Infants who require positive pressure ventilation at birth are considered to be at risk for subsequent compromise and are recommended to receive postresuscitation care. The supportive evidence and details of this care have not been fully investigated.

We investigate the need for postresuscitation care in infants who require positive pressure ventilation at birth, review the aspects of care needed, and explore the important risk factors most predictive of it. (Read the full article)

Primary ciliary dyskinesia presents in infancy with unexplained neonatal respiratory distress, yet diagnosis is often delayed until late childhood. Earlier diagnosis facilitates earlier onset of therapy, which may help to reduce long-term pulmonary morbidity and mortality.

A diagnostic workup for primary ciliary dyskinesia should be considered in a term infant presenting with unexplained respiratory distress and either lobar collapse, situs inversus, or a prolonged oxygen therapy requirement (>2 days). (Read the full article)

Increased central adrenergic activity occurs with opiate withdrawal. Clonidine is an effective drug as an adjunct to morphine in the treatment of neonatal abstinence syndrome. It is unclear whether clonidine is effective as single-drug therapy.

Clonidine, a α₂-adrenergic agonist, seems to be as effective as morphine when used as a single-drug therapy for neonatal abstinence syndrome. Its administration results in improvement in neurobehavioral performance. (Read the full article)

Surviving infants with neonatal encephalopathy treated with hypothermia have lower rates of moderate to severe cerebral palsy and cognitive impairment at 18 to 24 months. Limited data exist on the association between cognitive functioning and neuromotor, behavioral, and school outcomes.

Although the incidence of death or IQ <55 is reduced after therapeutic hypothermia, survivors of neonatal encephalopathy with and without cerebral palsy are at elevated risk for subnormal IQ and the need for specialized educational services at 6 to 7 years. (Read the full article)

Pediatric residents may not be achieving competency in neonatal intubation. Opportunities for intubation during residency are decreasing. A precise definition of competency during training is lacking.

Bayesian statistics may be used to describe neonatal intubation competency in residents. At least 4 successful intubations are needed to achieve competency. The first 2 intubation opportunities appear to predict how many intubation opportunities are ultimately needed to achieve competency. (Read the full article)

Although treatment of infection is a mainstay of neonatal intensive care, little attention has focused on the proportion of patient antibiotic exposures validated by clinical indications that are unambiguous.

Septic workups in 127 California NICUs reveal similar burdens of proven infection, yet patient antibiotic exposures in those NICUs vary 40-fold. Because antibiotic stewardship principles dictate that antibiotic use should correlate with burden of infection, some NICUs overuse antibiotics. (Read the full article)

Neonatal arterial ischemic stroke is associated with later cerebral palsy and cognitive impairment. Many studies on neonatal ischemic stroke are limited by modest sample sizes, and prospective studies that include outcomes assessments are scarce.

Results from this prospective, nationwide, population-based study provide information on the epidemiology, associated clinical variables, clinical manifestation, vascular distribution, and treatment of neonatal arterial ischemic stroke. The study also provides outcomes regarding motor function and cognition. (Read the full article)

Almost half of NICUs include low birth weight (<2.5 kg) as an inclusion criterion for car seat tolerance screening (CSTS), formerly car seat challenges. However, little is known about incidence and risk factors for failure in this group.

This is the largest study to date evaluating the incidence and predictors of CSTS failure in full-term low birth weight neonates. Epidemiologic data are provided to help guide future CSTS policies and protocol development for this group. (Read the full article)

Adding second-stage automated auditory brainstem response (ABR) testing for infants who failed the initial OAE test in a two-stage neonatal hearing screening has been shown to reduce false referrals to the hearing clinic.

Infants with hearing loss may be missed by a 2-stage hearing screening because they pass the automated ABR test. In our study, a significant number of infants with hearing loss >45 decibel hearing level passed screening with automated ABR. (Read the full article)

Use of a standard treatment protocol with stringent weaning guidelines for infants with neonatal abstinence syndrome supports improved outcomes including shorter duration of opioid exposure and length of hospital stay.

