lit Evaluating the Suitability of Roadway Corridors for Use by Monarch Butterflies By www.trb.org Published On :: Wed, 22 Apr 2020 13:00:58 GMT The charismatic and familiar monarch butterfly serves as a flagship species for pollinator conservation, and gives rights-of-way entities opportunities to engage a diverse array of stakeholders who are invested in not only restoring monarch numbers to sustainable levels, but also mitigating many other environmental and economic issues. This pre-publication draft of the TRB National Cooperative Highway Research Program's NCHRP Research Report 942 Pre-Pub: Evaluating the Suitability of Roadway Corridors fo... Full Article http://www.trb.org/Resource.ashx?sn=cover_nchrp_rr_942
lit Highway Capacity Manual, Sixth Edition: A Guide for Multimodal Mobility Analysis By www.trb.org Published On :: Mon, 27 Apr 2020 11:54:52 GMT Now available to order from the TRB Bookstore, the Highway Capacity Manual, Sixth Edition: A Guide for Multimodal Mobility Analysis (HCM) provides methods for quantifying highway capacity. In its current form, it serves as a fundamental reference on concepts, performance measures, and analysis techniques for evaluating the multimodal operation of streets, highways, freeways, and off-street pathways. The Sixth Edition incorporates the latest research on highway capacity, quality of service, Active Traffic... Full Article http://www.trb.org/Resource.ashx?sn=HCM6cover
lit Bicyclist Facility Preferences and Effects on Increasing Bicycle Trips By www.trb.org Published On :: Tue, 28 Apr 2020 05:20:34 GMT Cyclists and noncyclists have a wide range of perceptions of on-street bicycling facility designs — including sharrows, bike lanes, and buffered bike lanes — along a variety of roadway types, with and without curbside automobile parking. The TRB National Cooperative Highway Research Program's NCHRP Research Report 941: Bicyclist Facility Preferences and Effects on Increasing Bicycle Trips provides insights from communities where on-road cycling for transportation is less common, particularly in the South... Full Article http://www.trb.org/Resource.ashx?sn=cover_nchrp_rpt_941a
lit Using GIS for Collaborative Land Use Compatibility Planning Near Airports By www.trb.org Published On :: Thu, 16 May 2019 06:02:24 GMT TRB’s Airport Cooperative Research Program (ACRP) Research Report 200: Using GIS for Collaborative Land Use Compatibility Planning Near Airports offers guidance for using Geographic Information Systems (GIS) as a collaboration tool to encourage compatible land use around airports. The report is designed to help airport and community planners seeking to work together to protect existing and future airport development as well as maintain safety and improve quality of life for those living and working near ... Full Article http://www.trb.org/Resource.ashx?sn=Cover_acrp_rpt_200
lit Guidebook on Effective Land Use Compatibility Planning Strategies for General Aviation Airports By www.trb.org Published On :: Wed, 13 Nov 2019 12:40:58 GMT Incompatible land uses can threaten the safe utility of airports and expose people living and working nearby to potentially unacceptable levels of noise or safety risk. At the state level, all 50 states have enacted some form of airport zoning legislation since the 1950s. The majority of states (90 percent) have enacted laws mandating or enabling local governments to adopt, administer, and enforce airport zoning regulations. The TRB Airport Cooperative Research Program's ACRP Research Report 206: Guidebo... Full Article http://www.trb.org/Resource.ashx?sn=cover_acrp_rpt_206
lit National Politics With Ken Rudin By tracking.feedpress.it Published On :: Tue, 05 May 2020 11:34:26 +0000 President Donald Trump maintained over the weekend that it’s safe for states to reopen during the pandemic and voiced support for anti-lockdown protesters that have rallied at statehouses in Ohio and Michigan. Former Vice President Joe Biden breaks weeks of silence and flatly denied the sexual assault allegation brought against him by former Senate aide Tara Reade, telling MSNBC “it never, never happened.” Full Article
lit 2020 Forum on COVID-19, AVs, and Shared Mobility By www.trb.org Published On :: Fri, 08 May 2020 08:33:55 GMT The National Academies/TRB Forum on Preparing for Automated Vehicles and Shared Mobility is hosting a webinar on Wednesday, May 13 at 2:00 – 3:30 PM Eastern to focus on the role of AV and Shared mobility in light of COVID-19. The online event is free and open to the public, but registration is required . Speakers include: Effect of COVID-19 on AVs , Annie Chang and Ed Straub of SAE International Effect of COVI19 on Shared Mobility , Susan Shaheen of University of California, Berkeley COVID-19 and New Par... Full Article
lit Impacts on Practice: New International Arrivals Facility Will Enhance Customer Experience at Seattle–Tacoma International Airport By www.trb.org Published On :: Fri, 01 Nov 2019 12:00:20 GMT In 2017, when leadership at Seattle–Tacoma International Airport (Sea-Tac) decided to build a new International Arrivals Facility (IAF), they knew they had to leverage airport resources in a cost-effective manner to enhance customer experience. At nearly 50 years old, the existing facility could no longer accommodate Sea-Tac’s demand for international travel, which grew 107 percent from 2007 to 2017. The latest issue of the TRB Airport Cooperative Research Program's (ACRP) Impacts on Practice serie... Full Article http://www.trb.org/Resource.ashx?sn=cover_acrp_iop_059
lit 2020 Conference on Sustainability and Emerging Transportation Technology - Will not be held as scheduled By www.trb.org Published On :: Thu, 07 May 2020 05:47:16 GMT TRB has been closely monitoring the evolving situation related to the coronavirus disease (COVID-19) outbreak. The health and safety of our volunteers, sponsors, meeting guests, staff, and the greater community are of utmost importance to us. In light of the current situation, we have decided that the event cannot be held as scheduled. Convened by Transportation Research Board, the Sustainability and Emerging Transportation Technology (SETT) Conference was to be held on August 31 – September 2, 2020, at ... Full Article
lit 2020 Forum on COVID-19, AVs, and Shared Mobility By www.trb.org Published On :: Fri, 08 May 2020 08:33:55 GMT The National Academies/TRB Forum on Preparing for Automated Vehicles and Shared Mobility is hosting a webinar on Wednesday, May 13 at 2:00 – 3:30 PM Eastern to focus on the role of AV and Shared mobility in light of COVID-19. The online event is free and open to the public, but registration is required . Speakers include: Effect of COVID-19 on AVs , Annie Chang and Ed Straub of SAE International Effect of COVI19 on Shared Mobility , Susan Shaheen of University of California, Berkeley COVID-19 and New Par... Full Article
