An overview of the Ebola virus outbreak in West Africa that has been described by the World Health Organization as the largest, most severe and most complex outbreak in the history of the disease.

The epidemic began at the end of 2013, in Guinea. From there it spread to Liberia, Sierra Leone, Nigeria and Senegal. Many of the affected countries face enormous challenges in stopping its spread and providing care for all patients.

Thousands of people have died and many are at risk as the fatality rate from this virus is very high. As the crisis worsens, as well as the enormous health challenges involved, the social and economic consequences may set these countries back, reversing some gains a number of these countries have made in recent years.

This new page includes more information on the above issues.

Read full article: Ebola Outbreak In West Africa

Souad Amiar
Apr 15, 2020; 0:jlr.ILR120000753v1-jlr.ILR120000753
Images in Lipid Research

Karen Grépin, assistant professor of global health policy at New York University, has been examining the pledges made by the international community to help fight the ebola virus outbreak - was it really too little, too late? Read her full analysis: http://www.bmj.com/content/350/bmj.h376

In 2014, Oliver Johnson was a 28 year old British doctor, working on health policy in Sierre Leone after finishing medical school. Also working in Freetown was Sinead Walsh, then the Irish Ambassador to the country. Then the biggest outbreak of Ebola on record happened in West Africa, starting in Guinea and quickly spreading to Liberia, Sierre...

Ebola Virus (EBOV) is among the most devastating pathogens causing fatal hemorrhagic fever in humans. The 2013–2016 epidemics resulted in over 11000 deaths, while another outbreak is currently ongoing. Since there is no FDA-approved drug so far to fight EBOV infection, there is an urgent need to focus on drug discovery. Considering the tight correlation between the high EBOV virulence and its ability to suppress the type-I Interferon (IFN-I) system, identifying molecules targeting viral protein VP24, one of the main virulence determinants blocking IFN response, is a promising novel anti-EBOV therapy approach. Hence, in the effort of finding novel EBOV inhibitors, a screening of a small set of flavonoids was performed, showing that Quercetin and Wogonin can suppress the VP24 effect on IFN-I signaling inhibition. The mechanism of action of the most active compound, Quercetin, showing an IC₅₀ value of 7.4 μM, was characterized to significantly restore the IFN-I signaling cascade, blocked by VP24, by directly interfering with the VP24 binding to karyopherin-α and thus restoring P-STAT1 nuclear transport and IFN genes transcription. Quercetin significantly blocked viral infection, specifically targeting EBOV VP24 anti-IFN-I function. Overall, Quercetin is the first identified inhibitor of the EBOV VP24 anti-IFN function, representing a molecule interacting with a viral binding site that is very promising for further drug development aiming to block EBOV infection at the early steps.

The DRC’s Ebola epidemic will be declared over on 12 April but there’s little time to celebrate as the country pivots towards tackling the coronavirus

Fresh cases of Ebola have been detected just days before the deadly epidemic in the eastern Democratic Republic of the Congo was to be declared over

The shipment of Ebola and henipavirus samples to Wuhan has given rise to groundless conspiracy theories involving Xiangguo Qiu. But there is no evidence whatsoever tying her to COVID-19

Leading medical experts have described trials for a drug which could treat coronavirus as "a really promising first step" towards overcoming the disease.

The United States has authorised the emergency use of the Ebola drug remdesivir for treating coronavirus, clearing the way for the potential treatment of 140,000 patients around the country.

South Korea says that remdesivir, traditionally used in treating Ebola, may not be effective enough in treating COVID-19 patients.

Posted by Roger Bate Cairo, Egypt – While its economy is still suffering from weak tourism, its new government is trying to do its best to bolster its modest regulatory structures to oversee medicines. With a population of approaching 90 million, Africa’s third most populous nation, is an important final destination for medicines, and a key transit point too. But it’s not just good medicines that Egypt needs to assess and ensure are procured, it has to prevent the bad &ndash [...]

Virginia Bioinformatics Institute Video Case Study

Top virologist Peter Piot spent 1 week at a London hospital in April and has been recovering at home since

The ‘Mick Jagger of microbes’ on a life of fighting disease — and the severity of the current crisis

'We should not underestimate the transmissibility' of this disease, Paul told a conservative radio show host.

The Dept of Commerce says 74m US residents travelled internationally in 2015 - a 9% rise on the previous year. Of those, 33m travelled overseas, with the UK the most popular destination.

US researchers have published early data which suggests a drug, called remdesivir, pictured, could effectively treat people with coronavirus.

Pauline Cafferkey, 43 (pictured) from Glasgow, who first contracted the killer bug in 2014, welcomed the 'two amazing boys' at 10am on Tuesday.

South Sudan is the 'most vulnerable' of the countries neighbouring the Democratic Republic of the Congo, experts said, where 1,522 people have died of Ebola since the outbreak began in August.

