Amphiphilic biomimetic phosphorylcholine-containing silicone compounds for use in both topical and internal applications as components in biomedical devices. The silicone compounds, which include zwitterionic phosphorylcholine groups, may be polymerizable or non-polymerizable. Specific examples of applications include use as active functional components in ophthalmic lenses, ophthalmic lens care solutions, liquid bandages, wound dressings, and lubricious and anti-thrombogenic coatings.

An approach for introspection of a software component and generation of a conditional memory dump, a computing device executing an introspection program with respect to the software component is provided. An introspection system comprises one or more conditions for generating the conditional memory dump based on operations of the software component. In one aspect, a computing device detects, through an introspection program, whether the one or more conditions are satisfied by the software component based on information in an introspection analyzer of the introspection program. In addition, the computing device indicates, through the introspection program, if the one or more conditions are satisfied by the software component. In another aspect, responsive to the indication, the computing device generates the conditional memory dump through the introspection program.

In a wireless communication system, a compact control signaling scheme is provided for signaling the selected retransmission mode and codeword identifier for a codeword retransmission when one of a plurality of codewords being transmitted over two codeword pipes to a receiver fails the transmission and when the base station/transmitter switches from a higher order channel rank to a lower order channel rank, either by including one or more additional signaling bits in the control signal to identify the retransmitted codeword, or by re-using existing control signal information in a way that can be recognized by the subscriber station/receiver to identify the retransmitted codeword. With the compact control signal, the receiver is able to determine which codeword is being retransmitted and to determine the corresponding time-frequency resource allocation for the retransmitted codeword.

A logical operations functional block for an execution unit of a processor includes a first input data link for a first operand and a second input data link for a second operand. The execution unit includes a register connected to an error correction code detection unit. The logical operations functional block includes a look-up table configured to receive an error correction code syndrome from the error correction code detection unit. The logical operations functional block also includes a multiplexer configured to receive an output signal from the look-up table at a first input and the first operand at a second input, wherein an output of the multiplexer is coupled to the first input data link of a logical functional unit.

A two step process for the destruction of a precursor material using a steam plasma in a three zone reactor wherein the precursor material is hydrolyzed as a first step in the high temperature zone of the reactor, followed by a second step of medium temperature oxidation of the reactant stream in the combustion zone of the reactor where combustion oxygen or air is injected and immediate quenching of the resulting gas stream to avoid the formation of unwanted by-products. A related apparatus includes a non transferred direct current steam plasma torch, an externally cooled three zone steam plasma reactor means for introducing the precursor material into the plasma plume of the plasma torch, means for introducing the combustion air or oxygen into the combustion zone, means for exiting the reactant mixture from the reactor and means for quenching the reactant mixture located at the exit end of the reactor.

There is disclosed a silicone rubber composition curable by a radial ray comprising, at least, (A) an organopolysiloxane shown by the following general formula (1), (B) a phenyl ester derivative having an acryl group, (C) a sensitizer sensitized by a radial ray, and (D) a photosensitive dye, wherein each R1, R2, and R3 independently represents a monovalent hydrocarbon group having 1 to 10 carbon atoms; X represents the same or different monovalent organic group having an acryl group or a methacryl group. As a result, there is provided a silicone rubber composition capable of being cured by irradiation of a radial ray whereby showing excellent adhesion with various substrates, capable of forming a cured film, and capable of easily distinguishing whether it is cured or not by observing appearance when not irradiated with a radial ray.

3-Esters and 3-amides of thioxanthone bearing alkyl chains of appropriate length and can be used as photoinitiators or sensitizers in photopolymerizable systems, in particular for the preparation of coatings compatible with the food use.

The present invention relates to a process comprising the steps of reacting a reactive mixture comprising at least one silicone-containing component, at least one hydrophilic component, and at least one diluent to form an ophthalmic device having an advancing contact angle of less than about 80°; and contacting the ophthalmic device with an aqueous extraction solution at an elevated extraction temperature, wherein said at least one diluent has a boiling point at least about 10° higher than said extraction temperature.

