Framed prints of Steven Camley's cartoons are available by calling 0141 302 6210.

Monday 13 January: Royals’ family meeting

This week, our resident cartoonist turned his pen on the Coronavirus outbreak, Bernie Sanders rising popularity in the United States and the battle for an SNP seat at Holyrood.

This week, our resident cartoonist turned his pen on the Coronavirus outbreak, bullying claims surrounding the home secretary and Scotland making in to the world list of top beaches.

Framed prints of Steven Camley's cartoons are available by calling 0141 302 6210

Most childhood HIV is acquired through perinatal transmission, some of which is preventable. Practitioners need to understand what proportion of perinatally acquired HIV infections are attributable to missed prevention opportunities.

Missed prevention opportunities include lack of early HIV testing for pregnant women; suboptimal use of antiretroviral medications during pregnancy, labor, or delivery or for the neonate; breastfeeding; and vaginal delivery when maternal viral load was ≥1000 copies/mL. (Read the full article)

Most acute wheezing episodes in preschool children are associated with rhinovirus, which decreases extracellular adenosine triphosphate levels, leading to airway surface liquid dehydration and submucosal edema, which cause failure of mucus clearance. These children respond poorly to available treatments.

Hypertonic saline inhalation, a pro–airway surface liquid hydration therapy, significantly decreases both length of stay by 33% (1 day) and the absolute risk of hospitalization by 30% in preschool children presenting with acute wheezing episode to the emergency department. (Read the full article)

Hypertonic saline (3% and 5%), has been shown to improve clinical severity scores and reduce inpatient length of stay, and was associated with a trend toward lower admission rate in acute bronchiolitis.

We are not aware of any previous data using 7% hypertonic saline in bronchiolitis. Our results suggest that 7% saline does not lower clinical severity of illness, admission rate, or length of stay, when compared with normal saline. (Read the full article)

The Dallas String Quartet will deliver its passionate fusion of classical and contemporary music to the Community Arts Center at 7:30 p.m. Thursday, March 19.

Norton Family's wealth of features and easy setup make it easy for parents to track and manage their children's activity across many devices, though it doesn't work on Macs.

Daniela Claudio Pagán, a graphic design senior from Puerto Rico, has been named the College of Arts and Architecture's 2020 student marshal.

Six Penn State faculty members have received the 2020 George W. Atherton Award for Excellence in Teaching.

The Estádio do Dragão, home of 2004 European champions Porto, will stage the 2020/21 season-opener.

Manchester City defeated Liverpool on penalties to set up a semi-final with Barcelona, victors at Atlético Madrid, while Porto beat Tottenham Hotspur and face Chelsea, who won at Real Madrid.

Leverkusen's tie with Porto hangs in the balance as the German club travel to Portugal defending a 2-1 lead.

Lewes --

WHEN: 6:00 a.m. until 9:00 a.m. on Sunday, March 22, 2020

WHERE: Route 24/John J. Williams Highway between Hollymount Road and Robinsonville Road at Burtons Pond near Lewes

WHAT: DelDOT announces to motorists that a portion of Route 24/John J. Williams Highway will be closed at Burtons Pond to place a barge in the pond. [More]

Lewes --

WHEN: 6:00 a.m. until 9:00 a.m. on Sunday, April 5, 2020

WHERE: Route 24/John J. Williams Highway between Hollymount Road and Robinsonville Road at Burtons Pond near Lewes

WHAT: DelDOT announces to motorists that a portion of Route 24/John J. Williams Highway will be closed at Burtons Pond for the removal of the barge at the pond. [More]

Young entrepreneurs are crushing it on collecting personal data

Get your real-time, live, streaming music ad free, even on the subway

How digital payments take all the fun out of buried treasure

Brands may be watching your every move, but hey...at least you get a great CX

Winds are from the West at 16.1 gusting to 20.7 MPH (14 gusting to 18 KT). The pressure is 1011.2 mb and the humidity is 75%. The wind chill is 22. Last Updated on May 9 2020, 11:56 am EDT.

Microsoft Windows suffers from an NtFilterToken ParentTokenId incorrect setting that allows for elevation of privileges.

On Thursday, Puerto Rico’s Governor Ricardo Rosselló signed into law the Puerto Rico Energy Public Policy Act which lays the groundwork for the island’s transition to 100 percent clean energy by 2050.

When Hurricane Maria devastated Puerto Rico, it cut short nearly 3,000 lives, displaced thousands of families, and subjected the commonwealth to the longest energy blackout in U.S. history. This tragedy invited a new vision for Puerto Rico’s battered electric grid, and I hoped that a central tenet of the rebuilding effort would be an aggressive move toward safe, abundant and resilient clean energy.

Environmental Defense Fund (EDF) this week unveiled a vision to collaborate with communities, technical experts, businesses and investors to build low-carbon microgrids in Puerto Rico, and bring reliable, clean and affordable electricity to rural areas of the island. As described at the “BlackStart 2019: Future of Energy Summit” in San Juan, the new initiative will help modernize Puerto Rico’s electric grid and improve the system’s resilience.

On Thursday, Puerto Rico’s Governor Ricardo Rosselló signed into law the Puerto Rico Energy Public Policy Act which lays the groundwork for the island’s transition to 100 percent clean energy by 2050.

When Hurricane Maria devastated Puerto Rico, it cut short nearly 3,000 lives, displaced thousands of families, and subjected the commonwealth to the longest energy blackout in U.S. history. This tragedy invited a new vision for Puerto Rico’s battered electric grid, and I hoped that a central tenet of the rebuilding effort would be an aggressive move toward safe, abundant and resilient clean energy.

