Bela Fleck & Abigail Washburn, Chris Knight, Sue Foley, The Quebe Sisters and Maya de Vitry, live on Mountain Stage with Larry Groce.Support for this podcast is provided by Adventures on the Gorge. https://adventuresonthegorge.com/

In a span of 13 days, Raymond Lee and his brother, William, lost sister Regina Lim Lee, 58; mother, Susie Chin Lee, 82; and sister Willa, 60, to the novel coronavirus. Three beloved women gone in less than two weeks.

Three young sisters work together to fulfil their dream of owning and operating their own Hereford stud and, despite drought and study, they are making a success of it.

For years, the Cerpas sisters engaged in friendly competition, running their own dress shops. Now they've come together to make face masks.

PRINCESS Beatrice was to join her sister, Princess Eugenie, in entering married life this month before the coronavirus pandemic hit. Now, the couple will have to wait before they can finally tie the knot, similarly to Beatrice and her husband, Jack Brooksbank.

Sex (Psychology) -- Social aspects.

Source: www.mirror.co.uk - Saturday, May 09, 2020
At least the garish crystal cheetah clutches aren't as saucy as the hamper sent to Kim Kardashian from cheeky Khloé as the family shower each other with odd gifts

Periodontitis as a biofilm-associated inflammatory disease is highly prevalent worldwide. It severely affects oral health and yet closely links to systemic diseases like diabetes and cardiovascular disease. Porphyromonas gingivalis as a ‘keystone' periodontopathogen drives the shift of microbe-host symbiosis to dysbiosis, and critically contributes to the pathogenesis of periodontitis. Persisters are a tiny subset of biofilm-associated microbes highly tolerant to lethal treatment of antimicrobials, and notably metronidazole-tolerant P. gingivalis persisters have recently been identified by our group. This study further explored the interactive profiles of metronidazole-treated P. gingivalis persisters (M-PgPs) with human gingival epithelial cells (HGECs). P. gingivalis cells (ATCC 33277) at stationary phase were treated with lethal dosage of metronidazole (100 μg/ml, 6 hours) for generating M-PgPs. The interaction of M-PgPs with HGECs was assessed by microscopy, flow cytometry, cytokine profiling and qPCR. We demonstrated that the overall morphology and ultra-cellular structure of M-PgPs remained unchanged. Importantly, M-PgPs maintained the capabilities to adhere to and invade into HGECs. Moreover, M-PgPs significantly suppressed pro-inflammatory cytokine expression in HGECs at a comparable level with the untreated P. gingivalis cells, through the thermo-sensitive components. The present study reveals that P. gingivalis persisters induced by lethal treatment of antibiotics could maintain their capabilities to adhere to and invade into human gingival epithelial cells, and perturb the innate host responses. Novel strategies and approaches need to be developed for tackling P. gingivalis and favourably modulating the dysregulated immuno-inflammatory responses for oral/periodontal health and general wellbeing.

Caseum, the central necrotic material of tuberculous lesions, is a reservoir of drug-recalcitrant persisting mycobacteria. Caseum is found in closed nodules and in open cavities connecting with an airway. Several commonly accepted characteristics of caseum were established during the preantibiotic era, when autopsies of deceased tuberculosis (TB) patients were common but methodologies were limited. These pioneering studies generated concepts such as acidic pH, low oxygen tension, and paucity of nutrients being the drivers of nonreplication and persistence in caseum. Here we review widely accepted beliefs about the caseum-specific stress factors thought to trigger the shift of Mycobacterium tuberculosis to drug tolerance. Our current state of knowledge reveals that M. tuberculosis is faced with a lipid-rich diet rather than nutrient deprivation in caseum. Variable caseum pH is seen across lesions, possibly transiently acidic in young lesions but overall near neutral in most mature lesions. Oxygen tension is low in the avascular caseum of closed nodules and high at the cavity surface, and a gradient of decreasing oxygen tension likely forms toward the cavity wall. Since caseum is largely made of infected and necrotized macrophages filled with lipid droplets, the microenvironmental conditions encountered by M. tuberculosis in foamy macrophages and in caseum bear many similarities. While there remain a few knowledge gaps, these findings constitute a solid starting point to develop high-throughput drug discovery assays that combine the right balance of oxygen tension, pH, lipid abundance, and lipid species to model the profound drug tolerance of M. tuberculosis in caseum.