An optical component and an electrical board that have a low coefficient of linear expansion and small mold shrinkage, a method for producing the optical component, and a method for producing the electronic board are provided. An optical component includes a polymer having a repeating structural unit represented by general formula (1) where R1 and R2 each independently represent —H or —CH3; m and n each independently represent an integer in the range of 0 to 3; asterisk denotes a dangling bond that bonds to one of Xa and Xb; and —H bonds to the other one of Xa and Xb.

A UV curable silicone rubber composition is provided. The composition does not undergo curing failure, foaming, and other undesirable conditions even if a water-containing inorganic filler such as zeolite were added. A UV curable silicone rubber composition comprising (A) 100 parts by weight of an organopolysiloxane having at least 2 alkenyl groups per molecule represented by the average compositional formula (I): R1aSiO(4-a)/2 (I) (wherein R1 is independently a substituted or unsubstituted monovalent hydrocarbon group, and a is a positive number of 1.95 to 2.05); (B) 1 to 300 parts by weight of an inorganic filler having a water content of at least 0.5% by weight; (C) 0.1 to 50 parts by weight of an organohydrogenpolysiloxane having at least 2 silicon-bonded hydrogen atoms per molecule; and (D) a catalytic amount of a photoactive platinum complex curing catalyst.

A heat-resistant cured product is efficiently produced by obtaining a semi-cured product where a curable resin composition containing a (meth)acrylate monomer, a non-conjugated vinylidene group-containing compound and a thermal radical-polymerization initiator is processed by at least one of photoirradiation and heating to give a semi-cured product having a complex viscosity of from 105 to 108 mPa·s at 25° C. and at a frequency of 10 Hz; and putting the semi-cured product in a forming die for pressure formation therein, and heating it therein for thermal polymerization to give a cured product.

A bridge includes a Peripheral Component Interconnect Express interface supporting at least two lanes, an Extensible Host Controller Interface, and a Universal Serial Bus 3.0 root hub. The Peripheral Component Interconnect Express interface is used for coupling to a host. Each lane of the at least two lanes provides a highest data transmission speed. The Extensible Host Controller Interface is coupled to the Peripheral Component Interconnect Express interface for storing data transmitted by the Peripheral Component Interconnect Express interface. The Universal Serial Bus 3.0 root hub includes a first controller and a second controller. The first controller and the second controller are used for controlling data transmission of four ports, and a highest data transmission speed provided by each port of the four ports is not more than the highest data transmission speed provided by the lane.

The present invention relates to 1,4-diethynylbenzene derivatives having substituents in the 2,3-position (cf. formula I, Claims), to the use thereof for high-frequency components, to liquid-crystalline media comprising the compounds, and to high-frequency components, in particular antennae, especially for the gigahertz range, comprising these media. The liquid-crystalline media serve, for example, for the phase shifting of microwaves for tuneable ‘phased-array’ antennae.

Provided is an oil-in-water silicone emulsion composition that has a low silicone oligomer content, and that can form, even without the use of an organotin compound as a curing catalyst, a cured film that exhibits satisfactory strength and satisfactory adherence to a substrate, through the removal of water fraction. An oil-in-water silicone emulsion composition comprising (A) 100 mass parts of a polyorganosiloxane that contains in each molecule at least two groups selected from the group consisting of a silicon-bonded hydroxyl group, alkoxy group, and alkoxyalkoxy group, (B) 0.1 to 200 mass parts of a colloidal silica, (C) 0.1 to 100 mass parts of an aminoxy group-containing organosilicon compound that has in each molecule an average of two silicon-bonded aminoxy groups, (D) 1 to 100 mass parts of an ionic emulsifying agent, (E) 0.1 to 50 mass parts of a non-ionic emulsifying agent, and (F) 10 to 500 mass parts of water.

Disclosed is a novel system and method to select software components. A set of available software components are accessed. Next, one or more dimensions are defined. Each dimension is an attribute to the set of available software components. A set of coherence distances between each pair of the available software components in the set of available software components is calculated for each of the dimensions that have been defined. Each of the coherence distances are combined between each pair of the available software components that has been calculated in the set of the coherence distances into an overall coherence degree for each of the available software components. Using the overall coherence degree, one or more software components are selected to be included in a software bundle.

