en

Synchronization of user interactive events with on-screen events during playback of multimedia stream

A method includes receiving, at a multimedia device, a data stream representing multimedia content, the data stream comprising first timing information for the multimedia content, and metadata representing interactive event information associated with the multimedia content, the metadata comprising second timing information for the interactive event information. During the playback of the multimedia content, a first user interactive event is identified that is associated with a first time point in the playback of the multimedia content based on the interactive event information, and the first user interactive event is performed concurrent with the first time point in the playback of the multimedia content.




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Adlite rich media solutions without presentation requiring use of a video player

The present invention provides techniques relating to rich media advertising. Techniques are provided in which an advertiser-provided image-based component of an advertisement creative is matched with an advertiser-provided audio component of the advertisement creative. A rich media advertisement may be served that includes the image-based component and a synchronously presented audio component. Presentation of the rich media advertisement on a user computer may not require downloading or utilization of a video player.




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Advertisement delivering system based on digital television system and mobile communication device

A digital television system is connected to a mobile computing and communication device through an ad hoc communication link. A program broadcasted by the television system includes a plurality frames delivered in a sequential manner. A user can freeze a frame by employing the mobile device. The frame can then be transmitted to the mobile device and be redisplayed on the mobile device. The redisplayed frame includes visible symbols pointing to displayed items associated with advertising messages. The frame can also be stored in a photograph folder for the user to view the frame and associated advertising messages in a later time.




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System and method in a television system for presenting information associated with a user-selected object in a television program

A system and method in a television system for presenting information associated with a user-selected object in a television program is provided. An identity of a user-selected object in a television program being presented to a user is determined. Based at least in part on the identity of the user-selected object in the television program, information to present to the user is determined. The determined information is presented to the user on a television display.




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Providing content responsive to multimedia signals

A method of providing information including providing a communication session of at least one of audio and video media and applying automatic recognition to media transferred on the communication session. An advertisement is selected by a processor, based on the automatic recognition and non-advertisement information is selected by the processor, responsive to the automatic recognition. The selected advertisements and the selected non-advertisement information, are presented during the communication session.




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System and method for simultaneously broadcasting multiple media-components

Disclosed herein is a system and method for simultaneously broadcasting video components (VSs). In one example, a method includes an automation-system (AS) selecting a log entry including (i) a first identifier that maps to a first VC, and (ii) a second identifier that maps to a second VC; a recording-and-playout device (RAPD) retrieving the first VC; the RAPD sending the retrieved first-VC to an encoder; the encoder generating a first transport-stream (TS) having (i) program-identification (PID) data, and (ii) payload data including the sent first-VC; the encoder sending the generated first-TS to a first outbound-broadcast device (OBD); the encoder sending the generated first-TS to a transport-stream splicer; the AS loading the splicer with the second VC; the splicer generating a second TS having (i) the PID data of the generated first-TS, and (ii) payload data including the loaded second-VC; and the splicer sending the generated second-TS to a second OBD.




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Media content discovery in an integrated media service that distributes media content by way of a plurality of different media distribution models

An exemplary method includes a media service provider system 1) providing an end user of an integrated media service with access to a media program by way of a plurality of different media distribution models, 2) maintaining a catalog that includes comprehensive information about the media program, the comprehensive information being an aggregate of non-redundant information about the media program obtained from a plurality of independent source catalogs corresponding to the plurality of different media distribution models, and 3) providing, based on the comprehensive information included in the catalog, a media service user interface that supports discovery of the comprehensive information about the media program regardless of a user interface context from which a user request for information about the media program is received. Corresponding systems and methods are also described.




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Media content spatial navigation

A method and system of providing a content guide that identifies a spatial relationship between the elements in the content guide is described. A controller receives electronic program guide data. The received electronic program guide data is parsed to identify a plurality of programs listed in the electronic program guide and data corresponding to at least one program description attribute for the identified programs. A relationship is determined between each identified program based on the at least one program description attribute. At least one cluster is generated and includes at least one of the plurality of identified programs based on the determined relationship. A user interface display processor generates a user interface display image representing a clustered content guide and including the at least one generated cluster enabling the user to view the relationship of the plurality of programs.