lit Subsurface Utility Engineering Information for Airports By www.trb.org Published On :: Thu, 19 Jul 2012 04:29:14 GMT TRB’s Airport Cooperative Research Program (ACRP) Synthesis 34: Subsurface Utility Engineering Information for Airports examines ways in which information on subsurface utilities is collected, maintained, and used by airports, their consultants, and the U.S. Federal Aviation Administration to help increase the effectiveness of, and enhance safety during, infrastructure development programs at airports. The report also compares the current state of technology and effective processes from other industry se... Full Article http://www.trb.org/Resource.ashx?sn=coveracrpsyn034copy
lit Guidebook for Incorporating Sustainability into Traditional Airport Projects By www.trb.org Published On :: Sun, 04 Nov 2012 21:38:38 GMT TRB’s Airport Cooperative Research Program (ACRP) Report 80: Guidebook for Incorporating Sustainability into Traditional Airport Projects describes sustainability and its potential benefits, and identifies different applications of sustainable initiatives in traditional airport construction and everyday maintenance projects. The printed version of the report includes a CD-ROM that includes an airport sustainability assessment tool (ASAT) that complements the guidebook and may be used to assist in identif... Full Article http://www.trb.org/Resource.ashx?sn=cover_acrp_rpt_080copy
lit Revolving Funds for Sustainability Projects at Airports By www.trb.org Published On :: Fri, 13 Sep 2019 08:55:17 GMT Airports continually balance demands to improve infrastructure within the realities of available budgets. Green revolving funds (GRFs) offer an alternative approach for investing in projects that generate operational savings. These funds work by tracking verified cost reductions from implemented actions, and then transferring those savings to a reserve that provides capital for future qualified projects such as energy system upgrades. A number of universities have managed GRFs for over a decade. Municipa... Full Article http://www.trb.org/Resource.ashx?sn=cover_acrp_rpt_205
lit Using GIS for Collaborative Land Use Compatibility Planning Near Airports By www.trb.org Published On :: Thu, 16 May 2019 06:02:24 GMT TRB’s Airport Cooperative Research Program (ACRP) Research Report 200: Using GIS for Collaborative Land Use Compatibility Planning Near Airports offers guidance for using Geographic Information Systems (GIS) as a collaboration tool to encourage compatible land use around airports. The report is designed to help airport and community planners seeking to work together to protect existing and future airport development as well as maintain safety and improve quality of life for those living and working near ... Full Article http://www.trb.org/Resource.ashx?sn=Cover_acrp_rpt_200
lit Integrating Sustainability Planning and the Environmental Review Process By www.trb.org Published On :: Mon, 18 Nov 2019 12:20:41 GMT Environmental regulations have long required airports to undertake review of many actions associated with planning and development. More recently, airports have embraced sustainability as a means for ensuring the long-term viability and community benefits of their facilities. The TRB Airport Cooperative Research Program's ACRP Research Report 209: Integrating Sustainability Planning and the Environmental Review Process is designed for airport industry practitioners who are interested in gaining a better ... Full Article http://www.trb.org/Resource.ashx?sn=cover_acrp_rpt_209
lit Guidebook on Effective Land Use Compatibility Planning Strategies for General Aviation Airports By www.trb.org Published On :: Wed, 13 Nov 2019 12:40:58 GMT Incompatible land uses can threaten the safe utility of airports and expose people living and working nearby to potentially unacceptable levels of noise or safety risk. At the state level, all 50 states have enacted some form of airport zoning legislation since the 1950s. The majority of states (90 percent) have enacted laws mandating or enabling local governments to adopt, administer, and enforce airport zoning regulations. The TRB Airport Cooperative Research Program's ACRP Research Report 206: Guidebo... Full Article http://www.trb.org/Resource.ashx?sn=cover_acrp_rpt_206
lit Communication Strategies for Airport Passenger Access and Mobility By www.trb.org Published On :: Fri, 22 Nov 2019 12:48:58 GMT Access to relevant, precise, and timely information is crucial for a pleasant experience in air travel. Travelers with cognitive and sensory disabilities, aging travelers, and travelers with limited English proficiency need alternative approaches to those provided for general travelers for accessing and communicating air travel information. The TRB Airport Cooperative Research Program's ACRP Synthesis 101: Communication Strategies for Airport Passenger Access and Mobility details how airports and airline... Full Article http://www.trb.org/Resource.ashx?sn=cover_acrp_syn_101-2
lit Zemřel Little Richard, idol Elvise i Paula McCartneyho a jeden z otců rock´n´rollu By www.reflex.cz Published On :: Sat, 09 May 2020 17:10:00 +0200 Ve věku 87 let dnes zemřel jeden z otců zakladatelů rock´n´rollu Little Richard (vlastním jménem Richard Wayne Penniman). S odvoláním na jeho syna to na svém webu napsal časopis Rolling Stone. Příčina smrti zpěváka a klavíristy z amerického státu Georgia zatím není známá. Full Article
lit Literature: F/U/C/O By thefanlistings.org Published On :: Fri, 08 May 2020 12:21:36 +0000 Please include the full title on your forms and the authors last name first. Finished Literature River Rose and the Magical Christmas (Clarkson, Kelly); River Rose and the Magical Lullaby (Clarkson, Kelly) Moved Literature Fantasy (Genres); Vampire Chronicles, The: The Queen of the Damned (Rice, Anne) Closed Literature (Open for application) None on this update. […] Full Article Literature