The present invention is directed to a novel fragrance compound, 3-methyl-cyclohexadec-6-enone.

The present invention relates to a process for preparing cyclic compounds having at least eight carbon atoms and at least one keto group, to the cyclic compounds obtained by this process and to the use thereof, in particular as fragrance or for providing a fragrance.

The present invention relates to a method for preparing menthone, starting from isopulegol, using specific homogeneous catalysts.

In a process for the dehydrogenation of cyclohexanone to produce phenol, a feed comprising cyclohexanone is contacted with a dehydrogenation catalyst under dehydrogenation conditions comprising a temperature of less than 400° C. and a pressure of less than 690 kPa, gauge, such 0.1 to 50 wt % of the cyclohexanone in said feed is converted to phenol and the dehydrogenation product contains less than 100 ppm by weight of alkylbenzenes.

Disclosed is a method for preparing a compound of Formula 1 wherein Q and Z are as defined in the disclosure comprising distilling water from a mixture comprising a compound of Formula 2, a compound of Formula 3, a base comprising at least one compound selected from the group consisting of alkaline earth metal hydroxides of Formula 4 wherein M is Ca, Sr or Ba, alkali metal carbonates of Formula 4a wherein M1 is Li, Na or K, 1,5-diazabicyclo[4.3.0]non-5-ene and 1,8-diazabicyclo[5.4.0]undec-7-ene, and an aprotic solvent capable of forming a low-boiling azeotrope with water. Also disclosed is a method for preparing a compound of Formula 2 comprising (1) forming a reaction mixture comprising a Grignard reagent derived from contacting a compound of Formula 5 wherein X is Cl, Br or I with magnesium metal or an alkylmagnesium halide in the presence of an ethereal solvent, and then (2) contacting the reaction mixture with a compound of Formula 6 wherein Y is OR11 or NR12R13, and R11, R12 and R13 are as defined in the disclosure. Further disclosed is a method for preparing a compound of Formula 7 wherein Q and Z are as defined in the disclosure, using a compound of Formula 1 characterized by preparing the compound of Formula 1 by the method disclosed above or using a compound of Formula 1 prepared by the method disclosed above.

A process for preparing isophorone (3,5,5-trimethyl-2-cyclohexen-1-one) is provided wherein distillation vapors from the work-up of product fractions are recycled to earlier stages of operation of the process.

A process for preparing a particle defoamer. The particle defoamer of 55%-75% of a carrier, 15%-35% of a silicone emulsion, 3%-10% of a texturing agent and 2%-10% of a solvent, based on the total weight of the particle defoamer; the process for preparing the particle defoamer is: (1)first adding a carrier A1 into a mixer, and then adding thereto a silicone emulsion B1, and stirring uniformly; (2)adding a carrier component A2 to the mixture obtained in (1), and stirring uniformly; (3)adding a silicone emulsion B2 to the mixture obtained in (2), and, after uniformly stirring, adding the solvent thereto and stirring uniformly; and (4)pelleting and drying by baking the mixture obtained in(3), so as to produce the product.

An additive manufacturing method for forming nearly monolithic SRF niobium cavities and end group components of arbitrary shape with features such as optimized wall thickness and integral stiffeners, greatly reducing the cost and technical variability of conventional cavity construction. The additive manufacturing method for forming an SRF cavity, includes atomizing niobium to form a niobium powder, feeding the niobium powder into an electron beam melter under a vacuum, melting the niobium powder under a vacuum in the electron beam melter to form an SRF cavity; and polishing the inside surface of the SRF cavity.

There is described herein a superconducting segment and method of making same comprising one or several layers with very high electrical resistivity, acting as a current flow diverter when the current transfers from the superconductor to the stabilizer. The purpose of this current flow diverter is: i) to increase the contact resistance between the superconductor and the stabilizer, by reducing the contact area, and ii) to force the current to flow along a specific path, so as to increase momentarily the current density in a specific portion of the stabilizer. The consequence of i) and ii) is that heat generated at the extremities of the normal zone is increased and spread over a longer length along the superconducting segment, which increases the NZPV and thus, the uniformity of the quench.

