Hypoxia-inducible factor (HIF) is strikingly upregulated in many types of cancer, and there is great interest in applying inhibitors of HIF as anticancer therapeutics. The most advanced of these are small molecules that target the HIF-2 isoform through binding the PAS-B domain of HIF-2α. These molecules are undergoing clinical trials with promising results in renal and other cancers where HIF-2 is considered to be driving growth. Nevertheless, a central question remains as to whether such inhibitors affect physiological responses to hypoxia at relevant doses. Here, we show that pharmacological HIF-2α inhibition with PT2385, at doses similar to those reported to inhibit tumor growth, rapidly impaired ventilatory responses to hypoxia, abrogating both ventilatory acclimatization and carotid body cell proliferative responses to sustained hypoxia. Mice carrying a HIF-2α PAS-B S305M mutation that disrupts PT2385 binding, but not dimerization with HIF-1β, did not respond to PT2385, indicating that these effects are on-target. Furthermore, the finding of a hypomorphic ventilatory phenotype in untreated HIF-2α S305M mutant mice suggests a function for the HIF-2α PAS-B domain beyond heterodimerization with HIF-1β. Although PT2385 was well tolerated, the findings indicate the need for caution in patients who are dependent on hypoxic ventilatory drive.

Lipid-rich myelin forms electrically insulating, axon-wrapping multilayers that are essential for neural function, and mature myelin is traditionally considered metabolically inert. Surprisingly, we discovered that mature myelin lipids undergo rapid turnover, and quaking (Qki) is a major regulator of myelin lipid homeostasis. Oligodendrocyte-specific Qki depletion, without affecting oligodendrocyte survival, resulted in rapid demyelination, within 1 week, and gradually neurological deficits in adult mice. Myelin lipids, especially the monounsaturated fatty acids and very-long-chain fatty acids, were dramatically reduced by Qki depletion, whereas the major myelin proteins remained intact, and the demyelinating phenotypes of Qki-depleted mice were alleviated by a high-fat diet. Mechanistically, Qki serves as a coactivator of the PPARβ-RXRα complex, which controls the transcription of lipid-metabolism genes, particularly those involved in fatty acid desaturation and elongation. Treatment of Qki-depleted mice with PPARβ/RXR agonists significantly alleviated neurological disability and extended survival durations. Furthermore, a subset of lesions from patients with primary progressive multiple sclerosis were characterized by preferential reductions in myelin lipid contents, activities of various lipid metabolism pathways, and expression level of QKI-5 in human oligodendrocytes. Together, our results demonstrate that continuous lipid synthesis is indispensable for mature myelin maintenance and highlight an underappreciated role of lipid metabolism in demyelinating diseases.

A new NFC specification announced this week by the NFC Froum will allow future NFC enabled devices to offer wireless charging capabilities, which means a smartphone could be used to charge a small accessory like headphones.


According to the NFC Forum, the Wireless Charging Specification (WLC) will allow smartphones or other NFC charging devices to wirelessly charge small, battery-powered consumer and IoT devices at a power transfer rate of up to one watt.

The 1W rating is much slower than the Qi-based standard used by iPhones and other smartphones. Qi-based wireless charging on the iPhone maxes out at 7.5W, but is even faster on some Android devices.

Charging over NFC would require new hardware, and it's not a feature that can be added to existing devices. The NFC Forum believes the WLC specification could be used to complement Qi-based wireless charging.

It works using a single antenna to manage communications and charging, which is convenient for low-power devices like smart watches, fitness trackers, and earbuds that already use NFC for connectivity because there's no need to build in Qi support.

"The NFC Forum's Wireless Charging Technical Specification allows for wireless charging of small battery-powered devices like those found in many of the estimated 36 billion IoT devices in use today," said Koichi Tagawa, chair, NFC Forum. "NFC wireless charging is truly transformative because it changes the way we design and interact with small, battery-powered devices as the elimination of plugs and cords enables the creation of smaller, hermetically-sealed devices."

Apple in 2015 joined the NFC Forum and participates in the approval of new NFC specifications and developments.

Rumors in 2019 suggested that Apple was working on bilateral wireless charging that would allow its iPhones to charge the AirPods and the Apple Watch, but the feature was ultimately nixed. At the time, Apple analyst Ming-Chi Kuo said that the two-way wireless charging feature Apple was exploring did not meet Apple's requirements.

