sho BREAKING: 43-Yr-Old Father Of 9, Dollar Store Sec Guard, Shot DEAD While Allegedly Trying To Enforce MI Gov Whitmer’s Face Covering Exec Order By 100percentfedup.com Published On :: Wed, 06 May 2020 18:27:38 +0000 The following article, BREAKING: 43-Yr-Old Father Of 9, Dollar Store Sec Guard, Shot DEAD While Allegedly Trying To Enforce MI Gov Whitmer’s Face Covering Exec Order, was first published on 100PercentFedUp.com. Will the mainstream media report about the senseless death of a 43-year-old father of nine, who would have been alive today if it were not for VP wannabe, Gretchen Whitmer's executive order that forced him to respond to a customer not wearing a face mask? Continue reading: BREAKING: 43-Yr-Old Father Of 9, Dollar Store Sec Guard, Shot DEAD While Allegedly Trying To Enforce MI Gov Whitmer’s Face Covering Exec Order ... Full Article Featured Left News Politics
sho 77-Yr-Old MI Barber Defies Gov Whitmer’s Shutdown Order: ”I don’t need another mother” Shop Will Stay Open Until “Jesus walks in or until they arrest me” [VIDEO] By 100percentfedup.com Published On :: Wed, 06 May 2020 18:57:01 +0000 The following article, 77-Yr-Old MI Barber Defies Gov Whitmer’s Shutdown Order: ”I don’t need another mother” Shop Will Stay Open Until “Jesus walks in or until they arrest me” [VIDEO], was first published on 100PercentFedUp.com. Emergency orders that “non-essential businesses” remain closed during the Covid-19 crisis have devastated small business owners across America. A wave of business owners across the nation are defying executive orders by their governors and opening their businesses anyhow. Yesterday, we reported about a small business owner in the state of Michigan, where Governor Gretchen Whitmer […] Continue reading: 77-Yr-Old MI Barber Defies Gov Whitmer’s Shutdown Order: ”I don’t need another mother” Shop Will Stay Open Until “Jesus walks in or until they arrest me” [VIDEO] ... Full Article Featured Politics
sho Texas Gov Abbott Frees Salon Owner Shelley Luther: “Criminals shouldn’t be released to prevent COVID-19 just to put business owners in their place” By 100percentfedup.com Published On :: Thu, 07 May 2020 15:50:22 +0000 The following article, Texas Gov Abbott Frees Salon Owner Shelley Luther: “Criminals shouldn’t be released to prevent COVID-19 just to put business owners in their place”, was first published on 100PercentFedUp.com. Texas Governor Greg Abbott just changed the coronavirus order to free Salon A La Mode owner Shelley Luther from jail. Abbott tweeted out a comment about the poor treatment of the business owner: Throwing Texans in jail whose biz’s shut down through no fault of their own is wrong. I am eliminating jail for violating […] Continue reading: Texas Gov Abbott Frees Salon Owner Shelley Luther: “Criminals shouldn’t be released to prevent COVID-19 just to put business owners in their place” ... Full Article Breaking Featured Government Politics
sho Woman Shoots Three Teenage McDonald’s Workers For Telling Her She Couldn’t Eat In Dining Room Over COVID19 Restrictions By 100percentfedup.com Published On :: Fri, 08 May 2020 02:10:36 +0000 The following article, Woman Shoots Three Teenage McDonald’s Workers For Telling Her She Couldn’t Eat In Dining Room Over COVID19 Restrictions, was first published on 100PercentFedUp.com. An angry Oklahoma woman shot at a group of teenagers working at a local McDonald’s after they explained to her that the dining room was closed due to coronavirus restrictions. 32-year-old Gloricia Woody was arrested by the Oklahoma City Police and charged with the shooting. From the Oklahoma City Police -Last night, officers were called […] Continue reading: Woman Shoots Three Teenage McDonald’s Workers For Telling Her She Couldn’t Eat In Dining Room Over COVID19 Restrictions ... Full Article Featured Politics
sho BREAKING: New Docs Prove Obama Knew Details Of Flynn Wiretapping…Newly Surfaced Video Shows Obama Explaining How He Stays Out Of FBI Investigations By 100percentfedup.com Published On :: Fri, 08 May 2020 16:25:07 +0000 The following article, BREAKING: New Docs Prove Obama Knew Details Of Flynn Wiretapping…Newly Surfaced Video Shows Obama Explaining How He Stays Out Of FBI Investigations, was first published on 100PercentFedUp.com. Barack Obama knew. Documents released yesterday that were used to exonerate President Trump’s new NSA General Flynn, prove that President Barack Obama was aware of the details of Michael Flynn’s intercepted phone calls on December 16 with then-Russian Ambassador Sergey Kislyak. On January 5, 2017, then-Deputy Attorney General, Sally Yates attended an Oval Office meeting […] Continue reading: BREAKING: New Docs Prove Obama Knew Details Of Flynn Wiretapping…Newly Surfaced Video Shows Obama Explaining How He Stays Out Of FBI Investigations ... Full Article Featured Left News Political Correctness
sho Council votes against proposed cannabis store location in Lakeshore By windsor.ctvnews.ca Published On :: Fri, 8 May 2020 16:54:00 -0400 In Lakeshore, it may be a little while longer before a retail cannabis store opens. Full Article
sho Why China Should Be Wary of Devaluing the Renminbi By feedproxy.google.com Published On :: Thu, 29 Aug 2019 15:53:29 +0000 29 August 2019 David Lubin Associate Fellow, Global Economy and Finance Programme @davidlubin There are four good reasons why Beijing might want to think twice before using its currency to retaliate against US tariffs. 2019-08-29-Renminbi.jpg RMB banknotes. Photo: Getty Images The renminbi seems to be back in business as a Chinese tool of retaliation against US tariffs. A 1.5 per cent fall in the currency early this month in response to proposed new US tariffs was only a start. Since the middle of August the renminbi has weakened further, and the exchange rate is now 4 per cent weaker than at the start of the month. We may well see more of a ‘weaponized’ renminbi, but there are four good reasons why Beijing might be wise to think before shooting.The first has to do with how China seeks to promote its place in the world. China has been at pains to manage the collapse of its relations with the US in a way that allows it to present itself as an alternative pillar of global order, and as a source of stability in the international system, not to mention moral authority. This has deep roots.Anyone investigating the history of Chinese statecraft will quickly come across an enduring distinction in Chinese thought: between wang dao, the kingly, or righteous way, and ba dao, the way of the hegemon. Since Chinese thinkers and officials routinely describe US behaviour since the Second World War as hegemonic, it behoves Chinese policymakers to do as much as possible to stay on moral high-ground in their behaviour towards Washington. Only in that way would President Xi be able properly to assert China’s claim to leadership.Indeed, China has a notable track record of using exchange rate stability to enhance its reputation as a force for global stability. Both in the aftermath of the Asian crisis in 1997, and of the Global Financial Crisis in 2008, Chinese exchange rate stability was offered as a way of demonstrating China’s trustworthiness and its commitment to multilateral order.Devaluing the renminbi in a meaningful way now might have a different rationale, but the