Described herein are doppel-targeting molecules useful for inhibiting pathological angiogenesis and treating diseases and conditions associated with pathological angiogenesis, such as tumors, cancers, atherosclerosis, tuberculosis, asthma, pulmonary arterial hypertension (PAH), neoplasms and neoplasm-related conditions, and for detecting doppel expression in a subject. Related compositions and methods also are described.

Provided herein are methods of treatment to regenerate, restore or rejuvenate a tissue. Methods include making adult somatic and germ cells pluripotent for administration to a patient. Alternatively, created pluripotent cells may be differentiated to the desired tissue type and administered to a patient to repair or enhance the target tissue.

Non-naturally occurring peptides are provided that act as a Src SH2 domain antagonist of cardiotonic steroids. Pharmaceutical compositions comprising the peptides are also provided along with vectors encoding the peptides. Methods of treating a Src-associated disease and reducing Src activity in a cell are further provided and include administering or contacting a cell with an effective amount of the peptide.

The invention relates to polynucleotide agents targeting the complement component C5 gene, and methods of using such polynucleotide agents to inhibit expression of C5 and to treat subjects having a complement component C5-associated disease, e.g., paroxysmal nocturnal hemoglobinuria.

Provided herein are compositions and methods for modifying a predetermined nucleic acid sequence. A programmable nucleoprotein molecular complex containing a polypeptide moiety and a specificity conferring nucleic acid (SCNA) which assembles in-vivo, in a target cell, and is capable of interacting with the predetermined target nucleic acid sequence is provided. The programmable nucleoprotein molecular complex is capable of specifically modifying and/or editing a target site within the target nucleic acid sequence and/or modifying the function of the target nucleic acid sequence.

The invention provides diagnostic and therapeutic targets for pulmonary disease, in particular, fibrotic lung disease. The inventors have found that a genetic variant MUC5B gene is associated with increased expression of the gene, increased risk of developing a pulmonary disease, and an improved prognosis and survival among those developing the pulmonary disease.

Provided herein are methods for the prognosis of prostate cancer progression in a patient by analyzing the gene expression in a tumor sample obtained from the patient the prognosis of prostate cancer progression in a patient by analyzing the gene expression in a tumor sample obtained from the patient. In particular, gene expression levels of GCOM1, MEX3D, TRPM4, ATPAF1, PTRF, GLYATL1, FLNA, OBSCN, STRA13, WHSCl, ARFGAP3, KDM2A, FAM83H, CLDN7, CNOT6, and B3GNT9 are measured. Kits containing means for the measurement of gene expression as described herein and methods for treatment of prostate cancer are also provided.

Fibrous structures that exhibit a novel combination of properties and to methods for making such fibrous structures are provided.

Rebaudioside M compositions with improved aqueous solubility and methods for preparing the same are provided herein. The rebaudioside M compositions include (i) disordered crystalline compositions comprising rebaudioside M and rebaudioside D, (ii) spray-dried compositions comprising rebaudioside M, rebaudioside D and steviol glycoside mixtures and/or rebaudioside B and/or NSF-02, (iii) spray-dried compositions comprising rebaudioside M, rebaudioside D and at least one surfactant, polymer, saponin, carbohydrate, polyol, preservative or a combination thereof. Sweetened compositions, such a beverages, containing the rebaudioside M compositions with improved water solubility are also provided herein.

The brewing system disclosed herein includes a spinning or rotating inlet nozzle for use in intermixing hot water and coffee in a coffee cartridge. The inlet nozzle may include one or more flow ports that inject hot water into an inner chamber of the coffee cartridge at select angles, locations and pressures to create the desired fluidized mixture of hot water and beverage medium. Such an inlet nozzle may be adapted for use in commercial coffee brewers and the amount of coffee brewed may be user regulated with an external indicator dial coupled to a controller-regulated rheostat that governs fluid flow to the brewer head by taking readings from a pump, flow meter or strain gauge.

Pancake mixes comprising at least one type of whole grain flour, at least one natural sweetener, at least one fat and a leavening system are provided herein. Packaged food products comprising single-serving containers containing said pancake mixes, as well as methods of preparing pancakes, are also provided. The pancakes described herein are preferably 100% whole grain and free from preservatives and/or artificial colorings.

Cat food products are provided. The cat food product may comprise a single sealed container comprising 10 g to 40 g of a complete and balanced semi-moist or wet cat food, or may comprise a plurality of such sealed containers. Methods of providing a cat food are also provided and comprise filling a container with from 10 g to 40 g of a complete and balanced semi-moist or wet cat food and sealing the container.

