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An innocent party noisemaker...

Ousted vaccine expert Rick Bright said he is "frustrated at our inability to be heard as scientists."

Some Buckeyes are not comfortable being told by a "woman in power" to quarantine, one expert said.

"I think it's always important to think about suicide as individual vulnerabilities and context," Eric Caine said.

Although a robust inflammatory response is needed to combat infection, this response must ultimately be terminated to prevent chronic inflammation. One mechanism that terminates inflammatory signaling is the production of alternative mRNA splice forms in the Toll-like receptor (TLR) signaling pathway. Whereas most genes in the TLR pathway encode positive mediators of inflammatory signaling, several, including that encoding the MyD88 signaling adaptor, also produce alternative spliced mRNA isoforms that encode dominant-negative inhibitors of the response. Production of these negatively acting alternatively spliced isoforms is induced by stimulation with the TLR4 agonist lipopolysaccharide (LPS); thus, this alternative pre-mRNA splicing represents a negative feedback loop that terminates TLR signaling and prevents chronic inflammation. In the current study, we investigated the mechanisms regulating the LPS-induced alternative pre-mRNA splicing of the MyD88 transcript in murine macrophages. We found that 1) the induction of the alternatively spliced MyD88 form is due to alternative pre-mRNA splicing and not caused by another RNA regulatory mechanism, 2) MyD88 splicing is regulated by both the MyD88- and TRIF-dependent arms of the TLR signaling pathway, 3) MyD88 splicing is regulated by the NF-κB transcription factor, and 4) NF-κB likely regulates MyD88 alternative pre-mRNA splicing per se rather than regulating splicing indirectly by altering MyD88 transcription. We conclude that alternative splicing of MyD88 may provide a sensitive mechanism that ensures robust termination of inflammation for tissue repair and restoration of normal tissue homeostasis once an infection is controlled.

Protease-activated receptor 2 (PAR-2) is activated by secreted proteases from immune cells or fungi. PAR-2 is normally expressed basolaterally in differentiated nasal ciliated cells. We hypothesized that epithelial remodeling during diseases characterized by cilial loss and squamous metaplasia may alter PAR-2 polarization. Here, using a fluorescent arrestin assay, we confirmed that the common fungal airway pathogen Aspergillus fumigatus activates heterologously-expressed PAR-2. Endogenous PAR-2 activation in submerged airway RPMI 2650 or NCI–H520 squamous cells increased intracellular calcium levels and granulocyte macrophage–colony-stimulating factor, tumor necrosis factor α, and interleukin (IL)-6 secretion. RPMI 2650 cells cultured at an air–liquid interface (ALI) responded to apically or basolaterally applied PAR-2 agonists. However, well-differentiated primary nasal epithelial ALIs responded only to basolateral PAR-2 stimulation, indicated by calcium elevation, increased cilia beat frequency, and increased fluid and cytokine secretion. We exposed primary cells to disease-related modifiers that alter epithelial morphology, including IL-13, cigarette smoke condensate, and retinoic acid deficiency, at concentrations and times that altered epithelial morphology without causing breakdown of the epithelial barrier to model early disease states. These altered primary cultures responded to both apical and basolateral PAR-2 stimulation. Imaging nasal polyps and control middle turbinate explants, we found that nasal polyps, but not turbinates, exhibit apical calcium responses to PAR-2 stimulation. However, isolated ciliated cells from both polyps and turbinates maintained basolateral PAR-2 polarization, suggesting that the calcium responses originated from nonciliated cells. Altered PAR-2 polarization in disease-remodeled epithelia may enhance apical responses and increase sensitivity to inhaled proteases.

