len

Acting US Defence Secretary quits as domestic violence reports surface

Acting US Defence Secretary Patrick Shanahan has quit as reports of a domestic violence incident from nearly nine years ago surfaced marring his chances for confirmation even as Washington readies for a possible confrontation with Iran.




len

Google Calendar suffers global outage

Adding to the plethora of outages that apps from major tech giants have been suffering lately, Google's Calendar refused to work for over nearly three hours for users around the world.




len

Power engineering : advances and challenges / editors, Viorel Badescu, George Cristian Lazaroiu, Linda Barelli




len

Dramatexts : creative practice for senior drama students / Helen Strube...[et al.]




len

Theatre, education and performance the map and the story / Helen Nicholson

Nicholson, Helen, 1958-




len

Comedy under patriarchy : the power of seeing things whole / Helen Ferrara

Ferrara, Helen




len

Back to back theatre : performance, politics, visibility / edited by Helena Grehan and Peter Eckersall




len

Theatre & education / Helen Nicholson

Nicholson, Helen, 1958-




len

Theatre & violence / Lucy Nevitt

Nevitt, Lucy, author




len

Learning to teach drama 11-18 / Andy Kempe and Helen Nicholson

Kempe, Andy




len

New media dramaturgy : performance, media and new-materialism / Peter Eckersall, Helena Grehan, Edward Scheer

Eckersall, Peter, author




len

Performance and participation : practices, audiences, politics / edited by Anna Harpin & Helen Nicholson




len

The Wiley Handbook of What Works in Violence Risk Management: Theory, Research, and Practice


 

A comprehensive guide to the theory, research and practice of violence risk management

The Wiley Handbook of What Works in Violence Risk Management: Theory, Research and Practice offers a comprehensive guide to the theory, research and practice of violence risk management. With contributions from a panel of noted international experts, the book explores the most recent advances to the theoretical understanding, assessment and management of violent



Read More...




len

The Wiley Handbook of What Works in Violence Risk Management: Theory, Research, and Practice


 

A comprehensive guide to the theory, research and practice of violence risk management

The Wiley Handbook of What Works in Violence Risk Management: Theory, Research and Practice offers a comprehensive guide to the theory, research and practice of violence risk management. With contributions from a panel of noted international experts, the book explores the most recent advances to the theoretical understanding, assessment and management of violent



Read More...




len

Nanophysics, Nanomaterials, Interface Studies, and Applications: Selected Proceedings of the 4th International Conference Nanotechnology and Nanomaterials (NANO2016), August 24-27, 2016, Lviv, Ukraine / Olena Fesenko, Leonid Yatsenko, editors

Online Resource




len

Quaternary ecology, evolution and biogeography [electronic resource] / Valentí Rull.

London : Academic Press, 2020.




len

Highly Z-selective synthesis of 1,3-oxathiol-2-ylidenes and 4-methylene-oxazolidine-2-thiones via atom-specific 5-exo-dig cyclization of propargyl alcohol with isothiocyanate

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00083C, Paper
S. Antony Savarimuthu, D. G. Leo Prakash, S. Augustine Thomas, Thirumanavelan Gandhi, Mrinal K. Bera
The Z-selectivity observed in imine and alkene motifs after 5-exo-dig cyclization of propargyl alcohol and isothiocyanate is rare in the literature and this selectivity can be attributed to electronic and steric factors of the imine and alkene motif respectively.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




len

Selenium-promoted electrophilic cyclization of arylpropiolamides: synthesis of 3-organoselenyl spiro[4,5]trienones

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00609B, Paper
Ana Maria S. Recchi, Pedro H. P. Rosa, Davi F. Back, Gilson Zeni
A synthetic approach to regioselective synthesis of 3-organochalcogenyl spiro[4,5]trienones and 3-organochalcogenyl[4,5]triene-2,6-diones is described through the reaction of arylpropiolamides with an electrophilic chalcogen source.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




len

Proof of concept for poor inhibitor binding and efficient formation of covalent adducts of KRASG12C and ARS compounds

