A Welsh MP claims cases include workers with the NHS and in care homes.

Lockdown words of love and comfort across Ireland and the globe during the Covid-19 pandemic.

Omar Taylor is at home with his family after six weeks in hospital battling coronavirus.

Zookeepers are sharing a new challenge to help lift their spirits during the coronavirus lockdown.

Dozens of competitive eaters polish off their webcams in preparation for the yearly biscuit showdown.

Police Federation calls for anyone using coronavirus as a weapon automatically to be remanded in custody.

Google Chromebook Now Available for $299

Google Chromebook Now Available for $299

As the UK looks to lift restrictions, how do other European countries plan to re-open after lockdown?

Use our tool to check the meaning of key words and phrases associated with the Covid-19 outbreak.

How coping with OCD prepared one man for the challenges of the coronavirus pandemic.

The BBC speaks to unexpected sources who are supplying PPE amid coronavirus shortages.

Dr John Wright is intrigued by some singers who became ill long before the UK's first known Covid-19 case.

Photographer Tom Skipp's pictures of the many rainbows supporting the NHS across the city of Bristol.

Social distancing could mean prayer books cannot be shared and people cannot sing, religious leaders say.

More than 70 public figures sign an open letter to the prime minister calling for more transparency.

Around 50,000 coronavirus test samples had to be sent to the US due to "operational issues" in the UK, it has been revealed.

Filed under: North America, United States, Airports, Travel Security

Continue reading 4 Thanksgiving Travel Tips to Save You Time

4 Thanksgiving Travel Tips to Save You Time originally appeared on Gadling on Tue, 26 Nov 2013 11:30:00 EST. Please see our terms for use of feeds.

Filed under: Asia, Thailand

Not only are tourists still coming, but they've been arriving in increasing numbers in recent years, according to government data.

Continue reading Demonstrations in Thailand? No Problem, Travelers Say.

Demonstrations in Thailand? No Problem, Travelers Say. originally appeared on Gadling on Mon, 02 Dec 2013 11:26:00 EST. Please see our terms for use of feeds.

Filed under: North America, United States, Airlines, Airports, News

The new application process allows U.S. citizens to directly enroll in TSA Pre✓[TM], an expedited screening program that allows travelers to leave on their shoes, light outerwear and belt, keep their laptop in its case and their 3-1-1 compliant liquids/gels bag in a carry-on, in select screening lanes. To date, passengers have only been eligible through existing programs such as U.S. Custom and Border Protection's Global Entry program and frequent flier programs with certain airlines, but this announcement will allow travelers to apply directly for the expedited screening program.

Continue reading TSA Lets Travelers Apply for PreCheck

TSA Lets Travelers Apply for PreCheck originally appeared on Gadling on Wed, 04 Dec 2013 16:58:00 EST. Please see our terms for use of feeds.

Filed under: History, Blogs

A recently-released program called Mosaic was revolutionizing what might be possible on the World Wide Web. "What we hope you'll do," the editor [at O'Reilly Media] said, "is write columns for us - from the road. We'll publish them live, on the GNN [Global Network Navigator, O'Reilly's website], where people can read them as you travel." The Travelers' Center, he told me, would include a feature that sounded miraculous: A map would be displayed on their website, with dots showing the locations from where I'd sent back posts. People would simply click on those dots - and see the story I'd written from that location!

Continue reading Travel Blogging Turns 20 Today

Travel Blogging Turns 20 Today originally appeared on Gadling on Mon, 06 Jan 2014 17:31:00 EST. Please see our terms for use of feeds.

Filed under: Arts and Culture, North America, United States

With their reputations on the line, travel agents Joanne and Gary will tackle any request, no matter how impossible, and any client, no matter how unreasonable. Full of overzealous travelers, overbooked flights, and hoteliers who are just over it, Craving for Travel reminds us why we travel-and everything that can happen when we do.

