cancer risk Losing Weight May Help Lower Cancer Risk By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: Losing Weight May Help Lower Cancer RiskCategory: Health NewsCreated: 5/1/2012 11:00:00 AMLast Editorial Review: 5/1/2012 12:00:00 AM Full Article
cancer risk Can Blood Test Predict Breast Cancer Risk? By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: Can Blood Test Predict Breast Cancer Risk?Category: Health NewsCreated: 5/1/2012 4:05:00 PMLast Editorial Review: 5/2/2012 12:00:00 AM Full Article
cancer risk Y Chromosome Loss Linked to Higher Cancer Risk in Men By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: Y Chromosome Loss Linked to Higher Cancer Risk in MenCategory: Health NewsCreated: 4/28/2014 12:35:00 PMLast Editorial Review: 4/29/2014 12:00:00 AM Full Article
cancer risk Nail Salons' Drying Lamps Carry Small Cancer Risk By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: Nail Salons' Drying Lamps Carry Small Cancer RiskCategory: Health NewsCreated: 4/30/2014 7:36:00 PMLast Editorial Review: 5/1/2014 12:00:00 AM Full Article
cancer risk Switch From U.S. to African Diet May Lower Colon Cancer Risk in Blacks By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: Switch From U.S. to African Diet May Lower Colon Cancer Risk in BlacksCategory: Health NewsCreated: 4/28/2015 12:00:00 AMLast Editorial Review: 4/29/2015 12:00:00 AM Full Article
cancer risk Statins Might Not Lower Colon Cancer Risk: Study By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: Statins Might Not Lower Colon Cancer Risk: StudyCategory: Health NewsCreated: 4/26/2016 12:00:00 AMLast Editorial Review: 4/27/2016 12:00:00 AM Full Article
cancer risk Drinking Boosts Breast Cancer Risk for Black Women, Too By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: Drinking Boosts Breast Cancer Risk for Black Women, TooCategory: Health NewsCreated: 5/1/2017 12:00:00 AMLast Editorial Review: 5/2/2017 12:00:00 AM Full Article
cancer risk Bacterial Blood Infections Tied to Heightened Colon Cancer Risk By www.medicinenet.com Published On :: Thu, 23 Apr 2020 00:00:00 PDT Title: Bacterial Blood Infections Tied to Heightened Colon Cancer RiskCategory: Health NewsCreated: 4/22/2020 12:00:00 AMLast Editorial Review: 4/23/2020 12:00:00 AM Full Article
cancer risk Pancreatic Cancer Risk in Relation to Lifetime Smoking Patterns, Tobacco Type, and Dose-Response Relationships By cebp.aacrjournals.org Published On :: 2020-05-01T00:05:36-07:00 Background: Despite smoking being a well-established risk factor for pancreatic cancer, there is a need to further characterize pancreatic cancer risk according to lifespan smoking patterns and other smoking features, such as tobacco type. Our aim was to deeply investigate them within a large European case–control study. Methods: Tobacco smoking habits and other relevant information were obtained from 2,009 cases and 1,532 controls recruited in the PanGenEU study using standardized tools. Multivariate logistic regression analysis was performed to evaluate pancreatic cancer risk by smoking characteristics and interactions with other pancreatic cancer risk factors. Fractional polynomials and restricted cubic splines were used to test for nonlinearity of the dose–response relationships and to analyze their shape. Results: Relative to never-smokers, current smokers [OR = 1.72; 95% confidence interval (95% CI), 1.39–2.12], those inhaling into the throat (OR = 1.48; 95% CI, 1.11–1.99) or chest (OR = 1.33; 95% CI, 1.12–1.58), and those using nonfiltered cigarettes (OR = 1.69; 95% CI, 1.10–2.61), were all at an increased pancreatic cancer risk. Pancreatic cancer risk was highest in current black tobacco smokers (OR = 2.09; 95% CI, 1.31–3.41), followed by blond tobacco smokers (OR = 1.43; 95% CI, 1.01–2.04). Childhood exposure to tobacco smoke relative to parental smoking was also associated with increased pancreatic cancer risk (OR = 1.24; 95% CI, 1.03–1.49). Dose–response relationships for smoking duration, intensity, cumulative dose, and smoking cessation were nonlinear and showed different shapes by tobacco type. Effect modification by family history of pancreatic cancer and diabetes was likely. Conclusions: This study reveals differences in pancreatic cancer risk by tobacco type and other habit characteristics, as well as nonlinear risk associations. Impact: This characterization of smoking-related pancreatic cancer risk profiles may help in defining pancreatic cancer high-risk populations. Full Article