Samsung has implemented bilateral wireless charging in its smartphones, but the Wireless PowerShare option does not use NFC and is powered by the Qi-based charging coils in the device. Samsung's smartphones can charge other smartphones or accessories like headphones that support Qi wireless chargers.
This article, "New NFC Specification Will Let Smartphones Charge Small Devices" first appeared on MacRumors.com

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Cornel West and Tavis Smiley criticize President Barack Obama for being to the right of even President Richard Nixon. Continue reading →

Noor asks Hedges how the presidential nominees should respond to these types of terrorist attacks in the U.S. “Their response should be the end of the occupation in the Middle East and the cessation of saturation bombing by drones and military aircrafts and missiles in parts of Iraq and Syria and Pakistan and Yemen and Somalia,” Hedges responds. He goes on to explain how decades of foreign policy decisions made by both parties have created the circumstances for terrorist attacks. Continue reading →

There's got to be a reason for the Democrats to suppose to exist. And the reason the Democrats are supposed to exist is to be an opposition party to the Republicans. If you're in bed with the same people, taking money from the same people, you're no longer an opposition party. There's no reason for you to exist. And guess what? Don't be surprised that people don't vote for you. Continue reading →

IBM's Smarter Cities Challenge program (@CitiesChallenge) will be sending teams of company experts to five municipalities through 2018 to provide pro bono consultative advice on issues such as affordable housing, economic development, immigration, and public safety.

IBM's Smarter Cities Challenge program (@CitiesChallenge) will be sending teams of company experts to 16 municipalities around the world through 2016 to help cities with critical issues ranging from jobs creation, transportation, and public safety, to healthcare, revenue, social services, and public works.

ENGIE, a global leader in energy transition, today announced a new initiative with IBM. This nonexclusive, technological and commercial alliance is designed to improve the management of cities by looking at patterns, event correlation, anomaly detection and real-time data across all parts of cities.

IBM today unveiled a number of major additions to its Flex System portfolio. The offerings combine the latest server technology with new virtualization, networking and management tools, allowing clients to consolidate their existing IT infrastructures and reduce operating costs. This will help clients use smaller data center environments to quickly deploy, manage and secure increasingly larger clouds.

I lowered my NOx emissions by 234 PPM

As businesses increasingly recognize the opportunity to increase productivity, improve customer experiences and deliver new products and services through intelligent automation, Blue Prism and IBM have joined forces to deliver a secure, scalable and easy-to-use Digital Workforce for enterprises worldwide, such as Walgreens.

IBM realizó por 5ª ocasión en México la edición del concurso de emprendedores: IBM SmartCamp, organizado por el IBM Global Entrepreneur Program. El evento tuvo lugar en las instalaciones del espacio de co-working, CoWdf, de la Ciudad de México, resultando ganadora del primer lugar la startup Apli.jobs, en tanto que el segundo lugar fue otorgado a la startup Bayonet.io.

IBM announced today it is making up to €2.2 billion ($3 billion) available to finance IT initiatives in key economic stimulus projects in Europe and Asia-Pacific through IBM Global Financing, IBM’s lending and leasing business segment. Today’s announcement follows the availability of up to €1.5 billion ($2 billion) announced by IBM on April 30 to help jump start US economic stimulus programs.

IBM today announced new systems highly-tuned and optimised to help clients more quickly draw insights from vast amounts of data to anticipate emerging business trends, capture new opportunities and avoid risks. These new optimised systems support all environments in a data center, enabling clients to handle higher volumes of transactions and analyse data where it resides.

IBM will host New Zealand's first SmartCamp in Auckland on Sept. 17.

IBM today announced New Zealand startup Eight Wire as the 2015 winner of IBM SmartCamp Auckland. The data integration specialist was one of five IT startups from around New Zealand invited by IBM to participate in the competition.

IBM Poland and WINUEL SA (subsidiary of Sygnity Group), today announced the first Polish Smart Metering software package to enable intelligent electricity use in more than 15 million households in Poland. The solution was developed jointly with the IBM Software Laboratory in Krakow.

SAO PAULO and ARMONK, N.Y., Dec. 27, 2010 /PRNewswire/ -- The city government and IBM (NYSE: IBM) signed an agreement to build a public information management center for Rio de Janeiro. The Rio Operations Center, which will be located in Cidade Nova, will integrate and interconnect information from multiple government departments and public agencies in the municipality to improve city safety and responsiveness to various types of incidents, such as flash floods and landslides.