Fucosylation of the innermost GlcNAc of N-glycans by fucosyltransferase 8 (FUT8) is an important step in the maturation of complex and hybrid N-glycans. This simple modification can dramatically affect the activities and half-lives of glycoproteins, effects that are relevant to understanding the invasiveness of some cancers, development of mAb therapeutics, and the etiology of a congenital glycosylation disorder. The acceptor substrate preferences of FUT8 are well-characterized and provide a framework for understanding N-glycan maturation in the Golgi; however, the structural basis of these substrate preferences and the mechanism through which catalysis is achieved remain unknown. Here we describe several structures of mouse and human FUT8 in the apo state and in complex with GDP, a mimic of the donor substrate, and with a glycopeptide acceptor substrate at 1.80–2.50 Å resolution. These structures provide insights into a unique conformational change associated with donor substrate binding, common strategies employed by fucosyltransferases to coordinate GDP, features that define acceptor substrate preferences, and a likely mechanism for enzyme catalysis. Together with molecular dynamics simulations, the structures also revealed how FUT8 dimerization plays an important role in defining the acceptor substrate-binding site. Collectively, this information significantly builds on our understanding of the core fucosylation process.

Multidrug resistance (MDR) in cancer arises from cross-resistance to structurally- and functionally-divergent chemotherapeutic drugs. In particular, MDR is characterized by increased expression and activity of ATP-binding cassette (ABC) superfamily transporters. Sphingolipids are substrates of ABC proteins in cell signaling, membrane biosynthesis, and inflammation, for example, and their products can favor cancer progression. Glucosylceramide (GlcCer) is a ubiquitous glycosphingolipid (GSL) generated by glucosylceramide synthase, a key regulatory enzyme encoded by the UDP-glucose ceramide glucosyltransferase (UGCG) gene. Stressed cells increase de novo biosynthesis of ceramides, which return to sub-toxic levels after UGCG mediates incorporation into GlcCer. Given that cancer cells seem to mobilize UGCG and have increased GSL content for ceramide clearance, which ultimately contributes to chemotherapy failure, here we investigated how inhibition of GSL biosynthesis affects the MDR phenotype of chronic myeloid leukemias. We found that MDR is associated with higher UGCG expression and with a complex GSL profile. UGCG inhibition with the ceramide analog d-threo-1-(3,4,-ethylenedioxy)phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol (EtDO-P4) greatly reduced GSL and monosialotetrahexosylganglioside levels, and co-treatment with standard chemotherapeutics sensitized cells to mitochondrial membrane potential loss and apoptosis. ABC subfamily B member 1 (ABCB1) expression was reduced, and ABCC-mediated efflux activity was modulated by competition with nonglycosylated ceramides. Consistently, inhibition of ABCC-mediated transport reduced the efflux of exogenous C6-ceramide. Overall, UGCG inhibition impaired the malignant glycophenotype of MDR leukemias, which typically overcomes drug resistance through distinct mechanisms. This work sheds light on the involvement of GSL in chemotherapy failure, and its findings suggest that targeted GSL modulation could help manage MDR leukemias.

The U.S. refugee protection system, while generous in many respects, has become less robust over the last two decades. The unique and often diverse needs of emerging refugee populations have exposed severe limitations in the standard resettlement approach.This report examines U.S. legal and policy responses to those seeking protection and addresses the barriers, gaps, and opportunities that exist.

This report analyzes prenatal behaviors and birth outcomes of Black immigrant mothers, and finds that Black immigrant mothers are less likely to give birth to preterm or low-birth-weight infants than U.S.-born Black women, but more likely to experience these birth outcomes than other immigrant and U.S.-born women.

This report focuses on the development of children of Black immigrants in the United States, comparing against the outcomes for their peers in native-born and other immigrant families. It also compares these U.S. children to those in the United Kingdom, where there is a large Black immigrant population but a notably different policy context of reception.

MPI’s National Center on Immigrant Integration Policy convened a major public policy research symposium focused on young children of immigrants in the U.S.

Health Minister Dr Christopher Tufton and a 70-member team of healthcare workers are now in Dover, St Mary where they have been conducting house to house visits to test persons for COVID-19.  They have also been providing health...

(AP): South Korea’s capital, Seoul, has closed down more than 2,000 bars and other nightspots because of a new cluster of COVID-19 infections; Germany scrambled to contain fresh outbreaks at slaughterhouses; and...

GEORGETOWN, Guyana (CMC): THE CARIBBEAN Community (CARICOM) Council for Human and Social Development (COHSOD) on Education says regional students will sit the Caribbean Examinations Council-administered exams in July. The COHSOD meeting, which was...

