This webinar will provide delegates with an introduction to the rights of reverter, which may result in unexpected consequences where land ceases to be used for certain educational purposes....

As originally published on CoStar on 07 November 2019 In the first of a regular series, leading real estate lawyer Bruce Dear talks to a senior player in real estate over ...

There have been many examples of high profile health and safety incidents in recent years, including major rail disasters, the serious incident at Alton Towers and of course the tragedy at Grenfell Tower. These have rightly received high profile, wi...

The Citizens Advice Bureau has recently published a report highlighting concerns about the increasing use of charging orders in particular as well as enforcement in general and bankruptcy A charging order is a way of securing a judgment debt o...

Civil cases are usually built around two cornerstones: contemporaneous documents and witness statements. In 2019 the Business and Property Courts implemented a pilot with the aim of streamlining the process for the disclosure of contemporaneous docu...

On 29 September 2016, the French Competition Authority (l’Autorité de la concurrence - the “Autorité”) imposed a fine of EUR 2.4 million on 37 model agencies and their main trade association, the SYNAM, in relation to...

Hundreds of paramilitaries kept people off the streets and virtually all stores have been closed for at least a week. On Friday night, security forces fired tear gas at stone-throwing residents who ventured...

In early March, throngs of skiers flocked to Austria’s famed alpine resorts in Tyrol, completely unaware the new coronavirus was quietly working its way through the region.Thousands would become infected, bringing the virus home in Austria and beyond – to Germany, the US, Singapore and Hong Kong.Many have now filed legal complaints blaming local authorities in Tyrol for not acting quickly enough to protect travellers.“One of the key questions will be to find out when the authorities knew enough…

President Vladimir Putin told Russians they are “invincible” when they stand together as the country on Saturday marked the 75th anniversary of the end of second world war on lockdown from the coronavirus.With the number of virus cases surging and authorities urging Russians to stay in their homes, celebrations of this year’s Victory Day were muted after the Kremlin grudgingly agreed to postpone plans for a grand parade with world leaders.Instead of columns of military hardware and thousands of…

Ahmedabad, a city of 5.5 million, has become a major concern for authorities.

Strange particles observed by an experiment in Antarctica could be evidence of an alternative reality where everything is upside down

June 16 - With attention focused on the world's greatest soccer stars in Brazil, conservationists are working hard to promote the plight of the animal being used as the official World Cup mascot. Known as Fuleco on posters and banners throughout the country, the three-banded armadillo is in decline, and conservation groups say FIFA and the Brazilian government should be doing more during the World Cup to ensure the animal's long term survival. Rob Muir reports.

Olm are salamanders that spend all their lives in pitch-black caves, and it turns out they don’t move very much – sometimes lurking in the same spot for years

This pink manta ray, nicknamed Clouseau, has resurfaced off Australia’s coast. No one knows why it has a bubble-gum pink underside or if there are others out there

STAMFORD, Conn. –  SEPTEMBER 26, 2019 – HARMAN International, a wholly-owned subsidiary of Samsung Electronics Co., Ltd., focused on connected technologies for automotive, consumer and enterprise markets, today announced a new automotive partnership with...

There are around a hundred billion stars in the Milky Way, and most are rather humdrum – but the oddballs are so strange that they challenge our understanding of physics

Strange particles observed by an experiment in Antarctica could be evidence of an alternative reality where everything is upside down

Extraterrestrial oceans are an obvious place to search for alien life, but getting there and having a look won't be easy, says NASA's Kevin Hand in his book Alien Oceans

Weird blasts of radio waves from space called fast radio bursts have been baffling astronomers since they were discovered, but after finding one in our galaxy we may finally know what creates them

Title: Test Spots Potential Organ Donors Among Coma Patients
Category: Health News
Created: 4/26/2010 4:10:00 PM
Last Editorial Review: 4/27/2010 12:00:00 AM

Title: Quick Screening May Help Spot Autism in Babies
Category: Health News
Created: 4/28/2011 10:05:00 AM
Last Editorial Review: 4/28/2011 12:00:00 AM

Title: Heart Test Spots Sudden Death Risk in Young Athletes
Category: Health News
Created: 4/27/2012 2:05:00 PM
Last Editorial Review: 4/30/2012 12:00:00 AM

Title: Scientists Spot How Cox-2 Painkillers Raise Heart Risks
Category: Health News
Created: 5/2/2012 4:05:00 PM
Last Editorial Review: 5/3/2012 12:00:00 AM

Title: Brain Scans Spot Possible Clues to Chronic Fatigue Syndrome
Category: Health News
Created: 5/2/2014 12:35:00 PM
Last Editorial Review: 5/2/2014 12:00:00 AM

Title: Pediatrics Group Advises Doctors on How to Spot Child Abuse
Category: Health News
Created: 4/27/2015 12:00:00 AM
Last Editorial Review: 4/28/2015 12:00:00 AM

