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Ptaquiloside from bracken (Pteridium spp.) promotes oral carcinogenesis initiated by HPV16 in transgenic mice

Food Funct., 2020, 11,3298-3305
DOI: 10.1039/D0FO00207K, Paper
Rui M. Gil da Costa, Tiago Neto, Diogo Estêvão, Magda Moutinho, Ana Félix, Rui Medeiros, Carlos Lopes, Margarida M. S. M. Bastos, Paula A. Oliveira
Bracken (Pteridium spp.) is a common weed that is consumed as food especially in Asia, and is suspected of promoting carcinogenesis induced by papillomaviruses in the digestive and urinary systems.
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The effect of culinary doses of spices in a high-saturated fat, high-carbohydrate meal on postprandial lipemia and endothelial function: a randomized, controlled, crossover pilot trial

Food Funct., 2020, 11,3191-3200
DOI: 10.1039/C9FO02438G, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Kristina S. Petersen, Connie J. Rogers, Sheila G. West, David N. Proctor, Penny M. Kris-Etherton
Lower doses of spices (2 and 6 g) than previously tested may attenuate postprandial lipemia and impairments in endothelial function caused by a high-saturated fat, high-carbohydrate meal.
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Impact of functional foods and nutraceuticals on high blood pressure with a special focus on meta-analysis: review from a public health perspective

Food Funct., 2020, 11,2792-2804
DOI: 10.1039/D0FO00357C, Review Article
Kamesh Venkatakrishnan, Hui-Fang Chiu, Chin-Kun Wang
In recent times many researchers are expressing immense interest in nutraceuticals and functional foods for combating various diseases or abnormal conditions, especially against hypertension (HT).
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cis 9, trans 11, but not trans 10, cis 12 CLA isomer, impairs intestinal epithelial barrier function in IPEC-J2 cells and mice through activation of GPR120-[Ca2+]i and the MLCK signaling pathway

Food Funct., 2020, 11,3657-3667
DOI: 10.1039/D0FO00376J, Paper
Han Su, Weijie Zhao, Fenglin Zhang, Min Song, Fangfang Liu, Jisong Zheng, Mingfa Ling, Xiaohua Yang, Qiang Yang, Haiwen He, Lin Chen, Xumin Lai, Xiaotong Zhu, Lina Wang, Ping Gao, Gang Shu, Qingyan Jiang, Songbo Wang
In vitro and in vivo studies show that c9, t11-CLA, but not t10, c12-CLA isomer, impairs intestinal epithelial barrier function in IPEC-J2 cells and mice via activation of GPR120-[Ca2+]i and the MLCK pathway.
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Study of viability of high pressure extract from pomegranate peel to improve carrot juice characteristics

Food Funct., 2020, 11,3410-3419
DOI: 10.1039/C9FO02922B, Paper
João P. Trigo, Elisabete M. C. Alexandre, Sara Silva, Eduardo Costa, Jorge A. Saraiva, Manuela Pintado
Extracts from fruit processing by-products usually present high amounts of bioactive compounds with several important activities such as antioxidant and antimicrobial capacities.
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Correction: 5-Heptadecylresorcinol attenuates oxidative damage and mitochondria-mediated apoptosis through activation of the SIRT3/FOXO3a signaling pathway in neurocytes

Food Funct., 2020, 11,3749-3749
DOI: 10.1039/D0FO90012E, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Jie Liu, Yu Wang, Yiming Hao, Zongwei Wang, Zihui Yang, Ziyuan Wang, Jing Wang
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Cherry stem infusions: antioxidant potential and phenolic profile by UHPLC-ESI-QTOF-MS