Continue reading Off-Broadway Comedy 'Craving for Travel' Showcases Travel Agents Trying to do the Impossible

Off-Broadway Comedy 'Craving for Travel' Showcases Travel Agents Trying to do the Impossible originally appeared on Gadling on Tue, 07 Jan 2014 10:19:00 EST. Please see our terms for use of feeds.

Filed under: Business, Europe, North America, Denmark, Iceland, Belize, United States

Continue reading Top 5 Family Travel Destinations for 2014 (and Possibly Beyond)

Top 5 Family Travel Destinations for 2014 (and Possibly Beyond) originally appeared on Gadling on Thu, 09 Jan 2014 13:09:00 EST. Please see our terms for use of feeds.

Filed under: Business, Talking Travel

Skift Acquires Gadling Travel From AOL originally appeared on Gadling on Thu, 12 Jun 2014 09:04:00 EST. Please see our terms for use of feeds.

Hairdressers have been forced to go underground as lockdown regulations stifle their livelihood and job security. For some, bootlegging has been 'life-saving'.

While the phased-in reopening of schools in South Africa in the midst of Covid-19 remains provisional and sensitive, the Western Cape Education Department has advised principals and school management teams to wait a few more days before returning.

A Canadian department store chain is calling it quits after more than a century in business.

The DML News App offers the best in news reporting.

The post REPORT: Rock vocalist’s daughter rescued from Peru by US Embassy amid coronavirus ban appeared first on Dennis Michael Lynch.

Flying in Canada during the time of COVID-19 requires a lot extra care, and CTV Senior Political Correspondent Glen McGregor gives a first-hand account on CTVNews.ca.

The city says couples can book its Helena Gutteridge Plaza at City Hall for just $85 and bring eight guests to have an outdoor, physically distant wedding ceremony.

A department store that served Vancouver's Gastown and Downtown Eastside neighbourhoods for decades is closing, along with four other Army and Navy locations, because of the COVID-19 pandemic.

The following article, Rep. Ilhan Omar Asks For Contributions To Her Campaign To Help MN Food Bank…Food Bank Director Says Omar Has Nothing To Do With Project: “I have no idea where this money is going”, was first published on 100PercentFedUp.com.

Ilhan Omar is a lot of things. First, and foremost, she’s deceitful. David Steinberg of PJ Media was one of the first investigative journalists to break the story about the anti-Semitic, freshman lawmaker’s marriage to her immigrant brother while she was still married to her first husband, who she has since divorced after having an […]

Continue reading: Rep. Ilhan Omar Asks For Contributions To Her Campaign To Help MN Food Bank…Food Bank Director Says Omar Has Nothing To Do With Project: “I have no idea where this money is going” ...

geoffiths posted a photo:

Challenge #17 the inspiration for today’s photo is to come from the VERY next thing you audibly hear. I heard someone say "Welcome" so my interpretation was a future of getting close again would be welcome.

Elizabeth Spiers wrote about an incident where Jared Kushner used the memorial of an employee to congratulate himself for success.

"I think it's always important to think about suicide as individual vulnerabilities and context," Eric Caine said.

China's National Health Commission reported 14 new confirmed coronavirus cases on May 9, the highest number since April 28, including the first for more than a month in the city of Wuhan where the outbreak was first detected late last year. While China had officially designated all areas of the country as low-risk last Thursday, the new cases according to data published on Sunday represent a jump from the single case reported for the day before. The new Wuhan case, the first reported in the epicentre of China's outbreak since April 3, was previously asymptomatic, according to the health commission.

The government said it's distributing the promising coronavirus drug, remdesivir, to some hard-hit states. Eventually, all 50 states should get it.

In a tweet Saturday morning, Tesla's chief executive said it would file a lawsuit against county officials over not being able to run its factory.

