One hundred forty-three years ago, women's suffrage advocate Elizabeth Cady Stanton faced a conundrum: With the Civil War over, Stanton had to decide whether to support the 14th and 15th amendments to the Constitution, which enabled black men to vote -- at a time when white women such as herself...

London : J. Churchill, 1865.

Presently H1-B visas are frequently used by established companies and less by startups because the former, get the advantage in dealing with time and cost factors.US Immigration and the status of start upsThe present visa policies followed by U.S. make…

When California voted to get 100 percent of its electricity from renewable sources by 2045, it sent a signal to the market about which types of power generation technologies will remain competitive into the future. And according to Mike Ferguson, Director, North America Energy Infrastructure and Sustainable Finance with S&P Global Ratings, what California does, other states may soon follow.

The bioprocessing industry uses recombinant mammalian cell lines to generate therapeutic biologic drugs. To ensure consistent product quality of the therapeutic proteins, it is imperative to have a controlled production process. Regulatory agencies and the biotechnology industry consider cell line "clonal origin" an important aspect of maintaining process control. Demonstration of clonal origin of the cell substrate, or production cell line, has received considerable attention in the past few years, and the industry has improved methods and devised standards to increase the probability and/or assurance of clonal derivation. However, older production cell lines developed before the implementation of these methods, herein referred to as "legacy cell lines," may not meet current regulatory expectations for demonstration of clonal derivation. In this article, the members of the IQ Consortium Working Group on Clonality present our position that the demonstration of process consistency and product comparability of critical quality attributes throughout the development life cycle should be sufficient to approve a license application without additional genetic analysis to support clonal origin, even for legacy cell lines that may not meet current day clonal derivation standards. With this commentary, we discuss advantages and limitations of genetic testing methods to support clonal derivation of legacy cell lines and wish to promote a mutual understanding with the regulatory authorities regarding their optional use during early drug development, subsequent to Investigational New Drug (IND) application and before demonstration of product and process consistency at Biologics License Applications (BLA) submission.

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Over the past two years, in a departure from the policy of reassurance it adopted in the late 1990s, China has managed to damage relations with most of its neighbors and with the United States. Mistrust of Beijing throughout the region and in Washington is palpable. Observers claim that China has become more assertive, revising…

I request you to kindly give me your advise on GST which is going to be implemented very shortly. Thanks and Regards, Varadarajan Kasturi..

Before we start, let’s have a brief introduction on HTML5 framework. A HTML5 mobile application is a web page or series of web pages...

The Outlander PHEV can be charged overnight at home, run on electric-only power or operate in hybrid mode, switching between petrol and electric power, depending on which is most efficient.

A bike owner usually thinks of two-wheeler insurance as a formality. It is often perceived as an added cost instead of a financial cushion. Bikers might boast about their knowledge regarding tuning, maintaining, and beautifying their beloved two-wheelers but the same

Australia. Parliament. Joint Standing Committee on Trade and Investment Growth, author, issuing body

Tanzanian encounters with chilling lionesses and pioneering women