Stephen Fry

Mike Tobin started his career as a telecommunications apprentice and by the age of 27 he was monitoring the vital signs of the three astronauts in Apollo 11 from Canberra.

(United States Second Circuit) - Questions on appeal concern cross-jurisdictional tolling of a class action. Because the appeal presents state law questions that New York’s courts have yet to address, the court certifies the case to the New York Court of Appeals.

(United States Second Circuit) - Questions on appeal concern cross-jurisdictional tolling of a class action. Because the appeal presents state law questions that New York’s courts have yet to address, the court certifies the case to the New York Court of Appeals.

We estimate valuations of time using detailed consumer choice data from a large European ride hail platform, where drivers bid on trips and consumers choose between a set of potential rides with different prices and waiting times. We estimate consumer demand as a function of prices and waiting times. While demand is responsive to both, price elasticities are on average four times higher than waiting-time elasticities. We show how these estimates can be mapped into values of time that vary by place, person, and time of day. Regarding variation within a day, the value of time during non-work hours is 16% lower than during work hours. Regarding the spatial dimension, our value of time measures are highly correlated both with real estate prices and urban GPS travel flows. A variance decomposition reveals that most of the substantial heterogeneity in the value of time is explained by individual differences as opposed to place or time of day. In contrast with other studies that focus on long run choices we do not find evidence of spatial sorting. We apply our measures to quantify the opportunity cost of traffic congestion in Prague, which we estimate at $483,000 per day.

Feminism and art.

Antonenko, Andrii, 1922-

Ceftobiprole medocaril is an advanced-generation cephalosporin prodrug that has qualified infectious disease product status granted by the US-FDA and is currently being evaluated in phase 3 clinical trials in patients with acute bacterial skin and skin structure infections (ABSSSIs) and in patients with Staphylococcus aureus bacteremia. In this study, the activity of ceftobiprole and comparators was evaluated against more than 7,300 clinical isolates collected in the United States from 2016 through 2018 from patients with skin and skin structure infections. The major species/pathogen groups were S. aureus (53%), Enterobacterales (23%), Pseudomonas aeruginosa (7%), β-hemolytic streptococci (6%), Enterococcus spp. (4%), and coagulase-negative staphylococci (2%). Ceftobiprole was highly active against S. aureus (MIC_50/90, 0.5/1 mg/L; 99.7% susceptible by EUCAST criteria; 42% methicillin-resistant S. aureus [lsqb]MRSA[rsqb]). Ceftobiprole also exhibited potent activity against other Gram-positive cocci. The overall susceptibility of Enterobacterales to ceftobiprole was 84.8% (>99.0% susceptible for isolate subsets that exhibited a non-extended-spectrum β-lactamase [lsqb]ESBL[rsqb]-phenotype). A total of 74.4% of P. aeruginosa, 100% of β-hemolytic streptococci and coagulase-negative staphylococci, and 99.6% of Enterococcus faecalis isolates were inhibited by ceftobiprole at ≤4 mg/L. As expected, ceftobiprole was largely inactive against Enterobacterales that contained ESBL genes and Enterococcus faecium. Overall, ceftobiprole was highly active against most clinical isolates from the major Gram-positive and Gram-negative skin and skin structure pathogen groups collected at U.S. medical centers participating in the SENTRY Antimicrobial Surveillance Program during 2016–2018. The broad-spectrum activity of ceftobiprole, including potent activity against MRSA, supports its further evaluation for the potential ABSSSI indication.

Ceftobiprole is an advanced-generation broad-spectrum cephalosporin antibiotic with potent and rapid bactericidal activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus, as well as susceptible Gram-negative pathogens, including Pseudomonas sp. pathogens. In the case of Pseudomonas aeruginosa, ceftobiprole acts by inhibiting P. aeruginosa penicillin-binding protein 3 (PBP3). Structural studies were pursued to elucidate the molecular details of this PBP inhibition. The crystal structure of the His-tagged PBP3-ceftobiprole complex revealed a covalent bond between the ligand and the catalytic residue S294. Ceftobiprole binding leads to large active site changes near binding sites for the pyrrolidinone and pyrrolidine rings. The S528 to L536 region adopts a conformation previously not observed in PBP3, including partial unwinding of the α11 helix. These molecular insights can lead to a deeper understanding of β-lactam-PBP interactions that result in major changes in protein structure, as well as suggesting how to fine-tune current inhibitors and to develop novel inhibitors of this PBP.

Novartis Vaccines & Diagnostics Inc. and Novartis Pharmaceuticals Corporation have agreed to pay $72.5 million to resolve civil False Claims Act allegations arising from the marketing of the cystic fibrosis drug TOBI.

Forget about wood construction; cardboard could be the Next Big Thing.

It takes a while to get into this book because first you have to navigate a prologue and not one but two forewords, the first by the author’s 11-year-old grandson, who reveals that at 4 a.m. without make-up Stephanie Beacham has green skin, witch-like hair and gives him nightmares, muses JOHN HARDING

The 31-year-old mogul announced on Monday morning that she will be releasing her first ever 'visual autobiography' - simply titled Rihanna - through publisher Phaidon.

The singer and actress, 31, used the enormous hardback book to protect her modesty after going completely naked in her latest Instagram post.

Mr Turnbull's autobiography has sparked controversy after it featured bizarre claims about members of the Liberal Party including current leader Scott Morrison.

Australia's 29th prime minister released his autobiography A Bigger Picture on Monday for the price of $55.

He's the proud father of four adorable daughters. And on Thursday, Brendon Fevola took to Instagram to share a cheeky snap of him enjoying some adorable father-daughter time

Laura Tobin broke down in tears on Good Morning Britain on Friday as she fulfilled her 'childhood dream' by visiting NASA.

Oxford : Oxford University Press, 2019.

New York, NY : Oxford University Press, 2019.

Hayden Library - PN6714.K86 2018

Hayden Library - PN2287.M374 A3 2015

Rotch Library - N6770.L6495 2018

Dewey Library - JZ4839.D56 2019

Dewey Library - JZ5675.T62 2018

Dewey Library - JZ4850.H66 2019

Cambridge, Mass. : National Bureau of Economic Research, 2020

Schleifer, Tobias, author

Hayden Library - PQ3949.2.C65 Z4613 2017

Hayden Library - GV1469.3.E27 2014

Hayden Library - GV1469.17.S63 T63 2013

Online Resource

MEDIA PhonCD P P946

MEDIA PhonCD P586 fan

Hayden Library - PS228.B6 C365 2018

Hansen, Kathryn, author

STACK SCORE Mu pts R736 lardbp

Dewey Library - BF378.A87 O74 2019

Tobin, Joseph Jay

Online Resource

Autor: Herele, Tobias
Erschienen 1684
BSB-Signatur Res/2 Bavar. 980,2#Beibd.205

URN: urn:nbn:de:bvb:12-bsb11121330-5
URL: http://reader.digitale-sammlungen.de/de/fs1/object/display/bsb11121330_00001.html/

Berlin : Springer, 2006

The panelists talk to Tobi Reiss, the creator of BonsaiJS.

Keener, Craig S., 1960- author