The present invention is directed to recombinant thraustochytrids that grow on sucrose and cell cultures comprising the recombinant thraustochytrids as well as methods of producing cell cultures, biomasses, microbial oils, compositions, and biofuels using the recombinant thraustochytrids.

An adaptor tool comprises a locking pin removably engaged with a main body defining a hook portion. The main body is configured to pivot about a pivot pin. The adaptor tool further includes a first link having first and second ends, and a first contact face. The first link is configured to receive the locking pin. A second link includes first and second ends, and a second contact face. The second link is pivotally coupled to the main body via the pivot pin. At least a third link includes first and second ends, and a third contact face. The first, second, and at least third links are pivotally coupled end-to-end such that the first, second, and third contact faces define a circular opening. The circular opening is configured to receive a workpiece such that rotational force applied to the main body rotates the adaptor tool and the workpiece.

A method for assembling a structure is described. The method includes locating a position in an assembly stack-up where a one-sided fastener is to be installed, drilling a hole through the assembly stack-up at the position, countersinking the hole to a specified depth, operating a calibrated probe to determine at least parameter associated with one or more of the hole and the stack-up proximate the hole, inserting the one-sided fastener into the hole, applying a rotational torque to the one-sided fastener to complete installation of the one-sided fastener, and comparing a measurement of angular displacement required to complete installation of the one-sided fastener to a range of angular displacement indicative of correct installation of the fastener.

Tools (100) are provided for use in uncapping one or more of a plurality of linearly-oriented, spaced-apart tubes; each cap having a cap upper surface with a depression. The tools comprise a body (30) having first portion (40) for engagement by a user and a second portion (50) for engaging a plurality of caps. The second portion comprises a plurality of spaced-apart projections (60). Each projection is configured for releasably engaging a cap. The projection may comprise two or more spaced-apart projection elements (62,64). Optionally, the first portion is configured in a non-coplanar relationship with respect to the second portion. Methods of use are also provided.

A composite material includes a composite body having a composite surface, and a reinforcing element extending through the composite body in a first plurality of stitches and a second plurality of stitches. The first plurality of stitches are aligned relative to the composite surface substantially similarly to each other. The second plurality of stitches are aligned relative to the composite surface substantially dissimilarly to each other.

Systems and methods for creating quilt blocks are provided. In one embodiment, a method for creating a quilt block with a computerized embroidery machine includes sewing placement stitching on a backing according to a placement stitching pattern provided by instructions for at least partially creating a quilt block comprised of one or more pieces, providing directions for placing one or more pieces of the quilt block on a corresponding portion of the placement stitching on the backing, and sewing the one or more pieces to the backing in accordance with the instructions.

A carpet and method for producing same that comprises an enhanced seam suitable for separation of an installation portion of the carpet and sacrificial edge portions of the produced carpet.

The present disclosure relates to methods and apparatuses for assembling diapers, each including a chassis connected with front and back elastic belts. As discussed in more detail below, opposing end regions of the chassis are connected with regions of the elastic belts where the elasticity of the elastic belts has been removed or deactivated. An elastic laminate may be formed by continuously bonding elastic strands between a first continuous substrate layer and a second continuous substrate layer such that the elastic strands are bonded to both the first substrate layer and the second substrate layer in heavy-bond regions. And the elastic strands are bonded to the first substrate layer and/or the second substrate layer with in light-bond regions. The elastic strands are then intermittently deactivated by cutting the strands into one or more discrete pieces in the light-bond regions. The discrete pieces retract and remain in the light-bond regions.

A method includes performing a patterning step on a layer using a process gas. When the patterning step is performed, a signal strength is monitored, wherein the signal strength is from an emission spectrum of a compound generated from the patterning step. The compound includes an element in the patterned layer. At a time the signal strength is reduced to a pre-determined threshold value, the patterning step is stopped.

A composition comprising at least one nutrient element, wherein the at least one nutrient element possesses a relative energy-state value greater than the relative energy-state value of the at least one nutrient element in a preexisting state, the composition being effective, perhaps because of the greater energy-state value, to improve the ability of a soil, when combined with the composition, to support plant growth better than the soil, when not combined with the composition. Also a composition comprising at least one nutrient element, wherein the composition possesses an energy spectrum more positive than the energy spectrum of the composition in a preexisting state, the composition being effective, perhaps because of the more positive energy spectrum, to improve the ability of a soil, when combined with the composition, to support plant growth better than the soil, when not combined with the composition. Methods of making and using the same for improving soil, plants, plant growth, seeds, and/or plant products, including quality of plant products, are also disclosed, as well as improved soil, seeds, including quality of seeds, plants, and/or plant products, including quality of plant product.