The present invention relates to a method for speaker recognition, comprising the steps of obtaining and storing speaker information for at least one target speaker; obtaining a plurality of speech samples from a plurality of telephone calls from at least one unknown speaker; classifying the speech samples according to the at least one unknown speaker thereby providing speaker-dependent classes of speech samples; extracting speaker information for the speech samples of each of the speaker-dependent classes of speech samples; combining the extracted speaker information for each of the speaker-dependent classes of speech samples; comparing the combined extracted speaker information for each of the speaker-dependent classes of speech samples with the stored speaker information for the at least one target speaker to obtain at least one comparison result; and determining whether one of the at least one unknown speakers is identical with the at least one target speaker based on the at least one comparison result.

A portable communication device for phone calling is herein disclosed and enabled. The portable communication device includes a USB interface for connecting to an external USB port of a computing device for enabling phone calling services using the portable communication device. Upon connecting the portable communication device to the external USB port of the computing device, a phone calling software component or data stored in the portable communication device may execute for enabling phone calling services. The portable communication device may also include one or more ports, and may include an interface for Ethernet connection for connecting to the Internet and for making phone calls without the need for connecting the portable communication device to the external USB port. The portable communication device may further include a Wi-Fi wireless component for local wireless communication, and may be implemented as an adapter-sized dongle for providing phone calling services.

An equatorial sundial apparatus with an adjustable base assembly utilizing one or more concave cylindrical focusing mirrors. One of the benefits that is derived from this apparatus is the use of one or more concave cylindrical mirrors to project a focused beam of light onto a calibrated surface from which the time can be read. This sundial has the additional benefit of not suffering from blurring of the time indicator in a shadow or non-focused beam of light typical of other sundials. This sundial's focused light forms a sharply demarcated indicator from which time can be read to the minute. A further benefit of this apparatus is the ability to incorporate multiple concave cylindrical focusing mirrors to reduce the size of the visual field or screen where the time is read and to incorporate various shapes and designs for ornamental purposes without significant compromise of the sundials accuracy for telling time. An additional benefit of this apparatus is the ability to quickly, accurately and easily adjust the apparatus to the proper tilt upon setup according to the latitude where it will be located by means of an adjustable base assembly.

The present invention concerns a TCTP antagonist, in particular a nucleic acid targeting an m RNA encoding Translationally-Controlled Tumor Protein (TCTP), wherein said nucleic acid is capable of reducing the amount of TCTP in cells, for use in the treatment or prevention of hormone-independent cancer or chemo-resistant cancer, such as an androgen-independent prostate cancer.

A peak-relevant value device acquires a peak-relevant value (for example, the peak value of an R wave (R peak value)) every cycle from an electrocardiogram acquired. The frequencies of the peak-relevant value acquired as time-series data and the magnitudes for the respective frequencies are analyzed. A peak-relevant value LF calculating device calculates an LF component (peak-relevant value LF component) from the frequency component of the peak-relevant value. An interval acquiring device acquires the interval between characteristic points of the electrocardiographic complex from the electrocardiogram acquired and the frequencies of the feature point interval acquired as time-series data to acquire the magnitudes of the respective frequency component are analyzed. An interval HF calculating device calculates the HF component from the frequency components of the feature point interval acquired and pain is judged on the basis of the variations of the peak-relevant value LF components and the interval HF components.

The present invention provides aryl ketone compounds and compositions containing them which facilitate the delivery of active agents. The aryl ketone compounds have the formula or a salt thereof, where n=1 to 9, and R1 to R5 are independently hydrogen, C1 to C4 alkyl, C1 to C4 alkoxy, C2 to C4 alkenyl, halogen, hydroxyl, —NH—C(O)—CH3, or —O—C6H5.

