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Identification of unusual phospholipids from bovine heart mitochondria by HPLC-MS/MS

Junhwan Kim
Dec 1, 2020; 61:1707-1719
Research Articles




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Deletion of lysophosphatidylcholine acyltransferase3 in myeloid cells worsens hepatic steatosis after a high fat diet

Thibaut Bourgeois
Dec 11, 2020; 0:jlr.RA120000737v1-jlr.RA120000737
Research Articles




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Lipid metabolism dysregulation in diabetic retinopathy

Julia V Busik
Dec 23, 2020; 0:jlr.TR120000981v1-jlr.TR120000981
Thematic Reviews




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Human CETP lacks lipopolysaccharide transfer activity, but worsens inflammation and sepsis outcomes in mice

Aloïs Dusuel
Dec 9, 2020; 0:jlr.RA120000704v1-jlr.RA120000704
Research Articles




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Mutation in the distal NPxY motif of LRP1 alleviates dietary cholesterol-induced dyslipidemia and tissue inflammation

Anja Jaeschke
Dec 9, 2020; 0:jlr.RA120001141v1-jlr.RA120001141
Research Articles




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Membrane-bound sn-1,2-diacylglycerols explain the dissociation of hepatic insulin resistance from hepatic steatosis in MTTP knockout mice

Abudukadier Abulizi
Dec 1, 2020; 61:1565-1576
Research Articles




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SCD1 promotes lipid mobilization in subcutaneous white adipose tissue

Ying Zou
Dec 1, 2020; 61:1589-1604
Research Articles




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Structure dynamics of ApoA-I amyloidogenic variants in small HDL increase their ability to mediate cholesterol efflux

Oktawia Nilsson
Nov 17, 2020; 0:jlr.RA120000920v1-jlr.RA120000920
Research Articles




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rHDL modelling and the anchoring mechanism of LCAT activation

Tommaso Laurenzi
Dec 2, 2020; 0:jlr.RA120000843v1-jlr.RA120000843
Research Articles




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Insights on the kinetics and dynamics of the furin-cleaved form of PCSK9

Carlota Oleaga
Nov 17, 2020; 0:jlr.RA120000964v1-jlr.RA120000964
Research Articles




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Apolipoprotein C3 and apolipoprotein B colocalize in proximity to macrophages in atherosclerotic lesions in diabetes

Jenny E. Kanter
Dec 8, 2020; 0:jlr.ILR120001217v1-jlr.ILR120001217
Images in Lipid Research




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Distinct patterns of apolipoprotein C-I, C-II and C-III isoforms are associated with markers of Alzheimers disease

Yueming Hu
Dec 11, 2020; 0:jlr.RA120000919v1-jlr.RA120000919
Research Articles




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Generation and validation of a conditional knockout mouse model for the study of the Smith-Lemli-Opitz Syndrome

Babunageswararao Kanuri
Nov 17, 2020; 0:jlr.RA120001101v1-jlr.RA120001101
Research Articles




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Perilipin 5 S155 phosphorylation by PKA is required for the control of hepatic lipid metabolism and glycemic control

Stacey N Keenan
Dec 17, 2020; 0:jlr.RA120001126v1-jlr.RA120001126
Research Articles




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Adiponectin forms a complex with atherogenic LDL and inhibits its downstream effects

Akemi Kakino
Nov 3, 2020; 0:jlr.RA120000767v1-jlr.RA120000767
Research Articles




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Update on LIPID MAPS classification, nomenclature, and shorthand notation for MS-derived lipid structures

Gerhard Liebisch
Dec 1, 2020; 61:1539-1555
Special Report




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Multi-modal Functional Imaging of Brown Adipose Tissue

Amanda D.V. MacCannell
Nov 18, 2020; 0:jlr.ILR120001204v1-jlr.ILR120001204
Images in Lipid Research




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Mass spectrometry characterization of light chain fragmentation sites in cardiac AL amyloidosis: insights into the timing of proteolysis [Genomics and Proteomics]

