Title: In Some Brain Bleeds, Patients Do Better at High-Volume Hospitals
Category: Health News
Created: 5/3/2012 6:05:00 PM
Last Editorial Review: 5/4/2012 12:00:00 AM

Title: Health Tip: Coping With Winter Nosebleeds
Category: Health News
Created: 1/10/2020 12:00:00 AM
Last Editorial Review: 1/10/2020 12:00:00 AM

Pharmacokinetic-based prophylaxis of replacement factor VIII (FVIII) products has been encouraged in recent years, but the relationship between exposure (factor VIII activity) and response (bleeding frequency) remains unclear. The aim of this study was to characterize the relationship between FVIII dose, plasma FVIII activity, and bleeding patterns and individual characteristics in severe hemophilia A patients. Pooled pharmacokinetic and bleeding data during prophylactic treatment with BAY 81-8973 (octocog alfa) were obtained from the three LEOPOLD trials. The population pharmacokinetics of FVIII activity and longitudinal bleeding frequency, as well as bleeding severity, were described using non-linear mixed effects modeling in NONMEM. In total, 183 patients [median age 22 years (range, 1-61); weight 60 kg (11-124)] contributed with 1,535 plasma FVIII activity observations, 633 bleeds and 11 patient/study characteristics [median observation period 12 months (3.1-13.1)]. A parametric repeated time-to-categorical bleed model, guided by plasma FVIII activity from a 2-compartment population pharmacokinetic model, described the time to the occurrence of bleeds and their severity. Bleeding probability decreased with time of study, and a bleed was not found to affect the time of the next bleed. Several covariate effects were identified, including the bleeding history in the 12-month pre-study period increasing the bleeding hazard. However, unexplained inter-patient variability in the phenotypic bleeding pattern remained large (111%CV). Further studies to translate the model into a tool for dose individualization that considers the individual bleeding risk are required. Research was based on a post-hoc analysis of the LEOPOLD studies registered at clinicaltrials.gov identifiers: 01029340, 01233258 and 01311648.

Glimpsing the horrors in Stephen King's mind

Leeds United legend and one of England's 1966 World Cup winners Norman Hunter has been admitted to hospital after testing positive for coronavirus.

Leeds United great Norman Hunter remains "severely unwell" in hospital almost a week after being admitted with coronavirus.

Welcome to the Evening Standard's LIVE coverage as the coronavirus crisis continues to heavily impact sport across the globe.

Former Leeds United manager Peter Reid led the tributes as club legend Norman Hunter passed away on Friday, aged 76, after contracting coronavirus.

England World Cup winner Norman Hunter has passed away aged 76 after contracting coronavirus.

Leeds United have renamed the South Stand at Elland Road after club legend Norman Hunter,

Former England and Leeds United defender Trevor Cherry has died at the age of 72.

Leeds United legend Norman Hunter died on Friday at the age of 76 after testing positive for coronavirus. "Leeds United are devastated to learn of the passing of club icon Norman Hunter at the age of 76," the club said in a statement. "Norman was taken to hospital last week after being diagnosed with COVID-19 and despite continuing to battle and the best efforts of NHS staff, he sadly lost his fight earlier this morning," the statement added.

Hunter made his Leeds debut in 1962 when he was just 18 years old. Hunter amassed a huge 726 appearances for Leeds United over a 14 year period, the club's most successful to date, earning the infamous nickname "Bites Yer Legs".

He won a total of 28 caps for England and was in the 1966 World Cup-winning squad, whilst was also the first winner of the PFA Players' Player of the Year in 1974.

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Minister omits eastern leg to Yorkshire in statement on high-speed rail project

The end of the year is a time for reflection, looking back at the great and the good of the sporting world and those moments that have shown the best of 2019. We don't care about that, though, do we?

EXCLUSIVE: It was Halloween at the player-manager's house and Anderlecht's Kemar Roofe discovered it was not enough to simply turn up to the party with his children in fancy dress.

Leeds Rhinos coach Richard Agar watched his side hammer Super League new boys Toronto Wolfpack 66-12 to keep them rooted to the foot of the table but tipped them to avoid relegation.

Leeds Rhinos could face punishment from the Rugby Football League after taking a decision not to travel to their Super League fixture with Catalans Dragons in Spain.

EXCLUSIVE INTERVIEW BY KIERAN GILL: The front page of The Glasgow Herald on Thursday April 16, 1970, was split in two. On the right-hand side, the headline read: 'Apollo 13 off course for the Earth.'

Tributes have been made for the late Norman Hunter from Sir Geoff Hurst, Robbie Fowler, Peter Reid, Jamie Carragher, Gary Neville and others who remember the Leeds legend.

Cherry who began his career with hometown club Huddersfield and also later played for and managed Bradford, earned 27 caps for England and captained the national side in his penultimate appearance.

