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[ASAP] A Grand Challenge. 3. Unbiased Phenotypic Function of Metabolites from Australia Plants <italic toggle="yes">Gloriosa superba</italic> and <italic toggle="yes">Alangium villosum</italic> against Parkinson

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00880




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Fun and games with JavaScript

#484 — April 17, 2020

Unsubscribe  :  Read on the Web

???? If you're bored this weekend at all, consider joining the latest Ludum Dare — it's an online game jam that's been taking place for 18 years and more JavaScript entries are appreciated against all the Unity crowd ????

JavaScript Weekly

Writing an 'Emulator' in JavaScript (and Interfacing with Multiple UIs) — This is really neat. Tania built a Chip-8 interpreter in JavaScript and has gone into quite a bit of detail about what was involved here. Lots of neat bits and pieces to pick up from this.

Tania Rascia

jQuery 3.5.0 Released — I know many of you will groan, but I’m delighted when I see a new jQuery release. It’s still so heavily used. No headline features though, this is a security fix for a cross-site scripting vulnerability, plus some tweaks and fixes in preparation for jQuery 4.0 (yes!)

Timmy Willison (jQuery Foundation)

Build a Game of Battleship with TypeScript & Java. Free Course — Join over 2000 developers creating a game of Battleship with TypeScript, Spring Cloud Stream (Java), and PubSub+. This free 30-minute course is a great way to learn the basics of messaging and event-driven architecture with the Aurelia framework.

Solace sponsor

Profiling React.js Performance — Goes into detail on aspects of the React Profiler API, React’s new experimental Interaction Tracing API, and measuring custom metrics using the User Timing API.

Addy Osmani

Userscripts are Fun and Still Very Much Relevant — ‘Userscripts’ are basically JavaScript programs that run in the context of other Web pages so you can add your own features. They were really popular for a while but still exist and are still a neat use case for using JavaScript to improve your Web experience.

Eldad Bercovici

Another Look at What's New in ECMAScript 2020 — We linked to Dr Axel’s roundup recently, but here’s another take, looking at dynamic imports, nullish coalescing, optional chaining, BigInt, and more.

Ianis T.

⚡️ Quick Releases

???? Jobs

JavaScript Developer at X-Team (Remote) — Join the most energizing community for developers. Work from anywhere with the world's leading brands.

X-Team

Senior JavaScript Developer (Warsaw, Relocation Package) — Open source rich text editor used by millions of users around the world. Strong focus on code quality. Join us.

CKEditor

Find a Job Through Vettery — Vettery specializes in tech roles and is completely free for job seekers. Create a profile to get started.

Vettery

???? Tutorials

How To Create a Particle Trail Animation in JavaScript — Particle animations are particularly (sorry) striking.. and in this article, Anna Prenzel shows how to easily create your own such effects with Anime.js.

Smashing Magazine

Strategies for Migrating to TypeScript — A quick overview of some strategies for migrating code bases from JavaScript over to TypeScript.

Dr. Axel Rauschmayer

Developing in a Monorepo While Still Using Webpack — Second part in a series discussing things the team at Etsy learned during the migration of a home-grown, Require.js-based build system to webpack, which took over a year.

Salem Hilal

A More Productive Way to Build Your JavaScript Apps — Write better code, debug it, and test it – all in one place. Try WebStorm. No configuration required.

WebStorm sponsor

▶  Let's Build a Digital Circuit Simulator in JavaScript — A special episode of the Low Level JavaScript series takes us on a brief journey into the world of digital logic.

Low Level JavaScript

How To Set Up an Express API Backend Project with PostgreSQL — A pretty extensive walkthrough of creating an HTTP API using Express with Node.js and Postgres on the backend, then deploying it all on Heroku.

Chidi Orji

Speed Up Your Angular App: 14 Optimization Tips — Tips on how to make your Angular app smaller, faster, and more responsive.

Marcelo Ricardo de Oliveira

Class-Related Types in TypeScript

Dr. Axel Rauschmayer

????▶ A Fireside Chat on the State of Microservices on April 21 — We recently helped The Software House with a developer survey (thanks to those who took it!) and now they’re doing a live chat on the state of microservices next Tuesday featuring Yan Cui, Alessando Vozza, and others.

The Software House

???? Code & Tools

Puppeteer 3.0: It Now Supports Firefox — Best known for as a way to headlessly control Chrome from Node, Puppeteer has recently seen some competition in the form of the cross-browser Playwright recently. But, no fear, Puppeteer is stepping up and can now work cross-browser too. We also learn Puppeteer is migrating to TypeScript.

