Mr. Albino has been endorsed by Marquis Who's Who as a leader in the writing industry

Applying this to financial markets helps investors to determine their chances of success in a fixed number of attempts (or trials). Another application of binomial distribution is to find out the probability of a company reporting positive growth in the EPS.

Everyone loves holidays, especially the annual colorful and vibrant Holi festival. Various companies hold special promotions to extend this magical time of ...

When the Kentucky Horse Racing Committee holds its next scheduled meeting on June 16, it will have a new chairman and four new members. On April 28, an executive order from Democratic Gov. Andy Beshear appointed Alan J. Leavitt, Dr. Naveed Chowhan, Jonathan Rabinowitz and James Edwin “Ed” Worley to the commission. Charles Francis O'Connor […]

The post Beshear Appoints Four New Kentucky Racing Commissioners, Rabinowitz New Chairman appeared first on Horse Racing News | Paulick Report.

A snake catcher believes the 80-kilogram monster is likely to have been imported illegally and may be euthanased due to the threat it poses to native ecosystems.

Bino might not be from Dallas, but they love each other.

Bino is ready for fans to clamor for an encore performance.

Bino might not be from Dallas, but they love each other.

Bino is ready for fans to clamor for an encore performance.

Veteran captain Andrew Campos, 50, was arrested only months after a search warrant uncovered multiple photos of the mobster and co-defendant Richard Martino making prison visits to imprisoned Mafioso Frank LoCascio, once the underboss to the infamous “Dapper Don” Gotti.

Scientists injected CRISPR gene-editing machinery into unfertilized eggs still developing in female lizards’ ovaries.

Arlene Smaldone
Jan 1, 2008; 21:46-49
Evidence-Based Clinical Decision Making

Cannabinoid hyperemesis syndrome is a relatively newly recognised condition - but, according to one study, can account for up to 6% of patients presenting to emergency departments. The causal mechanism is as yet unclear - but currently the only known way to prevent the syndrome is for the patient to stop their cannabis use. Yaniv Chocron, chief...

Paris : Doin, 1896.

Rockville, Maryland : National Institute on Drug Abuse, 1982.

Rockville, Maryland : National Institute on Drug Abuse, 1987.

María F. Gil–Leyva, Ramsés H. Mena, Theodoros Nicoleris.

Source: Electronic Journal of Statistics, Volume 14, Number 1, 1479--1507.

Abstract:
A new class of nonparametric prior distributions, termed Beta-Binomial stick-breaking process, is proposed. By allowing the underlying length random variables to be dependent through a Beta marginals Markov chain, an appealing discrete random probability measure arises. The chain’s dependence parameter controls the ordering of the stick-breaking weights, and thus tunes the model’s label-switching ability. Also, by tuning this parameter, the resulting class contains the Dirichlet process and the Geometric process priors as particular cases, which is of interest for MCMC implementations. Some properties of the model are discussed and a density estimation algorithm is proposed and tested with simulated datasets.

Zhengwei Liu, Qi Li, Fukang Zhu.

Source: Brazilian Journal of Probability and Statistics, Volume 34, Number 2, 251--272.

Abstract:
To predict time series of counts with small values and remarkable fluctuations, an available model is the $r$ states random environment process based on the negative binomial thinning operator and the geometric marginal. However, we argue that the aforementioned model may suffer from the following two drawbacks. First, under the condition of no prior information, the overdispersed property of the geometric distribution may cause the predictions fluctuate greatly. Second, because of the constraints on the model parameters, some estimated parameters are close to zero in real-data examples, which may not objectively reveal the correlation relationship. For the first drawback, an $r$ states random environment process based on the binomial thinning operator and the Poisson marginal is introduced. For the second drawback, we propose a generalized $r$ states random environment integer-valued autoregressive model based on the binomial thinning operator to model fluctuations of data. Yule–Walker and conditional maximum likelihood estimates are considered and their performances are assessed via simulation studies. Two real-data sets are conducted to illustrate the better performances of the proposed models compared with some existing models.

Bryan D. Martin, Daniela Witten, Amy D. Willis.

Source: The Annals of Applied Statistics, Volume 14, Number 1, 94--115.

Abstract:
Using a sample from a population to estimate the proportion of the population with a certain category label is a broadly important problem. In the context of microbiome studies, this problem arises when researchers wish to use a sample from a population of microbes to estimate the population proportion of a particular taxon, known as the taxon’s relative abundance . In this paper, we propose a beta-binomial model for this task. Like existing models, our model allows for a taxon’s relative abundance to be associated with covariates of interest. However, unlike existing models, our proposal also allows for the overdispersion in the taxon’s counts to be associated with covariates of interest. We exploit this model in order to propose tests not only for differential relative abundance, but also for differential variability. The latter is particularly valuable in light of speculation that dysbiosis , the perturbation from a normal microbiome that can occur in certain disease conditions, may manifest as a loss of stability, or increase in variability, of the counts associated with each taxon. We demonstrate the performance of our proposed model using a simulation study and an application to soil microbial data.

Brian Neelon.

Source: Bayesian Analysis, Volume 14, Number 3, 849--875.

Abstract:
Motivated by a study examining spatiotemporal patterns in inpatient hospitalizations, we propose an efficient Bayesian approach for fitting zero-inflated negative binomial models. To facilitate posterior sampling, we introduce a set of latent variables that are represented as scale mixtures of normals, where the precision terms follow independent Pólya-Gamma distributions. Conditional on the latent variables, inference proceeds via straightforward Gibbs sampling. For fixed-effects models, our approach is comparable to existing methods. However, our model can accommodate more complex data structures, including multivariate and spatiotemporal data, settings in which current approaches often fail due to computational challenges. Using simulation studies, we highlight key features of the method and compare its performance to other estimation procedures. We apply the approach to a spatiotemporal analysis examining the number of annual inpatient admissions among United States veterans with type 2 diabetes.

