This report describes the evidence for invasion of Pacific Northwest streams by Atlantic salmon (Salmo salar) that have escaped from marine salmon farms, and assesses the potential impact of farmed salmon invasion on native fishes inhabiting streams on National Forest System lands. The current risk to streams on National Forest lands in the Pacific Northwest from Atlantic salmon invasions appears to be low and is limited to a few areas in northwest Washington and southeast Alaska. However, long-term risks may be substantial if fish continue to escape from marine rearing pens or freshwater hatcheries. The two greatest threats appear to be that (1) Atlantic salmon could transmit a serious disease or parasite to native fishes, and (2) escaped salmon could eventually adapt to local conditions, leading to self-sustaining populations. If Atlantic salmon populations are eventually established, this species' preference for swiftly flowing stream habitats could facilitate competition with currently at-risk species such as steelhead (Oncorhynchus mykiss). This could result in a pattern of expansion similar to that observed in other nonnative aquatic plants and animals, in which a prolonged early colonization period is followed by a rapid phase of exponential growth as breeding populations adapt to local conditions.

Police hunt two men they believe broke into a Cherrybrook home and assaulted 86-year-old Colin Saliba, who sustained fatal head injuries in the attack, and his wife Josephine, who remains in hospital.

The 2016 killing of a Canberra man is portrayed as a "cold-blooded plan", designed to silence him over an earlier machete attack, on the first day of an ACT Supreme Court trial.

Scott Alan Murdoch, the man who stabbed Melbourne woman Kylie Blackwood and left her bleeding to death to be found by her 11-year-old twins, will have to serve at least 36 years before he is eligible for parole.

A man who had half his face shot off in a 2017 home invasion has fought back tears after a second man pleaded guilty in relation to his violent home invasion.

The victim of a violent home invasion in Newcastle has described his ongoing suffering and lifelong trauma after half his face was shot off in December 2017.

Repair specialists say it is part of a growing trend which has seen the invasive Asian house gecko destroying cooling systems across New South Wales and Queensland.

About 34,000 troops from several countries are playing out high-end war games in a mammoth training exercise designed to improve military cooperation.

The 20-year-old was reportedly shot in Hollywood Hills.

A LOCUST plague and the spreading coronavirus could cause famine of "biblical" proportions in East Africa, experts have warned.

Cholesterol/sphingolipid-rich membrane domains, known as lipid rafts or membrane rafts, play a critical role in the compartmentalization of signaling pathways. Physical segregation of proteins in lipid rafts may modulate the accessibility of proteins to regulatory or effector molecules. Thus, lipid rafts serve as sorting platforms and hubs for signal transduction proteins. Cancer cells contain higher levels of intracellular cholesterol and lipid rafts than their normal non-tumorigenic counterparts. Many signal transduction processes involved in cancer development (insulin-like growth factor system and phosphatidylinositol 3-kinase-AKT) and metastasis [cluster of differentiation (CD)44] are dependent on or modulated by lipid rafts. Additional proteins playing an important role in several malignant cancers (e.g., transmembrane glycoprotein mucin 1) are also being detected in association with lipid rafts, suggesting a major role of lipid rafts in tumor progression. Conversely, lipid rafts also serve as scaffolds for the recruitment and clustering of Fas/CD95 death receptors and downstream signaling molecules leading to cell death-promoting raft platforms. The partition of death receptors and downstream signaling molecules in aggregated lipid rafts has led to the formation of the so-called cluster of apoptotic signaling molecule-enriched rafts, or CASMER, which leads to apoptosis amplification and can be pharmacologically modulated. These death-promoting rafts can be viewed as a linchpin from which apoptotic signals are launched. In this review, we discuss the involvement of lipid rafts in major signaling processes in cancer cells, including cell survival, cell death, and metastasis, and we consider the potential of lipid raft modulation as a promising target in cancer therapy.