An esteramide compound of the following formula (I): R1OOC-A-CONR2R3 (I) is described, wherein: A is a covalent bond or a methylene group —CH2—;R1 is an optionally substituted, saturated or unsaturated aliphatic or cycloaliphatic hydrocarbon group including from 5 to 36 carbon atoms,R2 and R3, either identical or different, are groups selected from a hydrogen atom, and optionally substituted hydrocarbon groups, preferably including from 1 to 36 carbon atoms, andR2 and R3 not being simultaneously hydrogen atoms. Also described, are applications for using the esteramide compound, notably as a solvent.

Disclosed are methods of enhancing plant growth, comprising treating seed at least one month prior to planting with an effective amount of a plant signal molecule, wherein upon harvesting the plant exhibits at least one of increased plant yield measured in terms of bushels/acre, increased root number, increased root length, increased root mass, increased root volume and increased leaf area, compared to plants harvested from untreated seed, or compared to plants harvested from seed treated with the signal molecule just prior to or within a week or less of planting.

Methods of inducing bud break of deciduous fruit vines, trees, or shrubs following dormancy by the application of bud breaker compositions that do not contain hydrogen cyanamide.

A water-insoluble phosphate fertilizer, methods of producing, and methods of using the same are provided. The fertilizer may comprise at least one alkaline earth metal selected from calcium and magnesium and optionally at least one nutrient ion selected from the group consisting of potassium, ammonium, zinc, iron, manganese, copper, boron, chlorine, iodine, molybdenum or selenium. The fertilizer compounds are preferably water-insoluble, dilute acid-soluble, and free-flowing powders.

Methods are provided for processing municipal human waste such that the processed material is is greater than 99% free of pathogenic organisms. The processed material can be used as an organic fertilizer or a “Class A” organic fertilizer. The methods include reducing the moisture content of human sludge free of polymeric flocculant to less than about 30% moisture and processing the sludge through an extruder under conditions having a minimum temperature of about 140° C., a residence time of about 30 seconds, and an atmospheric pressure differential of about 40 atmospheres. The methods are economical and have numerous advantages including reduced use of fossil fuel, fast processing time, and production of an odor free organic fertilizer free of many land use restrictions.

A composition includes a first chelating agent, a second chelating agent, and a plurality of metal ions. In one embodiment, the second chelating agent includes citric acid and is different than the first chelating agent. A method for forming a composition includes mixing a first chelating agent, a second chelating agent, and a metal salt together to form a mixture and processing the mixture to form at least one of a granulated composition and a powdered composition. In some embodiments, the second chelating agent includes citric acid and is different than the first chelating agent.

An improved composition comprising substantial spherical UFP particles and an active agent, such as NBPT, and optionally other components is used as an additive for liquid and solid fertilizers, typically containing urea. Methods of making the compositions and their use are also disclosed.

Described herein are methods and systems for generating shared collaborative maps for planting or harvesting operations. A method of generating a collaborative shared map between machines includes generating a first map for a first machine based on a first set of data and generating a second map for a second machine based on a second set of data. The method further includes generating at least one shared collaborative map for at least one of the first and second machines based on the first and second maps.

A method for operating a window cover utilizes an extendible window cover having a first rail, a second rail and a pair of lift cords. The first and second rails of the window cover are movable relative to each other. According to the method, at least one of the first rail and the second rail is moved in a first direction to cause the lift cords to unwind from the lift cord pulleys, thereby rotating a lift cord pulley shaft and a set of gears. Further, at least one of the first rail and the second rail is moved in a second direction to cause the lift cords to wind on the lift cord pulleys, with the lift cord pulley shaft rotating in an opposite direction.

A window cover system includes an extendible window cover with a pair of lift cords. A lift cord pulley shaft is coupled to a pair of spaced apart lift cord pulleys. A spring drive unit has a beveled gear system with a first gear that is spring biased to resist rotation of first gear in one direction of rotation, and a second gear meshed with the first gear. The lift cord pulley shaft extends through the second gear and is configured to rotate therewith.