Food Funct., 2020, 11,3471-3482
DOI: 10.1039/C9FO02693B, Paper
Juliana Peixoto, Gerardo Álvarez-Rivera, Rita C. Alves, Anabela S. G. Costa, Nelson Andrade, Andreia Moreira, Alejandro Cifuentes, Fátima Martel, M. Beatriz P. P. Oliveira, Elena Ibáñez
This study highlights not only the antioxidant potential of cherry stem infusion but also the need to globally harmonize the control and regulation of herbal products.
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Correction: Matrix-mediated distribution of 4-hydroxy-2-hexanal (nonenal) during deep-frying of chicken breast and potato sticks in vegetable oil

Food Funct., 2020, 11,3750-3750
DOI: 10.1039/D0FO90018D, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Lukai Ma, Guoqin Liu, Weiwei Cheng, Xinqi Liu, Huifan Liu, Qin Wang
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Gut microbiota mediate the protective effects on endometritis induced by Staphylococcus aureus in mice

Food Funct., 2020, 11,3695-3705
DOI: 10.1039/C9FO02963J, Paper
Xiaoyu Hu, Ruiying Mu, Mingyue Xu, Xin Yuan, Peng Jiang, Jian Guo, Yongguo Cao, Naisheng Zhang, Yunhe Fu
Endometritis, the inflammation of the endometrial lining caused by bacterial pathogens, is associated with reproductive failure.
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Potential neurotoxicity of 5-hydroxymethylfurfural and its oligomers: widespread substances in carbohydrate-containing foods

Food Funct., 2020, Advance Article
DOI: 10.1039/C9FO02526J, Paper
Cheng Wang, Zhenru Liu, Tian Hu, Youjia Li, Rui Liu, Junjie Zhang, Huaizhen He
5-Hydroxymethylfurfural (5-HMF) and its acid-catalyzed oligomers can inhibit nerve cell proliferation and induce neurological deficits at near or below the reported 24 h dietary intake of 5-HMF in humans.
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Alleviating effects of noni fruit polysaccharide on hepatic oxidative stress and inflammation in rats under a high-fat diet and its possible mechanisms

Food Funct., 2020, 11,2953-2968
DOI: 10.1039/D0FO00178C, Paper
Xiaobing Yang, Wenjing Mo, Chuanjin Zheng, Wenzhi Li, Jian Tang, Xiaoyong Wu
Non-alcoholic fatty liver disease is associated with gut microbiota, oxidative stress, and inflammation.
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Ergosterol peroxide from Pleurotus ferulae inhibits gastrointestinal tumor cell growth through induction of apoptosis via reactive oxygen species and endoplasmic reticulum stress

Food Funct., 2020, Advance Article
DOI: 10.1039/C9FO02454A, Paper
Yi Yang, Xiaoyu Luo, Mayila Yasheng, Jun Zhao, Jinyu Li, Jinyao Li
Ergosterol peroxide was purified from Pleurotus ferulae by silica gel chromatography, Sephadex LH-20 chromatography and recrystallization and named as PFEP, which was identified by ESI-MS and NMR.
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Enzymatic hydrolysis of insect Alphitobius diaperinus towards the development of bioactive peptide hydrolysates

Food Funct., 2020, 11,3539-3548
DOI: 10.1039/D0FO00188K, Paper
Pedro Sousa, Sandra Borges, Manuela Pintado
Edible insects are a promising protein source for the future generation, due to their nutritional composition, sustainability and low environmental impact.
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The development of lentil derived protein–iron complexes and their effects on iron deficiency anemia in vitro

Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00384K, Paper
Ezgi Evcan, Sukru Gulec
Lentil derived proteins have the capacity to chelate iron minerals and hydrolysed protein–iron complexes have functional properties on iron deficiency anemia in in vitro by influencing mRNA levels of iron regulating genes.
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Correction: Efficacy of proprietary Lactobacillus casei for anti-tuberculosis associated gastrointestinal adverse reactions in adult patients: a randomized, open-label, dose–response trial