Mathias Bynens

Open-Source Serverless CMS Powered by React, Node.js and GraphQL API — Build dynamic websites and apps with Webiny. 100% powered by JavaScript. Deploy your sites to AWS Lambda.

Webiny Serverless CMS sponsor

Rome: An Experimental JavaScript Toolchain — A compiler, linter, formatter, bundler, testing framework and more. Started by Sebastian McKenzie (of Babel and Yarn fame), Rome is now a project from the React Native team at Facebook. Related repo.

Facebook

Vime: A New, Modern Media / Video Player for the Web — Aims to be a ‘modern alternative to Video.js and Plyr’: “The idea behind Vime is we want you to control the player, not the other way around.” Modular, tree-shakable, and with potential for a plugin ecosystem. GitHub repo.

Rahim Alwer

Vuln Cost: An Open Source Security Scanner for VS Code — Free Snyk-powered VS Code extension that finds security vulnerabilities in npm packages, providing feedback in-line with your code, such as how many vulnerabilities a package has.

snyk

ip-num: A Library to Work with ASN, IPv4, and IPv6 Numbers — Happy in both Node and the browser.

dadepo

Flip: Animated Flip Counter Plugin to Add a Countdown to a Website — Adds an animated dynamic countdown timer to a page. No dependencies, responsive and mobile friendly, and fits any language, locale, or time zone.

Rik Schennink

The Perfect Partner to MongoDB Atlas. Try It for Free

Studio 3T sponsor

A JavaScript API for Controlling 'Simpsons: Hit & Run' — Including this as a bit of fun if you fancy noodling on something odd. Remote controlling games from JS seems neat, although I suspect just getting this running would take a while..

Tavis Ormandy




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Medical inbound tourism poised to get a push: FAITH chairman Nakul Anand

Medical inbound tourism, already on the rise, will get a boost with addition of Tier-II and -III hospitals




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A big positive in this Budget is tax exemptions: PGIM India Mutual Fund CEO

Abolishing DDT will attract investments, said Ajit Menon, CEO of PGIM India Mutual Fund




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Budget stimulus unlikely to revive India's growth from slowdown: Experts

Economists and industry leaders said the budget proposals would provide some support to growth over the longer term but were insufficient to give it an immediate boost




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Budget's much-needed leg-up for small units: CRISIL SME Tracker

An evaluation of 13,000 MSMEs using the CRISIL Quantix database shows that working capital comprises over half of their need for debt




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Power industry hails proposal for smart prepaid metering across the country

Power ministry has been planning it for two years, but with limited success




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Budget 2020 has not accounted for telcos' AGR dues: DEA secretary

But receipts from firms stand at a whopping Rs 1.33 trillion for FY21




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LIC disinvestment: 100,000 employees stage walk-out across country

There are 13 unions in LIC, and employees and officers affiliated to 11 unions were on protest




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Economy fundamentals strong; markets show faith in Budget 2020: Sitharaman

FM says country's macroeconomic parameters are sound




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Understanding Depression and Distress Among Medical Students

Interview with Laura Weiss Roberts, MD, MA, author of Understanding Depression and Distress Among Medical Students




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he United States' Engagement in Global Tobacco Control

Interview with Lawrence O. Gostin, JD, author of The United States' Engagement in Global Tobacco Control




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Biosafety Concerns Involving Genetically Modified Mosquitoes to Combat Malaria and Dengue in Developing Countries

Interview with Lawrence O. Gostin, JD, author of Biosafety Concerns Involving Genetically Modified Mosquitoes to Combat Malaria and Dengue in Developing Countries




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Physician Communication in the 21st Century

Interview with Allan S. Detsky, MD, PhD, author of Physician Communication in the 21st Century




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Patient-Physican Communication: It's About Time

Interview with Wendy Levinson, MD, author of Patient-Physican Communication: It's About Time




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From Efficacy to Effectiveness in the Face of Uncertainty: Indication Creep and Prevention Creep

Interview with Benjamin Djulbegovic, MD, PhD, author of From Efficacy to Effectiveness in the Face of Uncertainty: Indication Creep and Prevention Creep




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Prevention of Melanoma With Regular Sunscreen Use

Interview with June K. Robinson, MD, author of Prevention of Melanoma With Regular Sunscreen Use




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Adjunctive Risperidone Treatment for Antidepressant-Resistant Symptoms of Chronic Military Service-Related PTSD

Interview with John H. Krystal, MD, author of Adjunctive Risperidone Treatment for Antidepressant-Resistant Symptoms of Chronic Military Service-Related PTSD




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Implementing Accountable Care Organizations: Ten Potential Mistakes and How to Learn From Them