lit "Wash Your Lyrics" Makes Handwashing a Little More Fun By teenhealthandwellness.com Published On :: Mon, 30 Mar 2020 09:42:10 -0400 One of the most important tips for protecting yourself from COVID-19 is to wash your hands for 20 seconds, or as long as it takes to sing “Happy Birthday” twice. British teen William Gibson decided he wanted the public to have more song options while fighting the spread of coronavirus. Gibson created an online tool that allows a user to enter the title of their chosen song and artist to automatically generate a poster. The poster matches lyrics from the song to a 13-step washing routine. The UK’s NHS Health Secretary Matt Hancock has publically praised Gibson’s initiative as the posters have been shared extensively on social media. Gibson thought it would be popular, but has still been surprised to see some of his favorite celebrities posting about it. Visit the Wash Your Lyrics website to create your own poster for washing hands with your favorite song. Full Article
lit Your Pet Loss Stories'I Can Smile A Little Now' By www.pet-loss-matters.com Published On :: Sun, 21 Jul 2013 11:19:23 -0400 I lost my beloved cat Gemma, seven months ago and when I think about her, I can smile a little. I can now think of the happy times and not that dreadful Full Article
lit Real Life Rainbow Bridge Stories'My Little Girl Candi' By www.pet-loss-matters.com Published On :: Sun, 21 Jul 2013 11:51:04 -0400 She passed away just not too long ago, 6-12-13. It was very hard for me to put her down. I had her for 21 years, going on 22 years. I know I feel her presence Full Article
lit Anti-Trump Ad Demonstrates Both The Streisand Effect & Masnick's Impossibility Theorem By www.techdirt.com Published On :: Fri, 8 May 2020 10:53:33 PDT Well, this one hits the sweet spot of topics I keep trying to demonstrate: both a Streisand Effect and Masnick's Impossibility Theorem. As you may have heard, a group of Republican political consultants and strategists, who very much dislike Donald Trump, put together an effort called The Lincoln Project, which is a PAC to campaign against Trump and Trumpian politics. They recently released an anti-Trump campaign ad about his terrible handling of the COVID-19 pandemic, called Mourning in America, which is a reference to Ronald Reagan's famous Morning in America campaign ad for the 1984 Presidential election. The new ad is, well, pretty powerful: And while it's unlikely to convince Trump fans deep into their delusions, it certainly got under the President's skin. He went on one of his famous late night Twitter temper tantrums about the ad, and later lashed out at the Lincoln Project when talking to reporters. He was super, super mad. And what did that do? Well, first it got the ad a ton of views. Earlier this week, one of the Lincoln Project's founders, Rick Wilson, noted that the ad had already received 15 million views across various platforms in the day or so since the ad had been released. Also, it resulted in the Lincoln Project getting a giant boost in funding: The Lincoln Project, which is run by Republican operatives who oppose President Donald Trump, raised $1 million after the president ripped the group on Twitter this week – marking it the super PAC’s biggest day of fundraising yet. Reed Galen, a member of the Lincoln Project’s advisory committee, told CNBC that the total came after the president’s Tuesday morning Twitter tirade in reaction to an ad titled “Mourning in America,” which unloads on Trump’s response to the coronavirus pandemic. It recently aired on Fox News, which Trump often watches and praises. Galen said it was the Lincoln Project’s best single-day fundraising haul Not only that, but it has opened up more opportunity for the Lincoln Project team to get their word out. With so much interest in the ad, it opened up opportunities for the project members to get their message in various mainstream media sources. Reed Galen wrote a piece for NBC: What we accomplished this week was not something to be celebrated. No commercial should have the power to derail the leader of the free world. And another Lincoln Project founder, George Conway (who, of course, is the husband of Trump senior advisor Kellyanne Conway), wrote something similar for the Washington Post: It may strike you as deranged that a sitting president facing a pandemic has busied himself attacking journalists, political opponents, television news hosts and late-night comedians — even deriding a former president who merely boasted that “the ‘Ratings’ of my News Conferences etc.” were driving “the Lamestream Media . . . CRAZY,” and floated bogus miracle cures, including suggesting that scientists consider injecting humans with household disinfectants such as Clorox. If so, you’re not alone. Tens of thousands of mental-health professionals, testing the bounds of professional ethics, have warned for years about Trump’s unfitness for office. Some people listened; many, including myself, did not, until it was too late. That's the kind of media exposure you can't buy, but which you get when you have a President who appears wholly unfamiliar with the Streisand Effect. And that then takes us to the Impossibility Theorem, regarding the impossibility of doing content moderation at scale well. After Trump's ongoing tirade, Facebook slapped a "Partly False" warning label on the video when posted on Facebook. While the whole situation is ridiculous, it's at least mildly amusing, considering how frequently clueless Trumpkins insist that Facebook censors "conservative" (by which they mean Trumpian) viewpoints. Also, somewhat ironic in all of this: the only reason that Facebook now places such fact check labels on things is because anti-Trump people yelled at how Facebook needed to do more fact checking of political content on its site. So, now you get this. Part of the issue is that Politifact judged one line in the ad as "false." That line was that Trump "bailed out Wall St. but not Main St." Politifact says that since the CARES Act Paycheck Protection Program has given potentially forgivable loans to some small businesses, and because the bill was done by Congress, not the President, that line is "false." And yet, because angry (usually anti-Trump) people demanded that Facebook do more useless fact checking, the end result is that the video now gets a "false" label. Of course, this shows both the impossibility of doing content moderation well and the silliness of betting big on fact checking with a full "true or false" claim. One could argue that that line has misleading elements, but is true in most cases. Tons of small businesses are shuttering. Many businesses have been unable to get PPP loans, and under the current terms of the loans, they're useless for many (especially if they have no work for people to do, since the loans have to be mostly used on payroll over the next couple months). But does that make the entire ad "false"? Of course not. And Rick Wilson is super mad about this. He's right to be mad about Politifact's designation, though it's really a condemnation of the religious focus on "true or false" in fact checking, rather