ex Tunisia in an Election Year: What Next? By f1.media.brightcove.com Published On :: Tue, 11 Jun 2019 00:00:00 +0100 Full Article
ex Screening Room: Brexit - Behind Closed Doors By f1.media.brightcove.com Published On :: Thu, 27 Jun 2019 00:00:00 +0100 Full Article
ex In Conversation With Bob Dudley, Group Chief Executive, BP By f1.media.brightcove.com Published On :: Wed, 10 Jul 2019 00:00:00 +0100 Full Article
ex Undercurrents: Summer Special - Andrés Rozental on Mexican Politics By f1.media.brightcove.com Published On :: Thu, 01 Aug 2019 00:00:00 +0100 Full Article
ex Peacemaking in an Era of Global Extremism By f1.media.brightcove.com Published On :: Mon, 04 Nov 2019 00:00:00 +0000 Full Article
ex Brexit in a Historical Context: Pursuing a Global Vision at the Expense of Domestic Harmony? By f1.media.brightcove.com Published On :: Tue, 12 Nov 2019 00:00:00 +0000 Full Article
ex Schapiro Lecture: The Would-Be Federation Next Door – What Next for Britain? By f1.media.brightcove.com Published On :: Thu, 06 Feb 2020 00:00:00 +0000 Full Article
ex How Far Does the European Union’s Influence Extend? By f1.media.brightcove.com Published On :: Wed, 26 Feb 2020 00:00:00 +0000 Full Article
ex Undercurrents: Episode 57 - Race in Westminster, and COVID-19 Expertise By brightcove.hs.llnwd.net Published On :: Thu, 11 Jun 2020 00:00:00 +0100 Full Article
ex Gene expression regulation by retinoic acid By www.jlr.org Published On :: 2002-11-01 James E. BalmerNov 1, 2002; 43:1773-1808Reviews Full Article
ex Lipid extraction by methyl-tert-butyl ether for high-throughput lipidomics By www.jlr.org Published On :: 2008-05-01 Vitali MatyashMay 1, 2008; 49:1137-1146Methods Full Article
ex Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein By www.jlr.org Published On :: 1997-11-01 DL BrasaemleNov 1, 1997; 38:2249-2263Articles Full Article
ex Quantitation of atherosclerosis in murine models: correlation between lesions in the aortic origin and in the entire aorta, and differences in the extent of lesions between sexes in LDL receptor-deficient and apolipoprotein E-deficient mice By www.jlr.org Published On :: 1995-11-01 RK TangiralaNov 1, 1995; 36:2320-2328Articles Full Article
ex Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression By www.jlr.org Published On :: 1996-05-01 K SchoonjansMay 1, 1996; 37:907-925Reviews Full Article
ex Use of cyclodextrins for manipulating cellular cholesterol content By www.jlr.org Published On :: 1997-11-01 AE ChristianNov 1, 1997; 38:2264-2272Articles Full Article
ex The amphipathic helix in the exchangeable apolipoproteins: a review of secondary structure and function By www.jlr.org Published On :: 1992-02-01 JP SegrestFeb 1, 1992; 33:141-166Reviews Full Article
ex Renata Dwan Joins as Deputy Director and Senior Executive Officer By www.chathamhouse.org Published On :: Tue, 18 Aug 2020 23:47:09 +0000 Renata Dwan Joins as Deputy Director and Senior Executive Officer News Release sysadmin 19 August 2020 Renata Dwan has been appointed deputy director and senior executive officer of Chatham House. Full Article
ex Strengthening Our Commitment to the Next Generation By www.chathamhouse.org Published On :: Mon, 09 Nov 2020 18:52:16 +0000 Strengthening Our Commitment to the Next Generation News Release NCapeling 9 November 2020 Panel of Young Advisers and Queen Elizabeth II Academy Ambassadors underscore our drive to reach, engage and inspire young people to change their world. Full Article
ex New Chatham House History Examines our Defining Moments By www.chathamhouse.org Published On :: Mon, 18 Jan 2021 16:38:45 +0000 New Chatham House History Examines our Defining Moments News Release NCapeling 18 January 2021 'A History of Chatham House: its People and Influence from the 1920s to the 2020s' will examine the impact on policymaking of our first 100 years. Full Article
ex Supporting Next Generation of Leaders in Sustainability By www.chathamhouse.org Published On :: Thu, 28 Jan 2021 21:51:39 +0000 Supporting Next Generation of Leaders in Sustainability News Release NCapeling 28 January 2021 A new programme offering paid internships for young people who are passionate about social, economic, and environmental sustainability has been launched. Full Article
ex Innovating Governance: Examples from the Digital Arena By www.chathamhouse.org Published On :: Tue, 09 Feb 2021 12:54:17 +0000 Innovating Governance: Examples from the Digital Arena 25 February 2020 TO 26 February 2020 — 10:00AM TO 11:30AM Anonymous (not verified) 9 February 2021 Chatham House The Inclusive Governance Initiative is launched with this roundtable on digital governance. The Inclusive Governance Initiative, a centenary project which is examining how to build more inclusive models and mechanisms of global governance fit for purpose in today’s world, is launched with this roundtable on digital governance. The event brings together a diverse and multidisciplinary group of leading experts to consider where and how early initiatives around governance of the digital sphere have succeeded – or not – and how they are evolving today. The conversation will include the debate between multilateral and multi-stakeholder approaches, the opportunities and challenges of collective non-binding commitments, and converting civil society collaboration into policy contribution. Full Article
ex The regional and international implications of restrictions to online freedom of expression in Asia By www.chathamhouse.org Published On :: Fri, 12 Mar 2021 12:25:49 +0000 The regional and international implications of restrictions to online freedom of expression in Asia 25 March 2021 — 12:30PM TO 1:30PM Anonymous (not verified) 12 March 2021 Online Panellists discuss the latest developments affecting online freedom of expression in the Asia region. Please note this is an online event. Please register using the link below to finalize your registration. In recent years, state-led clampdowns on online freedom of expression have become widespread in several countries across Asia, further intensified by the COVID-19 crisis. The reasons for this are complex and diverse – drawing upon history, culture and politics, in addition to external influences. Across the region, governments have been accused of silencing online criticism and failing to uphold rights to free speech. Individuals have been arrested, fined or attacked for the alleged spread of ‘fake news’, raising concern among human rights organizations. In some countries, this has culminated in the imposition of new social media rules, which could require social media companies to censor posts and share decrypted messages. In China, the government’s restrictive online regime has relied on a combination of legal, technical and manipulation tactics to manage control of the internet, and now includes attempts at censorship beyond its borders. Panellists will discuss the latest regional developments affecting online freedom of expression in the Asia region, and will consider the broader regional and international implications for technology governance. This webinar launches the publication Restrictions on online freedom of expression in China: The domestic, regional and international implications of China’s policies and practices. Full Article