cost to China’s claim to virtue, and its bid to offer itself as a guardian of global stability, might be considerable.That’s particularly true because of the second problem China has in thinking about a weaker renminbi: it may not be all that effective in sustaining Chinese trade. One reason for this is the increasing co-movement with the renminbi of currencies in countries with whom China competes.As the renminbi changes against the dollar, so do the Taiwan dollar, the Korean won, the Singapore dollar and the Indian rupee. In addition, the short-run impact of a weaker renminbi is more likely to curb imports than to expand exports, and so its effects might be contractionary. An ineffective devaluation of the renminbi would be particularly useless because of the third risk China needs to consider, namely the risk of retaliation by the US administration. Of this there is already plenty of evidence, of course.The US Treasury’s declaration of China as a ‘currency manipulator’ on 5 August bears little relationship to the actual formal criteria that the Treasury uses to define that term, but equally the US had warned the Chinese back in May that these criteria don’t bind its hand. By abandoning a rules-based approach to the definition of currency manipulation, the US has opened wide the door to further antagonism, and Beijing should have no doubt that Washington will walk through that door if it wants to.The fourth, and possibly most self-destructive, risk that China has to consider is that a weaker renminbi might destabilize China’s capital account, fuelling capital outflows that would leave China’s policymakers feeling very uncomfortable.Indeed, there is already evidence that Chinese residents feel less confident that the renminbi is a reliable store of value, now that there is no longer a sense that the currency is destined to appreciate against the dollar. The best illustration of this comes from the ‘errors and omissions’, or unaccounted-for outflows, in China’s balance of payments.The past few years have seen these outflows rise a lot, averaging some $200 billion per year during the past four calendar years, or almost 2 per cent GDP; and around $90 billion in the first three months of 2019 alone. These are scarily large numbers.The risk here is that Chinese expectations about the renminbi are ‘adaptive’: the more the exchange rate weakens, the more Chinese residents expect it to weaken, and so the demand for dollars goes up. In principle, the only way to deal with this risk would be for the People's Bank of China (PBOC) to implement a large, one-off devaluation of the renminbi to a level at which dollars are expensive enough that no one wants to buy them anymore.This would be very dangerous, though: it presupposes that the PBOC could know in advance the ‘equilibrium’ value of the renminbi. It would take an unusually brave central banker to claim such foresight, especially since that equilibrium value could itself be altered by the mere fact of such a dramatic change in policy.No one really knows precisely by what mechanism capital outflows from China have accelerated in recent years, but a very good candidate is tourism. The expenditure of outbound Chinese tourists abroad has risen a lot in recent years, and that increase very closely mirrors the rise in ‘errors and omissions’. So the suspicion must be that the increasing flow of Chinese tourists – nearly one half of whom last year simply travelled to capital-controls-free Hong Kong and Macao – is just creating opportunities for unrecorded capital flight.This raises a disturbing possibility: that the most effective way for China to devalue the renminbi without the backfire of capital outflows would be simultaneously to stem the outflow of Chinese tourists. China has form in this regard, albeit for differing reasons: this month it suspended a programme that allowed individual tourists from 47 Chinese cities to travel to Taiwan.A more global restriction on Chinese tourism might make a devaluation of the renminbi ‘safer’, and it would have the collateral benefit of helping to increase China’s current account surplus, the evaporation of which in recent years owes a lot to rising tourism expenditure and which is almost certainly a source of unhappiness in Beijing, where mercantilism remains popular.But a world where China could impose such draconian measures would be one where nationalism has reached heights we haven’t yet seen. Let’s hope we don’t go there.This article was originally published in the Financial Times. Full Article
sho Iran Workshop Series: Domestic, Regional and International Outlook By feedproxy.google.com Published On :: Wed, 19 Feb 2020 15:05:01 +0000 Invitation Only Research Event 17 December 2019 - 10:00am to 3:30pm Chatham House | 10 St James's Square | London | SW1Y 4LE After a summer of regional tensions and continued uncertainty regarding the future of the JCPOA, the Chatham House MENA Programme held a closed workshop to examine the impact of the Trump administration’s maximum pressure campaign.Discussions focused on the domestic developments and challenges inside Iran, prospects for new negotiations with Iran, and the regional issues facing the country. Participants also considered the differences between American and European approaches towards Iran. Event attributes Chatham House Rule Department/project Middle East and North Africa Programme, Iran Forum Reni Zhelyazkova Programme Coordinator, Middle East and North Africa Programme +44 (0)20 7314 3624 Email Full Article
Reni Zhelyazkova Programme Coordinator, Middle East and North Africa Programme +44 (0)20 7314 3624 Email
sho Britain should treat Europe as its ‘inner circle’ or risk losing international influence By feedproxy.google.com Published On :: Mon, 19 Oct 2015 09:05:23 +0000 13 October 2015 20151019BritanEuropeWorld.jpg British Prime Minister David Cameron sits with other world leaders at the G20 summit in Brisbane, Australia on 15 November 2014. Photo by Getty Images. Given the international context, it is in Britain’s best interests to treat Europe as the ‘inner circle’ of its foreign, security and international economic policy, argues Dr Robin Niblett, director of Chatham House, in a new paper.The British government’s approach since 2010 of seeking to enhance the UK's relations with the world’s emerging powers while balancing these with relationships with the United States and Europe has had only limited success. With constrained resources, and in the face of intense global economic competition, mounting security challenges and decaying international institutions, trying to commit the UK equally on all three fronts will not succeed in the future.Britain, Europe and the World: Rethinking the UK’s Circles of Influence calls for a different mindset and strategy towards the UK’s place in the world – one in which Britain is surrounded by three concentric circles of influence:The first or ‘inner circle’ is the EU, the region with which the UK’s relationships need to be strongest and most active.The ‘second circle’ consists of the protective and enabling set of economic and security relationships with the US.Finally, an ‘outer circle’ comprises the UK’s other key bilateral and institutional relationships.Should the UK vote to remain in the EU, policy-makers should