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Undercurrents: Episode 6 - Tribes of Europe, and the International Women's Rights Agenda at the UN




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The New Political Landscape in Germany and Austria




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Undercurrents: Episode 9 - Digital Subversion in Cyberspace, and Oleg Sentsov's Hunger Strike




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Frozen Conflict: The Transnistrian Dispute




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Dark Commerce: Technology’s Contribution to the Illegal Economy




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Undercurrents: Episode 27 - Financing for Developing Countries, and Investigative Journalism in West Africa




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The Battle for Tripoli




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The Secretome Profiling of a Pediatric Airway Epithelium Infected with hRSV Identified Aberrant Apical/Basolateral Trafficking and Novel Immune Modulating (CXCL6, CXCL16, CSF3) and Antiviral (CEACAM1) Proteins [Research]

The respiratory epithelium comprises polarized cells at the interface between the environment and airway tissues. Polarized apical and basolateral protein secretions are a feature of airway epithelium homeostasis. Human respiratory syncytial virus (hRSV) is a major human pathogen that primarily targets the respiratory epithelium. However, the consequences of hRSV infection on epithelium secretome polarity and content remain poorly understood. To investigate the hRSV-associated apical and basolateral secretomes, a proteomics approach was combined with an ex vivo pediatric human airway epithelial (HAE) model of hRSV infection (data are available via ProteomeXchange and can be accessed at https://www.ebi.ac.uk/pride/ with identifier PXD013661). Following infection, a skewing of apical/basolateral abundance ratios was identified for several individual proteins. Novel modulators of neutrophil and lymphocyte activation (CXCL6, CSF3, SECTM1 or CXCL16), and antiviral proteins (BST2 or CEACAM1) were detected in infected, but not in uninfected cultures. Importantly, CXCL6, CXCL16, CSF3 were also detected in nasopharyngeal aspirates (NPA) from hRSV-infected infants but not healthy controls. Furthermore, the antiviral activity of CEACAM1 against RSV was confirmed in vitro using BEAS-2B cells. hRSV infection disrupted the polarity of the pediatric respiratory epithelial secretome and was associated with immune modulating proteins (CXCL6, CXCL16, CSF3) never linked with this virus before. In addition, the antiviral activity of CEACAM1 against hRSV had also never been previously characterized. This study, therefore, provides novel insights into RSV pathogenesis and endogenous antiviral responses in pediatric airway epithelium.




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Templated folding of intrinsically disordered proteins [Molecular Biophysics]

Much of our current knowledge of biological chemistry is founded in the structure-function relationship, whereby sequence determines structure that determines function. Thus, the discovery that a large fraction of the proteome is intrinsically disordered, while being functional, has revolutionized our understanding of proteins and raised new and interesting questions. Many intrinsically disordered proteins (IDPs) have been determined to undergo a disorder-to-order transition when recognizing their physiological partners, suggesting that their mechanisms of folding are intrinsically different from those observed in globular proteins. However, IDPs also follow some of the classic paradigms established for globular proteins, pointing to important similarities in their behavior. In this review, we compare and contrast the folding mechanisms of globular proteins with the emerging features of binding-induced folding of intrinsically disordered proteins. Specifically, whereas disorder-to-order transitions of intrinsically disordered proteins appear to follow rules of globular protein folding, such as the cooperative nature of the reaction, their folding pathways are remarkably more malleable, due to the heterogeneous nature of their folding nuclei, as probed by analysis of linear free-energy relationship plots. These insights have led to a new model for the disorder-to-order transition in IDPs termed “templated folding,” whereby the binding partner dictates distinct structural transitions en route to product, while ensuring a cooperative folding.




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Making the Business Case for Nutrition Workshop

Invitation Only Research Event

28 January 2020 - 9:30am to 5:00pm

Chatham House | 10 St James's Square | London | SW1Y 4LE

A ground-breaking research project from Chatham House, supported by The Power of Nutrition, is exploring the business case for tackling undernutrition, micronutrient deficiencies and overnutrition. Companies across all sectors hold huge, transformative power to save countless lives and transform their own financial prospects. To act, they need more compelling evidence of the potential for targeted investments and strategies to promote better nutrition and create healthier, more productive workforces and consumers.

At this workshop, Chatham House will engage business decision-makers in a scenario exercise that explores different nutrition futures and their commercial prospects in each before examining what different strategies business can pursue to maximize future profitability through investments in nutrition.

Attendance at this event is by invitation only.




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Climate Change, Energy Transition, and the Extractive Industries Transparency Initiative (EITI)

Invitation Only Research Event

17 January 2020 - 9:30am to 5:00pm

Chatham House | 10 St James's Square | London | SW1Y 4LE

Climate change and energy transition are re-shaping the extractive sectors, and the opportunities and risks they present for governments, companies and civil society. As the central governance standard in the extractives sector, the EITI has a critical role in supporting transparency in producer countries.