cancer risk Prospective Association of Energy Balance Scores Based on Metabolic Biomarkers with Colorectal Cancer Risk By cebp.aacrjournals.org Published On :: 2020-05-01T00:05:36-07:00 Background: Energy balance–related factors, such as body mass index (BMI), diet, and physical activity, may influence colorectal cancer etiology through interconnected metabolic pathways, but their combined influence is less clear. Methods: We used reduced rank regression to derive three energy balance scores that associate lifestyle factors with combinations of prediagnostic, circulating levels of high-sensitivity C-reactive protein (hsCRP), C-peptide, and hemoglobin A1c (HbA1c) among 2,498 participants in the Cancer Prevention Study-II Nutrition Cohort. Among 114,989 participants, we verified 2,228 colorectal cancer cases. We assessed associations of each score with colorectal cancer incidence and by tumor molecular phenotypes using Cox proportional hazards regression. Results: The derived scores comprised BMI, physical activity, screen time, and 14 food groups, and explained 5.1% to 10.5% of the variation in biomarkers. The HR and 95% confidence interval (CI) for quartile 4 versus 1 of the HbA1c+C peptide–based score and colorectal cancer was 1.30 (1.15–1.47), the hsCRP-based score was 1.35 (1.19–1.53), and the hsCRP, C-peptide, and HbA1c-based score was 1.35 (1.19–1.52). The latter score was associated with non-CIMP tumors (HRQ4vsQ1: 1.59; 95% CI: 1.17–2.16), but not CIMP-positive tumors (Pheterogeneity = 0.04). Conclusions: These results further support hypotheses that systemic biomarkers of metabolic health—inflammation and abnormal glucose homeostasis—mediate part of the relationship between several energy balance–related modifiable factors and colorectal cancer risk. Impact: Results support cancer prevention guidelines for maintaining a healthful body weight, consuming a healthful diet, and being physically active. More research is needed on these clusters of exposures with molecular phenotypes of tumors. Full Article
cancer risk Harnessing Population Pedigree Data and Machine Learning Methods to Identify Patterns of Familial Bladder Cancer Risk By cebp.aacrjournals.org Published On :: 2020-05-01T00:05:36-07:00 Background: Relatives of patients with bladder cancer have been shown to be at increased risk for kidney, lung, thyroid, and cervical cancer after correcting for smoking-related behaviors that may concentrate in some families. We demonstrate a novel approach to simultaneously assess risks for multiple cancers to identify distinct multicancer configurations (multiple different cancer types that cluster in relatives) surrounding patients with familial bladder cancer. Methods: This study takes advantage of a unique population-level data resource, the Utah Population Database (UPDB), containing vast genealogy and statewide cancer data. Familial risk is measured using standardized incidence risk (SIR) ratios that account for sex, age, birth cohort, and person-years of the pedigree members. Results: We identify 1,023 families with a significantly higher bladder cancer rate than population controls (familial bladder cancer). Familial SIRs are then calculated across 25 cancer types, and a weighted Gower distance with K-medoids clustering is used to identify familial multicancer configurations (FMC). We found five FMCs, each exhibiting a different pattern of cancer aggregation. Of the 25 cancer types studied, kidney and prostate cancers were most commonly enriched in the familial bladder cancer clusters. Laryngeal, lung, stomach, acute lymphocytic leukemia, Hodgkin disease, soft-tissue carcinoma, esophageal, breast, lung, uterine, thyroid, and melanoma cancers were the other cancer types with increased incidence in familial bladder cancer families. Conclusions: This study identified five familial bladder cancer FMCs showing unique risk patterns for cancers of other organs, suggesting phenotypic heterogeneity familial bladder cancer. Impact: FMC configurations could permit better definitions of cancer phenotypes (subtypes or multicancer) for gene discovery and environmental risk factor studies. Full Article
