) is brought into a slip position and the second sub-transmission (7) is subsequently brought into a neutral position, the rotational speed of the electric machine (9) is increased at least to a starting rotational speed for the combustion engine (3) with the slip of the first clutch (6) being adjusted to maintain a forward torque of the motor vehicle, and the combustion engine (3) is started once its starting rotational speed has been reached. In addition, the invention relates to a device for operating a drive device of a motor vehicle.

A method of operating a drive-train of a vehicle that comprises a combustion engine whose torque for driving the vehicle can be transmitted to a drive output via a transmission, with a hydraulically actuated clutch when the clutch is engaged. An electric machine provides torque which can act upon the drive-train. The clutch is closed by filling the clutch with hydraulic fluid through a circuit by way of a pump which can be driven by the engine and the electric machine. The method is to engage the clutch when the combustion engine is initially off and/or when the electric machine is initially switched off, determining a driving dynamic based on the behavior of the driver and adjusting the speed of the electric machine based on the determined driving dynamic such that the greater the determined driving dynamic is, the more rapidly the clutch is filled by the pump.

Systems and methods for improving operation of a hybrid vehicle are presented. In one example, an electrical load may be automatically activated to consume electrical energy produced during driveline braking so that driveline braking may be extended. The electrical load may be a windscreen heater or other device.

Systems and methods for improving operation of a hybrid vehicle are presented. In one example, torque transferred via a driveline disconnect clutch is estimated based on characteristics of a torque converter to improve driveline operation.

The present invention is directed to the use of the peptide compound Ac-Arg-Phe-Met-Trp-Met-Arg-NH2 as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the present invention relates to pharmaceutical compositions preferably in form of a lyophilisate or liquid buffer solution or artificial mother milk formulation or mother milk substitute containing the peptide Ac-Arg-Phe-Met-Trp-Met-Arg-NH2 optionally together with at least one pharmaceutically acceptable carrier, cryoprotectant, lyoprotectant, excipient and/or diluent.

The present invention is directed to the use of the peptide compound Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the present invention relates to pharmaceutical compositions preferably in form of a lyophilizate or liquid buffer solution or artificial mother milk formulation or mother milk substitute containing the peptide Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 optionally together with at least one pharmaceutically acceptable carrier, cryoprotectant, lyoprotectant, excipient and/or diluent.

The present invention relates to fusion proteins comprising an antibody, functional fragment or functional derivative thereof having specific binding affinity to either the extracellular domain of oncofetal fibronectin (ED-B) or at least one of the extracellular domains of oncofetal tenascin fused to a cytokine selected from the group consisting of IL-10, IL15, IL-24 and GM-CSF, functional fragments and functional derivatives thereof. The invention is also directed to the use of at least one of said fusion proteins for the manufacture of a medicament. In particular, the invention concerns the use of said medicament for the treatment of tumors or chronic inflammatory diseases such as atherosclerosis, arthritis and psoriasis.

Peptides having a structure characterized by the presence of two loops constrained in cyclic structure by the presence of covalent bonds between amino acid side chains, the amino acid sequences of the first and the second loop being substantially homologues to that of loop 1 (residues 29-38) and of loop 4 (residues 92-97) of NGF, respectively, displaying nerve growth factor (NGF) agonist or partial agonist activity.

Plant viral vectors have great potential in rapid production of proteins, but no simple. Here a geminivirus-based system for high-yield and rapid production of oligomeric protein complexes, including virus-like particle (VLP) vaccines and monoclonal antibodies (mAbs) is described. In particular, a single vector that contains two non-competing replicons for transient expression in Nicotiana benthamiana leaves is described. The correct assembly of these subunit proteins into functional oligomeric structures (VLPs or full-size mAb) is also described. This system advances plant transient expression technology by eliminating the need for non-competing viruses, and thus, enhances the realistic commercial application of this technology for producing multiple-subunit protein complexes.

The invention relates to human medicine and to the use of epidermal growth factor (EGF) for preparing a pharmaceutical composition which is administered by infiltration into the periphery of nerve ganglia and/or trunks for the morphofunctional restoration of peripheral nerves in painful sensory-motor neuropathy as well as manifestations of ischemic neuritis. The invention also includes a composition containing EGF which can be formulated together with anesthetics or analgesics or encapsulated in microspheres and to the use thereof for the morphofunctional restoration of peripheral nerves in painful sensitive-motor-type diabetic neuropathy and the manifestations of ischemic neuritis.

Disclosed is a drug effective in the treatment of fibromyalgia. Basically, the disclosed therapeutic agent was created on the basis of experiments showing improvement in symptoms when etanercept was administered to patients suffering from fibromyalgia. Etanercept is known as a therapeutic agent for rheumatoid arthritis, and the JFIQ score of patients not suffering from fibromyalgia improved considerably in the preferred embodiment. In other words, a therapeutic agent for fibromyalgia is disclosed that contains etanercept as an active ingredient in an effective amount.

