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Vijay's maiden political entry was successful: Tamil megastar Rajinikanth




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Tamil star-turned-neta Vijay to embark on statewide tour in Dec




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Vijay chairs meeting of TVK leaders to finalise roadmap for his statewide tour




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How to identify hidden signs of your child's depression and how to go about it

This article will highlight common signs of depression in children and offer practical steps for parents to ensure their child gets the support needed to overcome these challenges.




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ModaXL 200 mg Review - Dosage, Interactions, Side Effects (Full Guide)

Want to order ModaXL 200 mg in 2024? Read this guide and learn more about the smart drug ModaXL. Safety, correct dosages, possible side effects, best places to buy the nootropic and much more in this helpful review.




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Defiant BRS MLA Mynampalli Hanumantha Rao to decide future course of action after talks with supporters

“I had not made any personal accusation against the Chief Minister K. Chandrashekhar Rao or the party. My grouse is against Mr. Harish Rao only,” he said.




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Sandeshkhali residents celebrate arrest of TMC leader Shahjahan Sheikh

The residents, who for the last few days have been protesting in the riverine Sandeshkhali area, came out in the streets as they distributed sweets and danced in joy




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Delhi coaching centre deaths: High Court to hear plea seeking setting up of panel to probe incident

The plea was mentioned for urgent hearing on July 30 before a bench of Acting Chief Justice Manmohan and Justice Tushar Rao Gedela which said the matter be listed on Wednesday




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Wayanad landslide: More than 1,000 government employees engaged in 24x7 relief operations, says CMO

The government staff are handling the coordination of the search and rescue effort, distribution of relief materials, counselling of landslide victims with medical conditions




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Parents hoping to adopt orphans of Wayanad landslide may not have their wish granted

It is estimated that the landslide has robbed five children of their parents; currently they are with their immediate relatives at the relief camp




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'Guided tour not good': Omar Abdullah slams govt for inviting foreign diplomats to see J&K polls

This "guided tour" is not a good thing, says Omar Abdullah, alleging the Centre wants to take credit for the people's participation in these polls "which is a betrayal with the people here"



  • Jammu and Kashmir Assembly

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Will protest inside, outside Parliament for J&K’s Statehood: Rahul Gandhi

Rahul Gandhi, in an election rally in Jammu, said the 2019 decision to bifurcate Jammu and Kashmir into two Union Territories was "a grave injustice"



  • Jammu and Kashmir Assembly

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Chess happened by accident but it was a happy accident: Vidit Gujrathi

It has not sunk in yet but I do know this achievement is going to stay with us for a long time, says Grandmaster Vidit Gujrathi




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Chess | Vantika happy to have redeemed herself and aided in her team’s victory




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WFI decides not to field team in Worlds in present circumstances

The WFI had announced that it would hold the trials in New Delhi on October 6 and 7 to select teams for the World under-23 championships and World championships respectively.




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ISSF president lauds Indian shooting




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Shooting | Vivaan Kapoor and Anantjeet Singh Naruka provide a sparkling finish for India in World Cup Final




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GOLF | Liz Young emerges champion after a roller coaster ride




ide

President-elect Trump at 312 electoral votes, Harris at 226

Donald Trump’s victory dims the hopes of Arizona Democrats, who sought to continue their ascendance, which began with the 2018 flip of a longtime GOP-held Senate seat and continued in 2020 and 2022




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Designated terrorist Arsh Dalla arrested by Canadian police after shooting incident, say sources

Though the police in Canada did not disclose the arrested person’s identity, sources in New Delhi claimed that he was believed to be Arsh Dalla, who ran terror modules on behalf of Hardeep Singh Nijjar.




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Sri Lanka President Anura Dissanayake promises return of Tamils’ land grabbed by state agencies 

Addressing a public rally in Jaffna in the Northern Province, Sri Lanka’s recently elected President assures conduct of provincial and local body elections; revival of industries in war-affected areas




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President-elect Trump to appoint former ICE director Tom Homan as U.S. 'border czar'

Mr. Homan, who served in the Trump administration for a year and a half during his first term, is also a contender for secretary of homeland security




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How a Trump presidency could lead to a purge at the Pentagon

Trump plans to purge ‘woke’ generals and civil servants, prioritising loyalty and potentially creating chaos in the military




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Mastermind of Karachi airport suicide attack arrested, says Pakistan police

The five militants were arrested last week from different parts of the restive Balochistan province, Umar Khatab, a senior official of the Sindh Counter-Terrorism Department, said




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President-elect Donald Trump chooses Elise Stefanik as Ambassador to United Nations

Nikki Haley, who challenged Mr. Trump for the GOP nomination, was among those who previously held the role in his first term.




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Georgia President calls for fresh election after contested vote

Georgian President Salome Zurabishvili calls for fresh elections amid allegations of electoral fraud, sparking crisis and international concern




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Israel FM Smotrich seeks annexation of West Bank during Trump presidency

The remarks came as Saudi Arabia held an extraordinary summit of Arab and Islamic leaders in Riyadh.