The present invention features monocyclic cyanoenone compositions and methods for using the same in the treatment of diseases such as cancer, inflammatory diseases and neurodegenerative diseases.

A dual end glycerol (meth)acrylate-modified silicone having formula (I): R1Me2SiO(R22SiO)aSiMe2R1 is novel. R1 is a mixture of 70-95 mol % of a group having formula (i) and 30-5 mol % of a group having formula (ii) wherein R3 is H or methyl, R2 is a monovalent hydrocarbon group which may be halogenated, Me stands for methyl, and a is an integer of 10-300.

Disclosed are novel ruthenium compounds of formula (Ia) and (Ib): wherein R1 and the moiety are defined herein. Also disclosed is a process for using these novel ruthenium compounds as catalysts for asymmetric hydrogenation and transfer hydrogenation of ketones with high reactivities and excellent selectivities.

A method of manufacturing a compound or a salt thereof expressed with a formula (III) below, characterized by causing a compound or a salt thereof expressed with a formula (I) below and a compound or a salt thereof expressed with a formula (II) below to react in the presence of carbonate and copper salt or in the presence of hydroxide salt, carbonate, and copper salt.

The invention relates to a process for preparing 1-aryl-pyrazol-3-one intermediates, tautomers, and salts thereof, to novel intermediates, and to the use of the intermediates in the preparation of sigma receptor inhibitors.

The present invention provides a diaryl sulfone compound represented by Formula (1) below: wherein R1 to R4 and R1' to R4' are the same or different; each represents hydrogen, C1-4 alkyl, or halogen; and R5 is (thio)glycidyl, acryloyl, or the like; and a method for producing the same. According to the present invention, a novel compound useful as a monomer for producing synthetic resin having a high refractive index and excellent transparency for optical materials can be efficiently produced with a simple production process, using an inexpensive material as a starting material.

Disclosed in the present invention is a novel histone deacetylase inhibitor of benzamides and use thereof. The inhibitor has good efficacy in treating diseases caused by abnormal gene expression, such as tumors, endocrine disorders, immune system diseases, genetic diseases and nerve system diseases. The histone deacetylase inhibitor of benzamides is a compound of the following general chemical structural formula (I) or a salt thereof.

The invention provides a method for synthesizing 7-Acetyleno quinone methide compounds that is safe and inexpensive. The method avoids the need for extremely cold reaction temperatures and unlike the prior art does not require any highly explosive materials. The method comprises the steps of: a) performing a condensation reaction between 3,5-di-tert-butyl-4-hydroxybenzaldehyde and a secondary amine thereby forming a secondary amine quinone methide intermediate;b) removing water from the secondary amine quinone methide intermediate by azeotropic distillation;c) adding the dehydrated secondary amine quinone methide intermediate to an organic medium containing a metal acetylide to form a Mannich base intermediate; andd) adding a release agent to the Mannich base intermediate to yield a 7-Acetyleno quinone methide.

Use of 9,10-anthraquinone compounds of formula (I) or pharmaceutical salts thereof or plant extracts containing said compounds in the preparation of anti-HCV medicaments is disclosed, in which Y1 are Y2 are independently hydrogen, hydroxyl or groups of formula (II); and R1, R2, R3, R4, R5 and R6 are independently hydrogen, hydroxyl, carboxyl, cyano group, nitro group, groups of formula (III) or groups selected from those substituted or unsubstituted groups: amino, C1-C6 aliphatic hydrocarbon, C3-C7 cyclic aliphatic hydrocarbon, C1-C6 alkoxy, C2-C7 carbalkoxy, C1-C4 acyloxy, C6-C20 aryl, or 5 to 7 members heterocyclic or benzoheterocyclic thereof; or R5 and R6 form the group of formula (IV). The compounds of present invention are cheap, safe and effective because that they mostly come from traditional Chinese medicines and have better anti-HCV effects and lighter side effects.

A way to formulate prasterone to both increase its oral bioavailability, and decrease the variability of its oral bioavailability. In contrast to the approach taught by the prior art, the instant approach is amenable to scale-up to commercial scale. Further, the resulting product is amenable to analysis using standard, known quantitative analytical techniques; thus, unlike the prior art approach, the instant approach may be used to manufacture a product in conformity with applicable regulatory standards.