ex Why the next generation is key to protecting human rights By www.chathamhouse.org Published On :: Wed, 23 Jun 2021 13:12:42 +0000 Why the next generation is key to protecting human rights Expert comment LToremark 23 June 2021 Strengthening youth participation in public affairs is essential to building inclusive and democratic societies that respect human rights. Young people have always been drivers of social and economic reform, and today’s global youth population is more numerous and interconnected than ever before. While they have been at the forefront of civic rights movements in recent years, young people are largely excluded from discussions around human rights norms and how to monitor their protection and defence. Today’s global youth population is more numerous and interconnected than ever before. Young people are consistently underrepresented in intergovernmental mechanisms and national dialogues, which not only squanders their potential to contribute to effective solutions but also risks disengagement and disillusionment with multilateralism more broadly, at a time when many are already warning of the fraying of the international liberal order. Although there are actors and initiatives working to lift barriers to youth participation in governance – such as the UN Secretary-General’s Envoy on Youth, Jayathma Wickramanayake, or the UN 2016 Not Too Young To Run campaign – these efforts tend to fall short in effecting real change and rarely translate into institutionalized procedures. While ‘the youth’ is a heterogenous group, comprising different ages, ethnicities, national identities and interests, their participation in realizing human rights is essential to addressing the current challenges and possibilities of human rights for future generations. This will help foster more effective solutions to rights-related challenges, re-build trust in the international human rights framework among younger demographics and broaden and deepen commitments to human rights across generations. Human rights policies and the online environment Young people tend to be more technologically literate than their predecessors and also represent the majority of internet users and social media consumers in many countries. They can therefore play a key role in innovating and imagining rights-based solutions to emerging problems for the human rights framework, such as illegitimate collection of data by governments and companies, microtargeting by online platforms, and the sharing of harmful content online. In many cases, international human rights practices have failed to keep pace with these changes and the challenges they bring. Younger demographics may also approach these novel human rights issues from different starting points. For example, a UK study found that 30 per cent of 18-24 year-olds were ‘unconcerned’ about data privacy compared with only 12 per cent of those aged 55-64, and it has been shown that younger people tend to be more discerning of fake news compared to older generations. There may be a need for human rights institutions and practitioners to acknowledge and bridge these gaps in perspective and understanding to ensure long-term support for proposed solutions. International cooperation for human rights protection It has been suggested that young people have reaped the benefits of previous human rights-based policy reforms and have a strong sense of what rights they are entitled to and why these need to be protected through an international framework. Young people are also generally more supportive of multilateralism compared to their older counterparts, as demonstrated by a 2020 survey by Pew Research Center on global attitudes, which showed that 72 per cent of respondents aged 18-29 stated they have a favourable view of the UN, compared with 58 per cent of respondents aged 50 and older. At a recent Chatham House workshop, young participants from countries as diverse as Lebanon, Kenya and the United States expressed concern that growing hostility towards globalization threatens to undo progress in human rights standards and multilateralism more broadly, progress that they have seen and benefitted from. The rise of nationalist and populist parties has also seen countries shift their attention inwards, as evidenced by former president Trump’s decision to withdraw the US from the Paris Agreement on climate change, and threats by Brazil’s president, Jair Bolsonaro, to follow suit. Engaging more actively with younger individuals on global human rights reform will help ensure the long-term relevance of multilateral cooperation as well as domestic buy-in of human rights commitments. Awareness of the interconnectivity of global problems Young people’s proficiency on online platforms has enabled greater coordination and knowledge sharing without geographical constraints, allowing young activists – like Greta Thunberg – to inspire global movements and foster online discussions about intersectional solutions to modern-day challenges. This intersectional and transnational lens will be a vital component of building solutions to politically or historically complex issues and can be leveraged to foster better understanding of competing human rights claims relating to issues such as land re-distribution in South Africa or limitations on freedom of movement during the COVID-19 pandemic. These democratic forums and platforms will ultimately help build a global community committed to and engaged with human rights. Tokenism can discourage future engagement and dilute the effectiveness of the forums in question. Capturing the next generation’s potential With these concerns and areas of potential in mind, how can human rights institutions and mechanisms create more meaningful avenues for youth input? Recent Chatham House research has suggested that multilateral institutions’ efforts to engage youth has often taken the form of ‘superficial listening’, for example inviting a high-profile youth actor to a one-off event or appointing youth delegates who are not able to participate in formal discussions or mainstream governance forums. While encouraging youth participation in meetings focused on human rights can lead to positive change, tokenism can discourage future engagement and dilute the effectiveness of the forums in question. Capitalizing on the potential of the next generation can be achieved through integrating youth councils and advisers into national and international human rights policy processes, as well as human rights institutions. A few replicable models are already operational, such as the Y7 and the Y20 delegations – the official youth engagement groups for the G7 and G20 – that advance evidence-based proposals to world leaders ahead of the G7 and G20 summits. Subscribe to our weekly newsletterOur flagship newsletter