than in focusing on what is misleading or not: But the ad doesn’t actually claim that small businesses received zero help. Rather, it makes the point that Main Street America is still seriously struggling as the economic fallout from the coronavirus pandemic continues. But Wilson is also mad at Facebook: Speaking exclusively to Mediaite, Wilson called the decision “the typical fuckery we’ve come to expect from both the Trump camp and their tame Facebook allies.” “Facebook is perfectly content to allow content from QAnon lunatics, anti-vaxxers, alt-righters, and every form of Trump/Russian — but I repeat myself — disinformation,” he pointed out. “This is a sign of just how powerfully ‘Mourning In America’ shook Donald Trump and his allies. Their attempt to censor our ad isn’t a setback for us; it’s a declaration of an information war we will win.” Separately, the Lincoln Project also sent out an email to supporters, again blaming Facebook: ... it's no secret that Facebook has stood by and done little to nothing as lie after lie — from the Liar-In-Chief himself — runs wild on their platform. (Oh, and let's also not forget the conspiracy theories, foreign disinformation campaigns and negligence that got Mark Zuckerberg questioned by the United States Congress.) But, this? This is an entirely different and dangerous kind of collusion. And what is Facebook's excuse for playing favorites with its recently-transferred former employees in the Trump campaign? They say a "fact-checker" labeled our claim that "Donald Trump helped bailout Wall Street, not Main Street" was untrue. ....Really? The email goes on to justify the "main street" line with a bunch of links, and then again argues that Facebook is "censoring the truth" to help Trump: Is that "Partly False?" Of course not. We told the truth about Donald Trump... He lost his damn mind over it on Twitter... Attacked us in front of Air Force One... Then sent his spin machine to discredit us... And now his allies at Facebook are doing his damage control by censoring the truth he doesn't like. I get the frustration -- and I find it at least a bit ironic that the whole "fact checking" system was a response to anti-Trump folks mad at Facebook for allowing pro-Trump nonsense to spread -- but this is just another example of the Impossibility Theorem. There is no "good" solution here. We live in a time where everyone's trying to discredit everyone they disagree with, and many of these things depend on your perspective or your interpretation of a broad statement, like whether or not Trump is helping "main street." We can agree that it's silly that Facebook has put this label on the video, but also recognize that it's not "Trump's allies at Facebook" working to "censor the truth he doesn't like." That's just absurd (especially given the reason the fact checking set up was put together in the first place). But, hey, outrage and claims of censorship feed into the narrative (and feed into the Streisand Effect), so perhaps it all is just designed to work together. Full Article
lit 11/22/15 - A little piece of her By www.tinyghosts.com Published On :: Monday, 23 Nov 2015 Full Article
lit 03/20/16 - One person split By www.tinyghosts.com Published On :: Monday, 21 Mar 2016 Full Article
lit Stop Throwing Away Those Little Silica Gel Packets! You and the Kids Can Use Them a Ton of Clever Ways By www.freerangekids.com Published On :: Wed, 06 May 2020 02:20:29 +0000 Parents, kids: Fear not the silica gel pack. Sure it says DO NOT EAT and THROW AWAY. But you should only follow one of those rules. Instead, save the packs and use them a whole lot of ways: Place them on the car dashboard by the windshield to keep it from fogging up. […] Full Article Miscellaneous
lit Utility Battery Projects Driven By Price Drops By www.futurepundit.com Published On :: 2017-02-04T12:40:18-08:00 For large electric power storage projects the cost of batteries has plummeted. 2008, when battery prices were 10 times higher than they are today. This advance is timely as photovoltaic electric power prices have dropped so far that in SoCal PV is causing a growing drop in mid-day demand and therefore a much bigger spike in evening demand. Therefore there's a growing need for a cheaper way to store power generated in mid day and deliver it in the evening. You can see how much solar power output surges each day in California by clicking on some of the Daily Renewables Watch links at the Cal ISO site (the organization that manages California's electric grid). The growing supply of wind... Full Article
lit Hepatic CEACAM1 expression indicates donor liver quality and prevents early transplantation injury By www.jci.org Published On :: Although CEACAM1 (CC1) glycoprotein resides at the interface of immune liver injury and metabolic homeostasis, its role in orthotopic liver transplantation (OLT) remains elusive. We aimed to determine whether/how CEACAM1 signaling may affect hepatic ischemia-reperfusion injury (IRI) and OLT outcomes. In the mouse, donor liver CC1 null mutation augmented IRI-OLT (CC1-KO→WT) by enhancing ROS expression and HMGB1 translocation during cold storage, data supported by in vitro studies where hepatic flush from CC1-deficient livers enhanced macrophage activation in bone marrow–derived macrophage cultures. Although hepatic CC1 deficiency augmented cold stress–triggered ASK1/p-p38 upregulation, adjunctive ASK1 inhibition alleviated IRI and improved OLT survival by suppressing p-p38 upregulation, ROS induction, and HMGB1 translocation (CC1-KO→WT), whereas ASK1 silencing (siRNA) promoted cytoprotection in cold-stressed and damage-prone CC1-deficient hepatocyte cultures. Consistent with mouse data, CEACAM1 expression in 60 human donor liver biopsies correlated negatively with activation of the ASK1/p-p38 axis, whereas low CC1 levels associated with increased ROS and HMGB1 translocation, enhanced innate and adaptive immune responses, and inferior early OLT function. Notably, reduced donor liver CEACAM1 expression was identified as one of the independent predictors for early allograft dysfunction (EAD) in human OLT patients. Thus, as a checkpoint regulator of IR stress and sterile inflammation, CEACAM1 may be considered as a denominator of donor hepatic tissue quality, and a target for therapeutic modulation in OLT recipients. Full Article
