mda Calcineurin Inhibition Causes {alpha}2{delta}-1-Mediated Tonic Activation of Synaptic NMDA Receptors and Pain Hypersensitivity By www.jneurosci.org Published On :: 2020-05-06T09:30:22-07:00 Calcineurin inhibitors, such as tacrolimus (FK506) and cyclosporine, are widely used as standard immunosuppressants in organ transplantation recipients. However, these drugs can cause severe pain in patients, commonly referred to as calcineurin inhibitor-induced pain syndrome (CIPS). Although calcineurin inhibition increases NMDAR activity in the spinal cord, the underlying mechanism remains enigmatic. Using an animal model of CIPS, we found that systemic administration of FK506 in male and female mice significantly increased the amount of α2-1–GluN1 complexes in the spinal cord and the level of α2-1–bound GluN1 proteins in spinal synaptosomes. Treatment with FK506 significantly increased the frequency of mEPSCs and the amplitudes of monosynaptic EPSCs evoked from the dorsal root and puff NMDAR currents in spinal dorsal horn neurons. Inhibiting α2-1 with gabapentin or disrupting the α2-1–NMDAR interaction with α2-1Tat peptide completely reversed the effects of FK506. In α2-1 gene KO mice, treatment with FK506 failed to increase the frequency of NMDAR-mediated mEPSCs and the amplitudes of evoked EPSCs and puff NMDAR currents in spinal dorsal horn neurons. Furthermore, systemic administration of gabapentin or intrathecal injection of α2-1Tat peptide reversed thermal and mechanical hypersensitivity in FK506-treated mice. In addition, genetically deleting GluN1 in dorsal root ganglion neurons or α2-1 genetic KO similarly attenuated FK506-induced thermal and mechanical hypersensitivity. Together, our findings indicate that α2-1–bound NMDARs mediate calcineurin inhibitor-induced tonic activation of presynaptic and postsynaptic NMDARs at the spinal cord level and that presynaptic NMDARs play a prominent role in the development of CIPS. SIGNIFICANCE STATEMENT Calcineurin inhibitors are immunosuppressants used to prevent rejection of transplanted organs and tissues. However, these drugs can cause severe, unexplained pain. We showed that calcineurin inhibition enhances physical interaction between α2-1 and NMDARs and their synaptic trafficking in the spinal cord. α2-1 is essential for calcineurin inhibitor-induced aberrant activation of presynaptic and postsynaptic NMDARs in the spinal cord. Furthermore, inhibiting α2-1 or disrupting α2-1–NMDAR interaction reduces calcineurin inhibitor-induced pain hypersensitivity. Eliminating NMDARs in primary sensory neurons or α2-1 KO also attenuates calcineurin inhibitor-induced pain hypersensitivity. This new information extends our mechanistic understanding of the role of endogenous calcineurin in regulating synaptic plasticity and nociceptive transmission and suggests new strategies for treating this painful condition. Full Article
mda convert ircx to ict or emDataFile for Voltus-fi By feedproxy.google.com Published On :: Thu, 30 Apr 2020 01:04:07 GMT Hi, I want to convert ircx file(which is from TSMC,inclued EM Information) to ict or emDataFile for Voltus-fi. I tried many way, but I can not make it. Can anyone give me some advice? and I do not installed QRC. below is some tools installed my server. IC617-64b.500.21 is used. Full Article