Bacterial persisters are phenotypic variants that temporarily demonstrate an extraordinary tolerance toward antibiotics. Persisters have been linked to the recalcitrance of biofilm-related infections; hence, a complete understanding of their physiology can lead to improvement of therapeutic strategies for such infections. Mechanisms pertaining to persister formation are thought to be associated with stress response pathways triggered by intra- or extracellular stress factors. Unfortunately, studies demonstrating the effects of osmolyte- and/or pH-induced stresses on bacterial persistence are largely missing. To fill this knowledge gap within the field, we studied the effects of various osmolytes and pH conditions on Escherichia coli persistence with the use of phenotype microarrays and antibiotic tolerance assays. Although we found that a number of chemicals and pH environments, including urea, sodium nitrite, and acidic pH, significantly reduced persister formation in E. coli compared to no-osmolyte/no-buffer controls, this reduction in persister levels was less pronounced in late-stationary-phase cultures. Our results further demonstrated a positive correlation between cell growth and persister formation, which challenges the general notion in the field that slow-growing cultures have more persister cells than fast-growing cultures.

Antituberculosis (anti-TB) drug development is dependent on informative trials to secure the development of new antibiotics and combination regimens. Clofazimine (CLO) and pyrazinamide (PZA) are important components of recommended standard multidrug treatments of TB. Paradoxically, in a phase IIa trial aiming to define the early bactericidal activity (EBA) of CLO and PZA monotherapy over the first 14 days of treatment, no significant drug effect was demonstrated for the two drugs using traditional statistical analysis. Using a model-based analysis, we characterized the statistically significant exposure-response relationships for both drugs that could explain the original findings of an increase in the numbers of CFU with CLO treatment and no effect with PZA. Sensitive analyses are crucial for exploring drug effects in early clinical trials to make the right decisions for advancement to further development. We propose that this quantitative semimechanistic approach provides a rational framework for analyzing phase IIa EBA studies and can accelerate anti-TB drug development.

Tamieka and Teya Garcia are making inroads in the boxing industry despite a life-threatening health condition that complicates their efforts to step inside the ring.

Five sisters make up a quarter of their tiny town's under-16s Aussie Rules team. They can't compete right now, but they are all determined to break into the professional ranks one day.

Loretta and Tracey Fergerson were indicted by a federal grand jury in the Middle District of Alabama on a variety of charges stemming from an identity theft and tax fraud conspiracy.

Loretta Fergerson and her sister, Tracey Fergerson, both of Montgomery, Ala., were each sentenced to 115 months prison for their involvement in a conspiracy to file claims for false income tax refunds using stolen identities, the Justice Department and Internal Revenue Service (IRS) announced today. U.S. District Judge Mark Fuller ordered the Fergerson sisters to pay $504,305 in restitution to the IRS.

Tight jackets and tunics in diaphanous materials replaced the more pragmatic, flowing qabas, Jahangir did not marry anyone after Noor Jahan, Women wore jamas of fine muslin, so sought-after that they were named running water and night dew. Pics/Courtesy Aleph

While we all remember the story of 16th century Timurid warrior and scholar Babur's arduous journey from Kabul to Punjab, from where he waged war on Delhi to become the first Emperor of the Mughal dynasty, little is known of the wives, sisters, daughters and aunts, who travelled with him, and helped him establish his empire in the Indian sub-continent.

A new book by Gurgaon-based author Ira Mukhoty, Daughters of the Sun (Aleph Book Company), is a first-of-its-kind attempt to chronicle the role of the women in building the empire, and whose stories have suffered the neglect of both, history and memory. "Women, in general, are a misremembered group in history," says Mukhoty, in an email interview. "Their achievements are constantly ignored or diminished in favour of the histories of men. For the Mughals, it is further complicated by the fact that a lot of the works are in Persian, a language that is seriously out of favour in India. There is a Persian document called the Pilgrims' Confidant, about the Haj pilgrim to Mecca, sponsored by Aurangzeb's daughter Zeb-un Nisa. I tried very hard to have the document translated into English, but was unable to. This is a beautifully illustrated manuscript, which may have interesting references to its imperial patron. The original document is, moreover, in a collection abroad, as are many Mughal documents following the great plunder by the British. So there are many layers obscuring the legacy of the Mughal women; language, despoliation and disinterest," she adds.