commit to placing the EU at the centre of Britain's foreign policy, using the country’s economic weight, diplomatic skills and networks to play a leading role in leveraging more effective EU-wide policies. Should the country vote to leave, the UK and the EU would enter an extended period of dislocation before arriving at a new, mutually diminished settlement. British policy-makers would be forced to deal and negotiate with the EU on critical policy issues from the outside. It is hard to see, argues Dr Niblett, how that could lead to EU policies or an international context more in line with British interests. Despite its structural flaws and competing national interests, the EU offers the best prospects for managing the rapidly changing global context, for three main reasons:First, it allows the UK to leverage the EU’s global economic weight to enhance the UK’s economic interests internationally, including securing beneficial trade agreements and contributing to EU and global standard-setting and rule-writing. Conversely, leaving would require the UK to renegotiate over 100 trade agreements, and would disadvantage UK interests in EU markets, including making EU governments less likely to liberalize services. Second, it gives the UK a say in designing new EU initiatives to strengthen both British and European security in the face of diverse threats, whether managing the flow of refugees and other emigrants; combatting terrorism; or managing a more assertive Russia and the fallout from a disintegrating Middle East. Third, cooperating with other EU members offers a way of maximizing opportunities to find joint solutions to shared problems, whether in terms of responding to climate change; managing growing cyber insecurity; reversing the decay of governance in failing states; or combating the rise of dangerous non-state actors.Dr Robin Niblett said:‘Britain is likely to be richer, safer and more influential in the coming decades if it treats Europe as the ‘inner circle’ of its foreign policy. For a mid-sized country like the UK, being a major player in a strong regional institution can offer a critical lever for international influence. In the UK’s case, this means choosing to be a leading player in the world’s principal civilian power, the European Union.’ Editor's notes Read Britain, Europe and the World: Rethinking the UK's Circles of InfluenceChatham House will host a press briefing with Dr Robin Niblett on Monday 19 October at 11:00-11:45 BST. To register, or for interview requests, please contact the press office.The views expressed in this paper are those of the author. Chatham House experts will publish a series of papers and commentaries in the run up to the UK’s referendum on its membership of the EU. The institute will also offer a platform for debate on the referendum and Britain’s role in Europe via a series of events and meetings.Read more about the EU referendum. Contacts Press Office +44 (0)20 7957 5739 Email Full Article
sho For a US Trade Deal, UK Should Secure Its Spot in TTIP After Brexit By feedproxy.google.com Published On :: Thu, 25 Aug 2016 13:39:08 +0000 25 August 2016 Marianne Schneider-Petsinger Senior Research Fellow, US and the Americas Programme @mpetsinger Having Britain as an additional party to a US−EU free-trade agreement would benefit all sides. 2016-08-25-UnionNY.jpg A Union flag hangs in the window of a British grocery store in New York City. Photo by Getty Images. Even though President Barack Obama cautioned that the UK would be at the ‘back of the queue’ for a trade agreement with the US if the country chose to leave the EU, in the post-Brexit world a deal might be struck more swiftly. Various ideas for bringing the UK and US into a formal trade arrangement have been floated – ranging from a bilateral UK-US trade deal, or the UK joining NAFTA (the North American Free Trade Agreement between the US, Canada and Mexico), to the UK becoming a part of the TPP (the Trans-Pacific Partnership that the US is pursuing with 11 other countries along the Pacific Rim). However, one option stands out: opening the Transatlantic Trade and Investment Partnership (TTIP), which the US and EU are currently negotiating, to the UK after Brexit.Good reasons for Britain in TTIPFirst, from the perspective of the UK, signing up to TTIP would mean a more comprehensive deal with the US than a bilateral UK−US trade agreement. For instance, Britain is very keen to include financial services regulation in any trade agreement with America, but given Washington’s reluctance, this ambition might only be achievable if other countries like France and Germany throw their financial weight into the negotiations.Second, continuing involvement in the TTIP negotiations allows London to begin securing its trade position with the US now. Though its influence in the EU may weaken as it heads for the exit, Britain could make the best use of influencing the EU position on TTIP while it is still a member. It could then accept the terms of TTIP and accede as a third party relatively quickly after exiting the EU. Official negotiations on a UK−US-only deal would have to wait until the UK has left the EU, as trade talks fall under the exclusive competence of the EU.Third, for the US and EU, having the UK as a party to TTIP would ensure the scale of the deal is not reduced, and thereby maintain the strategic appeal and ability to set global standards. At the moment, the UK is the EU’s second-largest economy, accounting for approximately 18 per cent of GDP. With Britain in TTIP, the sheer size of the transatlantic market space will have more pull for other countries to adopt the common transatlantic rules in order to gain market access.Fourth, the UK joining TTIP as a third party would establish the agreement as an ‘open platform’ that is available for other countries to join. Michael Froman, the United States trade representative, has characterized TTIP as being such an open agreement. EU representatives have been more ambivalent, though this is starting to change in the wake of Brexit. David O’Sullivan, the current EU ambassador to the US, recently said that as ‘we’ve always seen TTIP as a potential open platform, [the] UK could still benefit [from it] even not as a member of the European Union’. While now might not be the right time to expand the TTIP bloc beyond its original participants given that negotiations are already complex and drawn out, it would be beneficial for the negotiating partners to send a strong message that countries that are willing and able to commit to the high TTIP standards will be welcomed later on.Obstacles to Britain in TTIPBut before the UK could be added to TTIP after Brexit, major hurdles will have to be jumped and crucial questions answered. The first obstacle is actually getting a TTIP deal, which will require significant efforts by political leaders and negotiators on both sides of the Atlantic.Second, selling the ‘UK in TTIP option’ to Brexiteers will not be an easy task. After all, Leave campaigners argued that the US−EU deal might undermine the NHS and was thus presented as one of the reasons to cut loose from Brussels. As the major rationale behind TTIP is regulatory harmonization, if the UK were to sign up to TTIP it would still have to apply many EU rules. This, however, would