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Method and a system for television display of web feed content

A system and method are described that provide television content broadcast system subscribers with convenient access to aggregated web feed content. In one embodiment, a television content broadcast system (20) maintains a database (21) linking one or more particular subscribers with one or more sources of web feed content. The television content broadcast system (20) downloads web feed content for a subscriber from the one or more sources associated with the subscriber, either at the user's request or to a cache (22). The television content broadcast system (20) sends the downloaded web feed content through a web content interface (30(2)) to a television receiver (41), or through a web content interface (30(3)) to a local memory (51) in a set-top box (50). In another embodiment, the television content broadcast subscribers also have accounts on a web content aggregation system (10). Web content aggregation system (10) retrieves web feed content associated with the user, and sends the web feed content to television content broadcast system (20) for forwarding to the appropriate subscriber.




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Internet TV module for enabling presentation and navigation of non-native user interface on TV having native user interface using either TV remote control or module remote control

A display device such as a TV has both HDMI and IP network interfaces and uses the HDMI interface to exchange IP network parameters with an audio video application module (AVAM) upon HDMI connection. In this way, an IP-based peer-to-peer or client-server network connection can be automatically established to promote faster communication when sharing and executing applications between the devices than is typically available over the CEC link of HDMI.




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Method for virtual channel management, method for retrieving digital contents, and network-based multimedia reproduction system with virtual channels

A method for virtual channel management is provided. The method includes the following steps. In response to a command, a control unit of a network-based multimedia reproduction system determines whether the command is associated with virtual channel switching. When the command is associated with virtual channel switching, the control unit checks whether a channel value corresponding to the command exists in an application virtual channel table. When the channel value exists in the application virtual channel table, the control unit determines an application corresponding to the channel number from the application virtual channel table, and executes the application. According to a first operation parameter set corresponding to the application, the control unit sets the executed application to retrieve digital contents through a network unit of the network-based multimedia reproduction system.




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Media processing methods and arrangements

The present technology concerns cell phones and other portable devices, and more particularly concerns use of such devices in connection with media content (electronic and physical) and with other systems (e.g., televisions, digital video recorders, and electronic program directories). Some aspects of the technology allow users to easily transfer displayed content from cell phone screens onto a television screens for easier viewing, or vice versa for content portability. Others enable users to participate interactively in entertainment content, such as by submitting plot directions, audio input, character names, etc., yielding more engaging, immersive, user experiences. Still other aspects of the technology involve a program directory database, compiled automatically from information reported by network nodes that watch and identify content traffic passing into (and/or out of) networked computers. By identifying content resident at a number of different repositories (e.g., web sites, TV networks, P2P systems, etc.), such a directory allows cell phone users to identify the diversity of sources from which desired content can be obtained—some available on a scheduled basis, others available on demand. Depending on the application, the directory information may be transparent to the user—serving to identify sources for desired content, from which application software can pick for content downloading, based, e.g., on context and stored profile data. A great number of other features and arrangements are also detailed.




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Inflight entertainment system with selectively preloaded seat end video caches

An inflight entertainment (IFE) system preloads from head end equipment onto seat end video caches subsets of prerecorded video entertainment programs from a library of prerecorded video entertainment programs stored on the head end equipment. Preloading is done independent of play requests made by passengers using the IFE system. The selected subsets are selected using selection metrics such as program popularity, passenger demographics and/or passenger preferences. The same or a different subset may be selected for different passengers. As a result of the selective preloading of the seat end video caches, if the head end equipment or the distribution system becomes inoperable during the flight, the IFE system is able to continue to deliver a limited offering of popular, demographically indicated and/or passenger preferred video entertainment from the seat end video caches, without requiring a large multiplier in storage capacity or loading time.