provides a weekly round-up of content, plus receive the latest on events and how to connect with the institute. Enter email address Subscribe At the domestic level, grassroots youth-led movements can help bridge the gap between local constituencies and international policymakers, with youth activists on the ground helping to implement human rights standards and fighting against the spread of misinformation. Strong local networks and civic spaces are essential for pushing back against human rights abuses, and youth activists should be mobilized to connect the efforts of domestic and international bodies to the real issues on the ground; for example, canvassing grassroots youth networks on domestic and traditional customs before implementing development agendas around women’s rights. As well as providing insertion points for youth policy actors, human rights institutions must communicate their goals more effectively to younger generations and promote intergenerational and inclusive dialogue, for example by holding virtual consultations that give access to individuals from different backgrounds. Similarly, they should ask young people about their priorities for human rights reform using regular and accessible surveys or by sharing information on online platforms regularly used by this demographic. This will ensure lasting buy-in from the next generation, essential for the relevance and sustainability of the human rights framework in the years to come. This piece draws upon insights gathered at a workshop hosted by Chatham House in March 2021, which brought together the Institute’s networks of next generation groups including representatives of the QEII Academy Ambassadors, the Panel of Young Advisers, and the Common Futures Conversations community, as well as young members from the South African Institute of International Affairs. Full Article
ex Humanitarian exceptions: A turning point in UN sanctions By www.chathamhouse.org Published On :: Tue, 20 Dec 2022 14:44:17 +0000 Humanitarian exceptions: A turning point in UN sanctions Expert comment LJefferson 20 December 2022 The UN Security Council has adopted a cross-cutting exception for humanitarian action in UN sanctions. What does it cover? What must happen next? The UN Security Council has removed an obstacle to humanitarian work. On 9 December 2022, it adopted a resolution establishing a cross-cutting exception to existing – and future – UN financial sanctions for funds or assets necessary for humanitarian assistance and activities to meet basic human needs. In a coup for multilateralism, the council has been able to act, even when the Russian invasion of Ukraine has caused paralysis in other areas. Whilst sanctions are not intended to have adverse humanitarian consequences for civilian populations, aid agencies have argued for years that they do just this. Resolution 2664 – introduced by Ireland and the US, co-sponsored by 53 states, and adopted by 14 votes in favour, with India abstaining – is the culmination of a decade of engagement between humanitarian organizations and states to find ways of avoiding the adverse impact of sanctions on the most vulnerable: people relying on humanitarian action for survival. A reminder of the problem Whilst sanctions are not intended to have adverse humanitarian consequences for civilian populations, aid agencies have argued for years that they do just this. UN financial sanctions prohibit making funds or other assets available directly or indirectly to designated persons or entities. Without adequate safeguards, incidental payments made during humanitarian operations, or relief consignments that are diverted and end up in the hands of such persons or entities can violate this prohibition. Exceptions in Afghanistan and Haiti sanctions pave the way Humanitarian actors have been decrying and documenting the impact of sanctions on their operations for years. Ensuring that sanctions did not hinder the COVID-19 response was a turning point in states’ willingness to address the issue. The return to power of the Taliban in Afghanistan called for a more radical approach. Movement at Security Council level was gradual, starting off with demands in the renewals of certain country-specific sanctions that measures taken by member states to give effect to them comply with international law. The return to power of the Taliban called for a more radical approach. In December 2021, the Council adopted a broad exception to the Afghanistan financial sanctions, covering the provision, payment and processing of funds and assets necessary for humanitarian action and for activities to meet basic human needs. A similar exception was adopted – almost unnoticed – in October 2022 in the newly-established Haiti sanctions. These developments, coupled with the determination of elected Council member Ireland to find solutions, paved the way for the adoption of SCR 2664. The scope of the humanitarian exception SCR 2664 introduces a clear and broad exception that addresses the key challenges financial sanctions pose to humanitarian action. The exception expressly refers to the different ways in which funds or assets are allowed to reach designated persons or entities: by the provision of goods or payment of funds by humanitarian actors themselves; by the processing of funds by financial institutions; and by the provision of goods and services by other commercial actors whose services are necessary for humanitarian action such as insurers and freight companies. SCR 2664 introduces a clear and broad exception that addresses the key challenges financial sanctions pose to humanitarian action. The exception is broad in terms of the excluded activities: the provision of funds and assets necessary for humanitarian assistance and activities to meet basic human needs. The UN Somalia sanctions – the first, and for a decade the only, regime to include an express exception – exclude funds necessary for ‘humanitarian assistance’. SCR 2615 on Afghanistan added the expression ‘activities to meet basic human needs’. These go beyond humanitarian assistance, and have been interpreted as including activities necessary to sustain essential social services such as health and education, preserve essential community systems, and promote livelihoods and social cohesion. These are essentially development programmes. ‘Activities that support basic needs’ should be understood in a similar manner in SCR 2664. SCR 2664 is not, however, a ‘blanket’ exception. It only applies to financial sanctions. These are not the only type of restriction in UN sanctions that can hinder humanitarian action. For example, organizations that send commodities into the Democratic People’s Republic of Korea must still go through the notoriously slow procedure of authorization by the sanctions committee. Similarly, authorizations are still required for import of demining materials that fall within the scope of arms embargoes. Opportunities for further engagement and additional safeguards Recognizing that additional challenges