de

Clinical utility of serial analysis of circulating tumour cells for detection of minimal residual disease of metastatic nasopharyngeal carcinoma




de

Early assessment of <i>KRAS</i> mutation in cfDNA correlates with risk of progression and death in advanced non-small-cell lung cancer




de

Molecular profiling of stroma highlights stratifin as a novel biomarker of poor prognosis in pancreatic ductal adenocarcinoma




de

Comparative efficacy of a hydroxyapatite and a fluoride toothpaste for prevention and remineralization of dental caries in children




de

A questionnaire study on the impact on oral health-related quality of life by conventional rehabilitation of edentulous patient




de

A single-centre investigator-blinded randomised parallel-group study protocol to investigate the influence of an acclimatisation appointment on children’s behaviour during N<sub>2</sub>O/O<sub>2</sub> sedation as measured by psycho




de

Clinical and radiographic evaluation of indirect pulp treatment of young permanent molars using photo-activated oral disinfection versus calcium hydroxide: a randomized controlled pilot trial




de

Nanopore sequencing and the Shasta toolkit enable efficient de novo assembly of eleven human genomes




de

Author Correction: Genetic circuit design automation for the gut resident species <i>Bacteroides thetaiotaomicron</i>




de

The expression of YAP1 is increased in high-grade prostatic adenocarcinoma but is reduced in neuroendocrine prostate cancer




de

Telomere-based risk models for the early diagnosis of clinically significant prostate cancer




de

MHD surrogate model for convection in electromagnetically levitated molten metal droplets processed using the ISS-EML facility

npj Microgravity, Published online: 16 March 2020; doi:10.1038/s41526-020-0099-7

MHD surrogate model for convection in electromagnetically levitated molten metal droplets processed using the ISS-EML facility




de

Protein structural changes on a CubeSat under rocket acceleration profile

npj Microgravity, Published online: 23 April 2020; doi:10.1038/s41526-020-0102-3

Protein structural changes on a CubeSat under rocket acceleration profile




de

Ex situ determination of freely dissolved concentrations of hydrophobic organic chemicals in sediments and soils: basis for interpreting toxicity and assessing bioavailability, risks and remediation necessity




de

CRISPR off-target detection with DISCOVER-seq




de

Cellular thermal shift assay for the identification of drug–target interactions in the <i>Plasmodium falciparum</i> proteome




de

Daily blue-light exposure shortens lifespan and causes brain neurodegeneration in <i>Drosophila</i>




de

Short-term NAD<sup>+</sup> supplementation prevents hearing loss in mouse models of Cockayne syndrome




de

Repository of proposed pathways and protein–protein interaction networks in age-related macular degeneration




de

CMV-independent increase in CD27−CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians




de

Organotypic human skin culture models constructed with senescent fibroblasts show hallmarks of skin aging




de

Rituximab for desensitization during HLA-mismatched stem cell transplantation in patients with a positive donor-specific anti-HLA antibody




de

Donor-derived DNA variability in fingernails of acute myeloid leukemia patients after allogeneic hematopoietic stem cell transplantation detected by direct PCR




de

The HMGB1-RAGE axis modulates the growth of autophagy-deficient hepatic tumors




de

QKI deficiency leads to osteoporosis by promoting RANKL-induced osteoclastogenesis and disrupting bone metabolism




de

NF-kappa B interacting long noncoding RNA enhances the Warburg effect and angiogenesis and is associated with decreased survival of patients with gliomas




de

Cell Death & Disease




de

Tumor-selective delivery of antisense oligomers (antimiRs) against oncogenic microRNAs

miRNA-targeted antimiRs conjugated to a peptide with a low pH–induced transmembrane structure (pHLIP) could help treat solid tumors.




de

Extending therapeutic protein half-lives via fusion to affibodies with pH-dependent binding to neonatal Fc receptor

Fusing therapeutic proteins to affibodies with pH-dependent binding to neonatal Fc receptor could improve the proteins' half-lives.




de

Dermatophagoides pteronyssinus peptidase 1 (DERP1)

In vitro and rat studies suggest inhibiting the enzymatic activity of house dust mite (HDM) allergens could help treat allergic asthma.




de

Globohexaosylceramide (globo-H); stage-specific embryonic antigen-3 (SSEA-3); SSEA-4

Mouse studies suggest chemically modified carbohydrate conjugates could be useful as antigens for the development of cancer vaccines.




de

Epidermal growth factor receptor 1 (EGFR1; ErbB1; HER1); HER2 (EGFR2; ErbB2; neu); HER3 (EGFR3; ErbB3); VEGF

Tumor cell and mouse studies suggest tetravalent antibodies that target four different antigens could help treat cancers resistant to HER-targeted therapies.




de

Cyclin dependent kinase 7 (CDK7); v-myc myelocytomatosis viral related oncogene neuroblastoma derived (MYCN; NMYC)

In vitro and mouse studies suggest THZ1, a covalent CDK7 inhibitor, could help treat neuroblastoma and other cancers driven by MYCN and other c-MYC (MYC)-family oncoproteins.




de

Estrogen receptor; LYN kinase (LYN); phosphoinositide 3-kinase (PI3K)

Studies in mice and human samples suggest inhibiting LYN could help treat estrogen receptor–positive breast cancers resistant to anti-estrogen therapy.




de

Tissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue remodelling




de

Transcription factors in ferroptotic cell death




de

Oncolytic adenovirus encoding LIGHT (TNFSF14) inhibits tumor growth via activating anti-tumor immune responses in 4T1 mouse mammary tumor model in immune competent syngeneic mice




de

UNC5B mediates G2/M phase arrest of bladder cancer cells by binding to CDC14A and P53




de

Two-dimensional optical edge detection




de

Author Correction: Quantum wave–particle superposition in a delayed-choice experiment




de

Engineering nanomedicines through boosting immunogenic cell death for improved cancer immunotherapy




de

Cardamonin protects against lipopolysaccharide-induced myocardial contractile dysfunction in mice through Nrf2-regulated mechanism




de

Diabetes downregulates peptide transporter 1 in the rat jejunum: possible involvement of cholate-induced FXR activation




de

An in vitro Förster resonance energy transfer-based high-throughput screening assay identifies inhibitors of SUMOylation E2 Ubc9




de

Ex vivo pulsed dendritic cell vaccination against cancer




de

Cannabinoid CB<sub>2</sub> receptors mediate the anxiolytic-like effects of monoacylglycerol lipase inhibition in a rat model of predator-induced fear




de

A roadmap for development of neuro-oscillations as translational biomarkers for treatment development in neuropsychopharmacology




de

Correction: Ketamine metabolites, clinical response, and gamma power in a randomized, placebo-controlled, crossover trial for treatment-resistant major depression




de

Nuclear receptor crosstalk — defining the mechanisms for therapeutic innovation




de

Sweet signals — gut–brain circuit for sugar identified