Amyloid fibrils are polymeric structures originating from aggregation of misfolded proteins. In vivo, proteolysis may modulate amyloidogenesis and fibril stability. In light chain (AL) amyloidosis, fragmented light chains (LCs) are abundant components of amyloid deposits; however, site and timing of proteolysis are debated. Identification of the N and C termini of LC fragments is instrumental to understanding involved processes and enzymes. We investigated the N and C terminome of the LC proteoforms in fibrils extracted from the hearts of two AL cardiomyopathy patients, using a proteomic approach based on derivatization of N- and C-terminal residues, followed by mapping of fragmentation sites on the structures of native and fibrillar relevant LCs. We provide the first high-specificity map of proteolytic cleavages in natural AL amyloid. Proteolysis occurs both on the LC variable and constant domains, generating a complex fragmentation pattern. The structural analysis indicates extensive remodeling by multiple proteases, largely taking place on poorly folded regions of the fibril surfaces. This study adds novel important knowledge on amyloid LC processing: although our data do not exclude that proteolysis of native LC dimers may destabilize their structure and favor fibril formation, the data show that LC deposition largely precedes the proteolytic events documentable in mature AL fibrils.




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Problem Notes for SAS®9 - 66438: You see the message "The informat $ could not be loaded, probably due to insufficient memory" after attempting to insert data into a MySQL database

For data that is being loaded from a SAS Stored Process Server, an insertion process might fail to a MySQL database with a warning, as well as an error message that says "During insert: Incorrect datetime value…"




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Problem Notes for SAS®9 - 66537: SAS Customer Intelligence Studio becomes non-responsive when you delete a calculated variable from the Edit Value dialog box

In SAS Customer Intelligence Studio, you might notice that the user interface becomes unresponsive, as shown below: imgalt="SAS Customer Intelligence Studio UI becomes unresponsive" src="{fusion_66537




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Problem Notes for SAS®9 - 66539: A new calculated variable that you create in the Edit Value dialog box is not available for selection in SAS Customer Intelligence Studio

In SAS Customer Intelligence Studio, you can choose to create a new calculated variable in the Edit Value dialog box when you populate a treatment custom detail. Following creation of the new calculated




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Problem Notes for SAS®9 - 66544: You cannot clear warnings for decision campaign nodes in SAS Customer Intelligence Studio

In SAS Customer Intelligence Studio, you might notice that you cannot clear warnings for decision campaign nodes by selecting either the Clear Warnings  option or the Clear All Warnin




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Problem Notes for SAS®9 - 66527: Updating counts in a Link node in SAS Customer Intelligence Studio produces the error "Link: MAIQService:executeFastPath:"

In SAS Customer Intelligence Studio, the following error is displayed when you update a new Link  node in a diagram:   imgalt="Link: MAIQService:executeFastPath:" src="{fusion_665




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Problem Notes for SAS®9 - 66540: SAS Management Console and SAS Data Integration Studio might return the message "table failed to update" when you use the Update Metadata tool

You encounter this issue when the table metadata matches the data source. In this scenario, no metadata update is required.




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Problem Notes for SAS®9 - 66542: The initial loading of a rule set and a rule flow takes significantly longer in SAS Business Rules Manager 3.3 compared with release 3.2

In SAS Business Rules Manager 3.3, the initial loading of a rule set and a rule flow takes significantly longer than it does in release 3.2. When this problem happens, long time gaps are evident in the local




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Problem Notes for SAS®9 - 66524: SAS Visual Data Builder uses the wrong SAS Application Server for previewing and scheduling

If you have configured more than one SAS Application Server, then SAS Visual Data Builder might unexpectedly use the wrong application server when you preview or schedule queries. This problem occurs even though you h




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Problem Notes for SAS®9 - 66487: Authentication to the CAS server fails with the error "Access denied..." when initiated on a SAS/CONNECT server in a Microsoft Windows environment

You might see the following error messages: "ERROR: Connection failed. Server returned: SAS Logon Manager authentication failed: Access denied." and "ERROR: Unable to connect to Cloud Analytic Services host-name on port 5570. Veri




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Problem Notes for SAS®9 - 55516: Opening the Edit Action Columns dialog box requires that you wait up to a minute to display a window

Editing and/or saving an action column can take up to a minute to display a window. There are no workarounds identified at this time.