cancer risk Circulating Immune Cell Composition and Cancer Risk: A Prospective Study Using Epigenetic Cell Count Measures By cancerres.aacrjournals.org Published On :: 2020-05-04T05:35:17-07:00 Although ample evidence indicates that immune cell homeostasis is an important prognostic outcome determinant in patients with cancer, few studies have examined whether it also determines cancer risk among initially healthy individuals. We performed a case–cohort study including incident cases of breast (n = 207), colorectal (n = 111), lung (n = 70), and prostate (n = 201) cancer as well as a subcohort (n = 465) within the European Prospective Investigation into Cancer and Nutrition-Heidelberg cohort. Relative counts of neutrophils, monocytes, and lymphocyte sublineages were measured by qRT-PCR. HRs and 95% confidence intervals were used to measure the associations between relative counts of immune cell and cancer risks. When relative counts of immune cell types were taken individually, a significant positive association was observed between relative counts of FOXP3+ regulatory T cells (Tregs) and lung cancer risk, and significant inverse associations were observed between relative CD8+ counts and risks of lung and breast cancer (overall and ER+ subtype). Multivariable models with mutual adjustments across immune markers showed further significant positive associations between higher relative FOXP3+ T-cell counts and increased risks of colorectal and breast cancer (overall and ER− subtype). No associations were found between immune cell composition and prostate cancer risk. These results affirm the relevance of elevated FOXP3+ Tregs and lower levels of cytotoxic (CD8+) T cells as risk factors for tumor development.Significance:This epidemiologic study supports a role for both regulatory and cytotoxic T cells in determining cancer risk among healthy individuals.See related commentary by Song and Tworoger, p. 1801 Full Article
cancer risk Systemic Immune Response and Cancer Risk: Filling the Missing Piece of Immuno-Oncology By cancerres.aacrjournals.org Published On :: 2020-05-04T05:35:17-07:00 While immuno-oncology has made significant advances in activating local tumor immune responses, leading to improved outcomes, the role of systemic immunity in cancer incidence remains poorly understood. Le Cornet and colleagues prospectively studied circulating immune cells quantified by DNA methylation markers in relation to incidence of breast, colorectal, lung, and prostate cancer among initially healthy individuals. A positive association with cancer risk was observed for higher FOXP3+ T-cell–mediated immune tolerance and lower CD8+ T-cell–mediated cytotoxicity. Further studies of systemic immunity in cancer development are crucial to identify novel prediction markers and interventional targets for cancer immunoprevention.See related article by Le Cornet et al., p. 1885 Full Article
cancer risk Use of chemical hair products increases breast cancer risk By www.treehugger.com Published On :: Wed, 11 Dec 2019 07:00:00 -0500 A new study shows it's even higher for black women and frequent hair-dyers. Full Article Living
cancer risk Aspirin Reduces Bowel Cancer Risk By www.medindia.net Published On :: Aspirin was found to be associated with reduction in the risk of several cancers of the digestive tract, stated new study. The largest and most comprehensive Full Article
cancer risk COPD Associated With Lung Cancer Risk By www.medindia.net Published On :: In people who have never smoked, COPD (chronic obstructive pulmonary disease) is associated with an increased risk of lung cancer, stated research published in the journal Thorax. Full Article
cancer risk Eating Fiber-rich Food Daily can Cut Breast Cancer Risk By www.medindia.net Published On :: High total fiber consumption was associated with a decreased risk of breast cancer, reports a new study. The findings of the study are published in the journal iCANCER/i. Full Article
cancer risk Blood Infection With Certain Bacteria Linked to Colorectal Cancer Risk By www.medindia.net Published On :: An association between blood infections with certain anaerobic bacteria and increased risk of developing colorectal cancer has been revealed by new research Full Article
cancer risk Artificial intelligence helps assess cancer risk of lung nodules By www.medindia.net Published On :: CT scans for people at risk for lung cancer lead to earlier diagnoses and improve survival rates. A study published in American Journal of Respiratory Full Article