IBM annonce aujourd’hui que son nouveau cloud pour les fabricants d’appareils électroniques fournira à la TV connectée de Philips de nouveaux services internet, afin de proposer une gamme de services plus interactifs à des millions de téléspectateurs dans plus de 30 pays en Europe, mais aussi au Brésil et en Argentine.

IBM (NYSE: IBM) today announced that Queensland Sugar Limited (QSL), a global leader in raw sugar marketing that manages over 90 percent of Australia’s raw sugar exports, has selected IBM advanced storage systems to support rapidly growing data demands.

IBM (NYSE: IBM) today announced the successful delivery of the Core Services IT platform that supports the Australian Federal Government’s Standard Business Reporting (SBR) initiative, which aims to save businesses time, money and effort through the provision of an online reporting capability.

IBM (NYSE: IBM) today announced that the Gold Coast has been selected as a recipient of an IBM Smarter Cities Challenge grant (#smartercities). The grant will give the Gold Coast City Council the opportunity to work with a team of IBM experts to analyse and recommend ways to improve the city’s public safety disaster response capabilities.

Tasmania’s St Virgil’s College has signed a two-year agreement with IBM to equip staff and students with Apple iPads and Mobile Device Management (MDM) software as part of its digital education delivery commitment.

IBM (NYSE: IBM) today announced it has partnered with academia, government and industry to launch the Smart Transport Research Centre (STRC) based at Queensland University of Technology (QUT), which is being opened today by the Minister for Transport, the honourable Annastacia Palasczuk. IBM will contribute its global consulting expertise and technology in developing smarter traffic solutions to help make Australia’s transportation infrastructure smarter, improve commuter experiences and reduce environmental impact.

EnergyAustralia, the country’s largest electricity distribution network, today announced an agreement with IBM for the implementation of an energy network monitoring and control solution.

IBM today announced it has been selected by Australian energy provider Western Power as the systems integration and project management partner for its SmartGrid-Advanced Meter Infrastructure pilot program.

IBM (NYSE: IBM) today announced its role as the systems integration partner for the $100 million Smart Grid, Smart City initiative led by the EnergyAustralia consortium. IBM will play a pivotal role, as a member of the consortium, in the development of Australia’s first smart grid network, following the formal contract signing of the deal between EnergyAustralia and the Australian Government.

IBM collaborates with academia and industry to educate and prepare IT professionals, telecommunications engineers, and electrical power engineers for the electricity networks of the future

IBM (NYSE: IBM) today announced a business consulting and technology partnership with Yarra Valley Water to enhance the management and functionality of its assets and customer service to over 1.7 million people and 50,000 businesses throughout Melbourne now and in the future. Through this partnership Yarra Valley Water will gain access to critical insights to maximise asset performance and improve customer service outcomes across its operations.

Queensland Motorways has awarded IBM a technology and services contract to introduce automated free-flow tolling across south east Queensland’s toll roads.

IBM (NYSE: IBM) today announced that Digital Alchemy, a leading Australian database marketing service provider, has extended its commitment to IBM’s Enterprise Marketing Management (EMM) software to more quickly and easily enable cross-channel interactive campaigns for its clients.

IBM (NYSE: IBM) today announced that the Foundation for Young Australians has successfully integrated IBM’s SPSS analytics platform into its research capabilities, resulting in significant boosts to the organisation’s reputation as a national leader in its field.

Thank you, first and foremost, to theSwede. When I told you I wanted and needed to do some creative work, over a decade ago, you simply said "Okay" and were nothing but supportive. None of this would exist without you. Thank you as well to both Cannonball and Torpedo. Someday you'll be old enough to read these, and I hope you find them all as enjoyable, meaningful, and as embarrassing as they are/were intended to be.

Thank you to Mom, Dad, Hanna, Emma, my grandparents, all extended family, for giving me the experiences, insight, and humor that crafted STW. Thank you Mitch, Donna, and all for their support as well. Thank you to so many friends, innumerable to name. Your support has meant everything.

Thank you to classmates, advisors, and colleagues from the past 10 years at Cornell, NIST, and Northeastern, particularly to those who never found out about STW when it needed to remain a professional secret, and just as particularly to those who were in full support and encouragement when the secret came out. Thank you to so many students, but especially everyone from the NU ChemE class of 2015, who I am ever indebted to.