go counter to the arguments for leaving the EU in the first place.Third, it will be a challenging job for the UK to untangle its trade relationship with the EU while at the same time negotiating TTIP together with the EU. It would be easiest if the UK decided to remain a member of the EU customs union. Britain would then be required to impose the EU’s external tariffs on countries like the US. This would fit seamlessly with the ‘UK in TTIP’ option. But as the UK will most likely pull out of the customs union, it will be more complicated than that.Finally, the timing of Brexit and the TTIP negotiations could cause complications. In the unlikely event that a US-EU free trade deal is concluded and ratified while the UK is still a member of the EU, the agreement (or the parts of it that fall under national competence) would most likely continue to apply to Britain after Brexit without the need for accession. If the TTIP negotiations continue beyond Brexit, then the UK would move from negotiating as part of the EU bloc to becoming a third party. This raises the issue of whether the UK and EU continue to negotiate as one bloc vis-à-vis the US.Special economic relationshipStill, the depth of the economic ties between the US and UK means that the TTIP option is likely to be welcomed favourably by both countries. The US is the most important single export market for the UK, with goods and services worth £45 billion shipped in 2015. Last year, the US ranked third (after Germany and China) as a source for UK imports. With nearly $1 trillion invested in each other’s economies, the US and the UK are also each other’s largest investors. Given this special economic relationship, Britain is unlikely to be at the ‘back of the queue’ in any event. But the TTIP option is the best path to preserving and strengthening the relationship post-Brexit while also realizing the wider strategic benefits of a transatlantic trade agreement.A version of this article appeared on Real Clear World.To comment on this article, please contact Chatham House Feedback Full Article
sho Making the Business Case for Nutrition Workshop By feedproxy.google.com Published On :: Thu, 05 Dec 2019 12:15:01 +0000 Invitation Only Research Event 28 January 2020 - 9:30am to 5:00pm Chatham House | 10 St James's Square | London | SW1Y 4LE A ground-breaking research project from Chatham House, supported by The Power of Nutrition, is exploring the business case for tackling undernutrition, micronutrient deficiencies and overnutrition. Companies across all sectors hold huge, transformative power to save countless lives and transform their own financial prospects. To act, they need more compelling evidence of the potential for targeted investments and strategies to promote better nutrition and create healthier, more productive workforces and consumers.At this workshop, Chatham House will engage business decision-makers in a scenario exercise that explores different nutrition futures and their commercial prospects in each before examining what different strategies business can pursue to maximize future profitability through investments in nutrition.Attendance at this event is by invitation only. Department/project Energy, Environment and Resources Programme Full Article
sho The mRNA levels of heat shock factor 1 are regulated by thermogenic signals via the cAMP-dependent transcription factor ATF3 [Metabolism] By feedproxy.google.com Published On :: 2020-05-01T00:06:09-07:00 Heat shock factor 1 (HSF1) regulates cellular adaptation to challenges such as heat shock and oxidative and proteotoxic stresses. We have recently reported a previously unappreciated role for HSF1 in the regulation of energy metabolism in fat tissues; however, whether HSF1 is differentially expressed in adipose depots and how its levels are regulated in fat tissues remain unclear. Here, we show that HSF1 levels are higher in brown and subcutaneous fat tissues than in those in the visceral depot and that HSF1 is more abundant in differentiated, thermogenic adipocytes. Gene expression experiments indicated that HSF1 is transcriptionally regulated in fat by agents that modulate cAMP levels, by cold exposure, and by pharmacological stimulation of β-adrenergic signaling. An in silico promoter analysis helped identify a putative response element for activating transcription factor 3 (ATF3) at −258 to −250 base pairs from the HSF1 transcriptional start site, and electrophoretic mobility shift and ChIP assays confirmed ATF3 binding to this sequence. Furthermore, functional assays disclosed that ATF3 is necessary and sufficient for HSF1 regulation. Detailed gene expression analysis revealed that ATF3 is one of the most highly induced ATFs in thermogenic tissues of mice exposed to cold temperatures or treated with the β-adrenergic receptor agonist CL316,243 and that its expression is induced by modulators of cAMP levels in isolated adipocytes. To the best of our knowledge, our results show for the first time that HSF1 is transcriptionally controlled by ATF3 in response to classic stimuli that promote heat generation in thermogenic tissues. Full Article
sho Interpretation of Shotgun Proteomic Data: The Protein Inference Problem By feedproxy.google.com Published On :: 2005-10-01 Alexey I. NesvizhskiiOct 1, 2005; 4:1419-1440Tutorial Full Article
sho Comparison of Label-free Methods for Quantifying Human Proteins by Shotgun Proteomics By feedproxy.google.com Published On :: 2005-10-01 William M. OldOct 1, 2005; 4:1487-1502Research Full Article
sho Webinar: Global Economic Recovery and Resilience to Systemic Shocks By feedproxy.google.com Published On :: Fri, 17 Apr 2020 16:15:01 +0000 Corporate Members Event Webinar 20 May 2020 - 5:00pm to 5:45pmAdd to CalendariCalendar Outlook Google Yahoo Francesca Viliani, Consultant Researcher, Global Health Programme, Chatham House; Director, Public Health, International SOSSven Smit, Co-Chair, McKinsey Global Institute and Senior Partner, McKinsey & Company, AmsterdamChair: Creon Butler, Research Director, Trade, Investment & New Governance Models: Director, Global Economy and Finance Programme, Chatham House The outbreak of COVID-19 has demonstrated the wide-ranging and immediate impact a systemic shock can have on the global economy including the financial loss caused by the emergency shutdown of many retail operations, the loss of income for individuals who are forced to stay indoors and the major disruption to supply chains. The longer term impacts are still being realized and depend heavily on the ability of industry and the government to respond effectively to the direct economic shock caused by the pandemic.Systemic shocks like the COVID-19 pandemic demand immediate responses, but should also encourage governments and industries to re-examine their recovery processes, their resilience and their forward planning. In this webinar, the panellists will discuss the short and long-term impacts of the current crisis and explore how industry can help ensure that the global economy is able to recover from, and build resilience to, future systemic shocks. How do business leaders move from making decisions to reimagining a ‘new normal’ and reforming their practices? What are the critical decisions that businesses should consider when planning for this 'new normal'? And how far can these decisions be based on expected changes to governmental or intergovernmental regulation of different sectors? This event is part of a fortnightly series of 'Business in Focus' webinars reflecting on the impact of COVID-19 on areas of particular professional interest for our corporate members and giving circles.Not a corporate member? Find out more. Full Article