The coronavirus pandemic (COVID-19) has resulted in many opportunities for the health technology industry. Our usually technophobic population has been embracing technology more and more since the start of the restrictions due to the spread of...

This special issue focuses on The Role of Community Health Workers as First Responders in the COVID-19 Outbreak. 

Recorded May 5, 2020.

This is a part of the American Diabetes Associations ongoing project providing resources for practicing clinicians on the care of Diabetes during the Covid-19 pandemic.  Today’s discussion is an audio version of a webinar recorded on May 5, 2020.

Presented by:

Betsy Rodriguez, BSN, MSN, DCES
Centers for Disease Control and Prevention

Colleen Barbero, PhD
Centers for Disease Control and Prevention

Denise Octavia Smith, MBA, CHW, PN, SFC
National Association of Community Health Workers

This edited volume from the World Health Organization (WHO), which includes chapters written by MPI researchers, examines country-level responses to the international movement of health-care workers, both before and after adoption of the WHO’s Global Code of Practice on the International Recruitment of Health Personnel.

A webinar examining aspects of the implementation at state and local levels of the federal Workforce Innovation and Opportunity Act (WIOA) that may limit immigrant integration, along with a discussion on strategies that may help ensure more equitable access for immigrants and refugees to services provided under the law.  

It’s not just your waistline that suffers as you put on weight. Researchers are beginning to find puzzling new links between obesity, memory loss and dementia

Lucy Cheke and her colleagues at the University of Cambridge recently invited a few participants into her lab for a kind of ‘treasure hunt’.

The participants navigated a virtual environment on a computer screen, dropping off various objects along their way. They then answered a series of questions to test their memory of the task, such as where they had hidden a particular object.

Related: How your eyes betray your thoughts

Related: How to optimise your brain's waste disposal system

Related: Gut bacteria regulate nerve fibre insulation

Related: Obesity linked to memory deficits

New findings challenge our understanding of how the brain matures

Faces are important to us. From the moment we are are born, we prefer to look at faces than at other, inanimate objects, and, being social animals, we encounter faces every day of our lives. The face is the first thing we look to when identifying other people; faces also convey emotions, informing us of peoples’ mood, and from them we can usually determine a person’s sex and, sometimes, roughly how old they are. Eye movements can also reveal to us something about another person’s intentions.

Related: How your eyes betray your thoughts

Related: Live imaging of synapse density in the human brain

yesterday night i had come from the cold and i was freezing!. i immediately got into a hot shower - i don't know why but i started feeling dizzy: my vision started going and i was confused then my ears started ringing and i was scared. i shouted for someone and my brother came: he asked if i was ok but i said i felt dizzy and i couldn't really see him at all. i said i felt faint and he said sit down slowly - so i did. eventually i closed my eyes and it helped; i feel better now but why did it happen?!.

This report assesses the labor market outcomes of new immigrants in the Czech Republic, focusing on trends according to year of arrival, country of origin, gender, level of education, and sector of employment. The analysis suggests that the challenge of reducing obstacles to immigrant workers’ progression into more skilled employment are worth significant policy attention.

Part of a series exploring issues likely to be addressed by the new National Integration Plan, this webinar, with perspectives from MPI, the National Partnership for New Americans, and the National Skills Coalition, looks at the role of adult education and English language and skills training in the immigrant integration process.

Part of a series exploring issues likely to be addressed by the new National Integration Plan, this webinar, with perspectives from the cities of New York and Seattle and others delves into possible recommendations on federal coordination of local government immigrant integration initiatives, including language access. 

This webinar, with perspectives from MPI, the National Partnership for New Americans, and the National Skills Coalition, looks at the role of adult education and English language and skills training in the immigrant integration process.

Part of a series exploring issues likely to be addressed by the new National Integration Plan, this webinar, with perspectives from the cities of New York and Seattle and others examines possible recommendations on federal coordination of local government immigrant integration initiatives, including language access. 

On the last day of its week-long promotion, Super Lube Auto Centre's McPhillips Street location had dozens of health-care workers lining the streets in their vehicles as they waited for an oil change on the house.