cancer risk Artificial Reproduction is Associated With Prostate Cancer Risk By www.medindia.net Published On :: Prostate cancer has greater probabilities of happening in men who seek medical care for infertility and assisted reproduction compared to those who became fathers by natural means. Full Article
cancer risk Cancer Risk in Men Due To Loss of Function In Y-chromosome Genes By www.medindia.net Published On :: Men are at higher risk of cancer due to some fundamental biological mechanism that results in the loss of function in specific genes of the sex-determining Y chromosome, which is present only in men. Full Article
cancer risk Alcohol and Cancer Risk By feedproxy.google.com Published On :: 2018-09-17 12:00:00 -0400 A fact sheet that summarizes the evidence linking alcohol consumption to the risk of various cancers. Includes information about factors that affect the risk of alcohol-associated cancers, such as a person’s genes and tobacco use. Full Article
cancer risk Cell Phones and Cancer Risk By feedproxy.google.com Published On :: 2019-01-14 12:00:00 -0500 A fact sheet that outlines the available evidence regarding use of cellular/mobile telephones and cancer risk. Full Article
cancer risk Nail salon lamps may increase skin cancer risk By indianexpress.com Published On :: Fri, 02 May 2014 19:22:14 +0000 Full Article Life-style Lifestyle
cancer risk Vasectomy may up prostate cancer risk By indianexpress.com Published On :: Fri, 18 Jul 2014 18:57:16 +0000 Full Article Health Lifestyle
cancer risk Sugar addiction is key contributor to heart disease, cancer risk By indianexpress.com Published On :: Fri, 29 Aug 2014 19:31:07 +0000 Full Article India India Others
cancer risk Knowing cancer risk may not affect screening rate By indianexpress.com Published On :: Fri, 31 Oct 2014 21:59:56 +0000 Full Article Health Lifestyle
cancer risk JAMA Internal Medicine : Association of Organic Food Consumption With Cancer Risk By traffic.libsyn.com Published On :: Mon, 22 Oct 2018 15:00:00 +0000 Interview with Julia Baudry, PhD, author of Association of Frequency of Organic Food Consumption With Cancer Risk: Findings From the NutriNet-Santé Prospective Cohort Study, and Jorge E. Chavarro, MD, ScD, author of Organic Foods for Cancer Prevention—Worth the Investment? Full Article
cancer risk Eisai withdraws weight loss pills because of cancer risk By feedproxy.google.com Published On :: 22 Feb 2020 11:30:25 +0000 Full Article
cancer risk Asbestos inhalation poses cancer risks to workers and consumers By feedproxy.google.com Published On :: 31 Mar 2020 21:04:48 +0000 US EPA finds unreasonable risks for 6 current uses, including chlor-alkali diaphragms Full Article
cancer risk Cancer risk studies raise questions about the safety of long-lasting hair dyes By feedproxy.google.com Published On :: 03 May 2020 18:22:42 +0000 Long-lasting hair dyes are popular, and their safety has been well researched. But new epidemiology studies show their use correlates with increased risk of breast cancer Full Article
cancer risk Moderate Alcohol Consumption During Adult Life, Drinking Patterns, and Breast Cancer Risk By dx.doi.org Published On :: Tue, 01 Nov 2011 21:00:00 +0000 Interview with Wendy Y. Chen, MD, MPH, author of Moderate Alcohol Consumption During Adult Life, Drinking Patterns, and Breast Cancer Risk Full Article
cancer risk Detection of Breast Cancer With Addition of Annual Screening Ultrasound or a Single Screening MRI to Mammography in Women With Elevated Breast Cancer Risk By dx.doi.org Published On :: Tue, 03 Apr 2012 20:00:00 +0000 Interview with Wendie A. Berg, MD, PhD, author of Detection of Breast Cancer With Addition of Annual Screening Ultrasound or a Single Screening MRI to Mammography in Women With Elevated Breast Cancer Risk Full Article
cancer risk Association Between World Trade Center Exposure and Excess Cancer Risk By dx.doi.org Published On :: Tue, 18 Dec 2012 20:59:00 +0000 Interview with Steven D. Stellman, PhD, MPH, author of Association Between World Trade Center Exposure and Excess Cancer Risk Full Article
cancer risk Daytime sleepiness linked with diabetes, cancer risk in elderly: Study By indianexpress.com Published On :: Wed, 04 Mar 2020 07:00:38 +0000 Full Article Health Lifestyle
cancer risk Organic food may not lower cancer risk By indianexpress.com Published On :: Fri, 28 Mar 2014 11:08:40 +0000 Full Article Do not use - Food Lifestyle
