A l’occasion de l’anniversaire des 400 ans de la traversée du navire marchand Mayflower, le nouveau Mayflower Autonomous Ship (MAS) partira le 16 septembre 2020 de Plymouth au Royaume-Uni, pour rejoindre Plymouth dans le Massachussetts aux Etats-Unis. Sans équipage à bord, il sera le premier navire autonome de grande taille à traverser l’Atlantique. Cette traversée unique entremêlant passé, présent et futur propulsera le monde dans l’ère du navire autonome.

1. Tributes flow after death of veteran journalist Frank Crook  Sydney Morning Herald
2. Editor, broadcaster, raconteur and writer’s writer Frank Crook dies  Daily Telegraph
3. View Full coverage on Google News

Number 5: It's impossible to overwater terracotta pots. READ MORE...

On this week's show there's managerial change in North London but it's taken place at Sp*rs, who have made themselves even more unpalatable than ever by appointing Jose Mourinho. I'm joined by Philippe Auclair to discuss the firing of Pochettino and their embrace of evil, how it stacks up in the context of what's happening at Arsenal right now, Unai Emery's performance, the lack of fun around our games, and lots more. There's a good dollop of the usual waffle too, and some incredible singing from James as he reprises his Billboard Chart Number 1 from this week's Arsecast Extra.

Follow Philippe @PhilippeAuclair and vote for Arseblog the FSA Awards for Best Fan Media: https://www.surveymonkey.co.uk/r/fsa-awards-2019

See acast.com/privacy for privacy and opt-out information.

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August 11th, 2019
Flow Festival in Finland
Scheduled to start at 8:30 pm

In the US that's a start time of 1:30 pm eastern, 12:30 pm central, 11:30 am mountain, 10:30 am pacific.

There will be a livestream here and here, but you will probably need to use a VPN in most places.

Setlist: Shake Dog Shake, Burn, Fascination Street, Never Enough, Push, In Between Days, Just Like Heaven, Last Dance, Pictures of You, High, A Night Like This, Just One Kiss, Lovesong, From the Edge of the Deep Green Sea, A Strange Day, Play For Today, A Forest, Primary, 39, One Hundred Years

Encore: Lullaby, The Caterpillar, The Walk, Friday I'm in Love, Close to Me, Why Can't I Be You?, Boys Don't Cry.

Crystalline materials known as topological insulators conduct surface current perfectly, except when they don't. In two new studies published in the journal Science, Princeton researchers and their collaborators explain how these "fragile" poorly conducting topological states form, and how conductivity can be restored.

Princeton ecologists Peter and Rosemary Grant led a team of researchers to discover how genetics and hybridization affected the beak shape of finches on the Galápagos Islands.

My virtual trip has taken me to Denmark . Another country added to the list and another magnet purchased for the board in the kitchen . So thoughts on Denmark . I wonder what the roads will be like. Will they resemble the de dum de dum roads of Belgium or

Folks in the neighborhood where the 7-year-old was struck and killed 24 hours earlier couldn’t help but notice the new arrivals Friday: Two guards positioned at the intersection near a homemade memorial honoring the lost and lovable child.

Infomercial nostalgia, YouTube haircut tutorials and the piercing pain of at-home nose-waxing are at your fingertips.

For the best flavor, lightly char the outside of a whole cauliflower, then drench it in a bright lemon-tahini sauce.

For the best flavor, lightly char the outside of a whole cauliflower, then drench it in a bright lemon-tahini sauce.

When COVID-19 hit, spoken-word venues like Da Poetry Lounge and Olivia Open Mic went online, keeping verse flowing and raising funds for artists.

IndyStar walks through the closed gardens at Newfields, Friday, April 24, 2020.

Newfields' gardens usually draw thousands of visitors this time of year. While it's closed because of the coronavirus, see a photo tour of the blooms.

IndyStar walks through the closed gardens at Newfields, Friday, April 24, 2020.

Los Angeles' mayor allows wholesale dealers to start selling under strict social distancing guidelines.

Two Indians flown back from Gulf to Kerala test Covid-19 positive  Hindustan TimesView Full coverage on Google News

The Ottawa River Regulation Planning Board has released its final spring freshet forecast, which predicts a steady decrease in levels.