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Problem Notes for SAS®9 - 66509: Several procedures in SAS/STAT Software and SAS/QC Software generate incorrect results when an OBSMARGINS= data set is used

If the response variable is in the CLASS statement variable list before the class variables that also appear in the MODEL statement, and an OM-data-set is used, least squares means results for several of the statistical procedures are incorrect.




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Problem Notes for SAS®9 - 66391: Opening a database table returns a Segmentation Violation when you use the Metadata LIBNAME engine (META)

You might receive a Segmentation Violation when opening a database table in SAS. The SAS Log contains the error and traceback:


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Problem Notes for SAS®9 - 58465: SAS Life Science Analytics Framework 4.6 - Group membership removal fails with an exception for Process Flows that exist in the Recycle Bin

In SAS Life Science Analytics Framework 4.6, group membership removal fails with an exception if a user is set as assignee, a candidate, or a notification recipient in a user task for a Process Flow . The Process




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Problem Notes for SAS®9 - 33449: An error might occur when you use SAS 9 BULKLOAD= and BULKEXTRACT= options to load data to or extract data from the HP Neoview database on the HP Itanium platform

An error might occur when you use the SAS 9 BULKLOAD= and BULKEXTRACT= options load data to or extract data from HP Neoview on the HP Itanium platform. The problem occurs because Hewlett-Packard changed the name of one of




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Problem Notes for SAS®9 - 48028: Custom Time Frame-based data versions do not aggregate correctly when referenced in worksheets with standard hierarchy levels

In SAS Merchandise Financial Planning, custom time frame-based data versions do not aggregate correctly when referenced in worksheets with standard hierarchy levels. The data does not aggregate correctly from l




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Problem Notes for SAS®9 - 46544: Store layout view has some areas displayed with black fill rather than gray in SAS® Retail Space Management

In SAS Retail Space Management, it should be possible to click on any location object, then Show Properties, and change the location fill color. This can be done on the gray-filled objects. However, w




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Problem Notes for SAS®9 - 61815: SAS Episode Analytics 3.1 - Audit table is required in order to capture user interactions with the user interface

SAS  Episode Analytics 3.1 requires the ability to capture user interactions with the user interface for auditing purposes. To support the required functionality a new table has been add




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Problem Notes for SAS®9 - 65782: The PLM procedure incorrectly issues the message "ERROR: No valid observation in the OM= data set"

If the OBSMARGINS= or OM= option is specified in an LSMEANS, LSMESTIMATE, or SLICE statement and a user-defined format is applied to any of the effect variables in the OM-data-set , PROC PLM incorrectly stops proce




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Problem Notes for SAS®9 - 66535: You might intermittently see the error "RangeError: Maximum call stack exceeded..." when viewing a SAS Visual Analytics report

When viewing a SAS Visual Analytics report, you might intermittently see an error that includes content similar to the following:

Error Message:




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Problem Notes for SAS®9 - 66505: The OBS= option does not generate a limit clause when you use SAS/ACCESS Interface to PostgreSQL to access a Yellowbrick database

When you use SAS/ACCESS Interface to PostgreSQL to query a Yellowbrick database, the SAS OBS= option is not generating a limit clause on the query that is passed to the database. Click the



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Problem Notes for SAS®9 - 66511: A Russian translation shows the same value for two different variables in the Define Value dialog box for the Reply node in SAS Customer Intelligence Studio

In SAS Customer Intelligence Studio,  when you add  Reply- node variable values in the Define Value dialog box, you might notice that two identically labeled data-grid variables are




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Problem Notes for SAS®9 - 66095: The message "ERROR: Could not move and link one or more files to..." occurs while running a job-flow instance

In SAS Infrastructure for Risk Management, the message "ERROR: Could not move and link one or more files to..." occurs while running a job-flow instance if an orphaned folder exists in the persistent area.