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System and method for switching between media streams while providing a seamless user experience

An electronic device with one or more processors, memory and a display receives a first request to display a first video stream on the display. In response to receiving the first request, the electronic device displays the first video stream on the display. While displaying the first video stream on the display, the electronic device receives a second request to display a second video stream on the display. In response to receiving the second request, the electronic device displays at least a portion of the first video stream on the display concurrently with at least a portion of the second video stream, where the second video stream was received, at least in part, from a content source in response to a request from the electronic device to the content source for delivery of the second video stream from the content source.




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Methods, systems, and computer readable media for measuring multicast latency

Methods, systems, and computer readable media for measuring multicast latency are disclosed. According to one method, the method includes emulating one or more Internet protocol television (IPTV) user devices by generating channel leave and join requests. The method further includes monitoring network responses to the channel leave and join requests and calculating, during a cycle of channel leave and join requests for a user device and prior to repeating the cycle, at least one metric of latency associated with the channel leave and join requests.




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Systems and methods for prioritization of data for intelligent discard in a communication network

Systems and methods for optimizing system performance of capacity and spectrum constrained, multiple-access communication systems by selectively discarding packets are provided. The systems and methods provided herein can drive changes in the communication system using control responses. One such control responses includes the optimal discard (also referred to herein as “intelligent discard”) of network packets under capacity constrained conditions. Some embodiments inspect a video stream to determine priorities for various elements of the video stream. The elements may be discarding using the priorities. In various embodiments, the elements include frames, slices, macroblocks, and data partitions.




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Method and apparatus for extracting advertisement keywords in association with situations of video scenes

A method and apparatus for extracting advertisement keywords in association with situations of scenes of video include: establishing a knowledge database including a classification hierarchy for classifying situations of scenes of video and an advertisement keyword list, segmenting a video script corresponding to a received video in units of scenes, and determining a situation corresponding to each scene with reference to the knowledge database, and extracting an advertisement keyword corresponding to the situation of a scene of the received video with reference to the knowledge database.




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Thumbnail generation and presentation for recorded TV programs

Thumbnail images representative of recorded TV programs are generated and presented to aid a user in browsing the recorded TV programs. In one implementation, a temporary thumbnail image is generated when a TV program first starts recording. The temporary thumbnail is used to populate any user interface (UI) screens that reference the recoded TV program. Once the TV program has reached a threshold amount of recording (e.g., a prescribed duration of recording, or completion of the recording), a permanent thumbnail image is generated and associated with the TV program. The permanent thumbnail is then presented in any subsequent UI screens, replacing the temporary thumbnail. In another implementation, display of the thumbnail images in the UI screens may be further controlled by setting preferences, such as parental controls.




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System and method for managing, converting and displaying video content on a video-on-demand platform, including ads used for drill-down navigation and consumer-generated classified ads

A video-on-demand (VOD) content delivery system has a VOD Application Server which manages a database of templates ordered in a hierarchy for presentation of video content elements of different selected types categorized in hierarchical order. The templates include those for higher-order displays which have one or more links to lower-order displays of specific content. The VOD Application Server, in response to viewer request, displays a high-order templatized display, and in response to viewer selection of a link, displays the lower-order display of specific content. The hierarchical templatized displays enable viewers to navigate to an end subject of interest while having a unique visual experience of moving through a series of displays to the end subject of interest.




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System for adding or updating video content from internet sources to existing video-on-demand application of a digital TV services provider system