Peter M. Zygmunt
Jun 1, 2002; 22:4720-4727
Behavioral

Joshua A. Gordon
May 15, 1996; 16:3274-3286
Articles

EL Bienenstock
Jan 1, 1982; 2:32-48
Articles

Idiopathic acute eosinophilic pneumonia is a rare and potentially life-threatening condition that is defined by bilateral pulmonary infiltrates and fever in the presence of pulmonary eosinophilia. It often presents acutely in previously healthy individuals and can be difficult to distinguish from infectious pneumonia. Although the exact etiology of idiopathic acute eosinophilic pneumonia remains unknown, an acute hypersensitivity reaction to an inhaled antigen is suggested, which is further supported by recent public health risks of vaping (electronic cigarette) use and the development of lung disease. In this case, a patient with a year-long history of vaping in conjunction with tetrahydrocannabinol cartridge use who was diagnosed with idiopathic acute eosinophilic pneumonia with associated bilateral hilar lymphadenopathy is described.

Predischarge serum or transcutaneous bilirubinometry (TcB) measurements are recommended as appropriate screening options for identifying infants at risk for neonatal hyperbilirubinemia (NH). Visual inspection for jaundice is not reliable at identifying infants with NH in the community.

When compared with visual inspection alone, coordinated TcB screening for NH in acute-care and community settings is associated with significant improvements in laboratory utilization, patient care, convenience, and safety. (Read the full article)

The initial response to an addictive substance can facilitate repeated use: That is, individuals experiencing more positive effects are more likely to use that drug again. Increasing evidence suggests that psychoactive cannabinoid use in adolescence enhances the behavioral effects of cocaine. However, despite the behavioral data, there is no neurobiological...

Metastatic breast cancer is prevalent worldwide, and one of the most common sites of metastasis is long bones. Of patients with disease, the major symptom is pain, yet current medications fail to adequately result in analgesic efficacy and present major undesirable adverse effects. In our study, we investigate the potential of a novel monoacylglycerol lipase (MAGL) inhibitor, MJN110, in a murine model of cancer-induced bone pain. Literature has previously demonstrated that MAGL inhibitors function to increase the endogenous concentrations of 2-arachydonylglycerol, which then activates CB1 and CB2 receptors to inhibit inflammation and pain. We demonstrate that administration of MJN110 significantly and dose dependently alleviates spontaneous pain behavior during acute administration compared with vehicle control. In addition, MJN110 maintains its efficacy in a chronic-dosing paradigm over the course of 7 days without signs of receptor sensitization. In vitro analysis of MJN110 demonstrated a dose-dependent and significant decrease in cell viability and proliferation of 66.1 breast adenocarcinoma cells to a greater extent than KML29, an alternate MAGL inhibitor, or the CB2 agonist JWH015. Chronic administration of the compound did not appear to affect tumor burden, as evidenced by radiograph or histologic analysis. Together, these data support the application for MJN110 as a novel therapeutic for cancer-induced bone pain.

Wiarton Willie saw his shadow this morning, which means the cold weather will stick around.

There is low-quality evidence indicating that cannabinoids may be a safe alternative for a small but significant decline in subjective pain score when treating acute pain, reports a new study.

Imports - Travel Goods,Vanity Cases, Binocular & Camera Cases in Mexico decreased to 41148 USD THO in March from 69467 USD THO in February of 2020. Imports - Travel Goods,Vanity Cases, Binocular & C in Mexico averaged 56583.90 USD THO from 2014 until 2020, reaching an all time high of 75607 USD THO in May of 2019 and a record low of 41148 USD THO in March of 2020. This page includes a chart with historical data for Mexico Imports of Travel Goods,vanity Cases, Binocular &.

Concerned fans have urged Married At First Sight's Elizabeth Sobinoff to seek medical advice after spotting a suspicious mole on her chest.

Fans have voiced their concern for Elizabeth Sobinoff, calling the Married At First Sight star 'too skinny' after her recent weight loss.

Married At First Sight star Elizabeth Sobinoff showed off her svelte figure in a throwback snap shared to Instagram on Wednesday.

Fans have voiced their concern for Married At First Sight's Elizabeth Sobinoff, 28, just days ahead of her return to the show as an insider. 

Married At First Sight's Sam Ball has shared his thoughts on ex-'wife' Elizabeth Sobinoff's dramatic weight loss ahead of her return to the show this week

Returning bride Elizabeth Sobinoff shed an impressive 10kg following her ill-fated appearance on Married At First Sight last year.

Married At First Sight alum Sam Ball offered a shady response to his ex-'wife' Elizabeth Sobinoff's return to the franchise on Saturday.

Married At First Sight's Elizabeth Sobinoff has undergone one of the most dramatic physical transformations in the history of the franchise.

Ferrari have responded angrily after Red Bull driver Verstappen suggested the Italian team's poor performance on Sunday was linked to the closure of a potential engine loophole.

Elizabeth Sobinoff has hit back at critics with a cryptic message posted to her Instagram Stories on Friday. The 29-year-old former Married At First Sight star addressed wild rumours about herself.

The tweet was an apparent reference to claims made by President Trump and his supporters that his predecessor, Barack Obama, unlawfully spied on him and his campaign.

Alba was rescued from a cage in Borneo in 2017 where villagers were keeping her captive. She was underweight and riddled with parasites, but once rehabilitated released into the wild.