Org. Biomol. Chem., 2020, 18,3069-3081
DOI: 10.1039/D0OB00071J, Paper
Maria G. Khrenova, Anna M. Kulakova, Alexander V. Nemukhin
Comprehensive molecular modeling and kinetic analysis reveal a novel mechanism of the inhibition of the oncogenic mutant of the “undruggable” KRAS protein.
The content of this RSS Feed (c) The Royal Society of Chemistry




len

Stereoselective preparation of P,axial-stereogenic allenyl bisphosphine oxides via chirality-transfer

Org. Biomol. Chem., 2020, 18,3017-3021
DOI: 10.1039/D0OB00390E, Communication
Mao-Ran Qiu, Hong-Xing Zheng, Jing-Jing Ye, Bing-Xia Yan, Chang-Qiu Zhao, Qiang Li
Allenyl bisphosphine oxides having variable chirality were prepared in high dr, which was controlled by chiral carbon and phorphorus.
The content of this RSS Feed (c) The Royal Society of Chemistry




len

Construction of 2,3-disubstituted benzo[b]thieno[2,3-d]thiophenes and benzo[4,5]selenopheno[3,2-b]thiophenes using the Fiesselmann thiophene synthesis

Org. Biomol. Chem., 2020, 18,3164-3168
DOI: 10.1039/D0OB00300J, Paper
Roman A. Irgashev, Nadezhda S. Demina, Gennady L. Rusinov
A number of 2,3-disubstituted benzo[b]thieno[2,3-d]thiophenes and benzo[4,5]selenopheno[3,2-b]thiophenes have been obtained using a convenient approach based on the Fiesselmann thiophene synthesis.
The content of this RSS Feed (c) The Royal Society of Chemistry




len

Synthesis and aggregation behaviour of single-chain, 1,32-alkyl-branched bis(phosphocholines) – part 2: lateral chain length triggers self-assembling from sheets to fibres to vesicles

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00534G, Paper
Kai Gruhle, Max Tuchtenhagen, Sindy Müller, Gerd Hause, Annette Meister, Simon Drescher
The synthesis of six single-chain, alkyl-branched bolalipids and first investigations of the lyotropic behaviour of these lipids are reported.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




len

Half-sandwich (η5-Cp*)Rh(III) complexes of pyrazolated organo-sulfur/selenium/tellurium ligands: efficient catalysts for base/solvent free C–N coupling of chloroarenes under aerobic conditions

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00538J, Paper
Charu Sharma, Avinash Kumar Srivastava, Kamal Nayan Sharma, Raj Kumar Joshi
Three new Rh(III) complexes of organochalcogen (S/Se/Te) ligands were synthesized and along with a co-catalyst Cu(OAc)2, used for the base/solvent free catalysis of Buchwald type C–N coupling of amines and aryl chlorides under aerobic conditions.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




len

Electrochemical synthesis of selenyl-dihydrofurans via anodic selenofunctionalization of allyl-naphthol/phenol derivatives and their anti-Alzheimer activity

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00629G, Communication
Marcos R. Scheide, Alex R. Schneider, Guilherme A. M. Jardim, Guilherme M. Martins, Daniele C. Durigon, Sumbal Saba, Jamal Rafique, Antonio L. Braga
Herein, we report an eco-friendly, electrosynthetic approach for the intramolecular oxyselenylation of allyl-naphthol/phenol derivatives.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




len

Recent Progress on Transition Metal-catalysed Regioselective C–H Transformations Based on Noncovalent Interactions

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00703J, Review Article
Yoichiro Kuninobu, Takeru Torigoe
Transition metal-catalysed C–H transformations are powerful tools to obtain functionalised organic molecules from simple starting materials. To control regioselectivity is one of the most important issues in C–H transformations. Since...
The content of this RSS Feed (c) The Royal Society of Chemistry




len

Copper(I)/Ganphos catalysis: enantioselective synthesis of diverse spirooxindoles using iminoesters and alkyl substituted methyleneindolinones