lit Retrograde nerve growth factor signaling abnormalities in familial dysautonomia By www.jci.org Published On :: Familial dysautonomia (FD) is the most prevalent form of hereditary sensory and autonomic neuropathy (HSAN). In FD, a germline mutation in the Elp1 gene leads to Elp1 protein decrease that causes sympathetic neuron death and sympathetic nervous system dysfunction (dysautonomia). Elp1 is best known as a scaffolding protein within the nuclear hetero-hexameric transcriptional Elongator protein complex, but how it functions in sympathetic neuron survival is very poorly understood. Here, we identified a cytoplasmic function for Elp1 in sympathetic neurons that was essential for retrograde nerve growth factor (NGF) signaling and neuron target tissue innervation and survival. Elp1 was found to bind to internalized TrkA receptors in an NGF-dependent manner, where it was essential for maintaining TrkA receptor phosphorylation (activation) by regulating PTPN6 (Shp1) phosphatase activity within the signaling complex. In the absence of Elp1, Shp1 was hyperactivated, leading to premature TrkA receptor dephosphorylation, which resulted in retrograde signaling failure and neuron death. Inhibiting Shp1 phosphatase activity in the absence of Elp1 rescued NGF-dependent retrograde signaling, and in an animal model of FD it rescued abnormal sympathetic target tissue innervation. These results suggest that regulation of retrograde NGF signaling in sympathetic neurons by Elp1 may explain sympathetic neuron loss and physiologic dysautonomia in patients with FD. Full Article
lit TGF-β–induced epigenetic deregulation of SOCS3 facilitates STAT3 signaling to promote fibrosis By www.jci.org Published On :: Fibroblasts are key effector cells in tissue remodeling. They remain persistently activated in fibrotic diseases, resulting in progressive deposition of extracellular matrix. Although fibroblast activation may be initiated by external factors, prolonged activation can induce an “autonomous,” self-maintaining profibrotic phenotype in fibroblasts. Accumulating evidence suggests that epigenetic alterations play a central role in establishing this persistently activated pathologic phenotype of fibroblasts. We demonstrated that in fibrotic skin of patients with systemic sclerosis (SSc), a prototypical idiopathic fibrotic disease, TGF-β induced the expression of DNA methyltransferase 3A (DNMT3A) and DNMT1 in fibroblasts in a SMAD-dependent manner to silence the expression of suppressor of cytokine signaling 3 (SOCS3) by promoter hypermethylation. Downregulation of SOCS3 facilitated activation of STAT3 to promote fibroblast-to-myofibroblast transition, collagen release, and fibrosis in vitro and in vivo. Reestablishment of the epigenetic control of STAT3 signaling by genetic or pharmacological inactivation of DNMT3A reversed the activated phenotype of SSc fibroblasts in tissue culture, inhibited TGF-β–dependent fibroblast activation, and ameliorated experimental fibrosis in murine models. These findings identify a pathway of epigenetic imprinting of fibroblasts in fibrotic disease with translational implications for the development of targeted therapies in fibrotic diseases. Full Article
lit Pathogenesis of peritumoral hyperexcitability in an immunocompetent CRISPR-based glioblastoma model By www.jci.org Published On :: Seizures often herald the clinical appearance of gliomas or appear at later stages. Dissecting their precise evolution and cellular pathogenesis in brain malignancies could inform the development of staged therapies for these highly pharmaco-resistant epilepsies. Studies in immunodeficient xenograft models have identified local interneuron loss and excess glial glutamate release as chief contributors to network disinhibition, but how hyperexcitability in the peritumoral microenvironment evolves in an immunocompetent brain is unclear. We generated gliomas in WT mice via in utero deletion of key tumor suppressor genes and serially monitored cortical epileptogenesis during tumor infiltration with in vivo electrophysiology and GCAMP7 calcium imaging, revealing a reproducible progression from hyperexcitability to convulsive seizures. Long before seizures, coincident with loss of inhibitory cells and their protective scaffolding, gain of glial glutamate antiporter xCT expression, and reactive astrocytosis, we detected local Iba1+ microglial inflammation that intensified and later extended far beyond tumor boundaries. Hitherto unrecognized episodes of cortical spreading depolarization that arose frequently from the peritumoral region may provide a mechanism for transient neurological deficits. Early blockade of glial xCT activity inhibited later seizures, and genomic reduction of host brain excitability by deleting MapT suppressed molecular markers of epileptogenesis and seizures. Our studies confirmed xenograft tumor–driven pathobiology and revealed early and late components of tumor-related epileptogenesis in a genetically tractable, immunocompetent mouse model of glioma, allowing the complex dissection of tumor versus host pathogenic seizure mechanisms. Full Article
lit Donor glucose-6-phosphate dehydrogenase deficiency decreases blood quality for transfusion By www.jci.org Published On :: BACKGROUND Glucose-6-phosphate dehydrogenase (G6PD) deficiency decreases the ability of red blood cells (RBCs) to withstand oxidative stress. Refrigerated storage of RBCs induces oxidative stress. We hypothesized that G6PD-deficient donor RBCs would have inferior storage quality for transfusion as compared with G6PD-normal RBCs.METHODS Male volunteers were screened for G6PD deficiency; 27 control and 10 G6PD-deficient volunteers each donated 1 RBC unit. After 42 days of refrigerated storage, autologous 51-chromium 24-hour posttransfusion RBC recovery (PTR) studies were performed. Metabolomics analyses of these RBC units were also performed.RESULTS The mean 24-hour PTR for G6PD-deficient subjects was 78.5% ± 8.4% (mean ± SD), which was significantly lower than that for G6PD-normal RBCs (85.3% ± 3.2%; P = 0.0009). None of the G6PD-normal volunteers (0/27) and 3 G6PD-deficient volunteers (3/10) had PTR results below 75%, a key FDA acceptability criterion for stored donor RBCs. As expected, fresh G6PD-deficient RBCs demonstrated defects in the oxidative phase of the pentose phosphate pathway. During refrigerated storage, G6PD-deficient RBCs demonstrated increased glycolysis, impaired glutathione homeostasis, and increased purine oxidation, as compared with G6PD-normal RBCs. In addition, there were significant correlations between PTR and specific metabolites in these pathways.CONCLUSION Based on current FDA criteria, RBCs from G6PD-deficient donors would not meet the requirements for storage quality. Metabolomics assessment identified markers of PTR and G6PD deficiency (e.g., pyruvate/lactate ratios), along with potential compensatory pathways that could be leveraged to ameliorate the metabolic needs of G6PD-deficient RBCs.TRIAL REGISTRATION ClinicalTrials.gov NCT04081272.FUNDING The Harold Amos Medical Faculty Development Program, Robert Wood Johnson Foundation grant 71590, the National Blood Foundation, NIH grant UL1 TR000040, the Webb-Waring Early Career Award 2017 by the Boettcher Foundation, and National Heart, Lung, and Blood Institute grants R01HL14644 and R01HL148151. Full Article