remain, SCR 2664 requests the UN Secretary-General to draft a report on unintended adverse humanitarian consequences of all types of restrictions in UN sanctions. He is asked to include recommendations for minimizing and such unintended consequences, including by the adoption of additional cross-cutting exceptions. Humanitarian organizations have played a pivotal role in advancing the agenda. SCR 2664 is the result of their relentless engagement with the Security Council. It is not the end of the road. Other restrictions raise problems, and the Council has left the door open to finding ways of addressing them. Humanitarian organizations have played a pivotal role in advancing the agenda. SCR 2664 is the result of their relentless engagement with the Security Council. Humanitarian actors should seize this opportunity to provide information, identifying the problematic types of restrictions and their consequences on their operations as specifically as possible. What happens next? It is UN member states that implement UN sanctions. For SCR 2664 to be truly effective, it is imperative that states give effect to it in domestic law and practice. In doing so, they must not narrow the scope of the exception. Recent experience in Afghanistan has shown that even in situations when significant safeguards exist, key actors may be unaware of them or unclear as to their precise scope. Financial institutions in particular are fast to de-risk when sanctions are imposed, and remain wary of conducting transactions that they perceive as high-risk even though exceptions permit this. For SCR 2664 to be truly effective, it is imperative that states give effect to it in domestic law and practice. In doing so, they must not narrow the scope of the exception. OFAC – the Office of Foreign Assets Control in the US Treasury – has issued extensive guidance on the Afghanistan sanctions in the form of frequently asked questions. These have played an extremely important role in ensuring full advantage is taken of the exceptions. States should follow this example, and adopt guidance to raise awareness of the exception in SCR 2664 and to clarify its scope. A valuable precedent for autonomous sanctions SCR 2664 only applies to sanctions adopted by the UN Security Council. It does not extend to autonomous sanctions adopted by states or relevant international organizations such as the EU. Full Article
ex MicroRNA-98 reduces nerve growth factor expression in nicotine-induced airway remodeling [Gene Regulation] By www.jbc.org Published On :: 2020-12-25T00:06:30-08:00 Evolving evidence suggests that nicotine may contribute to impaired asthma control by stimulating expression of nerve growth factor (NGF), a neurotrophin associated with airway remodeling and airway hyperresponsiveness. We explored the hypothesis that nicotine increases NGF by reducing lung fibroblast (LF) microRNA-98 (miR-98) and PPARγ levels, thus promoting airway remodeling. Levels of NGF, miR-98, PPARγ, fibronectin 1 (FN1), endothelin-1 (EDN1, herein referred to as ET-1), and collagen (COL1A1 and COL3A1) were measured in human LFs isolated from smoking donors, in mouse primary LFs exposed to nicotine (50 μg/ml), and in whole lung homogenates from mice chronically exposed to nicotine (100 μg/ml) in the drinking water. In selected studies, these pathways were manipulated in LFs with miR-98 inhibitor (anti-miR-98), miR-98 overexpression (miR-98 mimic), or the PPARγ agonist rosiglitazone. Compared with unexposed controls, nicotine increased NGF, FN1, ET-1, COL1A1, and COL3A1 expression in human and mouse LFs and mouse lung homogenates. In contrast, nicotine reduced miR-98 levels in LFs in vitro and in lung homogenates in vivo. Treatment with anti-miR-98 alone was sufficient to recapitulate increases in NGF, FN1, and ET-1, whereas treatment with a miR-98 mimic significantly suppressed luciferase expression in cells transfected with a luciferase reporter linked to the putative seed sequence in the NGF 3'UTR and also abrogated nicotine-induced increases in NGF, FN1, and ET-1 in LFs. Similarly, rosiglitazone increased miR-98 and reversed nicotine-induced increases in NGF, FN1, and ET-1. Taken together, these findings demonstrate that nicotine-induced increases in NGF and other markers of airway remodeling are negatively regulated by miR-98. Full Article
ex Inhibition of the SUV4-20 H1 histone methyltransferase increases frataxin expression in Friedreich's ataxia patient cells [Gene Regulation] By www.jbc.org Published On :: 2020-12-25T00:06:30-08:00 The molecular mechanisms of reduced frataxin (FXN) expression in Friedreich's ataxia (FRDA) are linked to epigenetic modification of the FXN locus caused by the disease-associated GAA expansion. Here, we identify that SUV4-20 histone methyltransferases, specifically SUV4-20 H1, play an important role in the regulation of FXN expression and represent a novel therapeutic target. Using a human FXN–GAA–Luciferase repeat expansion genomic DNA reporter model of FRDA, we screened the Structural Genomics Consortium epigenetic probe collection. We found that pharmacological inhibition of the SUV4-20 methyltransferases by the tool compound A-196 increased the expression of FXN by ∼1.5-fold in the reporter cell line. In several FRDA cell lines and patient-derived primary peripheral blood mononuclear cells, A-196 increased FXN expression by up to 2-fold, an effect not seen in WT cells. SUV4-20 inhibition was accompanied by a reduction in H4K20me2 and H4K20me3 and an increase in H4K20me1, but only modest (1.4–7.8%) perturbation in genome-wide expression was observed. Finally, based on the structural activity relationship and crystal structure of A-196, novel small molecule A-196 analogs were synthesized and shown to give a 20-fold increase in potency for increasing FXN expression. Overall, our results suggest that histone methylation is important in the regulation of FXN expression and highlight SUV4-20 H1 as a potential novel therapeutic target for FRDA. Full Article
ex Assad’s extortion fails to ease Syria’s financial crisis By www.chathamhouse.org Published On :: Mon, 24 Feb 2020 14:55:32 +0000 Source Arab News URL https://www.arabnews.com/node/1625786 Release date 10 February 2020 Expert Haid Haid In the news type Op-ed Hide date on homepage Full Article
ex What's next for India's Muslims? By www.chathamhouse.org Published On :: Fri, 06 Mar 2020 16:32:27 +0000 Source The Independent URL https://www.independent.co.uk/voices/india-modi-muslims-delhi-riots-hindu-violen... Release date 04 March 2020 Expert Dr Gareth Price In the news type Op-ed Hide date on homepage Full Article