Inter-α-inhibitor is a proteoglycan essential for mammalian reproduction and also plays a less well-characterized role in inflammation. It comprises two homologous “heavy chains” (HC1 and HC2) covalently attached to chondroitin sulfate on the bikunin core protein. Before ovulation, HCs are transferred onto the polysaccharide hyaluronan (HA) to form covalent HC·HA complexes, thereby stabilizing an extracellular matrix around the oocyte required for fertilization. Additionally, such complexes form during inflammatory processes and mediate leukocyte adhesion in the synovial fluids of arthritis patients and protect against sepsis. Here using X-ray crystallography, we show that human HC1 has a structure similar to integrin β-chains, with a von Willebrand factor A domain containing a functional metal ion-dependent adhesion site (MIDAS) and an associated hybrid domain. A comparison of the WT protein and a variant with an impaired MIDAS (but otherwise structurally identical) by small-angle X-ray scattering and analytical ultracentrifugation revealed that HC1 self-associates in a cation-dependent manner, providing a mechanism for HC·HA cross-linking and matrix stabilization. Surprisingly, unlike integrins, HC1 interacted with RGD-containing ligands, such as fibronectin, vitronectin, and the latency-associated peptides of transforming growth factor β, in a MIDAS/cation-independent manner. However, HC1 utilizes its MIDAS motif to bind to and inhibit the cleavage of complement C3, and small-angle X-ray scattering–based modeling indicates that this occurs through the inhibition of the alternative pathway C3 convertase. These findings provide detailed structural and functional insights into HC1 as a regulator of innate immunity and further elucidate the role of HC·HA complexes in inflammation and ovulation.

Contact between inflammatory cells and endothelial cells (ECs) is a crucial step in vascular inflammation. Recently, we demonstrated that the cell-surface level of endomucin (EMCN), a heavily O-glycosylated single-transmembrane sialomucin, interferes with the interactions between inflammatory cells and ECs. We have also shown that, in response to an inflammatory stimulus, EMCN is cleared from the cell surface by an unknown mechanism. In this study, using adenovirus-mediated overexpression of a tagged EMCN in human umbilical vein ECs, we found that treatment with tumor necrosis factor α (TNF-α) or the strong oxidant pervanadate leads to loss of cell-surface EMCN and increases the levels of the C-terminal fragment of EMCN 3- to 4-fold. Furthermore, treatment with the broad-spectrum matrix metalloproteinase inhibitor batimastat (BB94) or inhibition of ADAM metallopeptidase domain 10 (ADAM10) and ADAM17 with two small-molecule inhibitors, GW280264X and GI254023X, or with siRNA significantly reduced basal and TNFα-induced cell-surface EMCN cleavage. Release of the C-terminal fragment of EMCN by TNF-α treatment was blocked by chemical inhibition of ADAM10 alone or in combination with ADAM17. These results indicate that cell-surface EMCN undergoes constitutive cleavage and that TNF-α treatment dramatically increases this cleavage, which is mediated predominantly by ADAM10 and ADAM17. As endothelial cell-surface EMCN attenuates leukocyte–EC interactions during inflammation, we propose that EMCN is a potential therapeutic target to manage vascular inflammation.

Migration and development have emerged as a pressing policy priority on the global agenda. This report identifies critical lessons from the past decade of policy experimentation and offers recommendations for migration and development policy.

MANCHESTER, England (AP): Paul Pogba and Marcus Rashford are expected to be available for Manchester United whenever the Premier League is allowed to resume after the suspension caused by the coronavirus outbreak. Whether United manager Ole Gunnar...

Cavalier’s technical director, Rudolph Speid, says the recent positive ranking by CIES (International Centre for Sports Studies) Football Observatory, a research group based in Switzerland, is a reflection of the work the club is doing in trying to...

When siblings Norma and Warren Williams left Jamaica to attend the funeral of a relative in Margate, South Florida, in February, they had no idea that a rapidly developing COVID-19 outbreak would have crippled global travel, leaving them stranded...

Losses within the entertainment industry are already estimated to be in the billions as the sector continues to reel from the impacts of COVID-19. Major events like Reggae Sumfest, which has already been cancelled this year, had an estimated...

This report focuses on the development of children of Black immigrants in the United States, comparing against the outcomes for their peers in native-born and other immigrant families. It also compares these U.S. children to those in the United Kingdom, where there is a large Black immigrant population but a notably different policy context of reception.