Sauropod dinosaurs grew to 25 metres or more in length and weighed several tonnes – but footprints in Texas seem to suggest they sometimes walked on just two legs

Title: Better Ways Needed to Track Drug Safety: Report
Category: Health News
Created: 5/1/2012 2:05:00 PM
Last Editorial Review: 5/2/2012 12:00:00 AM

Title: Could Facebook Assist Public Health Efforts to Track Obesity?
Category: Health News
Created: 4/26/2013 12:35:00 PM
Last Editorial Review: 4/29/2013 12:00:00 AM

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Title: Could Your Contact Lenses Track, Treat Your Diabetes?
Category: Health News
Created: 4/24/2020 12:00:00 AM
Last Editorial Review: 4/27/2020 12:00:00 AM

ABSTRACT

Over the past decade, Candida auris has emerged as an urgent threat to public health. Initially reported from cases of ear infections in Japan and Korea, C. auris has since been detected around the world. While whole-genome sequencing has been extensively used to trace the genetic relationships of the global emergence and local outbreaks, a recent report in mBio describes a targeted genotyping method as a rapid and inexpensive method for classifying C. auris isolates (T. de Groot, Y. Puts, I. Berrio, A. Chowdhary, and J. F. Meis, mBio 11:e02971-19, https://doi.org/10.1128/mBio.02971-19, 2020).

Reactive oxygen and nitrogen species have been implicated in many biological processes and diseases, including immune responses, cardiovascular dysfunction, neurodegeneration, and cancer. These chemical species are short-lived in biological settings, and detecting them in these conditions and diseases requires the use of molecular probes that form stable, easily detectable, products. The chemical mechanisms and limitations of many of the currently used probes are not well-understood, hampering their effective applications. Boronates have emerged as a class of probes for the detection of nucleophilic two-electron oxidants. Here, we report the results of an oxygen-18–labeling MS study to identify the origin of oxygen atoms in the oxidation products of phenylboronate targeted to mitochondria. We demonstrate that boronate oxidation by hydrogen peroxide, peroxymonocarbonate, hypochlorite, or peroxynitrite involves the incorporation of oxygen atoms from these oxidants. We therefore conclude that boronates can be used as probes to track isotopically labeled oxidants. This suggests that the detection of specific products formed from these redox probes could enable precise identification of oxidants formed in biological systems. We discuss the implications of these results for understanding the mechanism of conversion of the boronate-based redox probes to oxidant-specific products.

In obsessive–compulsive disorder (OCD), functional behaviors such as checking that a door is locked become dysfunctional, maladaptive, and debilitating. However, it is currently unknown how aversive and appetitive motivations interact to produce functional and dysfunctional behavior in OCD. Here we show a double dissociation in the effects of anxiogenic cues and sensitivity to rewarding stimuli on the propensity to develop functional and dysfunctional checking behavior in a rodent analog of OCD, the observing response task (ORT). While anxiogenic manipulations of perceived threat (presentation of threat-associated contextual cues) and actual threat (punishment of incorrect responding on the ORT) enhanced functional checking, dysfunctional checking was unaffected. In contrast, rats that had previously been identified as "sign-trackers" on an autoshaping task—and therefore were highly sensitive to the incentive salience of appetitive environmental cues—selectively showed elevated levels of dysfunctional checking under a range of conditions, but particularly so under conditions of uncertainty. These data indicate that functional and dysfunctional checking are dissociable and supported by aversive and appetitive motivational processes, respectively. While functional checking is modulated by perceived and actual threat, dysfunctional checking recruits appetitive motivational processes, possibly akin to the "incentive habits" that contribute to drug-seeking in addiction.

The SnotBot project uses drones, data, and deep learning to tell us about the health of whales and the oceans

Ken Staples joins the show and teaches Chris everything he’s doing wrong in The Division. Alice gets back into EVE and explains World War Bee...

"Fortnite" Party Royale had another big show on May 8. Here's everything you need to know about the Dillion Francis, Steve Aoki and deadmau5 concert that just took place.