“April showers bring May flowers.” Perhaps this is why May is National Flower Month. Indulge your green thumb with this week’s website picks about flowers.

If you’re training a machine learning model but aren’t sure how to put it into production, this book will get you there. Kubeflow provides a collection of cloud native tools for different stages of a model’s lifecycle, from data exploration, feature preparation, and model training to model serving. This guide helps data scientists build production-grade machine learning implementations with Kubeflow and shows data engineers how to make models scalable and reliable.

MPU 046: Workflows with Merlin Mann II « Mac Power Users

• Download MP3
• Huffduff It

I have the life that I have because I've made a lot of weird decisions, and they've worked out well.

Not gonna lie to you. I'm a huge nerd. Surprised?

Yep. I can recite big chunks of The Big Lebowski from memory. I can argue for an hour on the merits of Dick York over Dick Sargent. And, I can—and frequently do—catch myself thinking Catwoman, Batgirl, Princess Leia, and Emma Peel should have a light-hearted pillow fight that ends with an hour of genial french-kissing.

Pretty much like you, probably. I dunno, maybe your version includes Kitty Pryde. Po-tay-to/Po-taht-o, right?

Perhaps most saliently, by virtue of having spent a solid 2,399 days as a Fake Productivity Guru, I have been provided with an unquestionably Janusian monkey's paw of a gift; I now know a lot about workflows. Nerdy, nerdy workflows.

I can tell you a few things that almost always work, I can tell you a handful of things that almost never work, and—best or worst of all—I can tell you thousands of things that might work. Sometimes. Maybe. Kinda. For some people. For now.

And, at the risk of gay-marrying my arrogance to my hypocrisy, I can tell you that I also know enough about the unholy diarrhea of potential options for Theoretical Productivity to share two big patterns:

1. Getting your workflow right matters.
2. Getting your workflow right to the exclusion of the actual work is a fool's game.

But. Managing to get the most useful and most elegant and least fiddly mix of 1 and 2 right is super-hard. Especially for nerds. Especially for me.

So, as I type this today, I believe there can be no greater testament to these claims—or, at least, no greater place to test the veracity of these claims for yourself—than in this TWO AND A HALF HOUR-long interview for Mac Power Users.

It is reeeeeeeeally nerdy. Almost intolerably nerdy. Just…overwhelmingly nerdy.

But, man, is it ever really good, and really fat with the most insanely granular details of How I Work.

Lo, even these 928.5 days after officially retiring from productivity pr0n, my desire to not "vend stroke material for your joyless addiction to puns about procrastination and systems for generating more taxonomically satisfying meta-work" is tempered by a (widely under-reported) practical streak.

Yes: I continue to despise empty advice about rearranging deck chairs on The Titanic. But, yes: I do also still very much enjoy talking about how all the tips and tricks can or can't work in the context of work you care about. That matters. It really does.

So. Here goes. A one hundred and forty six minute-long, Joyce-ian amble through the Big Stuff and the Little Stuff. David and Katie were very patient.

How I name text files. Why I break iOS apps. Why I love the letter "x." Why I won't row out to islands any more. How a 115,000 word book manuscript is "like a house full of confederate money." How "The Cloud" broke in New Zealand. How I use MultiMarkdown, Scrivener, TextExpander, OmniFocus, TextMate, Notational Velocity, Dropbox, and an explosive combination of Elements, Notesy, Nebulous, Simplenote, CF Outliner, iThoughts, Instacast, Good Reader, and wow wow wow.

How I try not to fiddle—how I sometimes succeed and often don't. But, how I try.

Anyhow. There you go. A perfectly nerdy bookend to last year's first Magnum Opus MPU interview on these same topics, Mac Power Users Episode 46 is just insanely nerdy. And, what have you.

I hope you like it. I hope it's useful. I hope you don't use it to replace real work.

And, as ever, I really hope Batgirl starts having more sexy pillow fights.

Enjoy. And, God save you.

MPU 046: Workflows with Merlin Mann II « Mac Power Users

• Download MP3
• Huffduff It

1 August 2014 , Volume 70, Number 4

The map (click below to download the PDF) shows how the proportion of migrants living in countries of the European Union has changed since 1990.

