skeleton

AT#466 - Travel to Namibia's Skeleton Coast

Hear about travel to Namibia's Skeleton Coast as the Amateur Traveler talks again to Susan Portnoy of theinsatiabletraveler.com about her trip to this memorable reagion of Africa. Namibia is the size of France and Great Britain combined but with only 2 million people.




skeleton

African skeletons from early colonial Mexico tell the story of first-generation slaves

(Max Planck Institute for the Science of Human History) Three 16th-century skeletons from a mass burial in Mexico City highlight the role of the transatlantic slave trade in introducing and disseminating new pathogens to the Americas. Researchers from the Max Planck Institute for the Science of Human History and Escuela Nacional de Antropología e Historia in Mexico analyzed skeletal features, genetic data and isotopes to explore the life history of three enslaved Africans and explore the wide-ranging impacts of massive forced migration.




skeleton

The skeleton of a horse: right side view. Line engraving with etching by A. Bell, ca. 1790.

[Edinburgh], [between 1788 and 1797]




skeleton

Mechanistic Target of Rapamycin Regulates the Oligodendrocyte Cytoskeleton during Myelination

During differentiation, oligodendrocyte precursor cells (OPCs) extend a network of processes that make contact with axons and initiate myelination. Recent studies revealed that actin polymerization is required for initiation of myelination whereas actin depolymerization promotes myelin wrapping. Here, we used primary OPCs in culture isolated from neonatal rat cortices of both sexes and young male and female mice with oligodendrocyte-specific deletion of mechanistic target of rapamycin (mTOR) to demonstrate that mTOR regulates expression of specific cytoskeletal targets and actin reorganization in oligodendrocytes during developmental myelination. Loss or inhibition of mTOR reduced expression of profilin2 and ARPC3, actin polymerizing factors, and elevated levels of active cofilin, which mediates actin depolymerization. The deficits in actin polymerization were revealed in reduced phalloidin and deficits in oligodendrocyte cellular branching complexity at the peak of morphologic differentiation and a delay in initiation of myelination. We further show a critical role for mTOR in expression and localization of myelin basic protein (Mbp) mRNA and MBP protein to the cellular processes where it is necessary at the myelin membrane for axon wrapping. Mbp mRNA transport deficits were confirmed by single molecule RNA FISH. Moreover, expression of the kinesin family member 1B, an Mbp mRNA transport protein, was reduced in CC1+ cells in the mTOR cKO and in mTOR inhibited oligodendrocytes undergoing differentiation in vitro. These data support the conclusion that mTOR regulates both initiation of myelination and axon wrapping by targeting cytoskeletal reorganization and MBP localization to oligodendrocyte processes.

SIGNIFICANCE STATEMENT Myelination is essential for normal CNS development and adult axon preservation and function. The mechanistic target of rapamycin (mTOR) signaling pathway has been implicated in promoting CNS myelination; however, there is a gap in our understanding of the mechanisms by which mTOR promotes developmental myelination through regulating specific downstream targets. Here, we present evidence that mTOR promotes the initiation of myelination through regulating specific cytoskeletal targets and cellular process expansion by oligodendrocyte precursor cells as well as expression and cellular localization of myelin basic protein.




skeleton

Picking away at fossilized skeletons




skeleton

Tree-dwelling gray foxes decorate with skeletons

As the only canids that can climb trees, gray foxes frequently drag fawn and rabbit skeletons onto the branches with them.





skeleton

Mom says cemetery repeatedly removed playful skeleton decoration from her late son's grave

Christina Wohle of Francestown, New Hampshire lost her son Cole to a heart attack just days after his 18th birthday in July of 2016.




skeleton

Jenna Dewan shows off her pregnant tummy as she models a funny baby skeleton T-shirt

The star's boyfriend, who celebrated his birthday one day prior, also took to social media to show off his pretty lady and his growing baby.




skeleton

Swizz Beatz's 19 year old son Note Marcato confuses Grammy viewers with his bizarre skeleton paint

One of the most bizarre moments at the 2020 Grammy Awards came when host Alicia Keys was roaming the aisles and fans caught a glimpse of a young man wearing skeleton face paint.




skeleton

Skeleton remains found in remote property by a man cutting down trees in search for missing woman 

A man cutting down trees at a property off Tea Tree Road in Bindoon, 80 kilometres north of Perth, made the grim discovery on Sunday.




skeleton

Rita Ora smooches a skeleton in playful snap as she shares a look at immersive video experience

The singer, 29, had planned an event for her fans to experience the world of her latest music video How To Be Lonely which had to be made into a digital experience due to lockdown.