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Residents stage protest against pollution caused by Vijayawada Thermal Power Station

People residing in the colonies at Ferry, Kondapalli and Ibrahimpatnam organised a protest and appealed to the government to protect them from pollution




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A step-by-step guide to exploratory factor analysis with SPSS [electronic resource] / Marley W. Watkins.

New York, NY : Routledge, 2021.




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Capillary action-driven surface-enhanced Raman spectroscopy (SERS) for the identification of phthalocyanine blue in modern paintings based on the BPG spot test

Anal. Methods, 2024, 16,2147-2151
DOI: 10.1039/D3AY01378B, Technical Note
Shao-Chun Hsueh, Ling-Hsuan Wang, Yung-Chen Liao, Hui-Yu Chiang, Cheng-Huang Lin
A method for the extraction and accumulation of Ag nanoparticles utilizing capillary action through a piece of triangular-shaped cotton paper is reported.
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An on-line SPE-LC-MS/MS method for quantification of nucleobases and nucleosides present in biological fluids

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00100A, Paper
Yi-Ming Liu, Shuguan Wang, Amani Dickenson, Jinghe Mao, Xiaolin Bai, Xun Liao
A facile on-line SPE-LC-MS/MS method for quantification of nucleobases and nucleosides in urine and saliva.
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Aptamer aided plasmonic nano-urchin for reporter free surface-enhanced Raman spectroscopy analysis of cortisol

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00401A, Paper
Chengyu Li, Jing Hu, Nan Hu, Jianjun Zhao, Qianwen Li, Yanhui Han, Yanxiong Liu, Xufang Hu, Liyan Zheng, Qiu-E Cao
Cortisol is a vital glucocorticoid hormone reflecting stress levels and related disease processes. We present an aptamer functionalized plasmonic nano-urchin (α-FeOOH@Au-aptamer) aided cortisol capturing and Surface-enhanced Raman spectroscopy (SERS) analysis...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Luminescent and time-resolved determination of gemifloxacin mesylate in pharmaceutical formulations and spiked blood plasma samples using a lanthanide complex as a probe

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00236A, Paper
Gasser M. Khairy, Rania M. Goda, Zeinab M. Anwar, Mohamed M. Aboelnga, Axel Duerkop
A new luminescent europium probe for the determination of the antibiotic gemifloxacin is presented. Time-resolved luminescence enables its quantitation in pharmaceutical formulations and blood samples.
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Direct detection of dithiocarbamate fungicides by SALDI/MS using porous TiC ceramic powder as a substrate

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D3AY01533E, Paper
Hiroshi Moriwaki, Issey Osaka, Kotaro Hashimoto, Osamu Yamada
Direct detection of dithiocarbamate fungicides (DTCs) has been achieved by SALDI/MS using porous titanium carbide (TiC) ceramic powder as a substrate.
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Layer-by-layer assembly of homopolypeptide polyelectrolytes on asymmetric nanochannels for the detection of nickel ions

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00422A, Paper
Pengrong An, Jincan Yang, Tianming Wang, Saiwen Lu, Dehao Wang, Zhuoyue Wang, Chun-Lin Sun, Chuanguang Qin, Jun Li
We report PA-γ-PGA-modified asymmetric nanochannels that enable ultra-sensitive detection of Ni2+ (limit of detection is 1 × 10−8 M).
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A comprehensive HRMS methodology using LC-(ESI)-/GC-(APCI)-QTOF MS complementary platforms for wide-scope target screening of >750 pesticides in olive oil

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00181H, Paper
Open Access
Sofia K. Drakopoulou, Stefanos E. Kokolakis, Apostolos L. Karagiannidis, Marilena E. Dasenaki, Niki C. Maragou, Nikolaos S. Thomaidis
This study presents a robust and validated HRMS method for the determination of 771 pesticides in olive oil. LC-ESI/GC-APCI-QTOF MS was employed for the analysis.
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A highly sensitive and selective fluorescent biosensor for breast cancer derived exosomes using click reaction of azide–CD63 aptamer and alkyne-polymer dots

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00146J, Paper
Dumei Ma, Yiting Luo, Xiaoya Zhang, Zehu Xie, Yinghua Yan, Chuan-Fan Ding
A fluorescence method based on Cu-triggered click reaction of azide modified CD63 aptamer and alkyne capped Pdots was developed for breast cancer derived exosome detection.
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Analysis of brominide disinfection by-products in aquaculture water using ultra-high-performance liquid chromatography–quadrupole–time-of-flight mass spectrometry

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00396A, Paper
Weimin Yang, Yi Zhang, Jilong Huang, Xing Yang, Ning Jiang
Background: Halogenic disinfectants have been shown to produce toxic and carcinogenic disinfection by-products (DBPs) during water disinfection. Dibromohydantoin (DBDMH) is a commonly used water disinfectant in aquaculture. Aquaculture water has...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Monolith stationary phases prepared via cyclic anhydride ring-opening polymerization as tunable platforms for chromatographic applications