Methods and devices for inline sampling of a bulk material, such as a powder, are provided. The material's bulk density can be determined from samples drawn using methods and devices described herein. One embodiment of a method of sampling a material allows the material to flow through a sampling compartment, closes off the flow of material below the sampling compartment, builds up a column of material through the sampling compartment, shifts the sampling compartment to remove a slice of material in the column, and places the slice of material into a sample container. A device for sampling a material is provided in another embodiment. The device includes an inlet, an outlet aligned with the inlet, and a sample collector. The sample collector can include at least one through hole and be configured to move such that the at least one through hole can be moved into and out of alignment with the inlet and the outlet.

A device for controlling fluid flow pressure and flow rate is disclosed. The device includes a first orifice plate, a second orifice plate housed in a tubular structure. The first orifice plate includes a first orifice of a first diameter (d1) and the first orifice is positioned near an edge of the first orifice plate. The second orifice plate includes a second orifice of a second diameter (d2) and the second orifice is positioned near an edge of the second orifice plate. The tubular structure has an effective diameter (D) comprising the first orifice plate and the second orifice plate placed at perpendicular direction to the fluid flow within the tubular structure, separated by an optimum distance (X).

An equipment complex for deploying and recovering marine geophysical seismic or electric-survey bottom stations is mounted on a ship. The complex includes—a powered capstan, —rotatable turntables and rolls, —load-bearing units connected to the bottom stations by various fasten means and capable of winding onto the capstan and turntables, a work platform supporting a bottom station placed thereon, —an indicator for registration of the bottom stations' coordinates, mounted on the platform, —a limit switch mounted on the platform, switching ON when the bottom station is placed on the work platform, and OFF when it's removed therefrom providing for operation of the indicator. The complex may include floating buoys, damping loads, and halyards for deploying the stations. Methods for deploying and recovering the bottom stations using the equipment complex are described. Some recovering methods contemplate winding the load-bearing units onto the capstan, while switching the turntables for each subsequent load-bearing unit.

Marine vehicle systems and methods are disclosed. The marine vehicle can be buoyancy controlled, enabling efficient, extended use of the marine vehicle. Buoyancy actuation can enable roll, pitch, and yaw of the marine vehicle, as well as translation in any direction. One or more elastic bladders can be disposed on or in the marine vehicle. The bladders can be selectively inflated and deflated to control movement of the marine vehicle.

Methods and apparatuses for drying electronic devices are disclosed. Embodiments include methods and apparatuses that heat and decrease pressure within the electronic device. Some embodiments increase and decrease pressure while adding heat. Other embodiments include a desiccator for removing moisture from the air being evacuated from the electronic device prior to the air reaching an evacuation pump. Further embodiments detect humidity within the low-pressure chamber and determine when to increase and/or decrease pressure based on the humidity. Still further embodiments determine that the device is sufficiently dry to restore proper function based on the detected humidity, and in some embodiments based on the changes in humidity while pressure is being increased and/or decreased. Still further alternate embodiments automatically control some or all aspects of the drying of the electronic device. Additional embodiment disinfect the electronic device.

Systems and methods for separating fluids from drill cuttings. Specifically, the invention relates to shakers that incorporate a vacuum system and methods of operating such systems to effect a high degree of fluid separation. The system and methods are effective across a variety of screen sizes, vacuum flows and vacuum designs.

Systems and methods for efficient microwave drying of extruded honeycomb structures are disclosed. The methods include conveying first and second sets of honeycomb structures in opposite directions through multiple applicator cavities. Each honeycomb structure has a moisture content MC, and the honeycomb structures within each cavity define an average moisture content MCA between 40% and 60% therein. The methods include irradiating the first and second sets of honeycomb structures within the cavities with microwave radiation having an amount of input microwave power PI that results in an amount of reflected microwave power PR from the honeycomb structures, where PR

Earth-boring tools include a body, one or more blades projecting outwardly from the body, and cutting elements carried by the blade. The cutting elements include at least one shearing cutting element and at least one gouging cutting element. Methods of forming an earth-boring tool include mounting a shearing cutting element comprising an at least substantially planar cutting face to a body of an earth-boring tool, and mounting a gouging cutting element comprising a non-planar cutting face to the body of the earth-boring tool. The gouging cutting element may be positioned on the body of the earth-boring tool such that the gouging cutting element will gouge formation material within a kerf cut in the formation material by the shearing cutting element, or between kerfs cut in the formation material by a plurality of shearing cutting elements.