mda convert ircx to ict or emDataFile for Voltus-fi By feedproxy.google.com Published On :: Wed, 29 Apr 2020 09:40:07 GMT Hi, I want to convert ircx file(which from TSMC) to ict or emDataFile for Voltus-fi. I tried many way, but I can not make it. and I do not installed QRC. below is some tools installed my server. IC617-64b.500.21 is used. Full Article
mda Development of IFN-Stimulated Gene Expression from Embryogenesis through Adulthood, with and without Constitutive MDA5 Pathway Activation [INNATE IMMUNITY AND INFLAMMATION] By www.jimmunol.org Published On :: 2020-05-04T13:00:28-07:00 Key Points The augmented ISG profile of RdRP mice develops largely postnatally. Elevated ISG expression is then maintained through adulthood. The ISG signature in adults requires persistent type I IFN signaling. Full Article
mda POSTPONED — The Future of U.S. Foreign Policy: An Address by Senator John McCain (R-Az) By webfeeds.brookings.edu Published On :: Wed, 11 Jun 2014 08:15:00 -0400 Event Information June 11, 20148:15 AM - 9:15 AM EDTThe Brookings InstitutionFalk Auditorium1775 Massachusetts Ave., N.W.Washington, DC 20036 This event has been postponed, and will be rescheduled for a later date. With ongoing crises in Ukraine, Syria, and other regions of the world, U.S. global leadership is arguably as critical now as it has ever been. However, many question how the United States should exercise its leadership, what foreign policy agenda it should pursue, and how it should configure its military and security agencies going forward. In a recent speech at West Point, President Obama laid out his foreign policy agenda for the remainder of his presidency. While the Obama Administration will pursue the president’s agenda as laid out at West Point, others in Washington have different views on how best to manage U.S. foreign policy going forward. On June 11, the Foreign Policy Program at Brookings will host Senator John McCain (R-AZ), former presidential candidate and member of the Senate Committee on Foreign Relations, for an address on the future of U.S. foreign and security policy. The address will be introduced by Brookings Senior Fellow and Director of Research for Foreign Policy Michael O’Hanlon, and the discussion following the Senator’s address will be moderated by Senior Fellow Robert Kagan. After the program, Senator McCain will take audience questions. Join the conversation on Twitter using #McCain Full Article
mda LEED Goes 3.0 — and They Ain't Joking 'Round By www.treehugger.com Published On :: Wed, 13 May 2009 11:20:12 -0400 The USGBC, and their insanely popular rating system LEED, have been on the frontlines of the green building movement for quite a while. Everyone has taken a shot at them at least once. There’s all the talk about how the credits are Full Article Design
mda Twitter Q1: sales up 3% to $808M as it swings to a loss on COVID-19, mDAUS hit record 166M By techcrunch.com Published On :: Thu, 30 Apr 2020 11:11:30 +0000 Despite traffic for many online properties being at an all-time high, advertising has fallen off a cliff because of the downturn in consumer activity outside the home and the wider economic pressures resulting from the COVID-19 pandemic. And today, Twitter reported quarterly earnings that bore this trend out. The ad-based social networking and media company said that […] Full Article Finance Social TC coronavirus COVID-19 earnings social media Twitter
