Sandwiches are one of the best fast-foods that contain nutrient-rich grains and seeds. Sandwiches are the quickest solution to our hunger; easy to make and time saving, on top of that delicious if prepared with right ingredients.

Some boomers are going to be supporting three generations, but their kids are going to have it worse.

Multi-generation living may get even more multi-generational if current demographic trends — like boomers aging — continue.

A multi-compartmented food storage device having a top hermetic storage compartment, a bottom hermetic storage compartment and a central hermetic storage compartment that is interposed there between. Each of the top and bottom compartments being hingedly secured to the central compartment along an upper and lower end.

A sandwich cookie dipper for dipping sandwich cookies in milk includes a handle, a cookie cradle and a transition element that interconnects to and sets off the cookie cradle from the handle. The cookie cradle comprises a thin, resilient rod-like member configured to substantially conform to a part of an outer circumference of a crème layer sandwiched between two disk-like cookie members of a sandwich cookie. The sandwich cookie secured thereby is less likely to dislodge as it is dipped and brought to the cookie eater's mouth.

An assembly including a joining element and an object, the object having a first outer layer, a second outer layer, and a middle layer between the first and second outer layers. The object has an opening that extends through the first outer layer and the middle layer, and the joining element is anchored in the opening. The joining element includes a proximal end, a distal end, a contact face in the area of the proximal end, a wall anchoring portion, and a tubular portion. The contact face is engaged by a vibrating tool that applies mechanical vibration and axial force to the joining element. The joining element includes a thermoplastic material at least at the circumferential surface of the wall anchoring portion and at the distal end to anchor the joining element to the first and second outer layers, respectively.

The owners of Oakland's Homestead Restaurant have just debuted a new business concept that is meant to outlast the Covid-19 crisis.

Currently operating at the restaurant's 4029 Piedmont Ave. space Tuesdays through Saturdays from 10 a.m. to 6 p.m. via curbside pickup and Caviar or Doordash delivery, The Humble Sandwich comprises a selection of classic deli sandos made with the same high-quality ingredients for which the seven-year-old restaurant is revered.…

The owners of Oakland's Homestead Restaurant have debuted a new concept meant to outlast the COVID-19 crisis.

To celebrate National Nurses' Week, Ike's Love & Sandwiches is offering all healthcare workers with ID 50 percent off the price of their in-store takeout orders tomorrow, May 6.

Boasting over seventy locations in five states — including locations in Berkeley and Oakland — the cult-favorite San Francisco-based sandwich outfit is also donating hundreds of sandwiches throughout the next seven days to healthcare facilities throughout California and Arizona.…

Special guest Daniel Jalkut returns to the show. Topics include app notarization, nonconsensual technology (including Zoom, Dropbox, and Superhuman), and more.

Dieter Bohn joins the show to talk about the iPad Magic Keyboard, the new iPhone SE, and the state of Android flagship phones.

When Bennett Powell was a child, doctors thought he might never walk but now he's running, cycling and swimming as part of his third Ironman Australia race.

What do you get when you mix The Road Warrior, Escape From New York, plus a handful of other related movies.......you get Doomsday. The cannibal scenes in this movie inspired me to do a fan tribute video to Gwar's Meat Sandwich

The best grilled cheese sandwich recipes ever! A perfectly grilled/toasted cheese sandwich is one of the best things in life and a gourmet grilled cheese sandwich is even better! April is National Grilled Cheese Month and I have 30 amazing grilled cheese sandwich recipes for you, one for every day of the month! Grilled cheese...

Read On →

The post 30 Amazing Grilled Cheese Sandwiches appeared first on Closet Cooking.

Laotian food is really something special sure in most countries you could go out for dinner and a show. However when you step into Laos the Dinner is the show. Performance plays a big role in Laotian cuisine. Youll likely find a spectacle in e

Co-op is recalling Chicken and Stuffing Sandwich due to the possible presence of metal. The possible presence of metal makes this product unsafe to eat.

People wait in line for these giant ice cream-stuffed doughnuts, even on snowy winter days.

Being a Parable for the Edification of Independents Seeking Independence

THE PARABLE

THE OSTENSIBLE CUSTOMER enters a deli and saunters up to the counter. The deli is tended by its rakishly handsome owner, THE SANDWICH GUY.

"Hi," says The Sandwich Guy. "What looks good to you today?"

"Slow down," says The Ostensible Customer, as THE LUNCH RUSH starts trickling in. "Lots of delis want my business, so, first I need to really understand what you can do for me."