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Problem Notes for SAS®9 - 66507: The “RegisterFontTask" install task fails during out-of-the-box, add-on, or upgrade-in-place deployments if Hot Fix D7G004 is applied

The SAS 9.4M4 (TS1M4) Hot Fix D7G004 for ODS Templates installs national language support (NLS) content regardless of whether the languages were installed during the initial deployment. Having sparse




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Problem Notes for SAS®9 - 66494: A SAS Real-Time Decision Manager flow cannot be opened

In SAS Customer Intelligence, a decision campaign can become corrupted and impossible to open. When you try to open the campaign, an error message is displayed that asks you to check the SAS Customer Intel




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Problem Notes for SAS®9 - 66401: Using SAS Model Manager to publish a model to SAS Metadata Repository fails and generates an error

When you publish a model to SAS Metadata Repository by using SAS Model Manager, the publishing process fails and the following error is generated: "The model model-name has a function of ';Transformation';, which is not supported for




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Problem Notes for SAS®9 - 66504: Clicking a link to pass a group break value to a SAS Web Report Studio report returns an HTTP 400 error

SAS Web Report Studio enables you to link reports based on a group break value. However, when you click the link, it might fail with an HTTP 400 error. The exact message you see depends on which browser you are u




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Problem Notes for SAS®9 - 66496: Titles and footnotes do not span the full width of a page when you use the COLUMNS= option with the TAGSETS.RTF_SAMPLE tagset

Titles and footnotes do not span the entire width of the page when you use the COLUMNS= option with a value that is greater than 1 with the TAGSETS.RTF_SAMPLE tagset. When a value that is greater than 1 is specified for th




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Problem Notes for SAS®9 - 66500: A content release on the SAS Risk Governance Framework fails to load when you use SAS 9.4M7 (TS1M7) on the Microsoft Windows operating system

When you log on to the SAS Risk Governance Framework and choose a solution, the web application might fail to load the solution content. When the problem occurs, you continue to see "Loading..." on the screen, an




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Problem Notes for SAS®9 - 66294: The SAS Federation Server SPD driver fails to create a table that has a column name in UTF-8 encoding that also contains Latin5 characters

Certain tables that are created in SAS Scalable Performance Data (SPD) Server might not be displayed correctly by SAS Federation Server Manager. Tables that have Latin5 characters in column names encounter this




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WITHDRAWN: Structural and mechanistic studies of hydroperoxide conversions catalyzed by a CYP74 clan epoxy alcohol synthase from amphioxus (Branchiostoma floridae) [Research Articles]

This manuscript has been withdrawn by the Author.




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WITHDRAWN: The Fundamental And Pathological Importance Of Oxysterol Binding Protein And Its Related Proteins [Thematic Reviews]

This article has been withdrawn by the authors as part of this review overlapped with the contents of Pietrangelo A and Ridgway ND. 2018. Cellular and Molecular Life Sciences. 75; 3079-98.




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Fatty acid oxidation and photoreceptor metabolic needs [Thematic Reviews]

Photoreceptors have high energy-demands and a high density of mitochondria that produce adenosine triphosphate (ATP) through oxidative phosphorylation (OXPHOS) of fuel substrates. Although glucose is the major fuel for central nervous system (CNS) brain neurons, in photoreceptors (also CNS), most glucose is not metabolized through OXPHOS but is instead metabolized into lactate by aerobic glycolysis. The major fuel sources for photoreceptor mitochondria remained unclear for almost six decades. Similar to other tissues (like heart and skeletal muscle) with high metabolic rates, photoreceptors were recently found to metabolize fatty acids (palmitate) through OXPHOS. Disruption of lipid entry into photoreceptors leads to extracellular lipid accumulation, suppressed glucose transporter expression, and a duel lipid/glucose fuel shortage. Modulation of lipid metabolism helps restore photoreceptor function. However, further elucidation of the types of lipids used as retinal energy sources, the metabolic interaction with other fuel pathways, as well as the crosstalk among retinal cells to provide energy to photoreceptors is not yet known. In this review, we will focus on the current understanding of photoreceptor energy demand and sources, and potential future investigations of photoreceptor metabolism.