mda Twitter Q1: sales up 3% to $808M as it swings to a loss on COVID-19, mDAUS hit record 166M By feedproxy.google.com Published On :: Thu, 30 Apr 2020 11:11:30 +0000 Despite traffic for many online properties being at an all-time high, advertising has fallen off a cliff because of the downturn in consumer activity outside the home and the wider economic pressures resulting from the COVID-19 pandemic. And today, Twitter reported quarterly earnings that bore this trend out. The ad-based social networking and media company said that […] Full Article Finance Social TC coronavirus COVID-19 earnings social media Twitter
mda Don’t hold your breath — Biocon founder Kiran Mazumdar Shaw says India's Covid-19 vaccine will enter clinical trials in 9 months By www.businessinsider.in Published On :: Thu, 07 May 2020 04:08:22 GMT “Even after India approves the coronavirus vaccine, it might not be possible to produce more than 10-20 million doses in the first year.”The comments came from the Chairperson of Biocon in an exclusive chat with Business Insider.Syngene, a Biocon subsidiary, is involved in accelerating a bunch of initiatives to develop a vaccine for the novel coronavirus that is spreading around the world.There are at least six vaccines under development in India, of the total 100 around the world including from the likes of Sanofi, Altimmune, and Pfizer. “Indian vaccine programmes will take some time before they get into the clinical trials, I think between 6 to 9 months depending on the programme. At least the ones we are working on, I don’t think they can get to clinics before 9 months,” Kiran Mazumdar Full Article
mda Honor 9X vs Redmi Note 8 Pro vs Samsung Galaxy M30s: कीमत, फीचर्स और स्पेसिफिकेशंस की तुलनाखुद पता लगाइए नए साल में कौन—सा फोन खरीदने में है आपका फायदा By Published On :: Thu, 16 Jan 2020 07:04:13 GMT यदि आप 15 हजार रुपए के आसपास की रेंज में सबसे अच्छा स्मार्टफोन खरीदना चाहते हैं, तो आपके पास कई विकल्प मौजूद हैं। इन दिनों कई स्मार्टफोन कंपनियों ने मिड-रेंज सेगमेंट में कई लेटेस्ट फोन उतारे हैं। स्पेसिफिकेशंस को देखें तो हर फोन की अपनी खूबियां हैं और कमियां भी। ऐसे में आप खुद तुलना कर पता लगा सकते हैं कि आपको अपनी जरूरत के आधार पर कौन—सा फोन चुनना चाहिए। यहां हम आपकी सुविधा के लिए Honor 9X, Redmi Note 8 Pro और Samsung Galaxy M30s की तुलना कर रहे हैं, जो कि मिड—रेंज में बहुत ही बढ़िया स्मार्टफोन्स हैं। जानते हैं इनमें कौन-सा फोन आपकी जरूरतों के अनुसार बेहतर विकल्प साबित हो सकता है—Honor 9X vs Redmi Note 8 Pro vs Samsung Galaxy M30s: कीमतजहां Redmi Note 8 Pro 17 अक्टूबर, 2019 तथा Samsung Galaxy M30s 9 नवंबर, 2019 को भारतीय बाजार में लॉन्च हुए, वहीं Honor 9X हाल ही 14 जनवरी, 2020 को भारतीय मार्केट में लॉन्च हुआ है। कीमत में तुलना करें तो HONOR 9X के शुरुआती 4GB रैम मॉडल की कीमत 13,999 रुपए है। वहीं Redmi Note 8 Pro 14,999 रुपए तथा Samsung Galaxy M30s 13,999 रुपए की शुरुआती कीमत के साथ बाजार में उपलब्ध है। Honor 9X vs Redmi Note 8 Pro vs Samsung Galaxy M30s: डिजाइन और डिस्प्लेHONOR 9X में 3डी कर्व्ड प्लास्टिक डिजाइन है, जिसमें ग्लॉस टेक्सचर