lit Fetal alcohol spectrum disorder predisposes to metabolic abnormalities in adulthood By www.jci.org Published On :: Prenatal alcohol exposure (PAE) affects at least 10% of newborns globally and leads to the development of fetal alcohol spectrum disorders (FASDs). Despite its high incidence, there is no consensus on the implications of PAE on metabolic disease risk in adults. Here, we describe a cohort of adults with FASDs that had an increased incidence of metabolic abnormalities, including type 2 diabetes, low HDL, high triglycerides, and female-specific overweight and obesity. Using a zebrafish model for PAE, we performed population studies to elucidate the metabolic disease seen in the clinical cohort. Embryonic alcohol exposure (EAE) in male zebrafish increased the propensity for diet-induced obesity and fasting hyperglycemia in adulthood. We identified several consequences of EAE that may contribute to these phenotypes, including a reduction in adult locomotor activity, alterations in visceral adipose tissue and hepatic development, and persistent diet-responsive transcriptional changes. Taken together, our findings define metabolic vulnerabilities due to EAE and provide evidence that behavioral changes and primary organ dysfunction contribute to resultant metabolic abnormalities. Full Article
lit Little known beautiful places: Johns River – Westport, WA By www.jamieism.com Published On :: Tue, 07 Aug 2018 16:39:22 +0000 This isn’t in the photos, but it’s foggy and cold this morning in western Washington. It’s the weirdest summer I’ve ever experienced — foggy, frigid mornings, cool days, and then freezing nights! It’s not very pleasant for a desert creature like myself, but it’s quite nice to sit inside and write in my blog a least. I have to say, it sure is weird, though. It’s August and I wear a sweater or sweatshirt most of the time and then I’m still cold! ^^; There are a few sunny days here and there, though. I get out on those days, into the wilderness and bright blue beyond. Sometimes, I just drive and drive in my still-unnamed yellow bug, and other times I find something that not a lot of people know about. This is about one of them. ^^ I love to wander, to find all of the nooks and crannies of wherever I happen to be. Tourist sites? Well, they’re usually cool and I want to see them, but it’s the little, hidden things off the beaten trail that really get my soul revving. So, Johns River (no apostrophe, it was named back when apostrophes weren’t used on maps) was one of those things. I found out about it by googling and googling, thinking that someone, somewhere, must have written about something other than the two really traveled trails in Grays Harbor. I mean, this area is the gateway to the wild peninsula of Washington, where according to Stephanie Meyer and Patricia Briggs, vampires and werewolves run wild. I also loooooooove mountain meadows. Johns river is not in the mountains, so I suppose that it mostly qualifies as grassland surrounded by trees? It’s just a little concrete path, and it’s not even a mile (0.6 miles one way) long, but with the river on one side and a huge expanse of pasture to the other side, it took my breath away. Just look at this. Elk supposedly graze around here a lot, and I didn’t see any since I went during midday, but I bet it’s really a sight at sunset. It’s not far, so I will definitely have to come back. Can’t you just imagine little river sprites lounging on the bank, cleaning themselves? And little fairies flitting through the air? I bet this is a really magical place at sunset. The little shack in the distance is off the trail. It’s supposedly for hunters (YUCK) and photographers. It would make a wonderful place to watch the sprites from. This shack is at the very end of the trail, and the same thing. It’s boring inside. I didn’t see any geldings, but I saw a few mosquitoes and a spider. If you’re lucky enough to have a horse that loves to take you along on its adventures, you can continue. I was wearing shorts, so I didn’t go, because ticks! But I will come back. Yes, I will come back. :3 Road to nowhere. Ignore the buildings. They’re only there for magical curse removal. Here’s a panorama of wildness. I’m feeling really magical today, can’t you tell? I think it’s because I have Daniel Waples playing in the background, and it’s all foggy outside. That reminds me that I want a handpan so badly. I need to find a handpan that I can afford soooooo badly, because I think it’s a music that speaks to my inner essence. Does anyone know what these gorgeous purple flowers are? They’re not lavender. The River People watch over this creek. Be careful to please them. It’s me. Sometimes I wear bright colors, sometimes I wear pastels. I don’t think that a magical being has to stick to neutrals. (That hand thing is a shaka, a very cool gesture that I learned during my time in Hawaii that means “hang loose.” I like to think that it also means that you should be yourself and follow your instincts.) I think that I’ll go research handpans again. I should write down how much they cost so that I can be sure to stock my Airstream with one when I get it. ???? Here’s to the future! Excelsior! (Is that a good “to infinity, and beyond!!” kind of quote? If not, what should I use instead? I feel like “banzai!” is overused) Oh, and I’ve been arting on my Tumblr lately. I’ve been writing a serial ficiton that is mysterious connected to my soon-to-come comic, Denkiki on my other tumblr. Go check them out! I’m going to start using my mailing list soon, too, to keep people updated, so stay tuned and I’ll post the link soon! Or make it a popup, I’m not sure. But I want to offer something cool for when people sign up. ???? Chaoness!(779 geeks have read this) Full Article ☆ finding myself ☆ friends/family ☆ i heart travel ☆ i heart washington ☆ life ☆ photos ☆ wandering