• The Perks of Being A Wallflower Review
• Beasts of the Southern Wild Review
• What We Watched

Albert Chau and Man-Chun Lee
Trans. Amer. Math. Soc. 373 (2020), 3627-3647.
Abstract, references and article information

The banking sector today launched a scheme to alleviate the cashflow pressure faced by corporate customers in light of the economic challenges brought about by the COVID-19 outbreak.

Jointly announced by the Monetary Authority and the Banking Sector SME Lending Coordination Mechanism, the Pre-approved Principal Payment Holiday Scheme is estimated to cover more than 80% of all corporate borrowers in Hong Kong.

All corporate customers that have an annual sales turnover of $800 million or less and with no outstanding loan payments overdue for more than 30 days are eligible for the scheme.

Eligible customers’ loan principal payments due within a six-month period between May 1 and October 31 this year will be pre-approved for deferment.

The loans’ principal payments, including revolving facilities, will generally be deferred by six months, whereas trade facilities, given their short-term nature, will be deferred by three months.

The scheme does not cover syndicated loans or loans used for financing purchases of shares or other financial assets.

Banks will begin informing eligible customers of the pre-approval under the scheme as soon as practicable. Eligible customers do not need to apply. They only need to contact the bank within 14 days of the bank’s notice to confirm the detailed arrangements.

The authority has issued a circular requesting all banks to participate in the scheme and has received support from all 11 major lenders in the co-ordination mechanism.

It will monitor the scheme’s operation and maintain close dialogue with banks.

This SAS Note provides instructions about how to enable SAS Workflow Studio log generation and debugging in order to troubleshoot a problem in SAS Workflow Studio. On the client machine where&

(Clemson University) While the world admires the beauty and fragrance of flowers, most of us are missing out on the extraordinary processes these seemingly delicate life forms are carrying out every moment of the day. Matthew Koski, an assistant professor at Clemson, is not only paying attention, he is advancing his research with a three-year, $455,000 grant from the NSF for a study of flower adaptations titled 'Modifying the floral microenvironment: elevational divergence in floral thermoregulatory mechanisms.'

David Cluet
Apr 1, 2020; 19:701-715
Technological Innovation and Resources

Eelke P. Béguin
Apr 24, 2020; 0:RA120.001964v1-mcp.RA120.001964
Research

We present a technological advancement for the estimation of the affinities of Protein-Protein Interactions (PPIs) in living cells. A novel set of vectors is introduced that enables a quantitative yeast two-hybrid system based on fluorescent fusion proteins. The vectors allow simultaneous quantification of the reaction partners (Bait and Prey) and the reporter at the single-cell level by flow cytometry. We validate the applicability of this system on a small but diverse set of PPIs (eleven protein families from six organisms) with different affinities; the dissociation constants range from 117 pm to 17 μm. After only two hours of reaction, expression of the reporter can be detected even for the weakest PPI. Through a simple gating analysis, it is possible to select only cells with identical expression levels of the reaction partners. As a result of this standardization of expression levels, the mean reporter levels directly reflect the affinities of the studied PPIs. With a set of PPIs with known affinities, it is straightforward to construct an affinity ladder that permits rapid classification of PPIs with thus far unknown affinities. Conventional software can be used for this analysis. To permit automated analysis, we provide a graphical user interface for the Python-based FlowCytometryTools package.

The vessel wall is continuously exposed to hemodynamic forces generated by blood flow. Endothelial mechanosensors perceive and translate mechanical signals via cellular signaling pathways into biological processes that control endothelial development, phenotype and function. To assess the hemodynamic effects on the endothelium on a system-wide level, we applied a quantitative mass spectrometry approach combined with cell surface chemical footprinting. SILAC-labeled endothelial cells were subjected to flow-induced shear stress for 0, 24 or 48 hours, followed by chemical labeling of surface proteins using a non-membrane permeable biotin label, and analysis of the whole proteome and the cell surface proteome by LC-MS/MS analysis. These studies revealed that of the >5000 quantified proteins 104 were altered, which were highly enriched for extracellular matrix proteins and proteins involved in cell-matrix adhesion. Cell surface proteomics indicated that LAMA4 was proteolytically processed upon flow-exposure, which corresponded to the decreased LAMA4 mass observed on immunoblot. Immunofluorescence microscopy studies highlighted that the endothelial basement membrane was drastically remodeled upon flow exposure. We observed a network-like pattern of LAMA4 and LAMA5, which corresponded to the localization of laminin-adhesion molecules ITGA6 and ITGB4. Furthermore, the adaptation to flow-exposure did not affect the inflammatory response to tumor necrosis factor α, indicating that inflammation and flow trigger fundamentally distinct endothelial signaling pathways with limited reciprocity and synergy. Taken together, this study uncovers the blood flow-induced remodeling of the basement membrane and stresses the importance of the subendothelial basement membrane in vascular homeostasis.