The present invention relates to novel 4-pregenen-11β-17-21-triol-3,20-dione derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals, as modulators of glucocorticoid or mineralocorticoid receptors. The invention relates specifically to the use of these compounds and their pharmaceutical compositions to treat disorders associated with glucocorticoid or mineralocorticoid receptor modulation.

The disclosure provides compounds and methods of using Apogossypolone derivatives for treating diseases and disorders. In particular, the disclosure provides compounds of Formula I: or a pharmaceutically acceptable salt, hydrate, or solvate thereof, and provides methods for the preparation of compounds of Formula I; and methods for treating cancer, autoimmune diseases, and inflammation by administering a compound of Formula I.

The disclosure relates to novel C4 and C6 substituted androst-4-ene diones as well as andros-1,4-diene diones and derivatives thereof, their process of preparation, pharmaceutical compounds containing them, and the use of said compounds for the treatment of hormone-related disorders in mammals. This includes hormone-dependent cancers, particularly those caused by elevated levels of estrogen and its intermediates. These compounds can also be used in the treatment of other hormone-related disorders, including benign prostatic hyperplasia, cardiovascular disease, and neurodegenerative disorders.

The invention relates to 17-hydroxy-17-pentafluoroethyl-estra-4,9(10)-dien-11-aryl derivatives of formula I with progesterone-antagonizing action and methods of production thereof, use thereof for the treatment and/or prevention of diseases and use thereof for producing medicinal products for the treatment and/or prevention of diseases, in particular uterine fibroids (myomata, uterine leiomyomata), endometriosis, heavy menstrual bleeding, meningiomata, hormone-dependent breast cancers and menopause-associated complaints or for fertility control and emergency contraception.

The present invention comprises formulations comprising at least one pesticide and at least one co-polymer comprising a) 1-vinyl-2-pyrrolidinone as comonomer a); and b) 60-99 wt % at least one comonomer b) chosen from the group of laurylacrylate and vinyl ester of neodecanoic acid in polymerized form, methods of combating harmful insects and/or phytopathogenic fungi, a method of controlling undesired vegetation and methods of improving the health of plants based on the afore-mentioned formulations.

The use of substituted fused pyrimidinones and dihydropyrimidinones of the formula (I) or salts thereof where the radicals of the formula (I) are each as defined in the description, for enhancing stress tolerance in plants to abiotic stress, and for invigorating plant growth and/or for increasing plant yield.

The present weed reducing material reduces the necessary weed control work by making joint filling sand a hostile substrate for plant and fungus growth by using an environmentally acceptable slow release mineral additive. The additive, having similar grain size distribution, mechanical and rheological properties, forms an integral part of the joint filling sand. The specific gravity of the additive is lower than quartz sand imparting a tendency for the additive to migrate towards the top part of the joint. The additive leads to pore waters rich in sodium and at high pH, both qualities being maintained over long periods. The mixture of additive and sand is handled and applied using conventional laying techniques and equipment, observing usual precautions for mortar or cement mixes with sand. In the environment, reaction with CO2 in the air or in the soil porosity inactivates the causticity, yielding harmless carbonate salts.

A compound of the formula (1) wherein the substituents are as defined in claim 1, are useful as a pesticides.

The present invention relates to a pyridazinone compound of the formula (I): wherein R1 represents hydrogen, a C1-6 alkyl group, and the like, R2 represents halogen, a cyano group, a nitro group, a C1-6 alkoxy group, and the like, G represents hydrogen, and the like, Z represents halogen, a cyano group, a nitro group, a C1-6 alkyl group, and the like, and n represents an integer of 1-5 useful as an active ingredient in a herbicide and a noxious arthropod controlling agent.

A storage stable capsule suspension formulation comprising clomazone encapsulated within a polymeric shell wall of microcapsules, a process for the preparation thereof and method of controlling weeds utilizing said formulation.