This workshop will bring together experts from the energy and extractives sectors, governance and transparency, and climate risk and financial disclosure initiatives to discuss the role of governance and transparency through the transition. It will consider the appropriate role for the EITI and potential entry points for policy and practice, and the potential for coordination with related transparency and disclosure initiatives. 

Please note attendance is by invitation only.





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The finiteness of the spectrum of boundary value problems defined on a geometric graph

V. A. Sadovnichii, Ya. T. Sultanaev and A. M. Akhtyamov
Trans. Moscow Math. Soc. 80 (2020), 123-131.
Abstract, references and article information




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Justice for the Rohingya: Lessons from the Khmer Rouge Tribunal

8 April 2020

Sandra Smits

Programme Manager, Asia-Pacific Programme
The Cambodian case study illustrates the challenges of ensuring justice and accountability for the Rohingya in Myanmar.

2020-04-08-Rohingya.jpg

Coast guards escort Rohingya refugees following a boat capsizing accident in Teknaf on 11 February 2020. Photo: Getty Images.

International criminal justice provides a stark reminder that state sovereignty is not an absolute, and that the world’s most heinous crimes should be prosecuted at an international level, particularly where domestic systems lack the capacity or will to hold perpetrators to account. 

The post-Cold War period witnessed a dramatic rise in the number of international tribunals with jurisdiction over war crimes and serious human rights abuses in countries including Cambodia, East Timor, Rwanda, Liberia, Sierra Leone and Yugoslavia. With these processes approaching, or having reached the end of their dockets, many have called for the creation of new tribunals to address more recent conflicts, including the army crackdown in Myanmar in 2017 that resulted in evidence of crimes against humanity against the Rohingya

In January this year, the International Court of Justice (ICJ) imposed emergency provisional measures on Myanmar, instructing it to prevent genocidal violence against its Rohingya minority. But a final judgement is expected to take years and the ICJ has no way of enforcing these interim measures. Myanmar has already responded defiantly to international criticism

Model for justice

Myanmar is not the first country to face scrutiny for such crimes in Southeast Asia. The Extraordinary Chambers in the Courts of Cambodia (ECCC), more commonly known as the Khmer Rouge Tribunal was established in 1997 to prosecute Khmer Rouge leaders for alleged violations of international law and serious crimes perpetrated during the Cambodian genocide. This provides an opportunity to consider whether the Tribunal can act as a ‘hybrid’ model for justice in the region. 

The first lesson that can be taken from the Cambodian context is that the state must have the political will and commitment to pursue accountability. It was indeed the Cambodian government itself, who requested international assistance from the United Nations (UN), to organize a process for holding trials. The initial recommendation of the UN-commissioned Group of Experts was for the trial to be held under UN control, in light of misgivings about Cambodia’s judicial system. Prime Minister Hun Sen rejected this assessment and in prolonged negotiations, continued to spearhead the need for domestic involvement (arguably, in order to circumscribe the search for justice). This eventually resulted in the creation of a hybrid body consisting of parallel international and Cambodian judges and prosecutors with supermajority decision-making rules.   

It is worth noting that the Hun Sen government initially chose to do business with former Khmer Rouge leaders, until it became more advantageous to embrace a policy of putting them on trial. It is possible to infer from this that there will be no impetus for action in Myanmar until it is domestically advantageous to do so. At present, this appetite is clearly lacking, demonstrated by de-facto leader Aung San Suu Kyi shying away from accountability and instead defending the government’s actions before the ICJ.

One unique aspect of the Khmer Rouge Tribunal has been the vast participation by the Cambodian people in witnessing the trials as well as widespread support for the tribunal. This speaks to the pent-up demand in Cambodia for accountability and the importance of local participation. While international moral pressure is clear, external actors cannot simply impose justice for the Rohingya when there is no domestic incentive or support to pursue this. The reality is that the anti-Rohingya campaign has galvanized popular support from the country’s Buddhist majority. What is more, the Rohingya are not even seen as part of Myanmar so there is an additional level of disenfranchisement.

Secondly, the Cambodian Tribunal illustrates the need for safeguards against local political interference. The ECCC was designed as national court with international participation. There was an agreement to act in accordance with international standards of independence and impartiality, but no safeguards in place against serious deficiencies in the Cambodian judicial system. Close alliances between judges and the ruling Cambodian People’s Party, as well as high levels of corruption meant the tribunal effectively gave Hun Sen’s government veto power over the court at key junctures. Despite the guise of a hybrid structure, the Cambodian government ultimately retained the ability to block further prosecutions and prevent witnesses from being called. 