skeleton

Skeletons buried near Bamburgh Castle belonged to people who had travelled across the British isles

Over the past 20 years, experts from Durham University have been studying the remains of 110 Anglo-Saxons found buried in the dunes near the Northumberland castle.




skeleton

[ASAP] Acylphloroglucinol Derivatives with a Tricyclo-[4.4.1.1<sup>1,4</sup>] Dodecane Skeleton from <italic toggle="yes">Garcinia bracteata</italic> Fruits

The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.0c00637




skeleton

After Unnao, skeletons found in three other UP districts



  • DO NOT USE Uttar Pradesh
  • India

skeleton

Exoskeletons Will Make Work Weightless

Ekso Bionics, known for its powered therapeutic exoskeletons, is getting into the construction business with a new exoskeleton suit that makes hefting heavy tools a breeze. WIRED's Adam Rogers suits up for a test drive.




skeleton

Hyundai's Exo-Skeleton Makes Everyone an Iron Man

Hyundai, the car manufacturer, is getting into other forms of mobility and work with its two new exo-skeletons.




skeleton

Skeleton keys: the secret life of bone / Brian Switek

Browsery QM101.S5487 2019




skeleton

Plant triterpenoids with bond-missing skeletons: biogenesis, distribution and bioactivity

Nat. Prod. Rep., 2020, Advance Article
DOI: 10.1039/C9NP00030E, Review Article
Aldo Almeida, Lemeng Dong, Giovanni Appendino, Søren Bak
A comprehensive review of the overlooked class of plant specialized metabolites, bond-missing triterpenoids; their occurrence, biogenesis and medicinal bioactivities.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




skeleton

[ASAP] Fragrant Venezuelaenes A and B with A 5–5–6–7 Tetracyclic Skeleton: Discovery, Biosynthesis, and Mechanisms of Central Catalysts

ACS Catalysis
DOI: 10.1021/acscatal.0c01575




skeleton

Podcast: The rise of skeletons, species-blurring hybrids, and getting rightfully ditched by a taxi

This week we chat about why it’s hard to get a taxi to nowhere, why bones came onto the scene some 550 million years ago, and how targeting bacteria’s predilection for iron might make better vaccines, with Online News Editor Catherine Matacic. Plus, Science’s Alexa Billow talks with news writer Elizabeth Pennisi about the way hybrids muck up the concept of species and turn the evolutionary tree into a tangled web.   Listen to previous podcasts   [Image:  Raul González Alegría; Music: Jeffrey Cook]




skeleton

A promising anticancer drug: a photosensitizer based on the porphyrin skeleton

RSC Med. Chem., 2020, 11,427-437
DOI: 10.1039/C9MD00558G, Review Article
Qizhi Zhang, Jun He, Wenmei Yu, Yanchun Li, Zhenhua Liu, Binning Zhou, Yunmei Liu
This article reviews the research status of porphyrin photosensitizers; future perspectives and current challenges are discussed.
The content of this RSS Feed (c) The Royal Society of Chemistry




skeleton

[ASAP] Three-Dimensional Porous Carbon Skeleton Synthesized by a Template-Free and No-Post-Activation Process Applied for High-Performance Lithium–Sulfur Batteries

ACS Sustainable Chemistry & Engineering
DOI: 10.1021/acssuschemeng.9b07502




skeleton

The Bradys' strangest case or, The skeleton in the well




skeleton

Frank Merriwell on the desert or The mystery of the skeleton




skeleton

Seared with iron, or, The band of Skeleton Bar




skeleton

Billy, the cabin boy, or, The treasure of Skeleton Island




skeleton

Supplementary Materials for Late Pleistocene Human Skeleton and mtDNA Link Paleoamericans and Modern Native Americans




skeleton

Late Pleistocene Human Skeleton and mtDNA Link Paleoamericans and Modern Native Americans




skeleton

The growth pattern of Neandertals, reconstructed from a juvenile skeleton from El Sidrón (Spain)




skeleton

The excavation of buried articulated Neanderthal skeletons at Sima de las Palomas (Murcia, SE Spain)




skeleton

Upper Pleistocene Panthera leo spelaea (Goldfuss, 1810) skeleton remains from Praha-Podbaba and other lion finds from loess and river terrace sites in Central Bohemia (Czech Republic)




skeleton

Microscopic fungi on cadavers and skeletons from cave and mine environments




skeleton

[ASAP] Cytoskeleton-Inspired Artificial Protein Design to Enhance Polymer Network Elasticity

Macromolecules
DOI: 10.1021/acs.macromol.0c00514




skeleton

Skeleton keys : the secret life of bone / Brian Switek

Switek, Brian, author