I Love Biscuits and I have been searching for a quick and easy recipe to make in my countertop convection oven. Living in a hot climate – I don’t want to heat up the house with the regular oven and besides, I only want a small batch. This is a quick and easy Drop-Biscuit recipe that makes six biscuits. Plus, you can make it Vegan if you like! -- posted by Billy R.

By Peter Duru – Makurdi Governor Samuel Ortom of Benue state says he has no regrets revealing the identity of the state’s COVID-19 index case, Mrs. Susan Okpe, despite her desperate attempts to politicized the issue and whipped up ethnic sentiments. He insisted that the decision was made in the best interest of the people
Read More

The post I’ve no regrets revealing identity of COVID-19 index case in Benue – Ortom appeared first on Vanguard News.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

Knock, knock: it's Hunger

The post Cartoon: Carlos on the wolves at the door appeared first on The Mail & Guardian.

Data-driven decision making can be a powerful tool in the world of international development but it requires careful planning and management. 

Tom Gauld’s science cartoons appear weekly in New Scientist. He explains how he gets his ideas as his latest collection, Department of Mind-Blowing Theories, hits the shelves

Forrest Galante, a host of 'Extinct or Alive' on the 'Animal Planet,' recounts the locating of the Fernandina Island tortoise that hasn't been heard from since 1906. (Dan Fastenberg reports.)

Title: Dengue Fever a Major Cost Burden in Puerto Rico
Category: Health News
Created: 5/2/2012 6:05:00 PM
Last Editorial Review: 5/3/2012 12:00:00 AM

Title: Health Tip: Managing a Hammertoe
Category: Health News
Created: 5/4/2012 8:05:00 AM
Last Editorial Review: 5/4/2012 12:00:00 AM

ABSTRACT

Recognition modes of individual T cell receptors (TCRs) are well studied, but factors driving the selection of TCR repertoires from primary through persistent human virus infections are less well understood. Using deep sequencing, we demonstrate a high degree of diversity of Epstein-Barr virus (EBV)-specific clonotypes in acute infectious mononucleosis (AIM). Only 9% of unique clonotypes detected in AIM persisted into convalescence; the majority (91%) of unique clonotypes detected in AIM were not detected in convalescence and were seeming replaced by equally diverse "de novo" clonotypes. The persistent clonotypes had a greater probability of being generated than nonpersistent clonotypes due to convergence recombination of multiple nucleotide sequences to encode the same amino acid sequence, as well as the use of shorter complementarity-determining regions 3 (CDR3s) with fewer nucleotide additions (i.e., sequences closer to germ line). Moreover, the two most immunodominant HLA-A2-restricted EBV epitopes, BRLF1₁₀₉ and BMLF1₂₈₀, show highly distinct antigen-specific public (i.e., shared between individuals) features. In fact, TCRα CDR3 motifs played a dominant role, while TCRβ played a minimal role, in the selection of TCR repertoire to an immunodominant EBV epitope, BRLF1. This contrasts with the majority of previously reported repertoires, which appear to be selected either on TCRβ CDR3 interactions with peptide/major histocompatibility complex (MHC) or in combination with TCRα CDR3. Understanding of how TCR-peptide-MHC complex interactions drive repertoire selection can be used to develop optimal strategies for vaccine design or generation of appropriate adoptive immunotherapies for viral infections in transplant settings or for cancer.

IMPORTANCE Several lines of evidence suggest that TCRα and TCRβ repertoires play a role in disease outcomes and treatment strategies during viral infections in transplant patients and in cancer and autoimmune disease therapy. Our data suggest that it is essential that we understand the basic principles of how to drive optimum repertoires for both TCR chains, α and β. We address this important issue by characterizing the CD8 TCR repertoire to a common persistent human viral infection (EBV), which is controlled by appropriate CD8 T cell responses. The ultimate goal would be to determine if the individuals who are infected asymptomatically develop a different TCR repertoire than those that develop the immunopathology of AIM. Here, we begin by doing an in-depth characterization of both CD8 T cell TCRα and TCRβ repertoires to two immunodominant EBV epitopes over the course of AIM, identifying potential factors that may be driving their selection.

Recent advances in cough research suggest a more widespread use of cough-provocation tests to demonstrate the hypersensitivity of the cough reflex arc. Cough-provocation tests with capsaicin or acidic aerosols have been used for decades in scientific studies. Several factors have hindered their use in everyday clinical work: i.e. lack of standardisation, the need for special equipment and the limited clinical importance of the response. Cough-provocation tests with hypertonic aerosols (CPTHAs) involve provocations with hypertonic saline, hypertonic histamine, mannitol and hyperpnoea. They probably act via different mechanisms than capsaicin and acidic aerosols. They are safe and well tolerated and the response is repeatable. CPTHAs can assess not only the sensitivity of the cough reflex arc but also the tendency of the airway smooth muscles to constrict (airway hyper-responsiveness). They can differentiate between subjects with asthma or chronic cough and healthy subjects. The responsiveness to CPTHAs correlates with the cough-related quality of life among asthmatic subjects. Furthermore, the responsiveness to them decreases during treatment of chronic cough. A severe response to CPTHAs may indicate poor long-term prognosis in chronic cough. The mannitol test has been stringently standardised, is easy to administer with simple equipment, and has regulatory approval for the assessment of airway hyper-responsiveness. Manual counting of coughs during a mannitol challenge would allow the measurement of the function of the cough reflex arc as a part of clinical routine.

Purpose:

Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin cancer, which can be effectively controlled by immunotherapy with PD-1/PD-L1 checkpoint inhibitors. However, a significant proportion of patients are characterized by primary therapy resistance. Predictive biomarkers for response to immunotherapy are lacking.