When the problem occurs, you are unable to perform any workflow actions in a SAS solution that uses SAS Workflow Services.

The problem occurs on a content release on the SAS Risk Governance Framework.

The problem occurs on a content release on the SAS Risk Governance Framework.

You might see the following error in SAS Workflow Studio when you try to open the CECL_Cycle_AFS workflow template that is shipped with SAS Solution for CECL:

The pancreatic islet is a highly-vascularized endocrine micro-organ. The unique architecture of rodent islets, a so-called core-mantle arrangement seen in 2D images, led researchers to seek functional implications for islet hormone secretion. Three models of islet blood flow were previously proposed, all based on the assumption that islet microcirculation occurs in an enclosed structure. Recent electrophysiological and molecular biological studies using isolated islets also presumed uni-directional flow. Using intravital analysis of the islet microcirculation in mice, we find that islet capillaries are continuously integrated to those in the exocrine pancreas, which makes the islet circulation rather open, not self-contained. Similarly in human islets, the capillary structure was integrated with pancreatic microvasculature in its entirety. Thus, islet microcirculation has no relation to islet cytoarchitecture, which explains its well-known variability throughout species. Furthermore, tracking fluorescent-labeled red blood cells at the endocrine-exocrine interface revealed bi-directional blood flow, with similar variability in blood flow speed in both the intra- and extra-islet vasculature. To date, the endocrine and exocrine pancreas have been studied separately by different fields of investigators. We propose that the open circulation model physically links both endocrine and exocrine parts of the pancreas as a single organ through the integrated vascular network.

With passion, motivation and determination to go against what is deemed as conventional in today’s society, Flow hosted a staff summit ahead of the International Womens’ Day under the theme ‘Passion for Action’, which supports a collective will to...

As policymakers in a number of countries, the United States among them, debate limiting family-based immigration, this issue brief explores family-migration trends and policies in the United States, Australia, Canada, the United Kingdom, and several other European countries. Family admissions play a key role, even in countries that prioritize economic or other immigration streams.

This event focuses on the changing face of Mexican migration to the United States, Mexican immigrants' contributions to U.S. society and political and economic power, as well as that of those who have returned to Mexico.

The Cuban Revolution unleashed a massive exodus from the island. Cuba is now among the top origin countries of immigrants in the United States—where for decades they have received preferential treatment—with smaller numbers across Europe and Latin America. This article explores the evolution of Cuban migration, particularly within the context of the Cold War and shifting U.S. policies toward the country.

From earthquakes to drought, natural disasters and climate change played a key role in migration flows in 2015. Climate-induced migration surfaced as a concern at the United Nations Climate Change Conference (known as COP21) as international organizations and policymakers have begun to recognize the growing challenges, and potential protection obligations, of such movement.

War and impending famine in Yemen have captured significant attention. Yet often overlooked is the country’s role as the epicenter of one of the world’s busiest mixed migration routes, linking Africa, Asia, and Europe. This article examines the migration pathways to and through the country, push and pull factors, and the impact of civil war on human movement.

Testimony of Andrew Selee, President of MPI, before Senate Committee on Homeland Security and Governmental Affairs on April 4, 2019 regarding response to changing migration flows at the Southwest border.

Mexicans migrate to Canada in much smaller numbers than to the United States, yet over the last 30 years the country has become an increasingly attractive destination. Canada prioritizes highly skilled, educated Mexicans for permanent residency, but also attracts temporary workers from Mexico. This article examines Mexican migration to Canada and how it has been shaped by visa requirements, trade policy, and more.