ex Building better polymerases: Engineering the replication of expanded genetic alphabets [Molecular Biophysics] By www.jbc.org Published On :: 2020-12-11T00:06:20-08:00 DNA polymerases are today used throughout scientific research, biotechnology, and medicine, in part for their ability to interact with unnatural forms of DNA created by synthetic biologists. Here especially, natural DNA polymerases often do not have the “performance specifications” needed for transformative technologies. This creates a need for science-guided rational (or semi-rational) engineering to identify variants that replicate unnatural base pairs (UBPs), unnatural backbones, tags, or other evolutionarily novel features of unnatural DNA. In this review, we provide a brief overview of the chemistry and properties of replicative DNA polymerases and their evolved variants, focusing on the Klenow fragment of Taq DNA polymerase (Klentaq). We describe comparative structural, enzymatic, and molecular dynamics studies of WT and Klentaq variants, complexed with natural or noncanonical substrates. Combining these methods provides insight into how specific amino acid substitutions distant from the active site in a Klentaq DNA polymerase variant (ZP Klentaq) contribute to its ability to replicate UBPs with improved efficiency compared with Klentaq. This approach can therefore serve to guide any future rational engineering of replicative DNA polymerases. Full Article
ex The HRDC domain oppositely modulates the unwinding activity of E. coli RecQ helicase on duplex DNA and G-quadruplex [Enzymology] By www.jbc.org Published On :: 2020-12-18T00:06:18-08:00 RecQ family helicases are highly conserved from bacteria to humans and have essential roles in maintaining genome stability. Mutations in three human RecQ helicases cause severe diseases with the main features of premature aging and cancer predisposition. Most RecQ helicases shared a conserved domain arrangement which comprises a helicase core, an RecQ C-terminal domain, and an auxiliary element helicase and RNaseD C-terminal (HRDC) domain, the functions of which are poorly understood. In this study, we systematically characterized the roles of the HRDC domain in E. coli RecQ in various DNA transactions by single-molecule FRET. We found that RecQ repetitively unwinds the 3'-partial duplex and fork DNA with a moderate processivity and periodically patrols on the ssDNA in the 5'-partial duplex by translocation. The HRDC domain significantly suppresses RecQ activities in the above transactions. In sharp contrast, the HRDC domain is essential for the deep and long-time unfolding of the G4 DNA structure by RecQ. Based on the observations that the HRDC domain dynamically switches between RecA core- and ssDNA-binding modes after RecQ association with DNA, we proposed a model to explain the modulation mechanism of the HRDC domain. Our findings not only provide new insights into the activities of RecQ on different substrates but also highlight the novel functions of the HRDC domain in DNA metabolisms. Full Article
ex Existence and uniqueness result for reaction-diffusion model of diffusive population dynamics By www.ams.org Published On :: Tue, 01 Oct 2024 14:21 EDT A. Kh. Khachatryan, Kh. A. Khachatryan and A. Zh. Narimanyan Trans. Moscow Math. Soc. 83 (), 183-200. Abstract, references and article information Full Article
ex On functions of finite analytical complexity By www.ams.org Published On :: Tue, 01 Oct 2024 14:21 EDT M. A. Stepanova Trans. Moscow Math. Soc. 83 (), 1-13. Abstract, references and article information Full Article
ex Fossil Fuels Expert Roundtable: Forecasting Forum 2018 By www.chathamhouse.org Published On :: Mon, 18 Dec 2017 11:30:00 +0000 Fossil Fuels Expert Roundtable: Forecasting Forum 2018 12 February 2018 — 2:00PM TO 5:30PM Anonymous (not verified) 18 December 2017 Chatham House, London This forum will present the latest thinking from senior researchers on the dynamics that will affect fossil fuels investment and markets in the year ahead. The first session will assess the various factors keeping oil and gas prices from bouncing back and will consider conditions and political developments that could influence markets in the year ahead. The second session will assess the future of the power sector and what this means for the fossil fuels industry.Attendance at this event is by invitation only. Full Article
ex Fossil Fuels Expert Roundtable: How Solar is Shaping the Energy Transition By www.chathamhouse.org Published On :: Tue, 22 May 2018 14:00:00 +0000 Fossil Fuels Expert Roundtable: How Solar is Shaping the Energy Transition 1 June 2018 — 9:00AM TO 10:30AM Anonymous (not verified) 22 May 2018 Chatham House, London As global temperatures rise and extreme weather events multiply, doubts over the reality and imminence of climate change have dissipated. Despite this, there is a clear lack of urgency by governments to the approaching crisis. At this event, Prem Shankar Jha will set out what he believes are the three main causes for this inaction.Furthermore, he will argue that catastrophic climate change is imminent, but even if it weren’t, the risk is too great to ignore. Only a complete shift from fossil fuels by 2070 at the latest would provide reasonable certainty of avoiding irreversible consequences. This transition is not only possible but the technologies to enable it were harnessed four to nine decades ago – and all of them draw their primary energy from the sun. These technologies are already capable of delivering electricity, transport fuels, and petrochemicals at prices that are competitive with the current delivered cost of electricity in the US and Western Europe. So what is holding up the energy shift?Attendance at this event is by invitation only. Full Article
ex Flexible Distribution Systems: New Services, Actors and Technologies By www.chathamhouse.org Published On :: Tue, 31 Jul 2018 12:10:01 +0000 Flexible Distribution Systems: New Services, Actors and Technologies 4 September 2018 — 9:00AM TO 10:30AM Anonymous (not verified) 31 July 2018 Chatham House, London The pace of the energy transition is accelerating. Solar and wind are dramatically falling in cost and displacing fossil fuel generators. Simultaneously, the rapid uptake of electric vehicles and battery storage systems are beginning to send shock-waves through the electricity sector. As the proportion of distributed energy resources (DERs) connected to the distribution network grows, a significant opportunity is beginning to present itself. What if the concerns of renewable integration and associated costs could be solved by the smart integration of these DERs? By properly valuing the services DERs can provide, actively managing the distribution system and creating new market places, might a truly renewable electricity system capable of supporting the electrification of heat and transport be possible?During this roundtable, Andrew Scobie, CEO of Faraday Grid, will provide an overview of the challenges and opportunities faced within the distribution network and explain why the current system is no longer fit for purpose. This is the inaugural event in the Energy Transitions Roundtable (ETR) series. Full Article