Food Funct., 2020, 11,3751-3751
DOI: 10.1039/D0FO90017F, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Song Lin, Shanliang Zhao, Jiahong Liu, Jianwen Zhang, Chao Zhang, Haibo Hao, Yuxia Sun, Jing Cai, Yang Yang, Yan Ma, Yuanyuan Li, Jinyu Wang, Aiguo Ma
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Protective effect of ferulic acid on STZ-induced diabetic nephropathy in rats

Food Funct., 2020, 11,3706-3718
DOI: 10.1039/C9FO02398D, Paper
Min-you Qi, Xu-tao Wang, Hui-lin Xu, Zhang-liang Yang, Yin Cheng, Bin Zhou
Ferulic acid protects against diabetic nephropathy in STZ-induced rats by attenuating oxidative stress, inflammation, fibrosis and podocyte injury.
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The purification, structural characterization and antidiabetic activity of a polysaccharide from Anoectochilus roxburghii

Food Funct., 2020, 11,3730-3740
DOI: 10.1039/C9FO00860H, Paper
Yuntao Liu, Tingting Tang, Songqi Duan, Cheng Li, Qinlu Lin, Hejun Wu, Aiping Liu, Bin Hu, Dingtao Wu, Suqing Li, Li Shen, Wenjuan Wu
Anoectochilus roxburghii, a traditional Chinese medicinal herb, has been widely used for treating numerous chronic diseases.
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Comparison of the effects of resveratrol and its derivative pterostilbene on hepatic oxidative stress and mitochondrial dysfunction in piglets challenged with diquat

Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00732C, Paper
Hao Zhang, Yanan Chen, Yueping Chen, Peilu Jia, Shuli Ji, Jianxiong Xu, Yue Li, Tian Wang
Pterostilbene is more effective than resveratrol in alleviating liver injury, facilitating redox status, and improving mitochondrial function of piglets.
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Tomato seed oil attenuates hyperlipidemia and modulates gut microbiota in C57BL/6J mice

Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00133C, Paper
Wen-Sen He, Lingling Li, Jiaxin Rui, Junjie Li, Yuying Sun, Dandan Cui, Bin Xu
TSO can significantly improve fatty acid metabolism and cholesterol metabolism, thereby inhibiting obesity and hypercholesterolemia. TSO can favorably modulate the gut microbiota.
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Red ginseng protects against cisplatin-induced intestinal toxicity by inhibiting apoptosis and autophagy via the PI3K/AKT and MAPK signaling pathways

Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00469C, Paper
Jun-jie Zhang, Jian-qiang Wang, Xing-yue Xu, Jia-yu Yang, Zi Wang, Shuang Jiang, Ying-ping Wang, Jing Zhang, Rui Zhang, Wei Li
Although growing evidence has shown that ginseng (Panax ginseng C.A. Meyer.) exerts strong protective and preventive effects on cisplatin-induced side effects, the ameliorative effects of ginseng on intestinal damage caused by cisplatin are unknown to date.
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Physicochemical and antibacterial properties of fabricated ovalbumin-carvacrol gel nanoparticles

Food Funct., 2020, Accepted Manuscript
DOI: 10.1039/D0FO00755B, Paper
Shengqi Rao, Guang-wei Xu, Huawei Zeng, Xiang-feng Zheng, Qin Hu, Qi-Yan Wang, Zhenquan Yang, Xin'An Jiao
The applications of carvacrol are limited due to its poor stability, water solubility, and high volatility; however, ovalbumin can be used to encapsulate hydrophobic molecules, improve their aqueous solubility, and...
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Lactic acid bacteria alleviates polycystic ovarian syndrome by regulating sex hormone related gut microbiota

Food Funct., 2020, Accepted Manuscript
DOI: 10.1039/C9FO02554E, Paper
Yufeng He, Qianqian Wang, Xiu Li, Gang Wang, Jianxin Zhao, Hao Zhang, Wei Chen
Polycystic ovarian syndrome (PCOS) is a common endocrine disease across the world. Because gut microbiota play a key role in the pathogenesis of PCOS, probiotics may alleviate PCOS symptoms through...
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The effect of quercetin on endothelial cells is modified by heterocellular interactions

Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00141D, Paper
Open Access
Sarka Tumova, Michael J. Houghton, Gary Williamson
Single cell-type models are useful for determining mechanisms, but in vivo, cell–cell interactions are important, and neighbouring cells can impact endothelial cell function.
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Jiaogulan tea (Gpostemma pentaphyllum) potentiates the antidiabetic effect of white tea via the AMPK and PI3K pathways in C57BL/6 mice

Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00395F, Paper
Xiaoyan Xia, Jing Xu, Xude Wang, Hua Wang, Zhenchuan Lin, Keping Shao, LinLin Fang, Chenning Zhang, Yuqing Zhao
The use of plant-based beverages to interfere with the onset of diabetes may be a promising approach towards type 2 diabetes mellitus (T2DM).
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Hypoglycemic effects and modulation of gut microbiota of diabetic mice by saponin from Polygonatum sibiricum

Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00428F, Paper
Jiayuan Luo, Yangyang Chai, Min Zhao, Qingqi Guo, Yihong Bao
Polygonatum sibiricum is a medicinal and homologous plant grown in China. The saponin in Polygonatum sibiricum has shown its good hypoglycemic performance, and it can be developed as functional foods and drugs with hypoglycemic effect.
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Unveiling the bioactivity potential of Allium triquetrum L. lipophilic fraction: chemical characterization and in vitro antibacterial activity against methicillin-resistant Staphylococcus aureus

Food Funct., 2020, Accepted Manuscript
DOI: 10.1039/D0FO00769B, Paper
Samia Rabah, Kahina Kouachi, Patricia Ramos, Ana T. P. C. Gomes, Adelaide Almeida, Hayate Haddadi-Guemghar, Khodir Madani, Armando Silvestre, Sónia A. O. Santos
The lipophilic composition of Allium triquetrum L. bulbs, flowers and leaves was studied for the first time, by GC-MS. Sixty-two compounds were firstly identified in A. triquetrum L. Fatty acids...
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Mechanisms for Lactobacillus rhamnosus treatment of intestinal infection by drug-resistant Escherichia coli

Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00128G, Paper
Na Li, Bing Pang, Junjun Li, Guanwen Liu, Xiaoguang Xu, Dongyan Shao, Chunmei Jiang, Baowei Yang, Junling Shi
Reducing the viability of pathogens may also play an important role for the therapeutic effects of Lactobacillus rhamnosus SHA113 against multiple-drug-resistant E. coli, as well as influencing on the intestinal integrity and functions of animals.
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Dietary supplementation of L-arginine and N-carbamylglutamate enhances duodenal barrier and mitochondrial functions and suppresses duodenal inflammation and mitophagy in suckling lambs suffering from intrauterine-growth-restriction

Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00019A, Paper
Hao Zhang, Yi Ma, Mengzhi Wang, Mabrouk Elsabagh, Juan J. Loor, Hongrong Wang
The work aimed at investigating the effects of N-carbamylglutamate (NCG) or L-arginine (Arg) supplementation on the duodenal mitophagy, inflammation, and barrier function in suckling lambs suffering from intrauterine-growth-retardation (IUGR).
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Polysaccharides from Enteromorpha prolifera protect against carbon tetrachloride-induced acute liver injury in mice via activation of Nrf2/HO-1 signaling, and suppression of oxidative stress, inflammation and apoptosis

Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00575D, Paper
Fuchuan Guo, Xinyun Zhuang, Mengyuan Han, Wenting Lin
EPP protected against hepatic injury induced by CCl4-derived reactive intermediates through the suppression of hepatic oxidative stress, inflammation, and apoptosis.
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Effects of gastrodin against carbon tetrachloride induced kidney inflammation and fibrosis in mice associated with the AMPK/Nrf2/HMGB1 pathway