Title: Health Tip: Spotting Signs of Urinary Tract Infection
Category: Health News
Created: 5/1/2015 12:00:00 AM
Last Editorial Review: 5/1/2015 12:00:00 AM

Title: AHA News: Director John Singleton's Fatal Stroke Spotlights Black Americans' Hypertension Risk
Category: Health News
Created: 5/2/2019 12:00:00 AM
Last Editorial Review: 5/2/2019 12:00:00 AM

Title: Device Spots Lymphedema Early in Breast Cancer Patients, to Help Stop It
Category: Health News
Created: 5/2/2019 12:00:00 AM
Last Editorial Review: 5/3/2019 12:00:00 AM

Title: Necklace Spots A-Fib in Just Over 30 Seconds
Category: Health News
Created: 5/6/2020 12:00:00 AM
Last Editorial Review: 5/7/2020 12:00:00 AM

A necklace outfitted with a high-tech pendant may be able to screen for signs of an abnormal heart rhythm condition known as atrial fibrillation.

Title: Welcome to the 'Smart Toilet' That Can Spot Disease
Category: Health News
Created: 4/17/2020 12:00:00 AM
Last Editorial Review: 4/17/2020 12:00:00 AM

For decades, government, health systems, universities, foundations, exceptional individuals, and thought leaders across North Carolina have been testing, implementing, modifying, and just plain trying new ways of improving the way we seek, receive, and experience health care.

More recently, North Carolina has been striving to not simply address the cost, efficiency, and value that are so frustratingly elusive in health care, but also recognizing that we simply need to improve the health of our residents. We have looked to interventions both compatible with and beyond health care to do this.

The National Academy of Medicine, formerly the National Institute of Medicine, since 2016 has boldly laid out Vital Directions in Health Care, focusing on 19 priority issues and recommendations for health policy to better achieve health and well-being for all Americans. They have taken their show on the road, beyond the halls of Congress and think tanks and universities to the people on the ground in states across the country to present, discuss, listen, and learn how policy recommendations come to life.

This issue of the journal highlights the National Academy of Medicine bringing its spotlight to North Carolina last November, an acknowledgment that states are often where policy is put into action, and that North Carolina has been a leader in innovating, planning, implementing, and evaluating again and again to get better and better results for our residents. Pull your chair up to the edge of the stage for a good read in the glow of the spotlight.

Recent advances in the study and clinical applications of circulating tumor DNA (ctDNA) are limited by practical considerations of sample collection. Whole-genome sequencing (WGS) is increasingly used for analysis of ctDNA, identifying copy-number alterations and fragmentation patterns. We hypothesized that low-depth/shallow WGS (sWGS) data may be generated from minute amounts of cell-free DNA, and that fragment-size selection may remove contaminating genomic DNA from small blood volumes. Dried blood spots have practical advantages for sample collection, may facilitate serial sampling, and could support novel study designs in humans and animal models.We developed a protocol for the isolation and analysis of cell-free DNA from dried blood spots using filter paper cards and bead-based size selection. DNA extracted and size-selected from dried spots was analyzed using sWGS and polymerase chain reaction (PCR).Analyzing a 50 μL dried blood spot from frozen whole blood of a patient with melanoma, we identified ctDNA based on the presence of tumor-specific somatic copy-number alterations, and found a fragment-size profile similar to that observed in plasma DNA. We found alterations in different chromosomes in blood spots from 2 patients with high-grade serous ovarian carcinoma. Extending this approach to serial dried blood spots from mouse xenograft models, we detect tumor-derived cell-free DNA and identified ctDNA from the originally grafted ascites.Our data suggest that ctDNA can be detected and monitored in dried blood spots from archived and fresh blood samples, enabling new approaches for sample collection and novel study/trial designs for both patients and in vivo models.

Summary:

In this issue of Cancer Discovery, Li and colleagues provide a blueprint for the identification and functional validation of cancer-associated mutations in noncoding regions of the genome. Integration of whole-genome sequencing and high-throughput epigenome editing screens is starting to reveal the extent to which noncoding genetic lesions contribute to cancer.

See related article by Li et al., p. 724.

Summary:

Over the last two decades HER2 aberrations have been thoroughly investigated as potential therapeutic targets in advanced non–small cell lung cancer, with relatively modest results. Two articles published in this issue of Cancer Discovery further expand the knowledge on therapeutic exploitation of HER2 in lung cancer, addressing a large unmet medical need.

See related article by Li et al., p. 674.

See related article by Tsurutani et al., p. 688.

Summary:

The first basket clinical trial testing the BRAF inhibitor vemurafenib resulted in evidence of activity in 13 unique cancer types with BRAF^V600 mutations, but the response rates were variable. Therefore, different cancer histologies with the same driver oncogene display different degrees of oncogenic pathway addiction.

See related article by Subbiah et al., p. 657.