"Well," says The Sandwich Guy, "I guess I can try to do what I do for everybody here and make you a customized version of any of the 15 awesome sandwiches you see on my menu. What're you hungry for?"

"Easy, easy, Ricky Roma! Before I make any decisions here I'm going to need to know a lot more about my options. Why are you so obsessed with 'what I want?'"

"Okay, sorry," says The Sandwich Guy, uneasily eyeing the growing queue of The Lunch Rush now piling up behind The Ostensible Customer. "What else can I do to help here?"

"That's better," says The Ostensible Customer. "Let's start by sitting down for a couple hours and going over all the ingredients you have back there."

The Sandwich Guy laughs congenially and hands The Ostensible Customer a menu. "Friend, I can make you whatever you want, but, if it helps, the 15 sandwiches listed here show all the ingredients--right there between the name and the price..."

"Whoa, whoa, whoa! The price?!? Already you're reaching for my wallet? Jeez, I barely just arrived."

The Lunch Rush is getting restless and grumbling audibly.

"Well. You know. I do sell sandwiches for a living," says The Sandwich Guy. "Did you have a certain budget in mind for your lunch?"

"Oh, God, no. I'm nowhere near that point yet. I still need to learn a lot more about how you work, and so, obviously, I have no idea what I want to pay. Obviously."

"Okay," says The Sandwich Guy, "but...I can't do much for you here without knowing either what you want to eat or how much money you want to spend. You get that, right?"

The Ostensible Customer is miffed.

"Listen, here. What I 'get,' so-called Sandwich Guy, is that you're not going to rush me into some tricky lifetime sandwich commitment until I understand precisely who I'm working with. And, so far, I do not like what I see. Still. I intend to find out more. So, meet me in Canada tomorrow to talk about this for an hour."

The Lunch Rush begins waving their wallets as they lob their completed order forms at The Sandwich Guy's face.

"Sorry," says The Sandwich Guy. "I can't do that. How about I just make you a Reuben. It's really good, it's our most popular sandwich, and it only costs eight bucks."

"WHAT! EIGHT DOLLARS! 'Dollars' with a 'd?' That's way too much!"

"I thought you didn't have a budget," says The Sandwich Guy.

"Well, I don't. And, besides, I don't really 'need' a sandwich at all. Now, kindly fly to Canada."

"That's not going to happen, sir."

"Also," says The Ostensible Customer, "if I do decide to get a sandwich from you--and it's looking increasingly less likely that I will--I'll absolutely expect your deeply discounted price to reflect the fact that I'm not particularly hungry right now."

The Lunch Rush begins lighting torches and chanting a guttural chant, not unlike the haunting overtone singing of Tuvan herdsmen.

"Look," sighs The Sandwich Guy, "it sounds like you need a little more time. Here's a free Coke and a complimentary bowl of pickles. Please have a seat, take all the time you need, then just come on up whenever you're ready to order, okay?"

"‘READY?!?’ TO...‘ORDER?!?’ Are you out of your mind?"

"Mmmm...apparently."

Presently, The Ostensible Customer turns beet-red.

"This is an outrage! I can't even imagine how you stay in business when you treat your customers like this."

The Lunch Rush grows silent as The Sandwich Guy slowly leans over the counter and smiles--his nose one slice of corned beef from The Ostensible Customer's nose.

"Sir. First off: you aren't my customer yet. Right now, you're just some dude holding a bowl of free pickles."

"Buh?" fumbled The Ostensible Customer.

"And, second, the way I 'stay in business' is by making great sandwiches and having as few conversations like the one we're having as possible," The Sandwich Guy coos.

"Because, the truth is, my real customers are actually all those nice people standing behind you. They're the people who buy my sandwiches with real money over and over again. I really like them, and so I give them almost all of my attention."

The Sandwich Guy waves at The Lunch Rush. The Lunch Rush waves back. The Ostensible Customer looks stunned.

"Sir," says The Sandwich Guy "enjoy your Coke and your pickles with my compliments. But, please step aside. Because right now, there's a whole bunch of hungry people trying to buy sandwiches that won't require me flying to Canada. Next, please!"

The Lunch Rush roars approval. The Ostensible Customer is still stunned. Which is unfortunate.

Because, several men from the back of the line spontaneously rush forward to drag The Ostensible Customer, screaming and grasping, onto the busy sidewalk outside, where they proceed to devour his flesh like those street urchins who eat Elizabeth Taylor's cousin in Suddenly, Last Summer.