और राउंडेड एजेज हैं। सफायर ब्लू वेरियंट में लाइट के संपर्क में एक्स पैटर्न बहुत ही खूबसूरती के साथ नजर आता है। वहीं Redmi Note 8 Pro में ग्लास फिनिश तथा Samsung Galaxy M30s में प्लास्टिक फिनिश डिजाइन दिया गया है। HONOR 9X में 6.59-इंच का पॉप—अप डिस्प्ले है। जी हां, आपने सही पढ़ा! इतनी कम कीमत पर पहली बार आपको फ्रंट पॉप—अप कैमरा Honor 9X के साथ मिल रहा है। वहीं, Redmi Note 8 Pro में 6.53 इंच का ड्र्यू—ड्रॉप डिस्प्ले दिया गया है और Samsung Galaxy M30s में 6.4 इंच का यू ड्रॉप डिस्प्ले है। तीनों ही फोन्स में आपको 91 प्रतिशत या उससे अधिक का स्क्रीन टु बॉडी रेशियो मिलता है। इसके अलावा इन तीनो ही फोन्स में आपको पीछे की ओर फिंगरप्रिंट स्कैनर दिए गए हैं।Honor 9X vs Redmi Note 8 Pro vs Samsung Galaxy M30s: परफॉरमेंसपरफॉरमेंस के मामले में HONOR 9X किरिन 710 प्रोसेसर और ओक्टाकोर सीपीयू के साथ दिया जा रहा है। इसमें 4GB/6GB रैम और 128GB स्टोरेज दी गई हैं, जो इसे फास्ट फोन बनाते हैं।Redmi Note 8 Pro हेलियो G90T और Samsung Galaxy M30s एग्जाइनॉस 9611 प्रोसेसर पर रन करते हैं। HONOR का दावा है कि उसका होमग्रोन किरिन 710 प्रोसेसर स्मार्टफोन्स में फास्ट परफॉर्मेन्स की सभी जरूरतों को पूरा करता है और इसीलिए गेमर्स का फेवरेट है।Honor 9X vs Redmi Note 8 Pro vs Samsung Galaxy M30s: कैमराHONOR 9X में 16MP का AI pop-up कैमरा दिया गया है, जो सॉफ्ट लाइट, बटरफ्लाइ लाइट, स्कैटर्ड लाइट, स्टेज लाइट जैसे आठ अलग—अलग मोड्स पर बखूबी काम करता है। इसमें इंटेलिजेंट फॉल डिटेक्शन, डाउनलोड प्रेशर प्रोटेक्शन और डस्ट तथा स्प्लैश प्रोटेक्टशन भी दिया गया है। यानी फोन के गिरने पर आपका कैमरा बचा रहता है और दबाव, धूल व पानी के छींटों का भी कैमरे पर ज्यादा असर नहीं होता। इसके अलावा HONOR 9X में AI-इनेबल्ड ट्रिपल रियर कैमरा सेटअप भी दिया गया हैं। इसमें 48MP प्राइमरी लेंस, 8MP सुपर वाइड लेंस और 2MP डेप्थ सेंसर दिया गया हैं। इसके एआइ फीचर से यह 22 अलग—अलग श्रेणियों के 500 से अधिक परिदृश्यों की सही पहचान कर सकता है। Redmi Note 8 Pro में 20MP का ड्र्यू—ड्रॉप फ्रंट कैमरा दिया गया है, वहीं 64(GM1)+8+2+2MP का रेअर कैमरा सैटअप है। इसी तरह Samsung Galaxy M30s में भी ट्रिपल रियर कैमरा सेटअप मौजूद हैं। इसमें 48MP प्राइमरी लेंस, 8MP अल्ट्रा-वाइड लेंस और 5MP डेप्थ सेंसर दिया गया है। इसका फ्रंट या सेल्फी कैमरा 16MP का है।Honor 9X vs Redmi Note 8 Pro vs Samsung Galaxy M30s: जरूरत के अनुसार फैसलाअगर आप एक बढ़िया कैमरा और परफॉर्मेंस वाला स्टाइलिश फोन तलाश रहे हैं तो HONOR 9X से अच्छा फोन इस प्राइस रेंज में नहीं मिलेगा। HONOR 9X में आपको फ्रंट कैमरा 16MP का मिलेगा, जो पॉप—अप के साथ हर किसी को अपना दीवाना बना लेगा। जबकि आपको Redmi Note 8 Pro और Samsung Galaxy M30s में पॉप अप कैमरा नहीं मिलेंगे। इसके अलावा Honor 9X का 6.59 इंच का डिस्प्ले साइज भी बाकी दो फोन से ज्यादा है। इसके अलावा आपको रोम या स्टोरेज स्पेस भी HONOR 9X में 128 जीबी की मिलेगी। जबकि Redmi Note 8 Pro और Samsung Galaxy M30s के शुरुआती फोन्स में यह 64 जीबी ही है।Honor 9X का किरिन 710 प्रोसेसर Redmi Note 8 Pro के हेलियो G90T और Samsung Galaxy M30s के एक्जाइनॉस 9611 प्रोसेसर से परफॉर्मेंस के मामले में बेहतर है। किरिन 710 प्रोसेसर के साथ HONOR 9X में गेमिंग का अनुभव भी इन दोनो ही फोन्स से बेहतर है।