The present invention provides for a bio-mimetic polymer capable of catalyzing CO2 into a carbonate.

The present invention provides processes for the manufacturing of polypeptide conjugates. In particular, the invention provides methods for the purification of polypeptide conjugates, which include at least one polymeric modifying groups, such as a poly(alkylene oxide) moiety. Exemplary poly(alkylene oxide) moieties include poly(ethylene glycol) (PEG) and poly(propylene glycol). In an exemplary process, hydrophobic interaction chromatography (HIC) is used to resolve different glycoforms of glycoPEGylated polypeptides.

The present invention is relevant to human medicine, and, in particular, to the use of Epidermal Growth Factor (EGF) in a pharmaceutical composition, said composition is administered through infiltration at the periphery of nerve trunks and/or ganglia, for the morphofunctional restoration of peripheral nerves in painful, sensory-motor neuropathy, as well as ischemic neuritis. It is also relevant to an EGF containing composition, where this molecule can be formulated together with anesthetic or analgesic drugs, or encapsulated in microspheres, and their use for the morphofunctional restoration of peripheral nerves in painful, sensory-motor neuropathy, as well as in ischemic neuritis.

A cleaning system for use in a combine harvester including an auger bed mounted within a frame such that when the combine harvester is laterally inclined from the horizontal, the cleaning system, including the auger bed and a sieve, may be leveled or substantially leveled to a generally horizontal position. The auger bed can include a plurality of augers located side by side with their axes positioned generally longitudinally in the combine harvester.

A double function, hand operated meat tenderizer includes a handle with a blade segment clamped inside said handle; a generally flat plate attached to said handle by at least one slidably moving cylinder attached to a compressed spring, comprising at least one seat including a releasably attached spigot of the cylinder, wherein an end face of said plate is provided with a plurality of projections and flow-through slots aligned in evenly spaced relation, parallel to the spring axis, and wherein in a position of rest, ends of said blades are retracted in said flow-through slots.

Apparatuses and methods of use are provided that include a battery cell comprising a flexible resistive thermal device. The resistive thermal device includes a flexible conductive circuit that is positioned on or adjacent to the surface of the battery cell. Resistance measured in the conductive circuit is correlated with a temperature of the battery cell thereby allowing control of a cooling system and/or the charging/discharging rates of the battery cell to be adjusted in response to temperature. Flexibility of the resistive thermal device also accommodates dimensional changes in the battery cell.

In a method for operating a high-temperature fuel cell, which in normal mode of generating electrical power is supplied with liquid fuel, preferably diesel oil, and is preceded on the anode side by a reformer for liquid fuel, where at least part of the hot anode exhaust gas is recirculated into the anode circuit via a recirculation line. Upstream of a compressor preceding the reformer the liquid fuel is sprayed or injected into the hot anode exhaust gas, the quantity of air needed for reforming the liquid fuel being added to the mixture of anode exhaust gas and fuel. On change-over from normal operational mode to standby mode without power generation, the supply of liquid fuel and air is stopped and the gas mixture present in the anode circuit be permanently circulated. A defined amount of air being introduced into the anode circuit in order to remove deposits and contaminations in the high-temperature fuel cell following standby operation.

Mechanisms and methods for clamping force generation are described. In one embodiment, a clamping force generator system includes a permanent magnet bearing coupled to a traction ring and to a torque coupling. The traction ring can be provided with an electromagnetic bearing rotor and the torque coupling can be provided with an electromagnetic bearing stator. In some embodiments, a mechanical load cam, a permanent magnet bearing, and an electromagnetic bearing cooperate to generate a clamping force between the traction rings, the power rollers, and the idler. In other embodiments, a series of permanent magnet bearings and a mechanical bearing are configured to produce a clamping force. In one embodiment an electromagnetic bearing is coupled to a control system and produces an optimal clamping force that is associated with a torque transmitted in the transmission during operation. In some embodiments, a mechanical load cam produces a clamping force proportional to torque, while a permanent magnet bearing provides a minimum clamping force.

A motor-generator system for a vehicle, in which power transmission between a crankshaft of an engine and a motor-generator is performed by a V-belt wound around pulleys thereof, includes a speed controller controlling the rotational speed of the V-belt within a predetermined range and provided on a crankshaft pulley mounted on the crankshaft. The motor-generator system, among others, can maintain the power transmission force of the V-belt at a high level.

A head transducer, configured to interact with a magnetic recording medium, includes a first sensor having a temperature coefficient of resistance (TCR) and configured to produce a first sensor signal, and a second sensor having a TCR and configured to produce a second sensor signal. One of the first and second sensors is situated at or near a close point of the head transducer in relation to the magnetic recording medium, and the other of the first and second sensors spaced away from the close point. Circuitry is configured to combine the first and second sensor signals and produce a combined sensor signal indicative of one or both of a change in head-medium spacing and head-medium contact. Each of the sensors may have a TCR with the same sign (positive or negative) or each sensor may have a TCR with a different sign.

