The state is trying to fight an Education Department decision that it had not put enough money into special education in the 2010-11 school year.

Ron DeSantis had a thin record on K-12 issues as a Florida congressman, but as a first-term Republican governor he’s pushed an aggressive agenda on issues such as vouchers, teacher salaries and bonus pay, and even the common core.

Teachers across the state are outraged over a new rule that requires 15 hours of workforce-related professional development.

New state mandates start next school year aimed at identifying and supporting students with dyslexia. The 2016 law also led to development of training for teachers.

When Scott Gann learned his son Dustin had dyslexia, he was shocked at the school's reaction. No one there wanted to use the word.

This Quality Counts 2019 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes.

Many are whipsawed by shutdown recommendations aimed at stemming the coronavirus, and the logistical and financial consequences of those actions.

Alexandria Area High School was created to accommodate changes in education and technology.

The district’s chief of accountability, research, and equity talks about racism, racial equity, and the district’s search for a new student-safety strategy.

Recent Census data finds households in the South and Midwest lagging those in other regions in access to remote learning technologies and learning interactions with teachers and family members.

Former Red Wings general manager Ken Holland is taking on a new role with the NHL's league office

Emma Lingan and Eric Cruikshank discuss Washington Capitals center Dylan Strome, the Bruins and Red Wings coaches, Kirill Kaprizov's next contract and much more.

The New Jersey Devils will face former teammates Tomas Nosek, Jesper Boqvist, AJ Greer, and Dmitry Kulikov on Tuesday night in their game against the Florida Panthers.

With a need for youth in the system and for an urgent NHL course correction simultaneously, Pittsburgh will be a team to watch in the trade market

The second College Football Playoff rankings were released, with the big questions surrounding who would be No. 3 and where the SEC teams would land.

Texas A&M's Week 11 bye week was (hopefully) successful in terms of fixing the issues that plagued the Aggies, especially the defensive issues that led to 25 missed tackles in the 44-20 loss to South Carolina, which dropped the Aggies to No. 14 in the first Col

Where did Texas A&M land in the latest CFP bracket? Here’s the College Football Playoff picture for the Aggies and their path to the championship.

Georgia and Miami misery translates into joy for the Texas Longhorns. Thanks to losses by the 'Canes and Bulldogs on Saturday, the Horns move up two spots in the college football playoff ranki

Texas Longhorns fans were very happy after the second edition of the College Football Playoff rankings were released Tuesday.

But some Democrats say that could make the selection process more political.

A school leader outlines how research findings on reducing achievement gaps are reflected in practice at her New Mexico school.

In a case that has drawn the involvement of the Trump administration, a federal judge holds that state rules limiting in-person instruction are not infringing on federal constitutional rights.

A federal investigation of Chicago's failures to respond to sexual violence in schools raises troubling questions for school districts nationwide.

Nebraska women’s basketball star Alexis Markowski was named to the Preseason Women’s Top 50 Watch List for the John R. Wooden Award. This news was confirmed on Thursday per a release from the athletic department. The award is given annually to that season's mos

The No. 4 Texas Longhorns kicked off their season with a 119-47 win over Southeast Missouri State (SEMO) on Sunday at Moody Center. This victory marked Texas' 13th consecutive home opener win, establishing a strong start to the 2024-2

Onward State published a story this week that contained on-the-record comments from former Marquette players about Carolyn Kieger's coaching style.

On Wednesday at Moody Center, a Lamar team that went 24-7 last season should provide a tougher test for the Longhorns than in their season opener.

Elisa Mevius and Nani Falatea each scored 11 points and No. 25 Oregon routed North Texas 66-35 on Tuesday for its fourth straight victory. Mevius scored the final four points of the first quarter to give Oregon a 14-4 lead as North Texas was just 2 of 11 from the field. Falatea made the first field goal of the second quarter for a 17-6 lead and the Ducks led by double figures the rest of the way.

Tsuneya Ikezu
Oct 2, 2024; 44:e1170242024-e1170242024
Symposium

Corey M. Ziemba
Oct 16, 2024; 44:e0349242024-e0349242024
Systems/Circuits

Pietro Mazzoni
Apr 5, 2006; 26:3642-3645
BRIEF COMMUNICATION

Gijs Joost Brouwer
Nov 4, 2009; 29:13992-14003
BehavioralSystemsCognitive

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Articles

Uri Hasson
Mar 5, 2008; 28:2539-2550
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Jordan A. Taylor
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Umut Güçlü
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BehavioralSystemsCognitive

α-Neurexins are essential and highly expressed presynaptic cell-adhesion molecules that are frequently linked to neuropsychiatric and neurodevelopmental disorders. Despite their importance, how the elaborate extracellular sequences of α-neurexins contribute to synapse function is poorly understood. We recently characterized the presynaptic gain-of-function phenotype caused by a missense mutation in an evolutionarily conserved extracellular sequence of neurexin-3α (A687T) that we identified in a patient diagnosed with profound intellectual disability and epilepsy. The striking A687T gain-of-function mutation on neurexin-3α prompted us to systematically test using mutants whether the presynaptic gain-of-function phenotype is a consequence of the addition of side-chain bulk (i.e., A687V) or polar/hydrophilic properties (i.e., A687S). We used multidisciplinary approaches in mixed-sex primary hippocampal cultures to assess the impact of the neurexin-3α^A687 residue on synapse morphology, function and ligand binding. Unexpectedly, neither A687V nor A687S recapitulated the neurexin-3α A687T phenotype. Instead, distinct from A687T, molecular replacement with A687S significantly enhanced postsynaptic properties exclusively at excitatory synapses and selectively increased binding to neuroligin-1 and neuroligin-3 without changing binding to neuroligin-2 or LRRTM2. Importantly, we provide the first experimental evidence supporting the notion that the position A687 of neurexin-3α and the N-terminal sequences of neuroligins may contribute to the stability of α-neurexin–neuroligin-1 trans-synaptic interactions and that these interactions may specifically regulate the postsynaptic strength of excitatory synapses.

Recent visual experience heavily influences our visual perception, but how neuronal activity is reshaped to alter and improve perceptual discrimination remains unknown. We recorded from populations of neurons in visual cortical area V4 while two male rhesus macaque monkeys performed a natural image change detection task under different experience conditions. We found that maximizing the recent experience with a particular image led to an improvement in the ability to detect a change in that image. This improvement was associated with decreased neural responses to the image, consistent with neuronal changes previously seen in studies of adaptation and expectation. We found that the magnitude of behavioral improvement was correlated with the magnitude of response suppression. Furthermore, this suppression of activity led to an increase in signal separation, providing evidence that a reduction in activity can improve stimulus encoding. Within populations of neurons, greater recent experience was associated with decreased trial-to-trial shared variability, indicating that a reduction in variability is a key means by which experience influences perception. Taken together, the results of our study contribute to an understanding of how recent visual experience can shape our perception and behavior through modulating activity patterns in the mid-level visual cortex.