डालते हैं एक नजर, तीनों फोन्स के तुलनात्मक आंकड़ों पर— Honor 9X Redmi Note 8 Pro Samsung Galaxy M30s लॉन्च की तारीख 14 जनवरी, 2020 17 अक्टूबर, 2019 9 नवंबर, 2019 कीमत 13999/ 16999 14999/ 15999/17999 13999/ 16999 डिजाइन प्लास्टिक ग्लास प्लास्टिक ऑपरेटिंग सिस्टम एंड्रॉइड 9.0 एंड्रॉइड 9.0 एंड्रॉइड 9.0 डिस्प्ले आकार 6.59" पॉप—अप 6.53 ड्र्यू—ड्रॉप 6.4 U ड्रॉप रिजॉल्यूशन FHD+ FHD+ FHD+sAMOLED सीपीयू Kirin 710 Helio G90T Exynos 9611 फ्रंट कैमरा 16MP पॉप—अप 20MP ड्र्यू—ड्रॉप 16M ड्र्यू—ड्रॉप रेअर कैमरा 48+8+2MP 64(GM1)+8+2+2MP 48+8+5MP रैम 4/6GB 6/8GB 4/6GB रोम 128GB 64/128GB 64/128GB चार्जिंग टाइप टाइप—सी टाइप—सी टाइप—सी फिंगरप्रिंट अनलॉक पीछे की ओर पीछे की ओर पीछे की ओर स्क्रीन रेशिओ 91.0% 91.4% 91.4% Download Dainik Bhaskar App to read Latest Hindi News Today Honor 9X vs Redmi Note 8 Pro vs Samsung Galaxy M30s Full Article
mda [ASAP] Novel Dithiolane-Based Ligands Combining Sigma and NMDA Receptor Interactions as Potential Neuroprotective Agents By feedproxy.google.com Published On :: Fri, 10 Apr 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.0c00129 Full Article
mda MRI : the basics / Ray H. Hashemi, MD, PhD, (President and Medical Director, Advanced Imaging Center, Inc., Valencia/Palmdale/Lancaster/Ridgecrest, California), Christopher J. Lisanti, MD, Col (ret) USAF, MC, SFS, (Chief, Body MRI, Department of Radiology By prospero.murdoch.edu.au Published On :: Hashemi, Ray H., author Full Article
mda Polymer nanocomposites for advanced engineering and military applications / Noureddine Ramdani By library.mit.edu Published On :: Sun, 26 Jan 2020 06:23:19 EST Online Resource Full Article
mda Principles and applications of free space optical communications / edited by Arun K. Majumdar, Zabih Ghassemlooy, and A. Arockia Bazil Raj By library.mit.edu Published On :: Sun, 3 May 2020 06:37:44 EDT Online Resource Full Article
mda Shyamal Majumdar: Driverless cars? By www.business-standard.com Published On :: Thu, 06 Oct 2016 21:49:00 +0530 Despite leadership vacuum, state-run banks are slow in lateral recruitments Full Article Premium
mda It's summer — here comes the Mars e-mail! By www.moreheadplanetarium.org Published On :: Wed, 12 Aug 2009 07:00:00 EST Did you receive a "spam" e-mail about Mars? Full Article News Science
mda Mazumdar-Shaw recognised among world's top 20 inspirational leaders in Biopharma By economictimes.indiatimes.com Published On :: 2020-04-27T17:49:10+05:30 Biocon Executive Chairperson Kiran Mazumdar-Shaw has been recognised for her contribution to the world of medicine as an entrepreneur and innovative business leader, the Bengaluru-headquartered biopharmaceuticals company said in a statement. Full Article
mda JSJ 328: Functional Programming with Ramda with Christine Legge By devchat.tv Published On :: Tue, 28 Aug 2018 06:00:00 -0400 Panel: Joe Eames Aimee Knight AJ O'Neal Joe Eames Special Guests: Christine Legge In this episode, the JavaScript Jabber panel talks to Christine Legge about functional programming with Ramda. Christine is a front-end software engineer and just recently got a new job in New York working at Google. Ramda is a utility library in JavaScript that focuses on making it easier to write JavaScript code in a functional way. They talk about functional programming and what it is, using Ramda in Redux, and referential transparency. They also touch on why she first got into Ramda, compare Ramda to Lodash and Underscore, and more! In particular, we dive pretty deep on: Chirstine intro Works as a front-end software engineer What is Ramda? JavaScript Utility library