Michael Oliver has been keeping busy by providing a very modern take on Chelsea's 2-1 FA Cup final triumph over Leeds 50 years ago in the more than feisty replay at Old Trafford.

The 76-year-old, who played 726 games in 15 years at Elland Road, was admitted to hospital with Covid-19 earlier this month but failed to make a full recovery in devastating news for the club.

The banner was a home-made affair, just canvas strung between a pair of wooden poles. It was unfurled by Leeds United fans at the FA Cup final in 1972, with the message: 'Norman Bites Yer Legs.'

England's top football cop has said that playing football matches at their original venues would 'present challenges' to the police and has suggested that neutral venues be considered.

Leeds United have launched a bid to sign Croatia U21 international captain Ivan Sunjic. The 22-year old plays for Dinamo Zagreb who have already fielded an offer from Birmingham City.

ADAM LANIGAN AT ELLAND ROAD: Leeds United celebrated turning 100 years old in a fitting manner by moving back into the Championship's automatic promotion spots.

The Football Association could be called in to investigate the crowd disturbances that marred the end of the Championship match between Leeds United and Birmingham City.

ROSS HEPPENSTALL AT ELLAND ROAD: Marcelo Bielsa could not hide his frustration after a dramatic collapse saw Cardiff come back from the dead to destroy Leeds' seven-match winning streak.

ROSS HEPPENSTALL AT ST ANDREW'S: Marcelo Bielsa was asked afterwards how his heart had coped with such an extraordinarily thrilling encounter.

EXCLUSIVE: Sue Hepworth has claimed she put the question - 'Is the monarchy fit for purpose?' - forward to be used by host Julie Etchingham as she grilled Jeremy Corbyn and Boris Johnson.

The luxury development in Leeds features 150 flats across a six-storey building with students enjoying double beds, en suite bathrooms and flat screen TVs in their rooms and a gym on-site.

Britain’s third biggest supermarket is reported to have plans to slash around a tenth of Asda’s 2,500 jobs at its head office in Leeds, or around 250 roles.

A 25-year-old man was found with serous injuries before a police cordon was put in place after emergency services were called to Leeds city centre around 1.20pm.

Neil Wood abused his position as a manager at the Leeds and York NHS Trust to gets kickbacks from a company controlled by his wife Lisa.

Sophie Pointon (pictured), 22, told police officers that she had been sexually assaulted in the back of the cab she had been picked up in after a night out in Leeds city centre.

Laura Jane, from Leeds, said she was stunned when she heard a loud thud as the bird crashed into the glass and and left a body-shaped mark for proof.

Sophie Pointon, 22, whose dream was to become a police officer, falsely claimed she had been groped in the back of the cab after a night out in Leeds and has been jailed for 16 months.

Kevin Calvert was doing his regular journey home from Leeds to Bradford, in West Yorkshire, around 5pm earlier this month when he noticed the bus stop for a little longer than usual.

The man, from Hull, who cannot be named for legal reasons, was caught after allegedly arranging to meet up with the 'girl' in Leeds only to be confronted by members of The Innocence Keepers.

Barbara Milroy, 85, was found dangling from the second floor window of her bedroom by care staff before falling to the ground below at the Lofthouse Lodge in Wakefield, West Yorkshire.

Angi Strafford, from Leeds, was shocked by the wording on the back of Tesco's own brand pack of 100 disposable liners. She said the description suggests only women change the nappies.

Police are treating the abuse as hate crime the anti-Semitic messages after it was discovered at Etz Chaim synagogue, in Leeds, West Yorkshire.

Mia Wilson, 23, was on a First Bus in Leeds when she says a row broke out between a mother and the bus driver about a pram occupied by a cat (circled) taking up the remaining pushchair space.

An E-Class Mercedes appeared to be damaged by a disgruntled employee who spray painted abusive messages onto the car's bodywork in Leeds City Centre earlier today.

They've been enjoying a string of romantic dates since announcing their engagement last month.  And Jess and Dom treated themselves to another night on the tiles as they headed out in Leeds.

WARNING: Distressing content. Mother Gabriella Morley, of Bramley, Leeds, gave birth to her stillborn daughter Poppy after the baby was poisoned in the womb by a pregnancy-related liver condition.

Mother Emma Oliver, 43, of Gildersome, Leeds, West Yorkshire, has spoken out after her son, Daniel Long, took his own life at the age of 15.

The changes are the latest in a flurry of rate rises across easy access and fixed rate cash Isas as banks and building societies jostle to secure people's savings.

Shania Greenhall, from Leeds, was beaten with a ratchet as children fired fireworks at her and three friends on a grassy area near a school on Wednesday.

Adam Marr (pictured), 24, and three friends decided to dangerously walk across the transparent roof of Trinity Leeds retail outlet, some 100ft above the ground.