Lowering low-density lipoprotein cholesterol (LDL-C) levels remains a mainstay of cardiovascular disease prevention, but gaps in treatment remain, even in persons with hypercholesterolemia and greatly elevated LDL-C levels. Although well-described gene variants in the apolipoprotein B (APOB), low-density lipoprotein receptor (LDLR), and proprotein convertase subtilisin/kexin type 9 (PCSK9) genes explain small but important fractions of monogenic hypercholesterolemia, recent attention has turned to prognostication of cardiovascular disease using polygenic risk scores (PRS) that incorporate common genetic variants derived from large-scale genome-wide association studies of lipid subfractions. Earlier PRS considered only variants with genome-wide significance, and newer studies have focused on methods that better capture the variance conferred by millions of variants, suggesting an ability to identify risk equivalent to monogenic mutations. There remains a gap in evidence from prospective observational studies or treatment trials regarding the appropriate placement of PRS in risk assessment and lipid treatment decisions relative to information on rare monogenic gene variants, particularly in multiethnic populations.

This Special Communication proposes a classification of patients with left-ventricular disease according to the severity of mitral regurgitation that is proportionate vs disproportionate to left-ventricular end-diastolic volume.

This essay describes a physician’s experience of the sudden, unexplained death of her brother and her family’s discovery of the genetic cause.

With a date span of 1779 through 1955, the McManus-Young Collection provides a rich survey of the literature of "illusion practices," which includes works on conjuring, ventriloquism, fortune-telling, spiritualism, witchcraft, gambling, hypnotism, automata, and mind reading comprised of a gathering of thousands of pamphlets and offprints. This ephemeral literature is the backbone of modern...

Hayden Library - PQ7082.P7 C23 2018

Dewey Library - PQ7390.G773 D6613 2018

Do not race after riches, do not risk your life for success, or you will let slip the heaven within you.

O'Toole, Peter Martin, author

Australia. Parliament. Senate. Environment and Communications References Committee, author

Hogarth, Peter J

Castro, Peter, author

Australia. Parliament. Senate. Environment and Communications References Committee, author, issuing body

Yeo, Sue-Yee Sharon, author

Dinar, Shlomi, author

Knauss, John A., author

Zelko, Frank S

Bertness, Mark D., 1949-

Jarvis, W. Todd, author

Mirumachi, Naho, author

Niaounakis, Michael, author

Probert, P. Keith, author

Hart, Barry T., author

Miranda, Luiz Bruner de, author

Sverdrup, Keith A., author

Levinton, Jeffrey S., author

Frid, Chris, author

Carruthers, Jane, author