sho Alain de Botton on how the news should aim to improve our lives By feedproxy.google.com Published On :: Wed, 05 Feb 2014 12:47:15 +0000 6 February 2014 , Volume 70, Number 1 The author of books on love, religion and Proust, explains why the news agenda should be more positive Download PDF Agnes Frimston deBotton.jpg Photo: Getty Images Is the news our society’s religion today?In the developed economies, the news now occupies a position of power at least equal to that formerly enjoyed by the faiths. Matins has been transubstantiated into the breakfast bulletin, vespers into the evening report. It also demands that we approach it with some of the same deferential expectations we would once have harboured for the faiths. Here, too, we hope to receive revelations, learn who is good and bad, fathom suffering and understand the unfolding logic of existence. And here too, if we refuse to take part in the rituals, there could be imputations of heresy.What would you like the news to be?It feels like there is always an infinite amount of news, so much is happening in the world every day. Yet after a while it becomes clear that the same kinds of event are recurring again and again. The details change, but all circle round the same archetypal story. Men in highly responsible positions are coming unstuck because their desires lead them to do things that, when made public, are shameful.Identifying the underlying theme is more important in the long run than going through the details of every case. The news that matters is not so much that this MP or banker did what they did. What we need to address is why such things happen.How do you keep the public interested in the news that does matter?We cannot be collectively dragged into being more responsible through guilt. The Arctic ice is melting and this is going to have major, lasting implications for sea levels and weather around the world. A few people care a lot but, strangely, Taylor Swift’s legs are far more captivating. The starting point has to be indulgence towards the way our minds work. We are interested in Swift’s legs not because we are evil – but because we are wired in unhelpful ways. If we are going to be interested en masse in the defrosting poles, we need to take our fragilities on board and therefore get serious about trying to make important news not just ‘important’, but also beguiling. Then things stand a chance of changing.You argue that we should set aside ‘neutral reporting’. Are you asking for more bias?Many people imagine that what makes news organizations serious is their ability to provide us with information that is ‘unbiased’. But facts can only become meaningful and relevant to us when they slot into some picture of important or trivial, right or wrong. News organizations that vaunt their neutrality forget that neutrality is simply impossible. There is no risk-free, all-knowing sober set of answers to cling to. At heart, the word ‘bias’ simply alludes to the business of having a ‘take’ on existence. One may have a better or worse take, but one can’t make any sense of the flotsam of daily events in the news without having one. All of the figures we revere in history have been highly biased: each of them had a strong sense of what mattered and why, and their judgments were anything but perfectly balanced. They were just flavoured in the right way. We don’t need news stripped of bias, we need news presented to us with the best kinds of bias.What is the purpose of foreign reporting?Foreign reporting implicitly defers to the priorities of the state and of business, occupying itself almost exclusively with whom and where we should fight, trade or sympathize. But it should instead offer us a means by which to humanize the Other who instinctively repels, bores or frightens us and with whom we can’t, without help, imagine having anything in common.Foreign countries also furnish a scale against which our own nation and ways of living can be assessed; they may help us to see our national oddities, blind spots and strengths. Stories from them may lead us to a fresh appreciation of the imperfect freedoms and comparative abundance of our homelands, which otherwise would be treated only as matters for grumbling or blame. Alternatively, problems with which we are all too familiar may be revealed to have been solved better elsewhere.You mention the importance of historical perspective in reporting, so that we can respond to issues with context.Contrary to what the news usually suggests, hardly anything is ever totally new, few things are truly amazing and very little is absolutely terrible. The economic indices are grim, but we have weathered comparable drops many times over the past century and even the worst scenarios only predict that we will return to a standard of living we had a few decades ago. A bad avian flu may disrupt international travel and defeat known drugs for a while, but research will eventually understand and contain it. The floods look dramatic, but in the end, they will affect merely a fraction of the population and recede soon.How can photography change the way we report news?There are now more images than ever before in the coverage we consume, but the problem lies in the lack of ambition behind their production and display. We might usefully divide news photographs into two genres. The first are images of corroboration, which do little other than confirm something we have learnt about a person or an event through an accompanying article. The second is a rarer kind of image, the photograph of revelation, whose ambition is not simply to back up what the text tells us but to advance our level of knowledge to a new point. It sets out to challenge cliché. We have lost any sense of photography’s potential as an information-bearing medium, as a force to properly introduce us to a planet that we keep conceitedly assuming that we know rather well already.Do you feel oppressed by the news?The pressure of not missing out makes one feel one has to care about a given topic, even when one doesn’t want to. Take Mandela’s funeral. One was supposed to care a lot, and yet, you don’t. You know the reasons why it is important, but they don’t grip you because you are focused elsewhere on subjects that, while tiny in the grand scheme of things, matter a lot within your context. It would be dangerous if hardly anyone paid attention to what the Government was doing, or what was happening to the environment. But it is not right to go from this to the demand that everyone should be interested in every item whenever the news machine calls. We badly need people whose attention is not caught up in the trends of the moment and who are not looking in the same direction as everyone else. We need people scanning the less familiar parts of the horizon.Do you think we get the news we deserve?Much of what we now take for granted as news has its origins in the information needed by those people taking major decisions or who are at the centre of national affairs. Ease of communication and a generous democratic impulse means that selections from the knowledge base, originally designed for decision-makers, now gets routinely sent via the media to very large numbers of people. It is as if a dossier which might properly arrive upon the desk of a Minister has accidentally been delivered to the wrong address and ends up on the breakfast table of an electrician in Pitlochry. Every day the news gives us stuff that is both interesting for some people and irrelevant to you. No wonder we’re sometimes a bit bored. It’s not our fault. Full Article