ex Realizing the Potential of Extractives for Industrial and Economic Development By www.chathamhouse.org Published On :: Wed, 03 Oct 2018 17:10:01 +0000 Realizing the Potential of Extractives for Industrial and Economic Development 18 October 2018 — 5:30PM TO 7:00PM Anonymous (not verified) 3 October 2018 Chatham House | 10 St James's Square | London | SW1Y 4LE Over the past two decades, the extractives industries have risen in importance for many low- and middle- income countries their prospects for economic development and poverty reduction. During a period of rising commodities prices, the development of extractives became increasingly attractive to both governments and companies. There was - and remains - much discussion about their potential to support inclusive development.However, there are also risks and uncertainties associated with the extractives industries and many things can, and do, go wrong. Fluctuations in commodity prices can be hard to manage and can lead to considerable fiscal pressures. In the longer-term, climate change and the various policy responses to this, will profoundly affect the extractives sector as renewables replace fossil fuels in the global energy mix.Managing the extractives sectors will therefore remain highly challenging especially in low-income countries where institutions are often weak. This roundtable will bring together some of the foremost academics and practitioners working in the extractives industries and also in economic development to discuss a major new UNU-WIDER study Extractive Industries: The Management of Resources as a Driver of Sustainable Development.Attendance at this event is by invitation only. Full Article
ex The Impact of Brexit on Energy Transformation in the UK and EU By www.chathamhouse.org Published On :: Mon, 03 Dec 2018 14:20:01 +0000 The Impact of Brexit on Energy Transformation in the UK and EU 28 March 2019 — 8:15AM TO 9:45AM Anonymous (not verified) 3 December 2018 Chatham House | 10 St James's Square | London | SW1Y 4LE The UK’s decision to leave the EU will fundamentally reshape many of the UK’s policies and its relations with countries around the world. For energy and climate, the changes could be significant and will need to be managed carefully to secure ongoing investment, stable energy prices and ambitious climate objectives. The UK’s departure will also affect the balance of political support for climate and energy policies with the EU institutions and potentially impact upon regional initiatives. This roundtable will discuss:The impact on the energy sector of Brexit during the transition period through until December 2020 including the operation of interconnectors and access to the Internal energy market, ongoing engagement in European research collaboration and the replacement of European financial resources.The possible opportunities and risks for the UK’s energy sector in 2021 and beyond.The implications of Brexit on the EU’s energy and climate policy.The roundtable will discuss the role of the public and business in shaping the future deal as it will need to be ratified by the parliaments of all member states.Attendance at this event is by invitation only. Full Article
ex The Future of Food Post-Brexit By www.chathamhouse.org Published On :: Thu, 07 Feb 2019 10:00:02 +0000 The Future of Food Post-Brexit 26 February 2019 — 9:00AM TO 10:30AM Anonymous (not verified) 7 February 2019 Chatham House | 10 St James's Square | London | SW1Y 4LE For almost half a century, the UK’s food system – comprising the totality of food production, transport, manufacturing, retailing and consumption – has been intrinsically and intricately linked to its membership of the European Community and, subsequently, the EU. Arguably, for no other sectors are the challenges and opportunities of Brexit as extensive as they are for UK food and agriculture.Reforming the UK’s food system won’t be easy. The tight Brexit timeline, the complexities of negotiations and the political pressure to secure new trade deals could lead to decisions that are poorly conceived and become near impossible to correct.This event will explore the challenges of the UK’s ‘just in time’ food system which only maintains 5-10 days’ worth of groceries country-wide, what the impacts of structural changes will be post-Brexit such as longer inspections of food imports at the border and what the main priorities for policymakers should be in the event of a no-deal Brexit to ensure the country’s food-stock can satisfy demand. Full Article
ex Mining, Minerals and Metals Expert Roundtable: Forest-Smart Mining Report Launch By www.chathamhouse.org Published On :: Fri, 12 Apr 2019 13:30:02 +0000 Mining, Minerals and Metals Expert Roundtable: Forest-Smart Mining Report Launch 10 May 2019 — 5:30PM TO 6:30PM Anonymous (not verified) 12 April 2019 Chatham House | 10 St James's Square | London | SW1Y 4LE The impact of mining on forests has received relatively limited attention at the global level despite its implications for climate change, biodiversity and the wider Sustainable Development Goals. Three new studies – commissioned by the World Bank and the Program on Forests (PROFOR) and delivered by a consortium including Fauna and Flora International, Levin Sources, Fairfields Sustainability Consulting and Swedish Geological AB – shed new light on the impact of mining on deforestation, current practices to protect forests in mining areas and how ‘forest-smart’ mining policies, practices and partnerships can be scaled-up and accelerated. The report authors will introduce the key findings of the reports, as they relate to large-scale mining (LSM), artisanal and small-scale mining (ASM) and the implementation of biodiversity offset schemes, with a focus on landscape-level efforts that avoid or minimize adverse impacts on forests – and ideally result in a net gain for forest outcomes. The speakers will then set out policy and practical recommendations designed to support ‘forest-smart’ mining, conserve biodiversity and ensure a ‘well below 2c’ future, before opening up the discussion to participants. Full Article
ex Driven to Extraction: Can Sand Mining be Sustainable? By www.chathamhouse.org Published On :: Mon, 29 Apr 2019 11:10:01 +0000 Driven to Extraction: Can Sand Mining be Sustainable? 5 June 2019 — 1:30PM TO 3:00PM Anonymous (not verified) 29 April 2019 Chatham House | 10 St James's Square | London | SW1Y 4LE Sand is the most consumed raw material in the world after water and is a critical building block of the modern world. When bound with cement, it becomes concrete; when mixed with bitumen, it becomes asphalt; and when heated, it becomes glass. According to a recent UN Environment Programme report, the world extracts over 40 billion tonnes of sand and aggregates every year. This is the equivalent of 18 kilograms per day per person – or enough to build a wall of sand 27 metres wide and 27 metres high around the entire globe each year. Sand extraction on this scale, particularly when taken from riverine or coastal locations, can have serious environmental impacts on ecosystems, biodiversity and erosion. Control of sand resources has also proved a source of tension between countries and violence within them. With demand for sand set to increase dramatically in line with population growth and urbanization, and with growing policy attention on the decarbonization of cement and other industrial inputs, better understanding of these impacts is needed. Yet with limited data on sand extraction, trade and consumption, and little in the way of governance frameworks, developing policies and practices that help ensure sustainable sand supply chains is challenging. This roundtable will examine the environmental, economic and political implications of sand supply chains and discuss opportunities to help integrate sustainable policy and practice. Full Article