Described herein are methods for training a machine learning-based predictor of affective response to stimuli. The methods involve receiving samples comprising temporal windows of token instances to which a user was exposed, and target values representing affective response annotations of the user in response to the temporal windows of token instances. This data is used for the training of the predictor along with values indicative of the number of the token instances in the temporal windows of token instances, which are used to compensate for non-linear effects resulting from saturation of the user.

Embodiments of the invention relate to superabrasive compacts including multiple superabrasive cutting portions and methods of repairing a rotary drill bit that employs at least one of such superabrasive compacts.

A cutting table includes a cutting surface, an opposing surface, a cutting table outer wall, and one or more fins. The cutting table outer wall extends from the circumference of the opposing surface to the circumference of the cutting surface. The fins extend from a portion of the cutting surface to a portion of the cutting table outer wall. The cutting table is optionally leached prior to forming the fins. One or more fins are positioned in parallel with at least another fin in some embodiments. In some embodiments, the fins are positioned circumferentially around the cutting surface. In some embodiments, the cutting table is coupled to a substrate to form a cutter. The fins are formed either after or during the formation of the cutting table.

A method of manufacturing a roller cone drill bit may include forming a body of a single piece having an upper end and a lower end; machining at the lower end of the body at least two journals extending downward and radially outward from a central axis of the body; machining at least one of a ball passage, a hydraulic fluid passageway, a grease reservoir, and a lubricant passageway; and mounting roller cones on the at least two journals.

A method of thermo-mechanically processing a preform composed of tool steel and a tool to modify a workpiece. The preform has a region containing austenite. The method comprises establishing the region at a process temperature between a martensitic start temperature and a stable austenitic temperature. While at the process temperature, the region is deformed to change an outer dimension and to modify the microstructure to a depth of 1 millimeter or more. The tool comprises a member composed of tool steel. The member includes a first region that extends from the outer surface to a depth of greater than 1 millimeter and a second region. The first region includes a plurality of grains having an average misorientation angle greater than about 34°, an average grain size that is at least 10% smaller than the second region, and has a different grain orientation than the second region.

Earth-boring drill bits include a bit body, an element having an attachment feature bonded to the bit body, and a shank assembly. Methods for assembling an earth-boring rotary drill bit include bonding a threaded element to the bit body of a drill bit and engaging the shank assembly to the threaded element. A nozzle assembly for an earth-boring rotary drill bit may include a cylindrical sleeve having a threaded surface and a threaded nozzle disposed at least partially in the cylindrical sleeve and engaged therewith. Methods of forming an earth-boring drill bit include providing a nozzle assembly including a tubular sleeve and nozzle at least partially within a nozzle port of a bit body.

Systems and methods for fitness tracking are provided. An exercise apparatus is in networked communication with a fitness tracking computing system. The configuration and location of movable components of the exercise apparatus is determined based on sensors. This information is provided to the fitness tracking computing system via networked communication.

A device and methods for bilateral or unilateral physical therapy of lower limbs are disclosed. The device comprises a curved rail mounted on a base and a pair of support members configured to accommodate a portion of a leg of a person, and to slide along the curved rail. The curved rail allows lateral movements of the lower limbs with the support members, the movements being driven by a force of the lower limbs. The methods of the invention allow physical unilateral or bilateral therapy of lower limbs of a person. The initial reinforcement of the lower limbs of a person is improved by the use of this device, which reduces the friction or the resistance caused by the device during the prescribed movements. The invention provides to patients with severe lower limb disability, a physical therapy device that is easy to use with minimum supervision by a physical therapist.

Gas-generating devices with grain-retention structures and related methods and systems are described. In particular, gas-generating devices having at least one retention structure fixed to a frame and positioned between adjacent gas-generant grains arranged in a longitudinal stack. Fire suppression systems comprising such gas-generating devices are also described. Additionally, methods of manufacturing gas-generating devices, as well as methods of generating a gas and methods of suppressing a fire utilizing such gas-generating devices are described.

A substantially nitrocellulose-free insensitive gun propellant for barrel-type weapons is provided. The gun propellant includes at least one nitramine, such as HMX and/or RDX, a second energetic, and an inert binder system. The gun propellant is capable of producing a maximum projectile velocity exceeding 2680 ft/sec when fired from a 5 inch 54 caliber gun and gives a response to slow cook-off insensitive munitions testing of Type 4 or higher, and a response to fragment impact insensitive munitions testing of Type 3 or higher as measured by STANAG 4382 and STANAG 4496, respectively. Also provided is an ammunition round assembly, and an armament system.