Thank you to so many in the comics/creative community, especially Danielle Corsetto, Jon Rosenberg, Joan Cooke, Christopher Moore, Jessica Hagy, Holly and Jeffrey Rowland, Sara McHenry, Gary Tyrrell, Zach and Kelly Weinersmith, Matt Lubchansky, Monica Keszler, Ryan Walsh, every artist I have collaborated with, so so so many others. Thank you for all that you have done to bring me into your world, and for all that you have done for my career.

It's been a very long time since I worked there, but thank you as well to Three Point for all those experiences at creative writing that almost certainly led to the creation of STW.

Thank you to Westley, Sprite, Wakefield, Shiv, and Bitey, too. Why not.

And finally, thank you to all of you kind readers. For however long you have read STW, thank you. I am so incredibly humbled by your support and kindness and so incredibly grateful for all that you have given to STW as well. I wish all of you whatever joy and happiness that you deserve.

STW ran for 10+ years and 3500+ comics. It's as much yours as it is mine, now.

Thank you all, so harking much.

IBM (NYSE: IBM) today announced the successful implementation of a first of its kind smart grid data management platform, designed and built with Ausgrid to give the utility more data from part of its electricity distribution grid.

UPDATE: Both workshops filled very quickly. I only do these about once a year; apologies for the imbalance. I have set up a system so people who are potentially interested in future small-class lighting workshops can receive advance notice. More info here.

__________
I'll be teaching two, full-day lighting workshops in the suburban Baltimore/DC area on December 6 and 7.

They are two separate one-day events. These are small-group workshops, with a maximum class size of 12 people each day. These are shooting workshops, and you'll be behind (and/or in front of!) a camera for most of the day.

Assuming you arrive at this class with a basic understanding of f/stops and shutter speeds, you will leave with a strong foundation in the fundamentals of off-camera lighting. You will be comfortable using single and multiple lights both alone and/or balanced with a mix of ambient lighting.

All lighting gear will be provided. We will also provide lunch.

You will need to bring a camera that is adjustable in manual mode and has a hot shoe connection for a flash, a lens that covers normal and/or portrait range, one or two fully charged batteries and an empty storage card. Maybe a notebook and pen if you like.

That's it. Just show up ready to learn and to have fun. Leave the rest to me.


Details

Dates:
December 6 and 7, 2019

Time:
9:30am - 5:30pm

Price:
$259

Location:
Sandy Spring Friends Lyceum
17715 Meeting House Road
Sandy Spring, MD 20860


Note; These are the only small-class lighting workshops I'll be teaching in the US this year. In the past, these have tended to fill very quickly. So if this is something you'd like to do, I'd suggest signing up sooner rather than later.


Sign-Up Links

Friday, December 6 [FRIDAY'S CLASS HAS BEEN FILLED]

Saturday, December 7 [SATURDAY'S CLASS HAS BEEN FILLED]

IBM (NYSE: IBM) today announced Melbourne start-up Localz as the winner of IBM SmartCamp Australia 2015, a global competition that brings together entrepreneurs, investors and experienced mentors. Localz provides software that connects the digital and physical worlds for enterprise, using the latest micro-location technology to enhance customer’s in-store experience, improve asset and inventory tracking and provide frictionless mobile payments, at scale. One of the key differentiators of the solution is that it works across different technologies (iBeacons, Bluetoth Low Energy, GPS or even QR Codes).

We'll be at the Small Press Expo in Bethesda Maryland!

This is our first time at SPX! If you're there, feel free to stop by and see us in the Artist Alley – we'll be at table W49!

See you there! <3 -Hamlet

Koronavirová krize výrazně ovlivnila český pracovní trh. Ve srovnání s loňským rokem evidují personální agentury v posledních měsících přibližně poloviční nabídku nových pracovních pozic. Ubylo práce v gastronomii a cestovním ruchu, naopak logistika zažívá žně. Pro firmy zůstávají nejcennějšími pracovníky lidé z oblasti IT.

Zaměstnanci Škody Auto od pondělí začnou pracovat na tři směny, a to v závodech v Mladé Boleslavi a Kvasinách. Ve Vrchlabí zatím zůstává dvousměnný provoz, oznámil vedoucí komunikace podniku Tomáš Kotera. Automobilka obnovila výrobu 27. dubna ve všech třech českých závodech, ale jen na dvě směny. Obnovení výroby doprovází více než 80 hygienických opatření.