ex Nuclear Energy in a Post-Brexit Europe By www.chathamhouse.org Published On :: Wed, 18 Sep 2019 14:45:01 +0000 Nuclear Energy in a Post-Brexit Europe 11 October 2019 — 8:30AM TO 10:00AM Anonymous (not verified) 18 September 2019 Chatham House | 10 St James's Square | London | SW1Y 4LE Brexit will significantly change the balance within the EU in relation to nuclear energy. Apart from France and Finland, both of whose nuclear development programmes are behind schedule, the UK is the only member state in northern or western Europe currently investing in new nuclear capacity. Brexit will therefore leave the supporters of nuclear energy within the EU27 and the European Commission in a weaker position.The speaker will argue that at a time when the energy industry needs to accelerate its shift away from fossil fuels, and when the electricity generation industry must cut its carbon emissions faster than it has ever managed to do in the past, this change is unhelpful.The workshop will also address the need for additional interconnector capacity and the future of carbon-trading outside the EU emission trading system and how this relates to potential nuclear energy capacity.Attendance at this event is by invitation only. Full Article
ex What's next for environmental peacebuilding? Lessons learned and opportunities from conflict-affected states By www.chathamhouse.org Published On :: Mon, 08 Feb 2021 14:54:17 +0000 What's next for environmental peacebuilding? Lessons learned and opportunities from conflict-affected states 17 February 2021 — 3:00PM TO 4:00PM Anonymous (not verified) 8 February 2021 Online This event explores lessons and opportunities from conflict-affected states. In the field of peacebuilding, scholars and policymakers increasingly recognize the importance of environmental restoration, afforestation and infrastructural renewal for creating the sustainable livelihoods necessary for successful peacebuilding efforts. Featuring academics writing for International Affairs on environmental peacebuilding in Colombia, Yemen and the Sahel, this webinar discusses the policy implications of the turn to environmental peacebuilding. This event is part of the Chatham House’s Environment and Society Discussion Series in which the Energy Environment and Resources Programme brings together leading academics and policymakers to discuss key issues in environmental policy. In particular, this event focuses on the role of environmental peacebuilding in creating sustainable livelihoods. From the impact the destruction of infrastructure can have on poverty as a driver of conflict, to the role environmental peacebuilding can play in bringing communities together by creating sustainable shared spaces of employment, the importance of the environmental livelihood creation is difficult to overstate. Panellists focus on how policymakers can best encourage inclusive and sustainable livelihood creation and on addressing the key challenges such approaches face in the context of environmental peacebuilding efforts. Full Article
ex Loss and damage: Where are we now and what happens next? By www.chathamhouse.org Published On :: Mon, 17 Jan 2022 11:07:14 +0000 Loss and damage: Where are we now and what happens next? 25 January 2022 — 1:00PM TO 2:00PM Anonymous (not verified) 17 January 2022 Online This event discusses the progress of the loss and damage agenda within climate negotiations. Loss and damage refers to harms and destruction caused by climate change impacts that cannot be avoided through mitigation or adaptation. While it has gained increasing recognition in international climate change negotiations, turning the concept of loss and damage into tangible action for climate-vulnerable countries has been contentious. Loss and damage is interwoven with issues of fairness and equity. The issue is highly disputed due to its connection with the historical responsibility of developed countries in causing climate change, as well as associated calls for compensation from developing countries. At COP26, Scotland became the first government to pledge funds for loss and damage for countries in the Global South. However, most climate-vulnerable countries left disappointed by the failure of the Glasgow Climate Pact to secure the establishment of a dedicated loss and damage financing facility. Developing countries have made it clear that they will continue to push for a new financing facility in the Glasgow Dialogue, a set of international discussions on loss and damage kicking off in June. The Environment and Society Discussion Series is hosting two events on loss and damage ahead of that date. This first event outlines the key debates and discuss what progress has been made on advancing the loss and damage agenda within climate negotiations to date. The second event focuses on solutions and possible ways forward, looking ahead to the COP27 negotiations in Egypt later in 2022, where loss and damage is expected to be a high-profile agenda item. Full Article
ex What to Know About Hong Kong’s Chief Executive Election By www.chathamhouse.org Published On :: Mon, 27 Mar 2017 09:51:50 +0000 What to Know About Hong Kong’s Chief Executive Election Expert comment sysadmin 27 March 2017 Tim Summers looks at what we know about Carrie Lam, the territory’s new leader, and where Hong Kong politics goes from here. — A pro-democracy protester holds a yellow umbrella in front of Carrie Lam and her defeated opponents John Tsang and Woo Kwok-hing. Photo: Getty Images. Carrie Lam, formerly number two in the Hong Kong government, was selected as the Special Administrative Region’s new chief executive on 26 March. What does the process and her selection say about Hong Kong’s political future? Elections for Hong Kong’s top job are still within Beijing’s control. Due to the failure of political reform proposals in 2015, Lam was elected on the basis of 777 votes from the 1,194 members of the Chief Executive Election Committee. This ‘small-circle’ process was essentially the same as that used since 1997 (the only change being the expansion of the committee from its initial size of 800). The design of the process favours Beijing, and indeed Lam was the favoured candidate of the central government and many of its supporters in Hong Kong. But the influence of the central government has limits. The second-ranked candidate, former finance minister John Tsang (365 