The MP said the outbreak is 'very dangerous' after a two-day visit to the Democratic Republic of the Congo. Health officials have rejected proposals to declare a global emergency three times.

The World Health Organisation said it was 'time for the world to take notice' as the UN agency invoked its emergency provisions to contain the growing outbreak in DR Congo.

Scientists at Fort Detrick, Maryland, study Ebola, the plague (caused by the bacterium Yersinia pestis) and rabbit fever (caused by the bacterium tularemia).

Dr Catherine Houlihan, from Aberdeen, returned home to the UK from the African nation in June after spending a month at the heart of the epidemic in the North Kivu province.

The explosion, at the Vector laboratory in Siberia, left a worker with second and third degree burns. The lab is one of two places in the world which houses the smallpox disease.

The patient was rushed to Skane University Hospital in Lund on Monday after suffering symptoms linked to the killer virus. Doctors say they can't rule out Ebola until test results come back.

Several countries that have never experienced the problem, including Nigeria which is home to 191 million people, are particularly at risk - both now and in the years ahead.

The so-called Merck vaccine was approved his afternoon and is likely to get a full marketing licence from the European Commission within a few weeks.

On the heels of the WHO's declaration that Ebola is an 'international public health emergency of international concern,' Ebola screeners have been hired to test the blood of travelers at Dulles International Airport in DC.

On Thursday, the US Food and Drug Administration approved Ervebo, the first vaccine against Ebola to get green lit by American officials. It comes as a Congo outbreak rages on and has killed 4 in Uganda.

The Wuhan National Laboratory opened in January 2018, with the highest safety rating and plans to study SARS and Ebola. A Nature article warned that some were concerned over its safety.

Food and Drug Administration officials hit out at Purell's maker GOJO with a warning letter earlier this month, demanding that the company take down false claims it prevents flu.

The map tracks the lethal flu-like infection, which has killed more than 1,300 people and infected 60,000 - mostly in China - and pits it against SARS in 2003, swine flu in 2009 and Ebola in 2014.

A new animated video shows how 40 days into the coronavirus outbreak it infected more people than on the 40th day of the respective Ebola, swine flu, SARS and MERS outbreaks.

The elderly man was given the drug remdesivir after being hospitalised on March 7 and has now recovered and been allowed to go home. The drug has also shown good results in the US.

More than half of a group of severely ill COVID-19 patients improved after receiving Gilead's experimental drug remdesivir, doctors reported.

Noel Edmonds made a series of bizarre claims in a newly unearthed interview from 2015, where he said death does not exist and that Wi-fi poses a greater risk to health than Ebola.

The FDA may announce its decision allowing emergency use authorization of an antiviral remdesivir for coronavirus patients as early as Wednesday.

Remdesivir, an antiviral made by California-based Gilead Sciences, was shown to slash recovery times in a global trial of more than 1,000 patients, including Britons.

Two-thirds of severely ill coronavirus patients in the US, Canada, Europe and Japan improved after taking remdesvir, a US-made Ebola drug, while China canceled phase III of it trial

ಇಡೀ ವಿಶ್ವವೇ ಕೊರೊನಾವೈರಸ್‌ ಎಂಬ ಸಾಂಕ್ರಾಮಿಕ ಪಿಡುಗುನಿಂದ ತ್ತರಿಸುತ್ತಿರುವಾಗಲೇ ಈ ಹಿಂದೆ ಕಾಣಿಸಿಕೊಂಡು ಸಾವಿಗಟ್ಟಲೆ ಜನರ ಬಲಿಪಡೆದಿದ್ದ ಮತ್ತೊಂದು ಸಾಂಕ್ರಾಮಿಕ ಪಿಡುಗು ಎಬೋಲಾದ ಭಯ ಶುರುವಾಗಿದೆ. ಮಧ್ಯಪ್ರದೇಶದ ಕಾಂಗೋದಲ್ಲಿ ಏಪ್ರಿಲ್ 10ರಷ್ಟರಲ್ಲಿ 3456 ಜನರಲ್ಲಿ ರೋಗ ಕಂಡು ಬಂದಿದ್ದು, 2276 ಜನರು ಸಾವನ್ನಪ್ಪಿದ್ದಾರೆ ವಿಶ್ವ ಆರೋಗ್ಯ ಸಂಸ್ಥೆ ಹೇಳಿದೆ.

Ebola virus disease, also termed Ebola haemorrhagic fever is a disease of the humans caused by four strains of Ebola virus. Ebola was first discovered in the year 1976, and since then there have been many incidences of the diseases with

Browsery RC140.5.H38 2017

Andrea Marzi discusses a vaccine that is effective against Ebola in monkeys and David Grimm talks about weigh-loss surgery, carbon suckers, and sexist HVAC. Hosted by Sarah Crespi. [Img: NIAID]