In Myanmar, political interference could be a concern, but given there is no popular support for justice and accountability for crimes committed against the Rohingya, the prospects of a domestic or hybrid process remain unlikely. However, there are still international options. The investigation by the International Criminal Court (ICC) into crimes that may have taken place on the Myanmar–Bangladesh border represents a potential route for justice and accountability. The UN Human Rights Council has also recently established the Independent Investigative Mechanism for Myanmar (IIMM), mandated to collect and preserve evidence, as well as to prepare files for future cases before criminal courts.

Finally, the Cambodian case illustrates the culture of impunity in the region. The ECCC was conceived partly as a showcase for international standards of justice, which would have a ‘contagion effect’ upon the wider Cambodian and regional justice systems. 

Cambodia was notorious for incidents in which well-connected and powerful people flouted the law. This culture of impunity was rooted in the failure of the government to arrest, try and punish the Khmer Rouge leadership. The Tribunal, in holding perpetrators of the worst crimes to account, sought to send a clear signal that lesser violations would not be tolerated in the same way. Arguably, it did not achieve this in practice as Cambodia still has a highly politicized judicial system with high levels of corruption and clear limits to judicial independence

What this illustrates is that the first step towards accountability is strengthening domestic institutions. The United Nation’s Special Rapporteur on the situation of human rights in Myanmar has urged domestic authorities to embrace democracy and human rights, highlighting the need to reform the judicial system in order to ensure judicial independence, remove systemic barriers to accountability and build judicial and investigatory capacity in accordance with international standards. Based on this assessment, it is clear that domestic institutions are currently insufficiently independent to pursue accountability.

The ECCC, despite its shortcomings, does stand as proof that crimes against humanity will not go completely unpunished. However, a process does not necessarily equal justice. The region is littered with justice processes that never went anywhere: Indonesia, Nepal, and Sri Lanka. International recourse is also challenging in a region with low ratification of the ICC, and the absence of regional mechanisms like the Inter-American Court of Human Rights, the European Court of Human Rights, and the African Court on Human and Peoples’ Rights (although their remit is not mass atrocity prosecutions). 

The Cambodian case study illustrates the challenges of ensuring justice and accountability within the region. The end of impunity is critical to ensure peaceful societies, but a purely legalistic approach will fail unless it is supported by wider measures and safeguards. It is these challenges, that undermine the prospects for ensuring justice for the Rohingya within Myanmar.




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Tripping the Light-Fantastic

Invisibility is no longer confined to fiction. In a recent experiment, microwaves were bent around a cylinder and returned to their original trajectories, rendering the cylinder almost invisible at those wavelengths. This doesn't mean that we're ready for invisible humans (or spaceships), but by using Maxwell's equations, which are partial differential equations fundamental to electromagnetics, mathematicians have demonstrated that in some simple cases not seeing is believing, too. Part of this successful demonstration of invisibility is due to metamaterials electromagnetic materials that can be made to have highly unusual properties. Another ingredient is a mathematical transformation that stretches a point into a ball, "cloaking" whatever is inside. This transformation was discovered while researchers were pondering how a tumor could escape detection. Their attempts to improve visibility eventually led to the development of equations for invisibility. A more recent transformation creates an optical "wormhole," which tricks electromagnetic waves into behaving as if the topology of space has changed. We'll finish with this: For More Information: Metamaterial Electromagnetic Cloak at Microwave Frequencies, D. Schurig et al, Science, November 10, 2006.




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Trimming Taxiing Time

Researcher: Hamsa Balakrishnan, MIT. Hamsa Balakrishnan talks about her work to shorten airport runway queues.




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Nature strikes back

The earth we abuse and the living things we kill will, in the end, take their revenge; for in exploiting their presence we are diminishing our future. ~ Marya Mannes Each species represents a thread in the closely woven fabric of Nature. For centuries, we humans have prided ourselves on being the most 'evolved' species. Superior intelligence and technological capability have bred this arrogance.




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Has anyone tried adsterra network?




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CBD News: G8 Hokkaido Toyako Summit - A Historic Contribution to Biodiversity.




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CBD News: "Meeting the 2010 biodiversity target: A contribution to poverty alleviation and the benefit of life on Earth", Statement by Dr. Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity at the IUCN World Conservati




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CBD News: The President of the Conference of the Parties and Executive Secretary Congratulate Countries that Have Submitted on Time Their Fourth National Reports and Urge all Parties to Meet Their Reporting Obligations Under the Convention




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CBD News: Biodiversity and Climate Change: A CBD Contribution to the Copenhagen Climate Agreement.




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CBD Communiqué: G-77 Ministers Pay Special Tribute to CBD Secretariat's Leading Role in South-South Cooperation.