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00546K, Paper
Hao Cui, Ke Li, Yue Wang, Manman Song, Congcong Wang, Donghui Wei, Er-Qing Li, Zheng Duan, François Mathey
A copper/Ganphos-catalyzed asymmetric 1,3-dipolar cycloaddition of glycine iminoesters with alkyl substituted 3-methylene-2-oxindoles is described, producing the spiro[pyrrolidin-3,3'-oxindole]s in good yields with high ee.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




len

Blue emissive dimethylmethylene-bridged triphenylamine derivatives appending cross-linkable groups

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00622J, Paper
Kangyu Zhou, Hongfei Pan, Yongjie Zhang, Houchen Wang, Xiaofei Dong, Xiangkui Ren, Xianggao Li, Shirong Wang, Zhijian Chen
Blue-emissive and cross-linkable dimethylmethylene-bridged triphenylamine derivatives were synthesized and their optical and electrochemical properties were investigated.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




len

Synthesis and photophysical properties of selenopheno[2,3-b]quinoxaline and selenopheno[2,3-b]pyrazine heteroacenes

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00718H, Paper
Amol Sonawane, Atsushi Shimozuma, Taro Udagawa, Masayuki Ninomiya, Mamoru Koketsu
In this paper, we report the novel synthesis of three different heterocycles namely 2-arylselenopheno[2,3-b]quinoxaline, 3-(aryl/alkylselanyl)-2-arylselenopheno[2,3-b]quinoxaline and 6-phenyl-7-(arylselanyl)selenopheno[2,3-b]pyrazine derivatives from the corresponding 2,3-dichloroquinoxaline and 2,3-dichloropyrazine derivatives. Further, photophysical properties were investigated...
The content of this RSS Feed (c) The Royal Society of Chemistry




len

Synthesis of methylene cyclopropane-fused chromenes and dihydroquinolines by sequential [4 + 2]- and [1 + 2]-annulation

Org. Biomol. Chem., 2020, 18,3303-3311
DOI: 10.1039/D0OB00389A, Paper
Tianyu Lu, Xuange Zhang, Zhiwei Miao
A base promoted sequential [4 + 2]- and [1 + 2]-annulation of 2-hydroxychalcones or 2-tosylaminochalcones with prop-2-ynylsulfonium salts was developed.
The content of this RSS Feed (c) The Royal Society of Chemistry




len

A visible-light-induced “on–off” one-pot synthesis of 3-arylacetylene coumarins with AIE properties

Org. Biomol. Chem., 2020, 18,3346-3353
DOI: 10.1039/D0OB00479K, Paper
Xinjie Wu, Ming Jia, Mengmeng Huang, Jung Keun Kim, Zheng Zhao, Junkai Liu, Jinhu Xi, Yabo Li, Yangjie Wu
A mild one-pot approach to 3-arylacetylene coumarins with potential AIE activities was developed via photosensitizer-free photocatalysis and thermocatalysis.
The content of this RSS Feed (c) The Royal Society of Chemistry




len

Synthesis of α-CF3-substituted E-dehydroornithine derivatives via copper(I)-catalyzed hydroamination of allenes

Org. Biomol. Chem., 2020, 18,3274-3280
DOI: 10.1039/D0OB00580K, Paper
Anna N. Philippova, Daria V. Vorobyeva, Florian Monnier, Sergey N. Osipov
Novel α-CF3-substituted E-dehydroornithine derivatives have been synthesized via the Cu(I)-catalyzed hydroamination of α-CF3-α-allenyl-α-aminocarboxylates/phosphonates with different amines.
The content of this RSS Feed (c) The Royal Society of Chemistry




len

Genome editing and engineering: from TALENs, ZFNs and CRISPRs to molecular surgery / edited by Krishnarao Appasani, with a foreword by George M. Church

Hayden Library - QH440.G46 2018




len

Specimen science: ethics and policy implications / edited by Holly Fernandez Lynch, Barbara E. Bierer, I. Glenn Cohen, and Suzanne M. Rivera

Hayden Library - QH231.S64 2017




len

The dynamics of biological systems Arianna Bianchi, Thomas Hillen, Mark A. Lewis, Yingfei Yi, editors