A video-on-demand (VOD) content delivery system has a VOD Application Server which manages a database of templates ordered in a hierarchy for presentation of video content elements of different selected types categorized in hierarchical order. The templates include those for higher-order displays which have one or more links to lower-order displays of specific content. The VOD Application Server, in response to viewer request, displays a high-order templatized display, and in response to viewer selection of a link, displays the lower-order display of specific content. The hierarchical templatized displays enable viewers to navigate to an end subject of interest while having a unique visual experience of moving through a series of displays to the end subject of interest. For example, the higher-order display may be a product ad and the lower-order display may be an ad for a local retailer of the product. Similarly, a viewer can navigate from national product to local product ad, or classified ad category to specific classified ad, or bulletin board topic category to specific posting. In another embodiment, the VOD content delivery system is used to deliver consumer-generated classified ads on TV. A web-based Content Management System receives consumer-generated content uploaded online in industry-standard file formats with metadata for title and topical area, and automatically converts it into video data format compatible with the VOD content delivery system indexed by title and topical area. A User Interface for the system delivers listings data to the viewer's TV indexed by title and topical area, and displays a requested classified ad in response to viewer selection.




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Pressure sensitive adhesive composition for protective film having anti-static property and manufacturing process thereof

Provided is an adhesive composition for a protective film including an acrylic emulsion resin capable of providing contamination resistance on the film and low peel strength and minimizing generation of static electricity during peeling of the protective film. The acrylic emulsion resin includes a mixture including 80 to 99.9% by weight of a polymer of a (meth)acrylic acid ester monomer including a C1-C14 alkyl group and a (meth)acrylic acid ester monomer including an alkylene oxide unit, and 0.1 to 20% by weight of a monomer including a carboxyl group and/or a hydroxyl group or a combination thereof, and 5 to 30 parts by weight of a reactive emulsifier having a double bond structure radical-polymerizable with the polymer and including an alkylene oxide unit based on 100 parts by weight of the mixture.




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Generic approach for synthesizing asymmetric nanoparticles and nanoassemblies

A generic route for synthesis of asymmetric nanostructures. This approach utilizes submicron magnetic particles (Fe3O4—SiO2) as recyclable solid substrates for the assembly of asymmetric nanostructures and purification of the final product. Importantly, an additional SiO2 layer is employed as a mediation layer to allow for selective modification of target nanoparticles. The partially patched nanoparticles are used as building blocks for different kinds of complex asymmetric nanostructures that cannot be fabricated by conventional approaches. The potential applications such as ultra-sensitive substrates for surface enhanced Raman scattering (SERS) have been included.




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Electronic element having carbon nanotubes

An electronic element includes a substrate, and a transparent conductive layer. The substrate includes a surface. The transparent conductive layer is formed on a surface of the substrate. The transparent conductive layer includes at least one carbon nanotube layer. Carbon nanotubes in the carbon nanotube layer are adhered together by the van der Waals attractive force therebetween.




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Self-assembled silica condensates

Self-assembled silica condensates are described as well as their use in coating compositions. The self-assembled silica condensates can be formed from the hydrolysis of medium to long chain trialkoxy silane compounds. Coating compositions containing the self-assembled silica condensates can provide coatings having improved scratch and mar resistance and can have excellent recoat adhesion.




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Hot-dip galvanized steel sheet and alloyed hot-dip galvanized steel sheet, each having excellent workability, high yield ratio and high strength

Disclosed is a hot-dip galvanized steel sheet or an alloyed hot-dip galvanized steel sheet, which has a tensile strength of 980 MPa or more, excellent workability, high yield ratio and high strength. The hot-dip galvanized steel sheet or the alloyed hot-dip galvanized steel sheet is characterized by containing 0.12-0.3% by mass of C, 0.1% by mass or less (excluding 0% by mass) of Si, 2.0-3.5% by mass of Mn, 0.05% by mass or less (excluding 0% by mass) of P, 0.05% by mass or less (excluding 0% by mass) of S, 0.005-0.1% by mass of Al and 0.015% by mass or less (excluding 0% by mass) of N, with the balance made up of iron and unavoidable impurities. The hot-dip galvanized steel sheet or the alloyed hot-dip galvanized steel sheet is also characterized in that the metallic structure thereof contains bainite as a matrix structure, and the area ratio of ferrite is 3-20% and the area ratio of martensite is 10-35% relative to the entire structure.