Food Funct., 2020, Accepted Manuscript
DOI: 10.1039/D0FO00711K, Paper
J. Q. Ma, Yun-Zhi Sun, Qing-Lei Ming, Zhi-Kai Tian, Yu-Jia Zhang, Chan-Min Liu
Gastrodin (GAS), the main phenolic glycoside extracted from Gastrodia elata Blume, exhibited potential renoprotective properties. Here we examined the protective effects of GAS against carbon tetrachloride (CCl4)-induced kidney inflammation and...
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Adjunctive vitamin A and D during pulmonary tuberculosis treatment: a randomized controlled trial with a 2×2 factorial design

Food Funct., 2020, Accepted Manuscript
DOI: 10.1039/C9FO02751C, Paper
Jinyu Wang, Ke Xiong, Qiuzhen Wang, Shanliang Zhao, Yufeng Liu, Aiguo Ma
Background and objective: Vitamin A and D have immunoregulatory effects and may improve the response to pulmonary tuberculosis treatment. The interaction of vitamin A and D on pulmonary tuberculosis treatment...
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Be flexible with your financial plan, don't make big commitment

Clearly, these are unusual times. So, things need to be done differently




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Existing investors must book partial profits in gold to cut portfolio risks

New ones should build their allocation gradually upon corrections




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Motor, health segments see substantial fall in March for non-life insurers

Motor segment saw a 7 per cent decline in premiums, while health registered an 11 per cent decline in premiums




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Apple Names Jeff Williams Chief Operating Officer

Apple has announced that Jeff Williams has been named chief operating officer and Johny Srouji is joining Apple’s executive team as senior vice president for Hardware Technologies. Phil Schiller, senior vice president of Worldwide Marketing, will expand his role to include leadership of the App Store across all Apple platforms. Apple also announced that Tor Myhren will join Apple in the first calendar quarter of 2016 as vice president of Marketing Communications, reporting to CEO Tim Cook. “We are fortunate to have incredible depth and breadth of talent across Apple’s executive team. As we come to the end of the year, we’re recognizing the contributions already being made by two key executives,” said Cook. “Jeff is hands-down the best operations executive I’ve ever worked with, and Johny’s team delivers world-class silicon designs which enable new innovations in our products year after year.”






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Review: Special Ops

The world according to Neeraj Pandey. Observed by Sreehari Nair.




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Parliament must pass a law to build Ram Mandir: Suresh Jain

Interview with Vishwa Hindu Parishad leader




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India's democracy created dynasties: Kanchan Chandra

Interview with Author,Democratic Dynasties




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Improving quality of governance biggest challenge for India: Mark Tully

Interview with former BBC correspondent




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California county to Tesla: Must not reopen vehicle factory

California county to Tesla: Must not reopen vehicle factory




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3 more Indians in UAE lose jobs for 'Islamobhobic' social media posts

3 more Indians in UAE lose jobs for 'Islamobhobic' social media posts




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Indian-origin scientist identifies four possible drugs to treat Covid-19

Indian-origin scientist identifies four possible drugs to treat Covid-19




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Covid-19: India looks to lure more than 1,000 US companies out of China

Covid-19: India looks to lure more than 1,000 US companies out of China




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Italy claims to have developed the first COVID-19 vaccine: Here is what we know about all the potential coronavirus vaccines

Italy claims to have developed the first COVID-19 vaccine: Here is what we know about all the potential coronavirus vaccines




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Mother's Day special: How about buying your mother some jewellery in lockdown?

Mother's Day special: How about buying your mother some jewellery in lockdown?




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Puri Jagannadh appreciates singer Sagar for feeding street dogs

Puri Jagannadh appreciates singer Sagar for feeding street dogs




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Ariana Grande and Justin Bieber's quarantine anthem 'Stuck with U' is winning over the internet; watch

Ariana Grande and Justin Bieber's quarantine anthem 'Stuck with U' is winning over the internet; watch




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European 2021 equestrian championships cancelled

European 2021 equestrian championships cancelled