lit Rumor Claims watchOS 7 Will Have 'Mental Health Capabilities' to Detect Panic Attacks By www.macrumors.com Published On :: Fri, 08 May 2020 16:48:25 PDT Apple's next-generation Apple Watch and watchOS 7 will focus on new mental health capabilities, according to leaker Jon Prosser who recently spoke on the Geared Up podcast. The mention of new Apple Watch features comes towards the end of the podcast. The next-generation version of the Apple Watch, the Apple Watch Series 6, has been rumored to include a blood oxygen sensor, which Prosser says Apple will take advantage of to implement new mental health-related features, such as detecting panic attacks.What their biggest focus on is right now and I hope it comes this year, it might come next year, but I hope it's coming to WWDC is mental health capabilities. Where they can take the oxygen levels in your blood with your heart rate and determine if you're hyperventilating. They can identify a panic attack before it happens and warn you on your watch. Especially if you're driving, they'll ask you to pull over and they'll offer breathing exercises once you get pulled over.Prosser says that while he hopes the feature is released this year, "it might come next year." He also says he hopes for a WWDC unveiling, but if the new feature relies on a blood oxygen sensor in an unreleased version of the Apple Watch, it's not likely Apple will unveil the capability until the fall when new Apple Watch models that support it are released. There is, however, a possibility that it will be revealed at WWDC if older Apple Watch models have a latent ability to detect blood oxygen level, which is not clear at this time, or if the feature does not involve blood oxygen monitoring. The panic attack detecting rumor was first shared by EverythingApplePro and leaker Max Weinbach back in April, who said that the Apple Watch will also be able to determine when a user is experiencing high levels of stress. Weinbach and EverythingApplePro did not suggest the feature would rely on blood oxygen monitoring, however, and said that it would be available on the Apple Watch Series 4 or later. Hints that blood oxygen tracking capabilities are coming to a future version of the Apple Watch were found in a leaked version of iOS 14. Blood oxygen monitoring is an important feature because a drop in blood oxygen levels can suggest a serious respiratory or cardiac problem that requires immediate medical attention. Multiple prior rumors from Bloomberg and other sources have also indicated that the next-generation Apple Watch and watchOS 7 will include sleep tracking features, allowing the Apple Watch to measure sleep quality, length, and other metrics.Related Roundups: Apple Watch, watchOS 6Buyer's Guide: Apple Watch (Neutral)This article, "Rumor Claims watchOS 7 Will Have 'Mental Health Capabilities' to Detect Panic Attacks" first appeared on MacRumors.comDiscuss this article in our forums Full Article Apple Watch
lit Is Hillary Clinton an elitist? Do you charge $300,000 for a speech, and get a private jet, presidential suite at a luxury hotel, meals, etc.? By www.cpa-connecticut.com Published On :: Tue, 19 Aug 2014 20:37:16 +0000 Is your standard charge for a speech $300,000? According to an article appearing on the website of the Las Vegas Review-Journal, and a May 31, 2013 email, Clinton’s standard contract usually includes: Round-trip transportation on a chartered private jet “e.g., a Gulfstream … Continue reading → Full Article Accountants CPA Hartford Articles $104.9 million big fees for speeches Bill Clinton elitist Hillary Clinton
lit Bernie Sanders tells Wolf Blitzer that college tuition should be free and paid for by a tax on Wall Street Speculation By www.cpa-connecticut.com Published On :: Wed, 20 May 2015 02:40:43 +0000 Democratic presidential candidate Bernie Sanders (I-VT) on Tuesday unveiled a plan to address income inequality by taxing Wall Street speculation and using the money to eliminate college tuition. Continue reading → Full Article Accountants CPA Hartford Articles Bernie Sanders discusses Hillary Clinton Bernie Sanders for free college education Bernie Sanders introduces bill for free tuition Bernie Sanders tells Wolf Blitzer that college tuition should be free and paid for by a tax on Wall Street Speculation Clinton Questioned about Income Inequality CNN CNN Wolf Blitzer interview Bernie Sanders college education paid for by Wall Street speculation tax Democratic presidential primary 2016 May 19 2015 Race for the White House robin hood bill transcript video Wolf Blitzer
lit Senator Bernie Sanders appeals to the media to cover the serious issues of our country instead of political gossip during political campaigns By www.cpa-connecticut.com Published On :: Sun, 24 May 2015 17:37:46 +0000 SANDERS: ... there is more coverage about the political gossip of a campaign, about raising money, about polling, about somebody saying something dumb, or some kid works for a campaign sends out something stupid on Facebook, right? We can expect that to be a major story. But what your job is, what the media's job is, is to say, look, these are the major issues facing the country. We're a democracy. People have different points of view. Let's argue it. Continue reading → Full Article Accountants CPA Hartford Articles Accountants Accountants CPA Hartford Connecticut LLC barefoot accountant Berlin Connecticut Bernie Sanders Brian Stelter Certified Public Accountants CNN CNN Host CNN Reliable Sources Hartford Connecticut Hillary Clinton May 24 2015 media press campaign coverage Race to 2016 Reliable Sources Sanders asks why his only coverage is for attacking Clinton Sanders slams press coverage CNN Senator Bernie Sanders appeals to the media to cover the serious issues of our country instead of political gossip Senator Bernie Sanders appeals to the media to cover the serious issues of our country instead of political gossip during political campaigns Stelter William Brighenti CPA
lit Is Bernie Sanders out in far-left field or are both political parties out in far-right field By www.cpa-connecticut.com Published On :: Wed, 27 May 2015 14:41:54 +0000 Have you ever observed the mating dance of the birds of paradise? The male moves dramatically, and in response, the female inches away, but ultimately the male conquers the female, and achieves the purpose of this ritualistic, instinctive dance. Well, … Continue reading → Full Article Accountants CPA Hartford Articles Barack Obama Bernie Sanders Bill Clinton birds of paradise Corporate money dancing with the stars Democratic Leadership Council Democratic Party DLC Hillary Clinton hokey pokey income inequality Is Bernie Sanders out in far-left field or are both political parties out in far-right field kabuki theater Keystone XL Pipeline mating dance of birds of paradise populism Republican party Richard Nixon Ronald Reagan the hustle Trans-Pacific Partnership (TPP) Wall Street wealth inequality