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Electroluminescent device with quinazoline complex emitter

An OLED device comprises a cathode, an anode, and located therebetween a light-emitting layer containing a host material and a tris-C^N-cyclometallated complex of Ir or Rh wherein at least one of the ligands comprises a substituted quinazoline moiety. The device provides useful emission and stability attributes.




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***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***Organic light-emitting device

A heterocyclic compound represented by Formula 1 or Formula 2 below and an organic light-emitting device including the heterocyclic compound: wherein X1, X2, and R1 through R16 are defined as in the specification.




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Triphenylene-based compounds and organic electroluminescent device comprising same

The present invention relates to a triphenylene-based compound represented by the following Formula 1 and an organic electroluminescent device including the same, and the compound of the present invention has excellent hole injection and/or transporting ability, electron transporting ability, and/or light emitting ability, and particularly, green and red light emitting ability, and thus in an organic electroluminescent device containing the same as a light emitting host material, characteristics such as luminous efficiency, luminance, thermal stability, driving voltage, service life and the like may be improved. In the formula, each of A, L, X and R1 to R19 is the same as those as defined in Detailed Description.




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Fluorene compound and organic electroluminescent device using the same

The present invention discloses a new fluorene compound and organic EL device using the compound. The organic EL device employing the new fluorene compound as host material can lower driving voltage, prolong half-lifetime. The fluorene compound can functions as blue emitting host material of a light emitting layer and improve CIE color purity in blue emitting device. The fluorene compound are represented by the following formula(A): Wherein R1 to R6 are identical or different. R1 to R6 are independently selected from the group consisting of a hydrogen atom, a halide, alkyl group having 1 to 20 carbon atoms, a substituted or unsubstituted aryl group having 6 to 30 carbon atoms, a substituted or unsubstituted aralkyl group having 6 to 30 carbon atoms, a substituted or unsubstituted heteroaryl group having 6 to 30 carbon atoms. R7˜R13 are identical or different R7 to R13 are independently selected from the group consisting of hydrogen atom, halide, alkyl group, aryl group, heteroaryl group. m and n are independently an integer of 0 to 3, X is selected from carbon or nitrogen.




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Perpendicular magnetic recording disk with multiple magnetic layers and intermediate dual nucleation films for control of grain size

A perpendicular magnetic recording disk has a graded-anisotropy recording layer (RL) formed of at least two ferromagnetically exchange coupled CoPtCr-oxide magnetic layers (MAG1 and MAG2) with two nucleation films (NF1 and NF2) between the magnetic layers. NF1 is a metal film, preferably Ru or a Ru-based alloy like RuCr, sputter deposited on MAG1 at low pressure to a thickness between about 0.1-1.5 nm. NF2 is a metal oxide film, preferably an oxide of Ta, sputter deposited on NF1 at high pressure to a thickness between about 0.2-1.0 nm. MAG2 is sputter deposited over NF2. NF1 and NF2 provide a significant reduction in average grain size in the RL from a graded-anisotropy RL without nucleation films between MAG1 and MAG2, while also assuring that MAG1 and MAG2 are strongly exchange coupled.




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Organic compound, light-emitting element, light-emitting device, electronic device, and lighting device

A novel substance with which an increase in life and emission efficiency of a light-emitting element can be achieved is provided. A carbazole compound having a structure represented by General Formula (G1) is provided. Note that a substituent which makes the HOMO level and the LUMO level of a compound in which a bond of the substituent is substituted with hydrogen deep and shallow, respectively is used as each of substituents in General Formula (G1) (R1, R2, Ar3, and α3). Further, a substituent which makes the band gap (Bg) and the T1 level of a compound in which a bond of the substituent is substituted with hydrogen wide and high is used as each of the substituents in General Formula (G1) (R1, R2, Ar3, and α3).