Istrie patří k nejoblíbenějším částem Chorvatska. Jako skoro všude na světě se tam hoteliérský a restaurační byznys letos v březnu úplně zastavil, což si ještě nedávno nikdo nedokázal představit. Teď se ale blíží oživení. „Ani přinejmenším ale neočekáváme, že zopakujeme výsledky loňského roku,“ říká v rozhovoru šéf turistického sdružení celé oblasti Denis Ivošević.

Vroom.

Don't expect a pack of running fanatics swarming to the finish line at road races this year. But that doesn't mean that participants don't have options.

Most stakeholders agree that holding smaller competitions will be the best way forward post-lockdown.

Řada lidí přijde o práci a začne hledat novou. Už teď je dobré se na to připravit a před podpisem pracovní smlouvy vědět, na co si dát pozor. Je lepší kývnout na mzdový výměr, nebo na mzdu v pracovní smlouvě? A na co dalšího si dát pozor? Na otázky odpovídá advokát Pavel Nastis.

Zaměstnaní rodiče mají od dubna nově nárok na ošetřovné ve výši 80 procent denního vyměřovacího základu. Důvod zvýšení je jasný. Původních 60 procent většině rodin na pokrytí nákladů na provoz domácnosti nevystačilo. Potvrzuje to i případ paní Anny.

ingredients

• 1 apple, washed (peeled if not organic) ($.60)
• 1 cup mango,chunks, fresh or frozen ($1.00)
• 1 banana, sliced and frozen
• 1 handful kale leaves ($.50)
• 1/2 teaspoon cinnamon
• 1/4 teaspoon nutmeg
• 1 cup ice
• water for blending (more or less depending on how thick you like it)

This is just a super simple way to enjoy some of the apples that are in season right now! Blend all ingredients in a high powered blender until very smooth and enjoy!


nutritional information
calories: 230
fat: 4 gr
carbs:47 gr
protein: 6 gr

• 1 cup carrots, cut into chunks
• 1 banana, sliced and frozen
• 1 cup almond milk 
• 1 teaspoon cinnamon
• 1/2 teaspoon ginger
• 1/4 teaspoon allspice
• pinch nutmeg
• 1/2 cup chopped dates
• 1/4 cup chopped pecans or other nuts
• 1 cup chopped apples

directions

1. In a high powered blender, puree the carrots, banana, and almond milk until very smooth.
2. Add in the cinnamon, ginger, allspice, and nutmeg and pulse a few times to blend well.
3. Pour into a bowl and add the chopped dates, pecans, and apples. A sprinkle of coconut flakes goes well, too!

This raw and healthy pineapple party in your mouth is super simple and perfect for spring. Hawaiian pineapple season is April and May, even though they're available year round. Price and quality will be the best over the next few months so take advantage of this sweet abundance and enjoy this vegan treat for breakfast or an anytime snack.

Oh, and to make this extra thick and frosty, cube and freeze pineapple and any subsequent pineapple juice in ice cube trays. Store frozen cubes in plastic bags for ultra easy prep.



   




ingredients

• 3 cups chopped romaine (or favorite green) ($1.00)
• 1 cup cubed pineapple, frozen ($2.00)
• 1 banana, sliced and frozen ($.20)
• 2 tablespoons lemon juice (optional) ($.20)
• 1 teaspoon vanilla ($.10)
• 1 cup water
• 10 ice cubes
• stevia to taste (optional)

directions

• In a high powered blender, puree the greens until liquefied and very smooth. 
• Add the rest of the ingredients and puree until smooth.

nutritional information:      calories: 156      fat: 0 gr      carbs: 42 gr      protein: 3 gr



Speaking of pineapple ...

... this really cool little building was one of my favorite local landmarks. While on a bike ride the other day (hello warm weather!) I noticed the other day that it's gone! I'll miss it!! Maybe they got tired of me taking so many photos of it ... hmm.

You have to remind yourself this is good for you. It's so delicious it feels downright decadent. The hemp milk makes it super creamy and luscious.

ingredients

• 1 orange, peeled and frozen ($.50)
• 2 bananas, peeled, sliced, and frozen ($.40)
• 1 cup hemp milk ($1.00)
• 3 tablespoons cacao powder ($.30) 
• 1/2 teaspoon orange extract
• few drops stevia (optional)
• pinch salt
• 6 ice cubes
• water for blending, if necessary

directions

1. In a high speed blender, puree all ingredients until very smooth and creamy. 
2. Add water if needed for ease of blender or if a thinner smoothie is desired. 

nutritional information:      calories: 339      fat: 14 gr      carbs: 43 gr       protein: 8 gr