We demonstrate generalizability of a protocol-driven weaning strategy for improvement in hospital outcomes for neonatal abstinence syndrome. After adoption, adherent protocol-adopting centers improved outcomes and eliminated differences in outcomes compared with centers with preexisting stringent weaning protocols. (Read the full article)

Infants with neonatal abstinence syndrome are hospitalized for longer after birth and are more likely to be from highly vulnerable families. Determining long-term outcomes is difficult because this is a large and chaotic population.

(Read the full article)

Guidelines for postdischarge monitoring of hyperbilirubinemia for neonates of white descent are available from the American Academy of Pediatrics; however, such information for healthy term and late preterm Chinese neonates is lacking.

A classification model for predicting the risk of significant hyperbilirubinemia in Chinese neonates was developed that combines a transcutaneous bilirubin–based nomogram with clinical risk factors. It classified newborns into 6 risk groups, which can guide clinicians in planning appropriate follow-up strategies. (Read the full article)

Endotracheal intubation is a mandatory skill for neonatal trainees. It is a difficult skill to acquire, and success rates of junior doctors are low and falling.

Videolaryngoscopy allows the supervisor to share the intubator’s view of the airway and provide more informed guidance. Teaching intubation using a videolaryngoscope with the screen visible to the instructor results in significantly higher success rates for inexperienced doctors. (Read the full article)

The impact of neonatal abstinence syndrome is of concern because the number of newborns showing symptoms of withdrawal after intrauterine drug exposure is increasing worldwide. Newborns developing neonatal abstinence syndrome require prolonged medical treatment and longer hospital admission after birth.

This first randomized controlled trial presents data on newborns with neonatal abstinence syndrome treated with laser acupuncture. The findings suggest that adjuvant laser acupuncture has the potential to reduce duration of morphine therapy and length of hospital stay. (Read the full article)

Like many in Angola, Tchipangu did not have the financial means for an education. But this changed when a company decided to invest in her.

Millicent Collins
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Philip M. Farrell
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Intel has released some benchmarks for its next-gen Core i9 'Cascade Lake-X' processors, which will be arriving next month with a big price cut. The company is also slightly dropping prices on Core S-series chips that lack GPUs, and preparing to launch the Xeon W-2200 series.

This phase IIb randomized controlled trial demonstrates greater efficacy of phenobarbital than levetiracetam in the treatment of neonatal seizures; more adverse events occurred with phenobarbital.

Dover, DE – Just in time for the holidays, the happiest season of all will now also be the “hoppiest” with the addition of four new craft breweries to the Delaware on Tap mobile app. Each location offers a unique atmosphere and special take on the brewmaster’s art. They bring the number of craft breweries, wineries, […]

Governor Markell ordered flags to be lowered between March 7 and 11 as a mark of respect for the passing of former Delaware Judge and civil rights leader Leonard Williams.

Bajaj has used it’s existing Pulsar 150 platform to create the smaller Pulsar 125 Neon. The design, cycle parts, features and even the engine (stroke has been shortened and swept volume reduced) is borrowed from the bigger bike. The result is a good looking bike for those on a budget. How is it to ride […]

The White House has marked the victory over Nazi Germany in a tweet hailing the role of the US and the UK, while leaving out the nation that sacrificed the most – the Soviet Union. Netizens were quick to provide a history lesson.
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  Everywhere you look, there is a radical reimagining of the way we perceive technology. Cars are driving themselves, homes are maintaining themselves and in general, everybody is busy offering you thei...

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The regulatory norms with respect to provisioning and asset recognition are uniform for Indian banks’ domestic and foreign exposures.

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1 Seychellois Rupee = 574.321 Sierra Leonean Leone

1 Trinidad and Tobago Dollar = 1459.1044 Sierra Leonean Leone

1 Swedish Krona = 1009.0156 Sierra Leonean Leone

1 Slovak Koruna = 444.0241 Sierra Leonean Leone

1 Serbian Dinar = 90.9133 Sierra Leonean Leone

1 Polish Zloty = 2344.967 Sierra Leonean Leone

1 Qatari Rial = 2708.0175 Sierra Leonean Leone

1 Indian Rupee = 130.5891 Sierra Leonean Leone

1 Pakistani Rupee = 61.7601 Sierra Leonean Leone

1 Sierra Leonean Leone = 0.1207 Iraqi Dinar