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00251B, Paper
Ahmad Aqel, Ayman Ghafr, A. Yacine Badjah-Hadj-Ahmed, Zeid Abdullah ALOthman
Polymer monolithic stationary phases were prepared based on a cyclic anhydride as a reactive and tunable platform via ring-opening post-polymerization using primary amines; octadecylamine and benzylamine. The characterization techniques indicated...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Down to the wire: On the run-up to the U.S. presidential election

The U.S. presidential race is poised on a knife’s edge




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Sri Lanka’s verdict: On the Island nation’s ninth Presidential election

The spirit of the mandate of the presidential poll was clear — for change




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Neck and neck: On the U.S. presidential election

Trump and Harris offer U.S. voters vastly different choices 




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Discovery of highly potent SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5'-carboxamides

RSC Med. Chem., 2024, 15,3469-3476
DOI: 10.1039/D4MD00422A, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Hugo Kocek, Dominika Chalupská, Milan Dejmek, Alexandra Dvořáková, Michala Zgarbová, Michal Šála, Karel Chalupský, Petra Krafčíková, Tomáš Otava, Matúš Drexler, Eliška Procházková, Blanka Klepetářová, Milan Štefek, Ján Kozic, Helena Mertlíková-Kaiserová, Evzen Boura, Jan Weber, Radim Nencka
SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5'-carboxamides.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Sidechain structure–activity relationships of cyclobutane-based small molecule αvβ3 antagonists

RSC Med. Chem., 2024, 15,3616-3624
DOI: 10.1039/D4MD00306C, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Adam Throup, Manar Saleh Zraikat, Andrew Gordon, Shohreh Jafarinejad Soumehsaraei, Kathrin D. Haase, Laurence H. Patterson, Patricia A. Cooper, Katherine Hanlon, Paul M. Loadman, Mark Sutherland, Steven D. Shnyder, Helen M. Sheldrake
Cyclobutanes provide a versatile scaffold for the synthesis of small molecule integrin antagonists with good metabolic stability and in vivo tolerability.
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Development, biological evaluation, and molecular modelling of some benzene-sulfonamide derivatives as protein tyrosine phosphatase-1B inhibitors for managing diabetes mellitus and associated metabolic disorders

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00594E, Research Article
Nagat Ghareb, Khaled M. Darwish, Mohamed S. Nafie, Ranwa Elrayess, Noha M. Abourobe, Shaimaa A. Fattah, Reem M. Hazem, Eman T. Mehanna, Ranza Elrayess
One benzene-sulfonamide derivative exhibited potent protein tyrosine phosphatase-1B inhibition for managing diabetes mellitus and associated metabolic disorders.
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Human microbiome derived synthetic antimicrobial peptides with activity against Gram-negative, Gram-positive, and antibiotic resistant bacteria

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00383G, Research Article
Open Access
Walaa K. Mousa, Ashif Y. Shaikh, Rose Ghemrawi, Mohammed Aldulaimi, Aya Al Ali, Nour Sammani, Mostafa Khair, Mohamed I. Helal, Farah Al-Marzooq, Emilia Oueis
An AMP-derived short 15-mer peptide and its cyclic derivatives have low micromolar broad spectrum antibacterial activity, with rapid onset of bactericidal effect and a membrane-targeting mode of action.
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Amides of moronic acid and morolic acid with the tripeptides MAG and GAM targeting antimicrobial, antiviral and cytotoxic effects

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00742E, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Uladzimir Bildziukevich, Lucie Cerna, Jana Trylčová, Marie Kvasnicova, Lucie Rárová, David Šaman, Petra Lovecká, Jan Weber, Zdenek Wimmer
A series of amides of the selected plant triterpenoids, moronic acid and morolic acid, with the tripeptides MAG and GAM was designed and synthesized. Two required tripeptides 5 and 10...
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Novel benzenesulfonamides containing a dual triazole moiety with selective carbonic anhydrase inhibition and anticancer activity

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00617H, Research Article
Aida Buza, Cüneyt Türkeş, Mustafa Arslan, Yeliz Demir, Busra Dincer, Arleta Rifati Nixha, Şükrü Beydemir
In this research, a series of sulfonamides incorporating a 1,2,3-triazolyloxime substituted 1,2,3-triazolyl moiety was conceptualized, synthesized, and investigated as carbonic anhydrase inhibitors.
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Recent advances from computer-aided drug design to artificial intelligence drug design

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00522H, Review Article
Keran Wang, Yanwen Huang, Yan Wang, Qidong You, Lei Wang
CADD and AIDD contribute to the drug discovery.
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A novel approach for the synthesis of the cyclic lipopeptide globomycin

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00685B, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Samantha J. Bann, Stephen A. Cochrane
Lipid swapping: a new approach for the synthesis of globomycin that allows for facile lipid diversification.
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