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Belt drive arrangement for an auxiliary unit of a motor vehicle, motor vehicle, and method for operating an auxiliary unit of a motor vehicle

A belt drive arrangement for an auxiliary unit of a motor vehicle includes, but is not limited to a belt pulley for receiving a drive belt, a shaft of the auxiliary unit that can be driven with the torque of the belt pulley, and a clutch device for the releasable torque transmission between the belt pulley and the shaft of the auxiliary unit. The clutch device includes, but is not limited to an electromagnet and a spring element. The spring element is preloaded in such a manner that the clutch in a currentless state of the electromagnet is closed.




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Engine ignition-transmission shift interlock

A method for controlling a vehicle equipped with a manual transmission and engine includes automatically engaging a brake, locking the transmission in neutral and starting the engine, in response to a signal whose origin is remote from the vehicle representing a desired engine start; and automatically engaging a brake and locking the transmission in neutral in response to a second signal indicating that the driver has exited the vehicle while the engine is running.




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Method for controlling the engine of a motor vehicle having a manual transmission

In a motor vehicle having a manual transmission, for, in particular, limiting the engine speed during the start-up operation when fulfilling at least one permission criterion for the engine torque, the criterion depending on the driving state of the motor vehicle, a default engine torque is preset, which is specified according to at least one engine characteristic value and which can be reduced with regard to the set engine torque called for by the position of the accelerator pedal of the motor vehicle.




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Engine restart strategy

A method of controlling a vehicle, where the vehicle includes an internal combustion engine and a transmission having a neutral state and an engaged state, includes setting the state of the transmission. The state of the transmission is set as the neutral state or the engaged state based on a restart condition, where the restart condition is one of: (i) a no wheel torque restart condition, and (ii) a wheel torque restart condition. The method additionally includes starting the engine.




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Engaging force control of lockup clutch

A torque converter (1) connecting an engine (14) and a transmission (15) of a vehicle is provided with a lockup clutch (2), and a controller (5) is programmed to increase an engagement force of a lockup clutch (2) under open loop control before shifting to feedback control of the engaging force using a target slip rotation speed. When an engine output torque rapidly decreases during open loop control (S59, S60), the controller (5) decreases the engaging force according to a variation amount of the engine output torque (S61, S65), thereby preventing an unintentional sudden engagement of the lockup clutch (2) due to decrease in the engine output torque.




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Method and system for determining clutch assembly vent time for transmission shift control

A method and transmission control unit configured to improve shift event performance in a vehicle with an automatic transmission by determining a vent time for release of a clutch assembly in a transmission of a vehicle. The vehicle must be stopped and a gear selector in the vehicle must be set to a drive condition. If these conditions are met, the clutch assembly is vented. The vent time from when venting begins to when a turbine (or input shift) speed of the transmission rises is tracked. Once the turbine speed of the transmission rises, the clutch assembly is reapplied. The clutch assembly vent time is set based on the tracked vent time.




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Multi-speed transmission with an engine start/stop enabler

A transmission includes an input member, an output member, four planetary gear sets, and a plurality of torque transmitting mechanisms that are selectively engageable to establish at least ten forward speed ratios and at least one reverse speed ratio between the input member and the output member. The transmission further includes one or more locking mechanisms that engage one or more of the plurality of torque transmitting mechanisms during a start/stop event.




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Two-wheeled inverted pendulum vehicle and control method therefor

A two-wheeled inverted pendulum vehicle includes: single-winding first and second motors respectively rotating one of two wheels; first and second control systems respectively supplying drive currents to the first and second motors; a sensor detecting a physical quantity that varies with a turn of the vehicle; a dynamic brake unit being able to switch between active and inactive states of dynamic brake being applied to the first motor; and a control unit, when the control unit has determined that the vehicle is turning about the second motor side on the basis of the physical quantity while supply of drive current from the first control system to the first motor is inhibited, activating dynamic brake in the dynamic brake unit. The first control system, when an abnormality has been detected in the first control system, inhibits supply of drive current from the first control system to the first motor.




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Methods and systems for extending regenerative braking

Systems and methods for improving operation of a hybrid vehicle are presented. In one example, an electrical load may be automatically activated to consume electrical energy produced during driveline braking so that driveline braking may be extended. The electrical load may be a windscreen heater or other device.