sho Lola Shoneyin By feedproxy.google.com Published On :: Wed, 05 Feb 2014 14:57:35 +0000 6 February 2014 , Volume 70, Number 1 Creative righting of wrongs Shoneyin.jpg Binyavanga Wainaina, the Kenyan author, has come out as gay. Photo: Munshi Ahmed/Bloomberg via Getty Images Full Article
sho Syria Showcases the Failure to Engage Locals in Development By feedproxy.google.com Published On :: Thu, 20 Aug 2015 10:03:40 +0000 20 August 2015 Kholoud Mansour Former Academy Associate The problems of the international humanitarian response in the war-torn country are part of a broader difficulty in connecting development with local sustainability. 20150820UNSyriaEnvoys.jpg UN Deputy Special Envoy to Syria Ramzy Ezzeldin Ramzy, UNDP Representative in Syria Yacoub al-Helo and the commissioner general of UNRWA, Pierre Krahenbuhl, answer questions during an interview on 14 April 2015 in Damascus. Photo by Getty Images. The international community’s response to the Syria crisis has been unsatisfactory on many fronts, and humanitarian aid and development is no exception. While there has been renewed emphasis by development organizations on the importance of engaging local actors − notably highlighted in the new Sustainable Development Goals − the reality is this has been woefully lacking in practice. And Syria is simply one example of many where the failure of UN agencies and other humanitarian actors to partner with local actors has hampered the response to humanitarian crises.Double standardsThe problem is that international agencies usually have high and unfair expectations from Syrian individuals and organizations, requiring them to speak the ‘language’ of development, meet international standards, and demonstrate a wide range of expertise. However, these demands are not reciprocated by international organizations and experts being expected to have the same depth of knowledge of the local context in which they are operating. In addition, while Syrian actors are expected to be neutral, impartial and politically unaffiliated, foreign aid appears to be driven − explicitly and unashamedly − by the political objectives of the donor countries.There is a double standard at work. In many cases, international ‘experts’ on Syria have little local knowledge, but there are no channels to measure or question their level of expertise. At the same time, including local Syrians in decision-making is seen as a threat to predetermined objectives, rather than as an asset.Syrians could add an indispensable source of knowledge and context to international agencies, as well as add local credibility. But too often they are brought on board to be part of the humanitarian and development picture or to get their simple feedback for evaluation and needs assessment reports to satisfy donors’ requirements, rather than employed as an integral component of designing and implementing projects. Though some of this is down to a pretext of lack of capacity, it raises the question of whether there is an international political willingness and genuine organizational courage to involve Syrians at programming, decision and policy making-levels.The importance of localThe Syrian example is not isolated. While there is now a debate to encourage engaging local actors, this does not happen in practice. The Local to Global Protection Initiative study reported that local and national humanitarian actors received only 0.2% of the overall direct global humanitarian response in 2013.Moreover, the international humanitarian and development systems are designed, together with foreign aid policy, to be self-contained and to exclude local actors. This allows donor governments to use the systems as political tools for leveraging control. It is equally difficult for both outsiders as well as insiders to understand how the system really functions. The UN-led coordination structure is one example of the heavy international architecture that remains unable to reform itself, learn from its previous mistakes, or to engage with local actors.And that engagement matters. The Independent Research Forum emphasized in its brief in February 2014 how engaging local researchers and implementing bottom-up participatory learning can make countries better prepared to achieve the post-2015 Sustainable Development Goals. Those goals, as well as the upcoming World Humanitarian Summit, highlight the importance of including local actors in the humanitarian and development responses.Moving forwardFortunately, such initiatives are creating a momentum within the development community to make radical changes through bottom-up approaches that put sustainability into practice. But if the Sustainable Development Goals want to affect real change, there will have to be a significant drive to move from rhetoric and ‘intentions’ to reality and actions. Currently it seems that the international community prefers to simply maintain the current status quo. It only takes a brief reflection on how many Syrians are included in every project or programme and how many Syrians are in positions to contribute at the policy and decision-making levels to realise the scale of the impetus required to change this system. To make that change might provide an opportunity for Syrians to restore some of the ownership to the outcomes and decisions of their conflict.To comment on this article, please contact Chatham House Feedback Full Article
sho Keeping It Short By mythicscribes.com Published On :: Sun, 19 Apr 2020 20:00:09 +0000 You’ve got a short story that goes on too long? A chapter that reads at a dying snail’s pace? A challenge entry that trails beyond the maximum word count? You’re also relatively new to writing and haven’t yet dragged your way through all the millions of writing articles? If yes to the last and anything else to the rest, here’s your article. 1. Remove all redundancies. I repeat: Remove all redundancies. I repeat: …. “Unknown strangers” or “asked a question” can be removed right away. While it may sound silly, there’s a good chance you have a few of those rummaging around in your work for you to weed out. More significantly you will want to root out the various strings of wordy words writers conjure up. “At that point in time,” can be replaced with “back then,” or even “then,” if the placement in the sentence allows it. “Despite the fact” can be “although.” “Less than great,” is just a polite man’s “mediocre.” As a lone appreciator of purple prose I won’t tell you to always cull all of these combos, for there’s a time and place for everything and it’s called colle… a long-form story, but if you’re trying to shorten things up these are the first words to go. Continue reading Keeping It Short at Mythic Scribes. Full Article Writing Craft & Technique