votes), had not been encouraged to stand by Beijing, and a fourth candidate, Regina Ip (who did not obtain enough nominations to join the vote), reportedly also rejected suggestions from Beijing that she should not put herself forward. The Committee itself contained 325 individuals affiliated to or sympathetic to opposition parties and around 100 establishment figures who did not support Lam – most of whom voted for Tsang. Although Lam gained more votes than her predecessor, CY Leung, in 2012 (he obtained 689 votes after a controversial campaign when scandals undermined his main opponent), Beijing appears to have expended substantial political capital in securing her victory. Despite the closed process, public opinion matters. The campaign saw all the candidates actively seek not only the votes of committee members, but also wider popular support. This highlights the need for broader legitimacy, and the fact that public participation and media debate are central factors in Hong Kong’s open political culture. A number of opinion polls showed Lam to have notably lower levels of popular support than Tsang. This will constrain her ability to govern effectively and she will not be cut much slack by the Hong Kong population. There were protests at the election venue calling for ‘genuine universal suffrage’. The new chief executive is an economic interventionist. The two main candidates – Lam and Tsang – have different policy approaches. Tsang’s was a more liberal ‘laissez faire’ one. Lam is likely to continue the somewhat more interventionist approach of CY Leung, who intervened more than previous governments to try to stabilize property prices and make more land available for housing, as well as reinstating policies targeting poverty and agreeing measures to limit the social impact of rising numbers of visitors and money from mainland China. Political reform seems very far off. The third candidate, former judge Woo Kwok-hing, had the clearest position on the thorny issue of political reform. Many of the government’s critics see less prospect for progress here under Lam, who fronted the government’s consultation processes during the 2013–15 debates over political reform. Lam gave some conflicting signals during the campaign, and it remains to be seen whether she tries to restart the process. But given rising populism, the growing fragmentation and polarization of Hong Kong politics, and entrenched positions from both Beijing and the opposition, it will be even more difficult to obtain consensus on a way forward than when the last failed attempt at reform took place – a key indicator will be whether all political parties are willing to discuss compromises. July’s anniversary will be contentious. Following formal appointment by the central government, Lam’s term will begin on 1 July. This will also mark the 20th anniversary of the handover of Hong Kong to Chinese sovereignty in 1997, which will coincide with a planned visit by President Xi Jinping. This will no doubt spark protests; for many, the 20th anniversary of the handover will therefore be less a time for celebration than an opportunity for many to highlight concerns about the future of the former British colony. Full Article
ex The Migration-Deportation-Return Nexus By www.chathamhouse.org Published On :: Wed, 23 May 2018 15:30:01 +0000 The Migration-Deportation-Return Nexus 6 June 2018 — 1:00PM TO 5:30PM Anonymous (not verified) 23 May 2018 Chatham House, London In 2015, the unprecedented numbers of migrants crossing borders subjected the EU to extraordinary moral and political pressure, as the number of asylum-seekers soared 122 per cent to 1.3 million people.In response, the EU has sought to accelerate the deportation of failed asylum-seekers and migrants who arrive without proper documentation. The European Commission has recommended that “all leverage and incentives” be used to “ensure that third countries fulfil their international obligation to take back their own nationals residing irregularly in Europe.” The Valletta Action Plan, the EU-Turkey deal, the Brussels Agreement with Afghanistan, the EU deal with Nigeria and the new “results-oriented Partnership Framework” signal more restrictive approaches and an outsourcing of the securitization of migration. However, the EU’s attempt to reconcile its legal and humanitarian obligations with stronger measures has encountered some serious challenges.This roundtable stimulates dialogue on the circumstances surrounding migrant youth both in Afghanistan and the Edo state in Nigeria, and identifies key questions for further research on the ground.Contextualising young people’s experiences within a “migration-deportation-return” nexus provides an entry point for the identification of both the commonalities and specifics of the challenges and risks that migrant youth face.In line with UNICEF’s policy priorities related to children on the move, and initiating global debates in child rights and development, this collaboration forms part of the efforts that seek to inform global research and policy agenda for this most vulnerable of groups under the radar.The intended outcome of this collaboration is to begin developing a set of core objectives and indicators to help guide the EU, Afghanistan and Nigeria in their treatment of youth, and to facilitate improved donor and host government understanding of the issues.Participants include experts, researchers, academics, representatives of civil society and governmental institutions.Attendance is by invitation-only.The event is co-hosted with UNICEF Office of Research – Innocenti and the University of Cambridge. Full Article
ex Few hamiltonian cycles in graphs with one or two vertex degrees By www.ams.org Published On :: Mon, 21 Oct 2024 15:01 EDT Jan Goedgebeur, Jorik Jooken, On-Hei Solomon Lo, Ben Seamone and Carol T. Zamfirescu Math. Comp. 93 (), 3059-3082. Abstract, references and article information Full Article
ex Effective homology and periods of complex projective hypersurfaces By www.ams.org Published On :: Mon, 21 Oct 2024 15:01 EDT Pierre Lairez, Eric Pichon-Pharabod and Pierre Vanhove Math. Comp. 93 (), 2985-3025. Abstract, references and article information Full Article
ex Explicit calculations for Sono’s multidimensional sieve of ????₂-numbers By www.ams.org Published On :: Mon, 21 Oct 2024 15:01 EDT Daniel A. Goldston, Apoorva Panidapu and Jordan Schettler Math. Comp. 93 (), 2943-2958. Abstract, references and article information Full Article
ex A random active set method for strictly convex quadratic problem with simple bounds By www.ams.org Published On :: Mon, 21 Oct 2024 15:01 EDT Ran Gu and Bing Gao Math. Comp. 93 (), 2837-2860. Abstract, references and article information Full Article
ex From geodesic extrapolation to a variational BDF2 scheme for Wasserstein gradient flows By www.ams.org Published On :: Mon, 21 Oct 2024 15:01 EDT Thomas O. Gallouët, Andrea Natale and Gabriele Todeschi Math. Comp. 93 (), 2769-2810. Abstract, references and article information Full Article