Online Resource




len

Morphogenesis deconstructed: an integrated view of the generation of forms / Len Pismen

Online Resource




len

Civil war, mental illness, poverty, gang violence: the many roots of homelessness

We talked to homeless in different countries and they revealed housing insecurity's different causes around the world.




len

[ASAP] Effects of Trichloroethylene on the Expression of Long Intergenic Noncoding RNAs in B6C3F1 Mouse Liver

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.9b00382




len

[ASAP] Exposure to Trichloroethylene Metabolite <italic toggle="yes">S</italic>-(1,2-Dichlorovinyl)-L-cysteine Causes Compensatory Changes to Macronutrient Utilization and Energy Metabolism in Placental HTR-8/SVneo Cells

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.9b00356




len

Alfie Allen on Game of Thrones

Alfie Allen talks about his character Theon Greyjoy on the show Game of Thrones.




len

Teen Technorati - The LEGO Challenge: Creative Problem-Solving

In this episode of Teen Technorati, the 40 finalists are split up into teams and tasked with building a bridge made out of LEGO. Only one team emerges as the winner, but during the challenge the finalists’ leadership and problem-solving skills begin to surface. Plus, fellowship hopefuls Ishaan Gulrajani, Lucy Guo, Darby Schumacher, and Catherine Ray explain the concepts behind their individual Thiel projects.




len

WIRED’s Scott Dadich Takes the ALS Ice Bucket Challenge

Watch WIRED editor in chief Scott Dadich take the ALS Ice Bucket Challenge—while doing the math behind how long it would take for every person in the world to have completed the challenge. (Want to check our work? Go to http://wrd.cm/icebucketmath.) Scott's donated to help put an end to ALS. Go to alsa.org to learn how you can help too. Thanks to GQ’s Michael Hainey for the nomination. Scott’s paying it forward: Consider yourselves challenged, Chris Hardwick, Cindi Leive, and Carlton Cuse!




len

WIRED's Gadget Challenge - Can a Hand Vacuum Suck Up a Kiddie Pool of Fruity Pebbles?

Erik and Justin test out the most stylish gadgets available at this year’s WIRED Store. See what happens when the two get their hands on a Dyson handheld vacuum, the Ballo stool (a sleeker update to the balance ball chair), and a modern, Bluetooth-controlled gramophone.




len

WIRED's Gadget Challenge - Mind-Controlled Helicopters

What happens when you take hi-tech toys and put them into overdrive? Find out, as Justin and Erik test out a brain-controlled helicopter, littleBits circuit modules, and a wheeling app-controlled robot called Ollie.




len

WIRED's Gadget Challenge - LED Skateboard Battle

Erik and Justin try out fitness gadgets that promise to take your workout to the next level. Find out how JayBird’s BlueBuds X headphones, Withing’s Pulse 02 watch, and Sunset’s LED skateboard stack up when they get put to the test.




len

WIRED's Gadget Challenge - Exclusive WIRED Store Walk-Through

Can’t make it to the WIRED store in person? Take an exclusive tour of this year’s gadget haven and check out everything the store has to offer with Erik and Justin from Battle Damage.




len

Battle Damage - Valentine's Day Destroyed at 1000 Frames Per Second

Love is in the air—literally, 15 feet in the air. Erik and Justin get in the Valentine's Day spirit by doing what they do best—smashing stuff, in this case a box of chocolates, a vase of roses, and a bottle of wine.




len

Nerf's new challenge

Nerf is aiming its new shooters at girls. But do kids care about the marketing?




len

Star Wars Lego Destruction - A Millennium Falcon Lego Replica Plummets Into Jakku

Watch all 1,329 Lego pieces of a replica Star Wars Millennium Falcon plunge into the desert planet Jakku.




len

Think Like a Tree - How Moth Eyes Inspired the Camera Lens

Find out how camera lenses take after moths by mimicking the way they absorb and hold in light.




len

The Ultimate Valentine’s Day Gift Guide for Women | Sponsored Content

Valentine’s Day is just around the corner. Blogger Christen Rochon breaks down her top three picks for the lucky lady in your life. Brought to you by eBay