Interview with Stephen M. Shortell, PhD, MPH, MBA, author of Implementing Accountable Care Organizations: Ten Potential Mistakes and How to Learn From Them




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Association of Unconscious Race and Social Class Bias With Vignette-Based Clinical Assessments by Medical Students

Interview with Julie A. Freischlag, MD, author of Association of Unconscious Race and Social Class Bias With Vignette-Based Clinical Assessments by Medical Students




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Prediction of Erectile Function Following Treatment for Prostate Cancer

Interview with Martin G. Sanda, MD, author of Prediction of Erectile Function Following Treatment for Prostate Cancer




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Identification of Chronic Obstructive Pulmonary Disease in Lung Cancer Screening Computed Tomographic Scans

Interview with Pim A. de Jong, MD, PhD, author of Identification of Chronic Obstructive Pulmonary Disease in Lung Cancer Screening Computed Tomographic Scans




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Effect of Intracoronary Delivery of Autologous Bone Marrow Mononuclear Cells 2 to 3 Weeks Following Acute Myocardial Infarction on Left Ventricular Function: The LateTIME Randomized Trial

Interview with Jay H. Traverse, MD, author of Effect of Intracoronary Delivery of Autologous Bone Marrow Mononuclear Cells 2 to 3 Weeks Following Acute Myocardial Infarction on Left Ventricular Function: The LateTIME Randomized Trial




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ADHD Medications and Risk of Serious Cardiovascular Events in Young and Middle-aged Adults

Interview with Laurel A. Habel, PhD, author of ADHD Medications and Risk of Serious Cardiovascular Events in Young and Middle-aged Adults




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Association Between Marijuana Exposure and Pulmonary Function Over 20 Years

Interview with Stefan Kertesz, MD, author of Association Between Marijuana Exposure and Pulmonary Function Over 20 Years




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Universal Screening and Drug Treatment of Dyslipidemia in Children and Adolescents

Interview with Frederick P. Rivara, MD, MPH, author of Universal Screening and Drug Treatment of Dyslipidemia in Children and Adolescents




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Antiplatelet Therapy With Cangrelor in Patients Undergoing Cardiac Surgery: A Randomized Controlled Trial

Interview with Eric J. Topol, MD, author of Bridging Antiplatelet Therapy With Cangrelor in Patients Undergoing Cardiac Surgery: A Randomized Controlled Trial




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Detection of Breast Cancer With Addition of Annual Screening Ultrasound or a Single Screening MRI to Mammography in Women With Elevated Breast Cancer Risk

Interview with Wendie A. Berg, MD, PhD, author of Detection of Breast Cancer With Addition of Annual Screening Ultrasound or a Single Screening MRI to Mammography in Women With Elevated Breast Cancer Risk




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Association Between Helicopter vs Ground Emergency Medical Services and Survival for Adults With Major Trauma

Interview with Samuel M. Galvagno Jr, DO, PhD, author of Association Between Helicopter vs Ground Emergency Medical Services and Survival for Adults With Major Trauma




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Neonatal Abstinence Syndrome and Associated Health Care Expenditures: United States, 2000-2009

Interview with Stephen W. Patrick, MD, MPH, MS, author of Neonatal Abstinence Syndrome and Associated Health Care Expenditures: United States, 2000-2009




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Primary Health Care in Low-Income Countries: Building on Recent Achievements

Interview with Jeffrey D. Sachs, PhD, author of Primary Health Care in Low-Income Countries: Building on Recent Achievements




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If Accountable Care Organizations Are the Answer, Who Should Create Them?

Interview with Victor R. Fuchs, PhD, author of If Accountable Care Organizations Are the Answer, Who Should Create Them?




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Association Between Vaccination for Herpes Zoster and Risk of Herpes Zoster Infection Among Older Patients With Selected Immune-Mediated Diseases: Herpes Zoster and Immune-Mediated Diseases

Interview with Jeffrey R. Curtis, MD, MS, author of Association Between Vaccination for Herpes Zoster and Risk of Herpes Zoster Infection Among Older Patients With Selected Immune-Mediated Diseases: Herpes Zoster and Immune-Mediated Diseases




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HIV in Persons Born Outside the United States, 2007-2010

Interview with Adria Tassy Prosser, PhD, author of HIV in Persons Born Outside the United States, 2007-2010




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Association of Clopidogrel Pretreatment With Mortality, Cardiovascular Events, and Major Bleeding Among Patients Undergoing Percutaneous Coronary Intervention: A Systematic Review and Meta-analysis

Interview with Gilles Montalescot, MD, PhD, author of Association of Clopidogrel Pretreatment With Mortality, Cardiovascular Events, and Major Bleeding Among Patients Undergoing Percutaneous Coronary Intervention: A Systematic Review and Meta-analysis