Meanwhile, The Sandwich Guy goes back to making sandwiches. And, The Lunch Rush goes back to eating them.

THE MORAL(S)?

1. The Sandwich Guy can't do much for you until you're hungry enough to really want a sandwich.
2. Once you're hungry enough, you still have to pay money for the sandwich. This won't not come up.
3. Few people become "a good customer" without understanding both 1 and 2.
4. Few companies become "a smart business" without understanding 1, 2, and 3.
5. Basing his business on an understanding of 1, 2, 3, 4, and 5 doesn't make The Sandwich Guy a dick; it makes him a smart business.
6. If you vacation with Elizabeth Taylor? Seriously. Avoid provoking the cannibalistic rent boys.

THE HOPE

Me? I just very much hope it takes you far less than 15 years to see and accept these sorts of things. Both as a customer and as a business.

Guys, avoid working for anyone who's not hungry enough to compensate you for your sandwich. It literally doesn't pay.

THE RESERVE READING

• Bloodhounding Budgets - Cognition: The blog of web design & development firm Happy Cog

Tell them nicely that your price is a sucky $200K. The key here is to do so candidly, like you’re sitting on their side of the table and have to approve the budget with them. Admit that you’re way over the mark, and essentially apologize for it. I’ve said, “If you want to tell us to get lost, we understand”.

• Basement.org: Negotiation And Speculation: The Risk Of Selling Low

All those variables can change except your worth. That can’t change. It’s an undeniable fact beyond subjectivity and beyond the reality-bending rhetoric of your client-to-be. You are worth what you are worth and unless you’re feeling charitable something else has to give.

• Project Budgets and Secrets (thedesigncubicle.com)

Within the first few minutes of contact — in my effort to be as open and detailed on how I work as possible — the client counteracted by lying about not having a budget to clearly having a budget.

• Mule Design Studio’s Blog: Presenting Design Like You Get Paid For It

Unspoken expectations unmet lead to seething unspoken frustration which ultimately bursts forth in an ugly mess when you’ve run out of budget.

• Don’t Be Afraid of the S-Word :: Tips :: The 99 Percent

Remember that client who said that we were “pretty expensive” for them? A qualifying question in the first phone call could have saved us many hours of working on this deal. If you decide that the deal is unqualified, you just save it under another bucket: the unqualified deals bucket.

Delicious gourmet steak, onion and cheese sandwich

The Bombay toasty is a special sandwich sold on the streets of Bombay which is made with lots of fresh vegetables, mint chutney and butter.

From Gourmet magazine. -- posted by Vicki Kaye

Source: Gooseberry Patch, adapted -- posted by Sassy J

In vitro approaches for predicting drug-drug interactions (DDIs) caused by alterations in transporter protein regulation are not well established. However, reports of transporter regulation via nuclear receptor (NR) modulation by drugs are increasing. This study examined alterations in transporter protein levels in sandwich-cultured human hepatocytes (SCHH; n = 3 donors) measured by liquid chromatography–tandem mass spectrometry–based proteomic analysis after treatment with N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide (T0901317), the first described synthetic liver X receptor agonist. T0901317 treatment (10 μM, 48 hours) decreased the levels of organic cation transporter (OCT) 1 (0.22-, 0.43-, and 0.71-fold of control) and organic anion transporter (OAT) 2 (0.38-, 0.38-, and 0.53-fold of control) and increased multidrug resistance protein (MDR) 1 (1.37-, 1.48-, and 1.59-fold of control). The induction of NR downstream gene expression supports the hypothesis that T0901317 off-target effects on farnesoid X receptor and pregnane X receptor activation are responsible for the unexpected changes in OCT1, OAT2, and MDR1. Uptake of the OCT1 substrate metformin in SCHH was decreased by T0901317 treatment. Effects of decreased OCT1 levels on metformin were simulated using a physiologically-based pharmacokinetic (PBPK) model. Simulations showed a clear decrease in metformin hepatic exposure resulting in a decreased pharmacodynamic effect. This DDI would not be predicted by the modest changes in simulated metformin plasma concentrations. Altogether, the current study demonstrated that an approach combining SCHH, proteomic analysis, and PBPK modeling is useful for revealing tissue concentration–based DDIs caused by unexpected regulation of hepatic transporters by NR modulators.

Few things make as much sense as eating a harmful species, while sparing the threatened ones.