For only the second time in its near 80-year history, the American Geriatrics Society will award one of its highest honors typically reserved for individuals to West Health, a family of nonprofit organizations dedicated to lowering healthcare costs to enable older adults to successfully age in place.

In the ongoing struggle to address health care disparities in rural communities across the U.S., a recent Oregon State University study found that the perfect partner may be hiding in plain sight.

Joya Kazi’s work on Mindy Kaling’s ‘Never Have I Ever’ helps blend Indian and American cultures  indica News

Mother's Day Special: Experts reveal what kids can do to take care of their moms and their health  PINKVILLA

1. UFC 249: Justin Gaethje halts the Tony Ferguson vs Khabib Nurmagomedov storyline  Hindustan Times
2. UFC 249 news: Khabib Nurmagomedov tweets immediately after Tony Ferguson loses to Justin Gaethje  GIVEMESPORT
3. Twitter Salutes Tony Ferguson After Surviving a Barrage of Attacks From Justin Gaethje  Essentially Sports
4. UFC 249: ‘He is epitome of an athlete,’ Justin Gaethje full of praise for opponent Tony Ferguson  Hindustan Times
5. Justin Gaethje batters Tony Ferguson to win UFC interim lightweight title  ESPN India
6. View Full coverage on Google News

A Calgary coffee shop must close public access to its patio and dine-in services, Alberta Health Services says.

A thriving youth group and an Italian-language event encourage a team from OM Italy during a recent visit to OM’s ministry in Montenegro.

A new OM Italy team member participates in an English Scout Camp, which brings the Gospel to children and gives her new cultural insight.

Russian OMer Alexandra Bykova begins a Quilting Club to bring women closer to each other and to faith in Christ.

OM Philippines hosts camps for children affected by recent trauma that facilitate emotional restoration through dance, songs, crafts, Bible stories and more.

“God is working in this community,” James said. He and other Christians in his village are challenging the culture by living their lives for Christ.

Goran’s decision to follow Jesus challenged the cultural values and traditions he grew up with, causing him to live differently in his community.

OM Near East Field's internship school trains Arab Christians and others called to reach the Muslims of Iraq.

A long-time resident of Trench Town, Donnette Dowe has seen the trials of urban life up-close and personal. Like many inner-city Jamaican communities, crime, teen pregnancy and poverty are rife.The 50-year-old mother of five children (ages 26, 24, 21, 16 and 12) is director and tour manager for Trench Town Culture Yard, a renovated tenement which was once home to Bob Marley and his family.

Source: ftw.usatoday.com - Saturday, May 09, 2020
Justin Gaethje put on a show in front of zero fans Saturday night at UFC 249 in Jacksonville, Fla., winning the interim lightweight belt with a fifth-round TKO victory over the legendary Tony Ferguson after referee Herb Dean called the fight with just over a minute to go. But when it was time to get the belt from UFC boss Dana White, Gaethje wanted nothing to do with the impressive hardware as he quickly tossed it aside before talking to Joe Rogan in the Octagon. Why would he do that? Because interim belts in the UFC are pretty silly and Gaethje doesn’t want to waste his time celebrating an accomplishment that now sets him up to fight for the real lightweight belt against Khabib Nurmagomedov who still owns the belt and is one of the greatest fighters of all time. Look at how Gaethje treated his belt: Justin Gaethje tossed aside the interim lightweight title belt he won at #UFC249 "I'll wait for the real one." pic.twitter.com/GBxD1RUemj — ESPN (@espn) May 10, 2020 Seriously, he wanted nothing to do with that thing. He evenly let his coach leave Octagon with it: . @Justin_Gaethje truly wants no part of that interim belt. His head coach Trevor Wittman had to carry it out of the octagon. #UFC249 | More: https://t.co/N8mXceTwxO pic.twitter.com/MBDvMIHG1h — MMA Junkie (@MMAjunkie) May 10, 2020 Now that is one of the coolest things I’ve seen in the fight game for quite some time. Sure, we haven’t seen fighting in quite some time, eithe