A head transducer, configured to interact with a magnetic recording medium, includes a first sensor having a temperature coefficient of resistance (TCR) and configured to produce a first sensor signal, and a second sensor having a TCR and configured to produce a second sensor signal. One of the first and second sensors is situated at or near a close point of the head transducer in relation to the magnetic recording medium, and the other of the first and second sensors spaced away from the close point. Circuitry is configured to combine the first and second sensor signals and produce a combined sensor signal indicative of one or both of a change in head-medium spacing and head-medium contact. Each of the sensors may have a TCR with the same sign (positive or negative) or each sensor may have a TCR with a different sign.

A tolerance ring can include a generally cylindrical body having a sidewall. The sidewall can include a plurality of wave structures extending from the sidewall at regular intervals around the body, a first unformed section between a first pair of adjacent wave structures, and a second unformed section between a second pair of adjacent wave structures. The gap can extend along an entire length, L, of the body to establish a split in the body. The second unformed section can include a slot therein. The slot can have a length, LS, and LS≧80% L.

A tolerance ring can include a generally cylindrical body that can include a side wall. The sidewall can define a top and a bottom. Further, the sidewall can include a plurality of wave structures that can extend from the sidewall, a plurality of unformed sections, and a gap that can extend along the entire length of the body. Each unformed section can be located between a pair of adjacent wave structures. Further, the gap can establish a split in the body. The tolerance ring can also include at least one hole intersecting at least one of the wave structures to establish a perforated wave structure.

A bearing support plate for use in a generator has a radially enlarged flange with a first cylindrical portion extending from the flange in one direction which will provide a bearing support for an outer race of a ball bearing, and a radially inner cylindrical portion extending in an opposed direction that will be away from the ball bearing relative to the flange. The flange is generally cylindrical but has a truncated portion over a circumferential extent. The first cylindrical portion is formed with radially enlarged portions with intermediate radially thinner portions. The flange includes bolt holes circumferentially aligned with the radially thinner portions.

The present disclosure provides methods and apparatus for constructing a secure and flexible operating system. The presently disclosed system executes different user applications in different operating systems on different virtual machines. Each user application communicates with other processes via the hypertext transfer protocol (HTTP). In particular, each user application's user interface is implemented in a web browser that is running in its own operating system on its own virtual machine, and each user application interacts with the user interface by exchanging HTTP messages between the virtual machines.

Systems, methods, and computer program products for facilitating web-based interaction with a local system are disclosed. Such systems, methods, and computer program products provide an approach that allows a web client within in a web browser environment to access local hardware and local software—via a web server contained in the local system—in a local computer system. In response to a user input, the web client directs local hardware and local software to perform actions (e.g., writing files and taking pictures). Information related to such actions is returned to the web client via the local web server. The local computer system may be remotely located from the web client and such returned information may be stored and/or executed at a remote site (e.g., cloud database). Security layers may be provided to authenticate the user as well as user permissions for accessing the local computer system.

An information processing apparatus includes a transmission unit transmitting a command of a second operating system to the second operating system when receiving the command via a communication path which communicates under a control based on a first operating system, an extraction unit extracting data for the second operating system by analyzing the command transmitted from the transmission unit, and a writing unit writing the data extracted by the extraction unit as data constituting file system metadata of the second operating system.

A system and a method are disclosed for batch execution of system calls in an operating system. In one implementation, a processing device configures a system call batching buffer table in a user space of an operating system, the system call batching buffer table including a plurality of system call units, associates a system call number with the system call batching buffer table, and issues a trap instruction to a kernel of the operating system to execute at least one of the plurality of system call units, the trap instruction including the system call number.

A method and a processing device may be provided for state management of an operating system and applications. A framework may be provided for separating behaviorless state information from code or instructions for executing a method. Applications may have instances of state information derived from, or completely different from, instances of state information of an operating system. Instances of state information for an application may be layered over corresponding instances of state information of the operating system, such that the application and the operating system may have different views of the instances of the state information. At least one policy may be defined, which may include rules for resolving conflicts, information for providing a merged view of data from multiple repositories, default values for instances of data, as well as other information. In various implementations, referential integrity of state information may be guaranteed.

The present invention relates to a preparation method of a superabsorbent polymer, and specifically to a method of preparing a superabsorbent polymer including the steps of: preparing a hydrous gel phase polymer by thermal polymerizing or photo-polymerizing a monomer composition including a water-soluble ethylene-based unsaturated monomer and a polymerization initiator; drying the hydrous gel phase polymer; milling the dried polymer; classifying the milled hydrous gel phase polymer into two or more grades by particle size; adding a surface cross-linking agent to each hydrous gel phase polymer classified into two or more grades; and carrying out a surface cross-linking reaction of the hydrous gel phase polymer to which the surface cross-linking agent is added.