Ira Mukhoty

For Mukhoty, the idea of researching this book came to her when she stumbled on the story of Jahanara Begum, daughter of Emperor Shah Jahan, who reigned from 1628 to 1658. "The over-arching scope of her ambition, so clearly spelt out in all her works, took my breath away. At a time when even globally women were expected to live lives of quiet submission, Jahanara blazed such a fiery trail. And yet we really don't remember the extent of her achievements at all," she says.

The book is split into three parts. The first discusses the peripatetic queens, who travelled from Persia to Hindustan, and includes Khanzada Begum, Babur's elder sister, and his wife Dildar Begum, among others. The next talks of the wives during the imperial splendour. Here, Jahangir's wife Mehr-un-Nisa Begum alias Noor Jahan and Mumtaz Mahal — Shah Jahan's wife — find mention. The last section of the book takes us into the waning years of the Mughal empire, fraught with greed and overreaching ambition. The story of Jahanara Begum, the beloved eldest, unmarried daughter of Shah Jahan stands out here.

An interesting source for Mukhoty's book was Gulbadan Begum's Humayun-nama. Gulbadan was sister to Humayun and daughter to Babur, who arrived in Hindustan at the age of five. "She was asked many decades later by her grandnephew, Akbar, to write a biography of Babur and Humayun," Mukhoty writes in the book. "Gulbadan's account is a fascinating insight into the households of Babur and Humayun as seen by an insider. Her writing is forthright, frank and rambunctious," says Mukhoty. "It is her lack of a self-conscious eye on posterity, which made her account so invaluable. She gives us details which help us imagine a living, breathing space instead of a splendid, but unknowable place which the male biographers wrote about. Male historians of that time wrote in grave and obscure prose, about battles and ancestors. Gulbadan wrote about Humayun's opium habit and his relationship with one of his feisty wives," says the writer.

Among the Mughal women, whom Mukhoty has most affection for is Khanzada Begum, who at 65, rode on horseback through 750 km of icy passes to parley on behalf of her nephew, Humayun. "This fearless and indomitable lady made sacrifices all her life for the legacy of her younger brother Babur, and for the future of her family. She was constantly sent as peace ambassador to warring brothers and travelled endless miles through icy terrain on horseback. She wept upon seeing the infant Akbar, because he reminded her of her long dead 'baby' brother Babur. This gives us such a different insight into Babur too, no longer the marauding foreigner of legend but a dearly beloved and mourned brother," she says.

Mukhoty, however, finds Mumtaz Mahal to be the most voiceless of the lot she researched about — the irony being that she was also the most famous. "I think the Taj Mahal, and the 20th century construct of an 'exclusive love' that it generated is definitely the reason Mumtaz Mahal is viewed with affection by so many. But she left no writings, no substantial buildings, no clear evocation of an ambition. She was busy raising 14 children in 19 years, travelling the length and breadth of the country with her restless husband. She will forever be hidden by the splendour of the Taj Mahal."

Also Read: Mughal-Era Artefacts Seized From Antique Smuggler's Secret SoBo Godown

Catch up on all the latest Mumbai news, crime news, current affairs, and also a complete guide on Mumbai from food to things to do and events across the city here. Also download the new mid-day Android and iOS apps to get latest updates

Sonam Kapoor is currently in Delhi, with Anand Ahuja and the family, following the lockdown period according to the government protocol. The actress was in London but returned to the country with Anand after the coronavirus outbreak.

 

 

 

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I miss you all.. ☹️

A post shared by Sonam K Ahuja (@sonamkapoor) onApr 16, 2020 at 5:35am PDT

Being away from her family in Mumbai, she has been missing them loads, and constantly sharing throwback photos from the family album. Now, the actress' Fanclub has given a new awe-worthy post, which has Kapoor sisters Sonam and Rhea riding a bicycle. Take a look!

Anand Ahuja not only shared 'hearty eyed' emoticon but also took to his Instagram story. 

On the professional front, Sonam Kapoor was last seen in The Zoya Factor, which failed at the box-office. Abhishek Sharma directorial, also starring Dulquer Salmaan, could only manage lifetime collections of around Rs. 6.96 crores. Before this romantic comedy, Sonam Kapoor was seen playing a homosexual character in Ek Ladki Ko Dekha Toh Aisa Laga, opposite Rajkummar Rao and Regina Cassandra. Now, the actress is gearing up for Sujoy Ghosh's next production, which is the remake of the Korean film, Blind.

Speaking about Rhea Kapoor, the star kid turned producer with Aisha. She has produced Veere Di Wedding and Khoobsurat too, both starring sister Sonam.