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Method and system for engine control

Methods and systems are provided for controlling an engine system with a variable cam timing device. In one example, the variable cam timing device is operated to adjust engine valve timing differently at engine stop based on whether the engine stop is in response to an operator request or in response to an automatic controller initiated engine stop without an operator request.




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Microarray for detection of the deletion of exon 3 of the G-CSF gene

Disclosed are a method, a composition, a microarray, an antibody and a kit for diagnosis and prognosis of cancer, based on detection of deletion of the exon 3 region of G-CSF gene or levels of a mutated G-CSF protein having a deletion of an amino acid sequence corresponding to the exon 3 region, wherein the deletion of the exon 3 region of the G-CSF gene is used as a cancer biomarker.




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Method for the treatment of automimmune diseases comprising administering rapamycin and IL-10

The invention discloses a combined preparation containing IL-10 and rapamycin, able to induce immunosuppression and antigen-specific immune tolerance, and the use thereof in the treatment of diseases involving an excessive, dysfunctional or uncontrolled immune responses mediated by T cells.




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Derivatives of the NF-κB inducing enzyme, their preparation and use

The invention relates to the use of NF-κB inducing kinase (NIK) and related molecules for the modulation of signal activities controlled by cytokines, and some new such molecules.




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Use of the peptide RFMWMR as a therapeutic agent

The present invention is directed to the use of the peptide compound Ac-Arg-Phe-Met-Trp-Met-Arg-NH2 as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the present invention relates to pharmaceutical compositions preferably in form of a lyophilisate or liquid buffer solution or artificial mother milk formulation or mother milk substitute containing the peptide Ac-Arg-Phe-Met-Trp-Met-Arg-NH2 optionally together with at least one pharmaceutically acceptable carrier, cryoprotectant, lyoprotectant, excipient and/or diluent.




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Use of Gonadorelin as a therapeutic agent

The present invention is directed to the use of the peptide compound Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the present invention relates to pharmaceutical compositions preferably in form of a lyophilizate or liquid buffer solution or artificial mother milk formulation or mother milk substitute containing the peptide Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 optionally together with at least one pharmaceutically acceptable carrier, cryoprotectant, lyoprotectant, excipient and/or diluent.




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Recombinant chimeric protein of neutrophil inhibitory factor and hirugen, and pharmaceutical composition thereof

A chimeric protein containing neutrophil inhibitory factor and hirugen, the chimeric protein having an amino acid sequence that includes FPRPGSGG (SEQ ID NO:21) Also provided is a pharmaceutical composition comprising the chimeric protein, which can be used for treating or preventing cerebral injury and cerebral edema, or for inhibiting platelet aggregation.




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Antibiotic compositions for the treatment of gram negative infections

Provided herein are novel compounds and novel protected compounds that can be derived from polymyxin, including, e.g., polymyxin A. The novel compounds have antibacterial properties against a diverse range of Gram negative bacteria and reduced toxicity compared to polymyxins such as polymyxin A. Also provided are antibacterial pharmaceutical compositions containing the novel compounds and novel protected compounds, as well as methods for preparing the antibacterial compounds and protected compounds.




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Heterodimeric peptide compounds displaying NGF activity and their use to treat neurodegenerative disorders

Peptides having a structure characterized by the presence of two loops constrained in cyclic structure by the presence of covalent bonds between amino acid side chains, the amino acid sequences of the first and the second loop being substantially homologues to that of loop 1 (residues 29-38) and of loop 4 (residues 92-97) of NGF, respectively, displaying nerve growth factor (NGF) agonist or partial agonist activity.




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Immobilizing an entity in a desired orientation on a support material

The present invention relates to the identification and selection of attachment molecules that attach/immobilize an entity having a detectable activity or property on a support in an orientation that provides a detectable activity or property, and to surfaces made of the attachment molecules.