Astronomers using NASA’s Neil Gehrels Swift Observatory have tracked water loss from 2I/Borisov, the first known interstellar comet to visit our Solar System, as it approached and rounded the Sun. Their findings were published in the Astrophysical Journal Letters. 2I/Borisov was detected on August 30, 2019 by Gennady Borisov, an astronomer at the Crimean Astrophysical [...]

Use our interactive checklist to help fill up your museum with all the dinosaur fossils in Animal Crossing: New Horizons.

Microsoft's all-in-one Office app will pick up iPad mouse support sometime this year.

Read our live coronavirus updates HERE Coronavirus: The symptoms

The Government is to launch a review into why people from black, Asian and minority ethnic (BAME) backgrounds appear to be disproportionately affected by coronavirus.

More than a century ago, Einstein predicted how much the star's orbit changes, and now the data collected by scientists exactly matches his theory.

The Foreign Office's top civil servant has backtracked after saying ministers took a "political decision" not to take part in an EU scheme to get vital coronavirus equipment.

The spread of coronavirus through the UK population will be tracked with the help of a new study that the government hopes will help pin down immunity levels and infection rates.

A police officer made it just in time for the birth of his child after his test for coronavirus was fast-tracked and gave a negative result.

The adoption of "test, track and trace" could enable the coronavirus lockdown measures to be eased, Matt Hancock has said.

Officials 'massively ramping up efforts' to meet target as army is deployed to help establish mobile testing facilities

A person has died on the tracks at a busy north London Tube station.

Planning is fundamental for any business. We not only plan for good times, but also for bad. And these are indeed bad.

Labour has proposed legislation to deliver a dedicated fast-tracked fund for domestic abuse services affected by the coronavirus crisis.

More than three million Britons have downloaded an app designed by researchers at King's College London to track the symptoms of coronavirus.

The UK will use a mobile app to try and control the spread of coronavirus, Health Secretary Matt Hancock has said.

Person pronounced dead at the scene after incident early on Tuesday morning

Full-scale tracking and tracing of new coronavirus infections by the end of this month was today made an official Government target.

Companies are trying to figure out how to welcome back employees to their offices, and keep them safe once they return. The new normal might involve smartphone apps and badges to track employees.

Companies around the country are figuring out how to safely reopen office during the pandemic. The new normal might involve smartphone apps and badges to track employees.

US space agency satellites follow the melting trends in Antarctica and Greenland over 16 years.

A satellite mission that bounces laser light off the ice sheets of Antarctica and Greenland has found that hundreds of billions of tons' worth of ice are being lost every year due to Earth's changing climate. Scientists involved in NASA's ICESat-2 project report in the journal Science that the net loss of ice from those regions has been responsible for 0.55 inches of sea level rise since 2003. That's slightly less than a third of the total amount of sea level rise observed in the world's oceans over that time. To track how the ice sheets are changing, the ICESat-2… Read More

Both companies said privacy and preventing governments from using the system to compile data on citizens was a primary goal.

Without integrating into phones' operating systems, performance of contact-tracing apps is likely to be limited

A map of confirmed COVID-19 cases and deaths around the world. The respiratory disease has spread rapidly across six continents and has killed thousands of people.

• Alex Wurz calls measures to deal with coronavirus ‘immaculate’
  
• ‘F1 can be pioneer’ for other sports to follow, says GPDA chief

The Grand Prix Drivers’ Association is confident the precautions being taken by Formula One mean the sport stands every chance of resuming as planned in Austria on 5 July.

Alex Wurz, chairman of the GPDA, will reassure his members that Formula One has put the safety of everyone involved at the forefront of its plans to return to racing after attending a meeting with F1 and the FIA on Friday.

Searches for tracksuit bottoms are up 2000 per cent on last month, and fashion's high priestess has given her seal of approval

Hayfever season is just getting started

An obsession with tracking our nocturnal habits is keeping us awake at night, says Katie Strick

The service will facilitate streaming of established radio stations as well as the new Sonos Sound System station

They're a sure-fire way to up your WFH game

Struggling with restful sleep? The new Sleep Analyser mat could offer help and insights as to why

Log on to lockdown lifelines for parents