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CBD Communiqué: CBD Secretariat and the Institute of Energy and Environment of La Francophonie join Forces to Raise Awareness in French-Speaking Countries.




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CBD News: Statement to UNFCCC SBSTA 31: Agenda Item 5 Reducing Emissions from Deforestation in Developing Countries: Approaches to Stimulate Action.




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CBD News: Statement by Mr Ahmed Djoghlaf, The Executive Secretary of the Convention on Biological Diversity, on the Occasion of the Meeting For Promoting North-South, South-South And Triangular Cooperation For Sustainable Forest Management, 19 December 20




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CBD News: Opening Remarks by Mr. Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity, on the occasion of the Access and Benefit-Sharing Regional Consultations for Central and Eastern European Countries, 9-10 February 2010, Isle o




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CBD News: The CBD Secretariat will co-organize an International Conference on Biodiversity Conservation in Transboundary Tropical Forests, from 14-17 July, in Quito, Ecuador. The Conference will be organized jointly with IUCN and ITTO, as a contribution t




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CBD News: Statement by Mr Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity, on the occasion of the Trilateral Wadden Sea Conference, 17 March 2010, Sylt, Germany.




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CBD Press Release: President Lee of the Republic of Korea receives CBD Award for his contribution to biodiversity conservation and green growth




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CBD News: High-level Meeting of the General Assembly as a Contribution to the International Year of Biodiversity , 22 September 2010.




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CBD News: Statement by Mr Ahmed Djoghlaf, CBD Executive Secretary, on the occasion of the International Ministerial Conference of Mountain Countries on Climate Change, 4 October 2010, Kathmandu, Nepal




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CBD News: The UN Secretary-General Message to Closing Ceremony for the International Year of Biodiversity, Kanazawa, 18 December 2010. The UNSG Message is also available in Japanese on the Countries Celebrations page www.cbd.int/2010/country/?country=jp




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CBD News: 15e École d'été en évaluation environnementale Évaluation de la durabilité du développement urbain et industriel: outils d'analyse de l'empreinte écologique et des impacts sociaux et sanitaires




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CBD Press Release: International Policy Award for Visionary Forest Policies: Sixteen Countries Nominated by Experts.




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CBD Press Release: Montreal Marks the International Day for Biological Diversity as a Contribution to the Celebration of the 2011 International Year of Forests




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CBD Communiqué: Arabic version of CBD website inaugurated as a contribution to achieving the objectives of the United Nations Decade on Biodiversity




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CBD Press Release: The 6th INTERNATIONAL GREEN AWARDST opens for entries and searches the globe for the true unsung sustainability heroes.




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CBD Communiqué: Seychelles Makes Major Contribution to Aichi Biodiversity Targets




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CBD Press Release: Forest Policies from six countries shortlisted for Future Policy Award




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CBD Communiqué: United Nations Decade on Biodiversity launched in Havana for the countries of the Caribbean




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CBD Press Release: Future Policy Award celebrates solutions to save oceans and coasts: 31 policies from 22 countries and regions nominated




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CBD Press Release: How can we save the world's oceans and coasts? Five countries' ocean and coastal policies shortlisted for the 2012 Future Policy Award.




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CBD News: The New Delhi ASEAN-India Ministerial Statement on Biodiversity: Ministers responsible for the environment and their representatives of India and ASEAN countries have agreed to enhance awareness among all stakeholders, strive towards mainstreami




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CBD Communiqué: Hyderabad, 27 September 2012 - Some 2000 delegates from more than 150 countries will convene this coming Monday in Hyderabad, India, for the sixth meeting of the Conference of the Parties serving as the meeting of the Parties to the C




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CBD Press Release: At United Nations Biodiversity Conference, countries agree to double resources for biodiversity protection by 2015 - Special attention for biodiversity-rich marine areas among other key outcomes.




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CBD Press Release: Panama and Mauritius have become the 10th and 11th countries respectively to ratify the Nagoya Protocol on Access to Genetic Resources and the Fair and Equitable Sharing of Benefits Arising from their Utilization to the Convention on Bi




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CBD News: Albania, Botswana and the Federated States of Micronesia have become the 13th 14th and 15th countries to ratify the Nagoya Protocol on Access to Genetic Resources and the Fair and Equitable Sharing of Benefits Arising from their Utilization to t




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CBD News: Biodiversity Indicator Facilitators are now available to support the development and use of biodiversity indicators as part of NBSAP updating in their countries and regions. The Facilitators have been selected and trained by the Biodiversity Ind




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CBD News: Honduras and Tajikistan became the most recent countries to ratify the Nagoya Protocol on Access to Genetic Resources and the Fair and Equitable Sharing of Benefits Arising from their Utilization to the Convention on Biological Diversity.