The purpose of this document is to give guidance to Receiving Authorities on the evaluation of the GLP compliance status of nonclinical safety studies submitted for regulatory purposes. This guidance does not address the scientific evaluation and interpretation of the submitted data or the risk assessment based on these data.

Latest releases: AOPs are the central element of a toxicological knowledge framework, promoted by member countries through OECD, built to support chemical risk assessment based on mechanistic reasoning. Seven New AOPs have now been published.

Two new cases have been published that focus on use of metabolism information to support read-across and use of a combination of novel methods to identify potential endocrine disruptors, respectively. In addition a considerations document includes lessons and learnings from analysis across case studies and an analysis of uncertainties in six read-across cases.

On Thursday 26 September 2019, the OECD discussed "Finding Alternatives to Per- and Polyfluoroalkyl Substances of Concern: A Difficult and Continuing Challenge" with the participation of W.L. Gore & Associates, Inc. Presenters shared efforts, successes and challenges in eliminating per and polyfluorinated chemicals of environmental concern from the life cycle of consumer products.

On 27 September 2019, Anne Gourmelon of the Environment Directorate presented an overview of the various alternative test methods developed as OECD Test Guidelines and relevant guidance material to address eye irritation and serious eye damage for hazard classification of chemicals.

A major fruit crop of temperate regions, APPLE is consumed worldwide as fresh fruit, juice and other food products. This consensus document provides science-based key insights for the regulatory assessment of the environmental safety of genetically-engineered products: taxonomy, reproductive biology, genetics, hybridisation and introgression, and ecology.

This document is intended to provide universal Guiding Principles that should be considered when developing or augmenting systematic approaches to Weight of Evidence (WoE) for chemical evaluation and Key Elements to formulating a systematic approach to WoE. The ultimate goal is to facilitate that regulators follow a consistent, clear and transparent delivery of evidence using the Principles and Elements described in this document.

The Chemical Safety and Biosafety Progress Report is released every eight months. Its purpose is to provide an update on the projects, events and activities. Information on new publications as well as dates and venues of upcoming events and meetings are given.

CEOs and corporate leaders on the lessons they have already learnt — and what happens next

Kew may be 70 times bigger than the Physic Garden, but historically Chelsea is the mother ship

Paris is organised around culture to a degree unimaginable in mercantile, muddled-up London

Victor Erice is one of those rare film directors who show time passing apparently at its own pace

Three recent decisions have brought this issue into focus – and all three are lamentable and incoherent

There are profound reasons for studying the languages, literature and civilisations of the Greeks and Romans

This is about reminding ourselves that we are animals, not adjuncts to computer terminals

Too many poets have turned inward, speaking to their fellows rather than to the wider world

Mussorgsky and Toulouse-Lautrec reached out to people treated as extras rather than full human subjects

Have we gone from protecting nature to managing it on behalf of the Earth’s dominant species?

‘There is a unique beauty to this time of year. Everything looks ghostly in the dense, opaque air’

Feelings of shame, unlike other emotions, are difficult to hide

The extraordinary thing about Roger Federer is that he still loves playing tennis after all these years

The story of Sisyphus compares quite well with the experience of zero-hours contracts

Taipei’s MRT is the only underground railway where someone has offered to tie up my shoelace

As I approached the hall where the relics of our vintage were assembled, I heard an unspirit-like roar

A country’s values come into focus when seen by an outsider, contrasting them with his native country

Caricaturist James Gillray was arrested over a print showing politicians kissing a new royal baby’s backside

Participation in the arts has a hugely positive impact on people’s health and wellbeing

Perhaps a lot of rugby has always been prosaic but I struggle to recall such a dearth of poetry

The quiet streets have that special Viennese quality of grandeur combined with melancholy and nostalgia

Isis could be seen as a vast and terrifying collective outbreak of the Freudian concept of ‘acting out’

Through this column, connections have been made and the conversation has broadened

After 11 years, Harry Eyres’ column has come to an end. Here’s his first, from January 17, 2004

The taming of the Tea Party leaves the GOP short on the ideological message the voters like

Obama is seeking to scale back US global responsibilities without signalling a retreat

The defenestration of Cantor sends a message to the cosy world of party bigwigs and donors

Assertions the patient ‘wouldn’t have wanted to suffer’ offer doctors too much leeway

The Ecclestone case illustrates that power is migrating away from votes and towards money

It would be wrong for charges against the Texas governor to be allowed through the courts

The conditions of managing this crisis are coming to resemble those at Chernobyl

A new book reveals how the very wealthy are shaping US society more than is commonly realised

From abortion to gay rights, he is unorthodox on Republican ‘values’, writes Christopher Caldwell

How the network upended American politics and news

Donald Trump’s campaign was about sociology not ideology

What cultural impact will the incoming president have? Prepare for a mash-up of Sinatra, sports stars and reality TV

The New Economy involves phasing out all aspects of the old, including personnel

The deal with Luxottica, worth €50bn, makes up for missed opportunities

The sports marketing and agency boss explains why the City of Angels is ready to play host

With new owners, falling viewers and spiralling costs, Formula One is at a crossroads

How the property dynamo went from a milk round to becoming a self-made billionaire

The man who invented China’s Singles Day eyes opportunity offline