Cholesterol/sphingolipid-rich membrane domains, known as lipid rafts or membrane rafts, play a critical role in the compartmentalization of signaling pathways. Physical segregation of proteins in lipid rafts may modulate the accessibility of proteins to regulatory or effector molecules. Thus, lipid rafts serve as sorting platforms and hubs for signal transduction proteins. Cancer cells contain higher levels of intracellular cholesterol and lipid rafts than their normal non-tumorigenic counterparts. Many signal transduction processes involved in cancer development (insulin-like growth factor system and phosphatidylinositol 3-kinase-AKT) and metastasis [cluster of differentiation (CD)44] are dependent on or modulated by lipid rafts. Additional proteins playing an important role in several malignant cancers (e.g., transmembrane glycoprotein mucin 1) are also being detected in association with lipid rafts, suggesting a major role of lipid rafts in tumor progression. Conversely, lipid rafts also serve as scaffolds for the recruitment and clustering of Fas/CD95 death receptors and downstream signaling molecules leading to cell death-promoting raft platforms. The partition of death receptors and downstream signaling molecules in aggregated lipid rafts has led to the formation of the so-called cluster of apoptotic signaling molecule-enriched rafts, or CASMER, which leads to apoptosis amplification and can be pharmacologically modulated. These death-promoting rafts can be viewed as a linchpin from which apoptotic signals are launched. In this review, we discuss the involvement of lipid rafts in major signaling processes in cancer cells, including cell survival, cell death, and metastasis, and we consider the potential of lipid raft modulation as a promising target in cancer therapy.

In 2011, declassified CIA documents shed light on a covert government program dating back to WWII

The Society for Research in Educational Effectiveness' annual conference here last week highlighted new ways the United States is learning from the United Kingdom both in research development and use in education.

US President Donald Trump has dismissed claims the foiled plot to kidnap Venezuelan President Nicolas Maduro had government backing, insisting he’d have done it differently – as a proper “invasion” with an “army.”
Read Full Article at RT.com

Venezuela will try two Americans captured during a failed bid by mercenaries to invade the country, President Nicolas Maduro said on Wednesday, as the United States vowed to “use every tool available”

Title: Caterpillar Invasion in London Puts People at Risk of Deadly Allergic Reactions
Category: Health News
Created: 4/30/2018 12:00:00 AM
Last Editorial Review: 5/1/2018 12:00:00 AM

Cholesterol/sphingolipid-rich membrane domains, known as lipid rafts or membrane rafts, play a critical role in the compartmentalization of signaling pathways. Physical segregation of proteins in lipid rafts may modulate the accessibility of proteins to regulatory or effector molecules. Thus, lipid rafts serve as sorting platforms and hubs for signal transduction proteins. Cancer cells contain higher levels of intracellular cholesterol and lipid rafts than their normal non-tumorigenic counterparts. Many signal transduction processes involved in cancer development (insulin-like growth factor system and phosphatidylinositol 3-kinase-AKT) and metastasis [cluster of differentiation (CD)44] are dependent on or modulated by lipid rafts. Additional proteins playing an important role in several malignant cancers (e.g., transmembrane glycoprotein mucin 1) are also being detected in association with lipid rafts, suggesting a major role of lipid rafts in tumor progression. Conversely, lipid rafts also serve as scaffolds for the recruitment and clustering of Fas/CD95 death receptors and downstream signaling molecules leading to cell death-promoting raft platforms. The partition of death receptors and downstream signaling molecules in aggregated lipid rafts has led to the formation of the so-called cluster of apoptotic signaling molecule-enriched rafts, or CASMER, which leads to apoptosis amplification and can be pharmacologically modulated. These death-promoting rafts can be viewed as a linchpin from which apoptotic signals are launched. In this review, we discuss the involvement of lipid rafts in major signaling processes in cancer cells, including cell survival, cell death, and metastasis, and we consider the potential of lipid raft modulation as a promising target in cancer therapy.