lit Berlin Connecticut needs candidates from a third political party to stop the strict partisan voting on the Town Council By www.cpa-connecticut.com Published On :: Sun, 05 Jul 2015 17:21:15 +0000 Berlin needs an independent candidate on its Town Council to counter and prevent the dominance of a major political party from unilaterally imposing its agenda and will on the citizens of Berlin. Our Town Council has been voting along strict party lines on key issues even though members pledged to reach across the aisle. It has dismissed or circumvented the results of referendums, reducing them to mere dog-and-pony shows. Berlin has more unaffiliated voters than those of the two major parties. Let's petition, nominate, and place on the ballot an independent candidate to represent these citizens and prevent the control of our Town by the dominant party on the Town Council. If interested, please contact us: berlinctpropertyownersassn@gmail.com. Continue reading → Full Article Accountants CPA Hartford Articles Berlin Connecticut Berlin Connecticut needs candidates from a third political party to stop the strict partisan voting on the Town Council Berlin Town Council democracy Democratic Party independent candidates independent party partisan politics Republican party special interests voting along strict party line
lit Julian Assange says that we must have political accountability–a general deterrence set to stop political organizations behaving in a corrupt manner. By www.cpa-connecticut.com Published On :: Fri, 29 Jul 2016 20:24:17 +0000 we know how politics works in the United States. Whoever—whatever political party gets into government is going to merge with the bureaucracy pretty damn fast. It will be in a position where it has some levers in its hand. And so, as a result, corporate lobbyists will move in to help control those levers. So it doesn’t make much difference in the end. What does make a difference is political accountability, a general deterrence set to stop political organizations behaving in a corrupt manner. Continue reading → Full Article Accountants CPA Hartford Articles Amy Goodman anti-Bernie Sanders propaganda Debbie Wasserman-Schultz Democracy Now DNC emails Julian Assange Julian Assange says that we must have political accountability--a general deterrence set to stop political organizations behaving in a corrupt manner. Julian Assange: Choosing Between Trump or Clinton is Like Picking Between Cholera or Gonorrhea Luis Miranda Morning Joe MSNBC Washington Post WikiLeaks
lit Michael Moore says middle class should vote for Trump to oppose elites, Corporate America, Wall Street, career politicians, media By www.cpa-connecticut.com Published On :: Thu, 27 Oct 2016 07:02:25 +0000 The middle class needs to vote for Donald Trump in order to oppose the elites, Corporate America, Wall Street, the career politicians, and the media, who have all conspired to destroy the middle class. Donald Trump is the Molotov cocktail, the human hand grenade, that every beaten-down, nameless, forgotten working stiff who used to be part of what was called the middle class can legally throw into the system that stole their lives from them. Continue reading → Full Article Accountants CPA Hartford Articles 35% tariff billionaires breakfast states Donald Trump elite class Ford Motor Company Hillary Clinton Michael Moore Michael Moore Explains Why Donald Trump Will Win! And Why He Should! Michael Moore says the middle class needs to vote for Donald Trump to oppose the elites and Corporate America and Wall Street and career politicians and the media Michigan middle class millionaire class November 8 Obamacare Bronze Plan October 25 2016 Ohio Pennsylvania the 1% the 99% the career politicians the media transcript Transcript of speech given by Michael Moore on October 24 2016 in Ohio Trump is the human hand grenade that the middle class can throw at the elite class and system Trump is the human hand grenade that they can legally throw into the system that stole their lives from them Trump is the human Molotov cocktail that the middle class can throw at the system Wisconsin
lit IBM Research Opens in South Africa; Cognitive Computing and the IoT help Track Diseases and Forecast Air Quality By www.ibm.com Published On :: Thu, 25 Aug 2016 10:08:02 GMT IBM Research today opened its second research location on the African continent and announced several new project collaborations in the areas of data driven healthcare, digital urban ecosystems and astronomy. Full Article Smarter Planet
lit IBM Names 16 Municipalities as IBM Smarter Cities Challenge Grant Winners By www.ibm.com Published On :: Tue, 12 May 2015 11:01:03 GMT IBM's Smarter Cities Challenge program (@CitiesChallenge) will be sending teams of company experts to 16 municipalities around the world through 2016 to help cities with critical issues ranging from jobs creation, transportation, and public safety, to healthcare, revenue, social services, and public works. Full Article Smarter Cities
lit ENGIE joins forces with IBM to deploy smarter cities solutions and improve the quality of life for citizens By www.ibm.com Published On :: Tue, 26 Jul 2016 03:30:17 GMT ENGIE, a global leader in energy transition, today announced a new initiative with IBM. This nonexclusive, technological and commercial alliance is designed to improve the management of cities by looking at patterns, event correlation, anomaly detection and real-time data across all parts of cities. Full Article Smarter Cities
lit A Little Confession… By www.bill-wilson.net Published On :: Thu, 16 Oct 2014 06:13:18 +0000 What would the Internet be without Wikipedia? I remember when it was still a brand new thing back in 2001... and what an awesome thing it was, and still is: the Open Source philosophy applied to human knowledge itself. Can you imagine not being able to look something up on Wikipedia, if only to get a […] Full Article Root Cause Analysis wiki
lit As Fifth Anniversary of Superstorm Sandy Approaches, U.S. Utility Companies Still Feel Underprepared for Weather-Related Outages By www.ibm.com Published On :: Thu, 24 Aug 2017 12:01:59 GMT Each year, weather-related power outages cost the U.S. economy as much as $33 billion a year. Additionally, one severe weather event has the potential to impact the daily lives and routines of millions of people. As 2017 marks the fifth anniversary of Superstorm Sandy, The Weather Company, an IBM Business (NYSE: IBM) and Zpryme are releasing the results of a survey that found that U.S. utility companies still feel underprepared for weather-related outages and that their reactive approach to outage prediction leads to lost time and resources. Full Article IBM Analytics