The Kapoor sisters own a fashion label called Rheason and the former has also turned producer and made the very successful Veere Di Wedding in 2018. The duo has been

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Strictly Come Dancing stars Oti and Motsi Mabuse dazzled on stage at the National Television Awards on Tuesday night.

The screen star, 29, joins Saoirse, 25, and Florence, 23, in a group prayer in an official image from upcoming period drama Little Women, set for release in December 25 2019.

The first official trailer for Greta Gerwig's adaptation of the Louisa May Alcott novel, Little Women, has been released.

A savvy mum and her sister have transformed an old TV cabinet into a modern statement piece using paint from Bunnings and accessories from Kmart.

The Argentine pontiff live-streamed an Easter Monday prayer from his private library as the Vatican and Italy entered a second month of restrictions on most outdoor activities.

They became one of the most memorable duos in My Kitchen Rules history thanks to their self-professed love of surgical enhancements. 

The One Kiss hitmaker, 24, stepped out with her beau's sisters Bella, 23, and Gigi, 24, as well as the latter's on-off partner Zayn, 27, for a family outing in New York on Saturday evening.

The model, 18, put on a showstopping display for her turn on the runway, wearing a black lace sleeveless dress with a sheer detail and a tassel embellishment.

The reality star, 39, took to Instagram to share a hilarious snap with her family dressed in matching leopard print onesies as part of a gallery for her family.

This is not your average spaghetti western thou as women are the lead and men play a supporting role

Fights between siblings are most often the most intense type of altercation out there, as was seen on Thursday night's no-holds-barred premiere of Keeping Up With The Kardashians.

Khloe was simply referring to her ex, daughter True's father Tristan Thompson.

Leonardo DiCaprio was spotted partying into the early morning hours with Kendall Jenner and Hadid sisters in Miami on Wednesday.

It is not easy getting all five of the Kardashian/Jenner sisters together in one room for a photo. But Kris Jenner managed to pull it off on Tuesday at her Christmas Eve party.

One day in and New York Fashion Week is in full effect,but one big name designer isn't in the Big Apple: Tom Ford. He instead held his show in LA with Kendall Jenner and Gigi and Bella Hadid.

Scrolling through the Kardashian family's multiple posts in the past 24 hours, one begins to wonder if sisters Kim, Khloe, Kourtney and Kendall are not in fact quietly seething.

The author of the best-selling memoir Inside Out was also with her daughter Rumer Willis, whom she had with ex-husband Bruce Willis. They have 26 years between them.

Jackie Simpson, 62, from Cleethorpes, and her sister Julie Ramsey, 60, a housekeeper, said they first travelled to the west African country for the music, because they 'love reggae and Bob Marley'.

Style Sisters – Gemma Lilly (left) 31, and Charlotte Reddington (right) 32, from Essex charge from £250 to more than £1,000 for wardrobe ‘detoxes. They worked with singer Alexandra Burke.

Julia Gailes, 48, from Co. Durham and Wendy Moffett, 57, from Bishop Auckland, found identical lumps in their breasts just weeks apart. Both have same strain of rare triple negative breast cancer.

Sarah Cockings (pictured), 36, who lives in Whitley Bay, Tyne and Wear, with her partner and three children, won £3,045,705 on April 30, 2005, when she was just 21.

Her hugely successful loungewear and intimates brand SKIMS, which launched in fall 2019, hit Nordstrom department stores earlier this month. And Kim Kardashian promoted her new restock.

The 40-year-old reality star, who quit the long-running family show, even showed her approval on one fan's tweet that called out Khloé Kardashian, 35, who tried to break up the explosive fist fight.

During her interview, Kim Kardashian revealed the entire 18th season had been filmed, except for the final episode, which was filmed individually by cast members as everyone had gone into quarantine.

Fights between siblings are most often the most intense type of altercation out there, as was seen on Thursday night's no-holds-barred premiere of Keeping Up With The Kardashians.

Khloe was simply referring to her ex, daughter True's father Tristan Thompson.

In addition, Khloé gifted Kim a 'Mommy's Little Quarantine Kit' complete with some Tom Ford fragrance, cannabis products and what appeared to be an adult toy.

Though the group of 19th-century British painters known as the Pre-Raphaelite Brotherhood were all men, women occupied unusually prominent positions in their world.

Taron Egerton brought his two half-sisters to the Golden Globes on Sunday night.