The translocated actin recruiting phosphoprotein (Tarp) is a multidomain type III secreted effector used by Chlamydia trachomatis. In aggregate, existing data suggest a role of this effector in initiating new infections. As new genetic tools began to emerge to study chlamydial genes in vivo, we speculated as to what degree Tarp function contributes to Chlamydia’s ability to parasitize mammalian host cells. To address this question, we generated a complete tarP deletion mutant using the fluorescence-reported allelic exchange mutagenesis (FRAEM) technique and complemented the mutant in trans with wild-type tarP or mutant tarP alleles engineered to harbor in-frame domain deletions. We provide evidence for the significant role of Tarp in C. trachomatis invasion of host cells. Complementation studies indicate that the C-terminal filamentous actin (F-actin)-binding domains are responsible for Tarp-mediated invasion efficiency. Wild-type C. trachomatis entry into HeLa cells resulted in host cell shape changes, whereas the tarP mutant did not. Finally, using a novel cis complementation approach, C. trachomatis lacking tarP demonstrated significant attenuation in a murine genital tract infection model. Together, these data provide definitive genetic evidence for the critical role of the Tarp F-actin-binding domains in host cell invasion and for the Tarp effector as a bona fide C. trachomatis virulence factor.

Asja Guzman, Rachel C. Avard, Alexander J. Devanny, Oh Sang Kweon, and Laura J. Kaufman

The study of cancer cell invasion in 3D environments in vitro has revealed a variety of invasive modes, including amoeboid migration, characterized by primarily round cells that invade in a protease- and adhesion-independent manner. Here, we delineate a contractility-dependent migratory mode of primarily round breast cancer cells that is associated with extensive integrin-mediated extracellular matrix (ECM) reorganization that occurs at membrane blebs, with bleb necks sites of integrin clustering and integrin-dependent ECM alignment. We show that the spatiotemporal distribution of blebs and their utilization for ECM reorganization is mediated by functional β1 integrin receptors and other components of focal adhesions. Taken together, the work presented here characterizes a migratory mode of primarily round cancer cells in complex 3D environments and reveals a fundamentally new function for membrane blebs in cancer cell invasion.

Your weekly selection of awesome robot videos

Travis Scott just headlined 'Fortnite' instead of Coachella, debuting a new song with Kid Cudi. It was trippy. There were flaming microphone stands.

The disease is like “a zombie walking the Earth,” wanting to kill humans, says the Canadian actor. “I think the best thing to do is stay in and let’s keep doing what we’re doing.”

FBI agents today arrested four people in connection with an armed home invasion robbery in Bartonsville, Penn.

After a four-day trial, a federal jury in the Eastern District of Pennsylvania found Tahn Le, 44, guilty on Jan. 20, 2012, of conspiracy to interfere with interstate commerce through multiple home invasion robberies and related firearms violations.

Tahn Le, 44, of Philadelphia, was sentenced today to 400 months in prison for his participation in a conspiracy to commit violent home invasion robberies of successful Asian business owners in Pennsylvania, New Jersey, Maryland and Virginia.

Misconceptions and outright misrepresentations of the role of oil in the Iraqi debacle remain, spawning conspiracy theories about conflicts from Libya, Syria and Gaza to Afghanistan.

A major report just released offers expensive technological solutions. We reivew options ranging from barriers to bow-hunting.

Alien Invasion Might Happen

Author Mohsin Hamid reads his short story 'Alien invasion in the G.L.A.C.', commissioned by the Financial Times for the new year.  

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Regime claims 8 people died in plot connected to foiled coup attempt launched from Colombia

Ever a man of the people. That was the key to that roaring following which it took time for the Americans to grasp as the tens of thousands hit Sin City for Mayweather fight week.

James Jeffrey, Washington's special envoy for Syria, said the number is 'now over 100' and said: 'We do not know where they are'.

The Kurdish forces who were guarding the al-Hol camp (pictured) have been distracted by the Turkish offensive and hundreds of guards have been pulled away.

Monty Don shared his advice for repelling snails and slugs in an extract from his classic book Gardening at Longmeadow. British gardening expert warns against using slug pellets.

A new documentary about George W. Bush sheds new light on the events after the September 11, 2001 attacks, which turned Bush into a wartime president.

The 'Nordic Nightmare' is on a high after his devastating stoppage of previously undefeated Adam Kownacki earlier this month, and is now just one win away from a potential fight with AJ.

Online Resource

Dewey Library - KZ4041.O43 2018

Rotch Library - DS288.Z313 2017