sho The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism By feedproxy.google.com Published On :: 2013-09-01 Gijs den BestenSep 1, 2013; 54:2325-2340Reviews Full Article
sho Virtual Roundtable: The Shock of Coronavirus – Hard Truths By feedproxy.google.com Published On :: Fri, 03 Apr 2020 14:50:01 +0000 Research Event 15 April 2020 - 3:00pm to 4:00pm Event participants Professor Adam Tooze, Kathryn and Shelby Cullom Davis Professor of History, Columbia UniversityDiscussant: Megan Greene, Dame DeAnne Julius Senior Academy Fellow in International Economics, Chatham House; Senior Fellow, Harvard Kennedy SchoolChair: Dr Leslie Vinjamuri, Director, US and the Americas Programme; Dean, Queen Elizabeth II Academy for Leadership in International Affairs, Chatham House This event is part of the Inaugural Virtual Roundtable Series on the US, Americas and the State of the World and will take place virtually only. Department/project US and the Americas Programme US and Americas Programme Email Full Article
sho Should the Super-Rich Pay for a Universal Basic Income? By feedproxy.google.com Published On :: Tue, 10 Apr 2018 00:00:00 +0100 Full Article
sho Should Debt in the Developing World be Cancelled? By feedproxy.google.com Published On :: Thu, 31 May 2018 00:00:00 +0100 Full Article
sho Can and Should Brexit Be Stopped? By feedproxy.google.com Published On :: Mon, 17 Sep 2018 00:00:00 +0100 Full Article
sho Who Should Regulate Free Speech Online? By feedproxy.google.com Published On :: Thu, 27 Jun 2019 00:00:00 +0100 Full Article
sho The Indo-Pacific: Geostrategic Perspectives to 2024 - Workshop 3 By feedproxy.google.com Published On :: Mon, 14 Oct 2019 09:10:01 +0000 Invitation Only Research Event 17 October 2019 - 9:30am to 2:00pm Institut Francais des Relations Internationales, 27 rue de la Procession, 75740 Paris Cedex 15, France This closed-door roundtable explores possible strategic shifts in the Indo-Pacific between now and 2024. Focusing on trade security, climate change disruptions and security cooperation, it aims to enhance the understanding of the regional goals of, and strategic relationships between, the key countries active in the region.The workshop is part of a larger project funded by the Strategic Policy Division of the Australian Department of Defence. The project includes workshops in the United States, the United Kingdom, France, Japan, India and the Pacific Islands (Tonga).Attendance at this event is by invitation only. Department/project Asia-Pacific Programme, Geopolitics and Governance, Sustainable and Inclusive Growth, Trade, Investment and Economics, Energy, Environment and Resources Programme, Geostrategic Outlook for the Indo-Pacific 2019-2024 Anna Aberg Research Analyst, Energy, Environment and Resources Programme 020 7314 3629 Email Full Article
sho Making the Business Case for Nutrition Workshop By feedproxy.google.com Published On :: Thu, 05 Dec 2019 12:15:01 +0000 Invitation Only Research Event 28 January 2020 - 9:30am to 5:00pm Chatham House | 10 St James's Square | London | SW1Y 4LE A ground-breaking research project from Chatham House, supported by The Power of Nutrition, is exploring the business case for tackling undernutrition, micronutrient deficiencies and overnutrition. Companies across all sectors hold huge, transformative power to save countless lives and transform their own financial prospects. To act, they need more compelling evidence of the potential for targeted investments and strategies to promote better nutrition and create healthier, more productive workforces and consumers.At this workshop, Chatham House will engage business decision-makers in a scenario exercise that explores different nutrition futures and their commercial prospects in each before examining what different strategies business can pursue to maximize future profitability through investments in nutrition.Attendance at this event is by invitation only. Department/project Energy, Environment and Resources Programme Full Article
sho The Indo-Pacific: Geostrategic Outlook to 2024 - Workshop 4 By feedproxy.google.com Published On :: Thu, 09 Jan 2020 11:15:01 +0000 Invitation Only Research Event 26 November 2019 - 9:30am to 12:00pm Gateway House, Stevens Street, Colaba This closed-door roundtable explores possible strategic shifts in the Indo-Pacific between now and 2024.Focusing on trade security, climate change disruptions and security cooperation, it aims to enhance the understanding of the regional goals of, and strategic relationships between, the key countries active in the region.The workshop is part of a larger project funded by the Strategic Policy Division of the Australian Department of Defence.The project includes workshops in the United States, the United Kingdom, France, Japan, India and the Pacific Islands (Tonga). Department/project Asia-Pacific Programme, Geopolitics and Governance, Sustainable and Inclusive Growth, Trade, Investment and Economics, Energy, Environment and Resources Programme Anna Aberg Research Analyst, Energy, Environment and Resources Programme 020 7314 3629 Email Full Article
sho The Indo-Pacific: Geostrategic Outlook From Now to 2024 - Workshop 5 By feedproxy.google.com Published On :: Mon, 17 Feb 2020 14:25:01 +0000 Invitation Only Research Event 18 February 2020 - 12:00pm to 4:30pm Langafonua Centre This roundtable explores possible strategic shifts in the Indo-Pacific between now and 2024. Focusing on trade security, climate change disruptions and security cooperation, it aims to enhance the understanding of the regional goals of, and strategic relationships between, the key countries active in the region.The workshop is part of a larger project funded by the Strategic Policy Division of the Australian Department of Defence. The project includes workshops in the United States, the United Kingdom, France, Japan, India and the Pacific Islands (Tonga). Department/project Asia-Pacific Programme, Sustainable and Inclusive Growth, Trade, Investment and Economics, Energy, Environment and Resources Programme Anna Aberg Research Analyst, Energy, Environment and Resources Programme 020 7314 3629 Email Full Article
sho Iran shot down a Ukrainian plane. How did Ukraine respond? By feedproxy.google.com Published On :: Fri, 06 Mar 2020 16:28:38 +0000 Source The Washington Post URL https://www.washingtonpost.com/politics/2020/01/17/iran-shot-down-ukrainian-plan... Release date 17 January 2020 Expert Orysia Lutsevych In the news type Op-ed Hide date on homepage Full Article