like Lodash and Underscore Lodash and Underscore VS Ramda Functional programming Ramda and Functional programming as a mindset Ramda at ZenHub Ramda with Redux and React What is referential transparency? Why would you use Ramda VS Lodash or Underscore? Why she first got into Ramda Didn’t always want to be a programmer Background in Math Learning functional programming as a new programmer Erlang DrRacket and Java Ramda makes it easy to compose functions Creating clean and reusable code How do you start using Ramda? And much, much more! Links: Ramda Lodash Underscore ZenHub Redux React Erlang DrRacket @leggechr Chirstine’s GitHub Sponsors Kendo UI Sentry Digital Ocean Picks: Charles Home Depot Tool Rental Podcast Movement CES VRBO Aimee Apple Cider Vinegar Jeremy Fairbank Talk – Practical Functional Programming AJ Goat’s Milk Joe Topgolf Framework Summit Christine Dan Mangan Reply All Podcast Full Article
mda Selective cytotoxic effect against the MDA-MB-468 breast cancer cell line of the antibacterial palindromic peptide derived from bovine lactoferricin By feeds.rsc.org Published On :: RSC Adv., 2020, 10,17593-17601DOI: 10.1039/D0RA02688C, Paper Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Andrea Barragán-Cárdenas, Maribel Urrea-Pelayo, Víctor Alfonso Niño-Ramírez, Adriana Umaña-Pérez, Jean Paul Vernot, Claudia Marcela Parra-Giraldo, Ricardo Fierro-Medina, Zuly Rivera-Monroy, Javier García-CastañedaThe cytotoxic effect against the breast cancer cell line MDA-MB-468 of the palindromic peptide LfcinB (21–25)Pal: 1RWQWRWQWR9 and its analogous peptides, obtained via alanine scanning, was evaluated.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
mda VersaStack solution by Cisco and IBM with Oracle RAC, IBM FlashSystem V9000, IBM Spectrum Protect [electronic resource] / Jon Tate, Dharmesh Kamdar, Dong Hai Yu, Randy Watson By prospero.murdoch.edu.au Published On :: Tate, Jon, author Full Article
mda Kiran Mazumdar-Shaw on her career: ‘I call myself an accidental entrepreneur' By feedproxy.google.com Published On :: 08 Mar 2020 06:10:00 +0000 Barred as a woman from becoming a brewer in India, Mazumdar-Shaw instead founded biotech firm Biocon and today focuses on affordable health care Full Article
mda Teaching and learning in saudi arabia: perspectives from higher education / edited by Amani K. Hamdan. By library.mit.edu Published On :: Sun, 14 Feb 2016 06:22:18 EST Rotch Library - LA1436.4 T43 2015 Full Article
mda Rabindranath & his many abodes / research & text, Shouvik Mukhopadhyay, Partha Sankha Majumdar, Ramanuj Mukherjee By grammy.mit.edu Published On :: Tues, 8 Nov 2016 Rotch Library - PK1725.M85 2014 Full Article
mda A new critical approach to the history of Palestine: Palestine history and heritage project 1 / edited by Ingrid Hjelm, Hamdan Taha, Ilan Pappe, and Thomas L. Thompson By grammy.mit.edu Published On :: Wed, 16 Oct 2019 Rotch Library - DS117.N49 2019 Full Article
mda Marriage record of Ramdazza, Isidoro and Sendoya, Maria By digital.lib.usf.edu Published On :: Mon, 02 Jun 2014 16:54:25 -0400 Full Article
mda How designer Riten Mozumdar shaped modern Indian aesthetics and sensibilities By indianexpress.com Published On :: Sat, 15 Feb 2020 04:30:18 +0000 Full Article Eye