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How and Why US Health Care Differs From That in Other OECD Countries

Interview with Victor R. Fuchs, PhD, author of How and Why US Health Care Differs From That in Other OECD Countries




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Bacterial Coinfection in Influenza: A Grand Rounds Review

Interview with Daniel S. Chertow, MD, MPH, author of Bacterial Coinfection in Influenza: A Grand Rounds Review




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Effect of Duloxetine on Pain, Function, and Quality of Life Among Patients With Chemotherapy-Induced Painful Peripheral Neuropathy: A Randomized Clinical Trial

Interview with Ellen M. Lavoie Smith, PhD, author of Effect of Duloxetine on Pain, Function, and Quality of Life Among Patients With Chemotherapy-Induced Painful Peripheral Neuropathy: A Randomized Clinical Trial




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Prevalence of a Healthy Lifestyle Among Individuals With Cardiovascular Disease in High-, Middle- and Low-Income Countries: The Prospective Urban Rural Epidemiology (PURE) Studyterview

Interview with Koon Teo, MB, PhD, author of Prevalence of a Healthy Lifestyle Among Individuals With Cardiovascular Disease in High-, Middle- and Low-Income Countries: The Prospective Urban Rural Epidemiology (PURE) Study




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Immunogenicity of 2 Doses of Human Papillomavirus Vaccine in Younger Adolescents Versus 3 Doses in Young Women: A Randomized Clinical Trial

Interview with Simon R. M. Dobson, MD, author of Immunogenicity of 2 Doses of Human Papillomavirus Vaccine in Younger Adolescents Versus 3 Doses in Young Women: A Randomized Clinical Trial




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Association Between Duration of Overall and Abdominal Obesity Beginning in Young Adulthood and Coronary Artery Calcification in Middle Age

Interview with Jared P. Reis, PhD, author of Association Between Duration of Overall and Abdominal Obesity Beginning in Young Adulthood and Coronary Artery Calcification in Middle Age




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Sofosbuvir and Ribavirin for Hepatitis C Genotype 1 in Patients With Unfavorable Treatment Characteristics: A Randomized Clinical Trial

Interview with Anthony S. Fauci, MD, author of Sofosbuvir and Ribavirin for Hepatitis C Genotype 1 in Patients With Unfavorable Treatment Characteristics: A Randomized Clinical Trial




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Universal Glove and Gown Use and Acquisition of Antibiotic-Resistant Bacteria in the ICU: A Randomized Trial

Interview with Anthony D. Harris, MD, author of Universal Glove and Gown Use and Acquisition of Antibiotic-Resistant Bacteria in the ICU: A Randomized Trial




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The Anatomy of Health Care in the United States

Interview with Hamilton Moses III, MD, author of The Anatomy of Health Care in the United States




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Outcomes Following Transcatheter Aortic Valve Replacement in the United States

Interview with Michael J. Mack, MD, author of Outcomes Following Transcatheter Aortic Valve Replacement in the United States




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Rates of Medical Errors and Preventable Adverse Events Among Hospitalized Children Following Implementation of a Resident Handoff Bundle

Interview with Amy J. Starmer, MD, MPH, author of Rates of Medical Errors and Preventable Adverse Events Among Hospitalized Children Following Implementation of a Resident Handoff Bundle




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Effect of Communication Skills Training for Residents and Nurse Practitioners on Quality of Communication With Patients With Serious Illness: A Randomized Trial

Interview with J. Randall Curtis, MD, MPH, author of Effect of Communication Skills Training for Residents and Nurse Practitioners on Quality of Communication With Patients With Serious Illness: A Randomized Trial




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Effect of Vitamin E and Memantine on Functional Decline in Alzheimer Disease: The TEAM-AD VA Cooperative Randomized Trial

Interview with Maurice W. Dysken, MD, author of Effect of Vitamin E and Memantine on Functional Decline in Alzheimer Disease: The TEAM-AD VA Cooperative Randomized Trial




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Tobacco Control and the Reduction in Smoking-Related Premature Deaths in the United States, 1964-2012

Interview with Theodore R. Holford, PhD, author of Tobacco Control and the Reduction in Smoking-Related Premature Deaths in the United States, 1964-2012




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Warfarin, Kidney Dysfunction, and Outcomes Following Acute Myocardial Infarction in Patients With Atrial Fibrillation

Interview with Juan Jesús Carrero, PhD(Pharm and Med), author of Warfarin, Kidney Dysfunction, and Outcomes Following Acute Myocardial Infarction in Patients With Atrial Fibrillation