sho The short variant of optic atrophy 1 (OPA1) improves cell survival under oxidative stress [Bioenergetics] By feedproxy.google.com Published On :: 2020-05-08T03:41:14-07:00 Optic atrophy 1 (OPA1) is a dynamin protein that mediates mitochondrial fusion at the inner membrane. OPA1 is also necessary for maintaining the cristae and thus essential for supporting cellular energetics. OPA1 exists as membrane-anchored long form (L-OPA1) and short form (S-OPA1) that lacks the transmembrane region and is generated by cleavage of L-OPA1. Mitochondrial dysfunction and cellular stresses activate the inner membrane–associated zinc metallopeptidase OMA1 that cleaves L-OPA1, causing S-OPA1 accumulation. The prevailing notion has been that L-OPA1 is the functional form, whereas S-OPA1 is an inactive cleavage product in mammals, and that stress-induced OPA1 cleavage causes mitochondrial fragmentation and sensitizes cells to death. However, S-OPA1 contains all functional domains of dynamin proteins, suggesting that it has a physiological role. Indeed, we recently demonstrated that S-OPA1 can maintain cristae and energetics through its GTPase activity, despite lacking fusion activity. Here, applying oxidant insult that induces OPA1 cleavage, we show that cells unable to generate S-OPA1 are more sensitive to this stress under obligatory respiratory conditions, leading to necrotic death. These findings indicate that L-OPA1 and S-OPA1 differ in maintaining mitochondrial function. Mechanistically, we found that cells that exclusively express L-OPA1 generate more superoxide and are more sensitive to Ca2+-induced mitochondrial permeability transition, suggesting that S-OPA1, and not L-OPA1, protects against cellular stress. Importantly, silencing of OMA1 expression increased oxidant-induced cell death, indicating that stress-induced OPA1 cleavage supports cell survival. Our findings suggest that S-OPA1 generation by OPA1 cleavage is a survival mechanism in stressed cells. Full Article
sho The Indo-Pacific: Geostrategic Outlook to 2024 - Workshop 4 By feedproxy.google.com Published On :: Thu, 09 Jan 2020 11:15:01 +0000 Invitation Only Research Event 26 November 2019 - 9:30am to 12:00pm Gateway House, Stevens Street, Colaba This closed-door roundtable explores possible strategic shifts in the Indo-Pacific between now and 2024.Focusing on trade security, climate change disruptions and security cooperation, it aims to enhance the understanding of the regional goals of, and strategic relationships between, the key countries active in the region.The workshop is part of a larger project funded by the Strategic Policy Division of the Australian Department of Defence.The project includes workshops in the United States, the United Kingdom, France, Japan, India and the Pacific Islands (Tonga). Department/project Asia-Pacific Programme, Geopolitics and Governance, Sustainable and Inclusive Growth, Trade, Investment and Economics, Energy, Environment and Resources Programme Anna Aberg Research Analyst, Energy, Environment and Resources Programme 020 7314 3629 Email Full Article
sho The Indo-Pacific: Geostrategic Outlook From Now to 2024 - Workshop 5 By feedproxy.google.com Published On :: Mon, 17 Feb 2020 14:25:01 +0000 Invitation Only Research Event 18 February 2020 - 12:00pm to 4:30pm Langafonua Centre This roundtable explores possible strategic shifts in the Indo-Pacific between now and 2024. Focusing on trade security, climate change disruptions and security cooperation, it aims to enhance the understanding of the regional goals of, and strategic relationships between, the key countries active in the region.The workshop is part of a larger project funded by the Strategic Policy Division of the Australian Department of Defence. The project includes workshops in the United States, the United Kingdom, France, Japan, India and the Pacific Islands (Tonga). Department/project Asia-Pacific Programme, Sustainable and Inclusive Growth, Trade, Investment and Economics, Energy, Environment and Resources Programme Anna Aberg Research Analyst, Energy, Environment and Resources Programme 020 7314 3629 Email Full Article
sho For Many Small Businesses, U.S. Coronavirus Aid Falls Short By www8.gsb.columbia.edu Published On :: Wed, 06 May 2020 17:45:47 +0000 Business Economics and Public Policy Healthcare Friday, May 1, 2020 - 13:45 Full Article
sho How to get the full URL from a list of short URLs? By forums.digitalpoint.com Published On :: Sat, 09 May 2020 04:42:30 +0000 Full Article
sho Report of the African Regional Workshop on the Nagoya - Kuala Lumpur Supplementary Protocol on Liability and Redress By www.cbd.int Published On :: Mon, 12 Sep 2011 00:00:00 GMT Full Article
sho Report of the Asia-Pacific Regional Workshop on the Nagoya - Kuala Lumpur Supplementary Protocol on Liability and Redress By www.cbd.int Published On :: Thu, 08 Dec 2011 00:00:00 GMT Full Article
sho Report of the Workshop on Capacity-building for research and information exchange on socio-economic impacts of Living Modified Organisms under the Cartagena Protocol on Biosafety By bch.cbd.int Published On :: Thu, 08 Mar 2012 00:00:00 GMT Full Article
sho Report of the workshop on capacity-building and exchange of experiences as related to the implantation of paragraph 2 of article 18 of the biosafety protocol now available. By www.biodiv.org Published On :: Fri, 13 Apr 2012 00:00:00 GMT Full Article
sho Report of the Pacific Sub-regional Workshop on Capacity-building for the Effective Implementation of the Biosafety Protocol By bch.cbd.int Published On :: Tue, 01 May 2012 00:00:00 GMT Full Article
sho Report of the Inter-Regional Workshop on Capacity Needs for the Implementation of the Nagoya - Kuala Lumpur Supplementary Protocol on Liability and Redress By www.cbd.int Published On :: Tue, 26 Jun 2012 00:00:00 GMT Full Article
sho Report of the Africa Regional Capacity-building Workshop on Public Awareness, Education and Participation concerning the Safe Transfer, Handling and Use of Living Modified Organisms By bch.cbd.int Published On :: Tue, 26 Feb 2013 00:00:00 GMT Full Article
sho Report of the Asia-Pacific regional training workshop on public awareness, education and participation concerning the safe transfer, handling and use of LMOs is now available. By bch.cbd.int Published On :: Tue, 30 Jul 2013 00:00:00 GMT Full Article
sho The Report of the Workshop of the Network of Laboratories for the Detection and Identification of LMOs is now available. By www.cbd.int Published On :: Tue, 11 Feb 2014 00:00:00 GMT Full Article
sho The report of the workshop of the Network of Laboratories for the Detection and Identification of Living Modified Organisms is now available. By www.cbd.int Published On :: Thu, 01 Oct 2015 00:00:00 GMT Full Article
sho The report of the GRULAC Workshop on the Detection and Identification of Living Modified Organisms is available. By www.cbd.int Published On :: Wed, 25 Jan 2017 00:00:00 GMT Full Article
sho The report of the workshop on developing capacity for national border controls on living modified organisms in small island developing States in the Caribbean is available. By www.cbd.int Published On :: Wed, 25 Jan 2017 00:00:00 GMT Full Article
sho The report of the workshop on developing capacity for national border controls on living modified organisms in Pacific small island developing States is now available. By bch.cbd.int Published On :: Wed, 21 Jun 2017 00:00:00 GMT Full Article
sho Why founders shouldn't worry about founder-market fit By www.techworld.com Published On :: Thu, 30 Jan 2020 09:00:00 GMT As the venture capital world gets a hot new buzz phrase in 'founder-market fit', serial founder Alex Depledge counters with her view that industry experience doesn't help founders crack a market Full Article
sho CBD Communiqé: Training Workshop for Government Officials in the Use of the Biosafety Clearing-House Successfully Concluded. By www.cbd.int Published On :: Sun, 11 May 2008 00:00:00 GMT Full Article