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BRO rescues 20 vehicles stuck in snow in J-K's Bandipora




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There will be census in country but not based on caste: Union Minister Shobha Karandlaje




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Rajnath Singh stresses on adaptive defence to cope with Age of Grey Zone, hybrid warfare




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Union Jal Shakti Minister CR Paatil chairs 13th high-powered review meeting of Brahmaputra Board




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Assam Governor attends Sainik school Goalpara's Diamond Jubilee celebrations




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French lower house rejects massively amended 2025 budget

Prime Minister Michel Barnier's minority government now has a largely free hand in submitting a cleaned-up text to the Senate upper house




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China's largest air show takes off with fighter jets, attack drones

China has poured resources into modernising and expanding its aviation capabilities as it faces off against the United States and others around regional flashpoints like Taiwan.




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5.3 magnitude earthquake jolts parts of Pakistan

No casualties have been reported so far for the earthquake that had its epicentre around the Hindukush mountain range




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Indonesia and Australia hold joint military drills after signing a new defense agreement

The Indonesian and Australian militaries are holding joint combat drills off Indonesia’s main island of Java with about 2,000 troops training in air, maritime, amphibious and land operations




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Discovery of hybrid Glypromate conjugates with neuroprotective activity against paraquat-induced toxicity

RSC Med. Chem., 2024, 15,3711-3727
DOI: 10.1039/D4MD00584H, Research Article
Sara C. Silva-Reis, Vera M. Costa, Daniela Correia da Silva, David M. Pereira, Xavier Cruz Correia, Xerardo García-Mera, José E. Rodríguez-Borges, Ivo E. Sampaio-Dias
A series of bicyclic-based Glypromate conjugates with reduction of protein aggregation elicited by Aβ25–35 and neuroprotective activity against paraquat-induced toxicity is reported, paving the way for the discovery of novel neurotherapeutics.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Hydrophobic CPP/HDO conjugates: a new frontier in oligonucleotide-warheaded PROTAC delivery

RSC Med. Chem., 2024, 15,3695-3703
DOI: 10.1039/D4MD00546E, Research Article
Miyako Naganuma, Nobumichi Ohoka, Motoharu Hirano, Daishi Watanabe, Genichiro Tsuji, Takao Inoue, Yosuke Demizu
A novel hydrophobic cell-penetrating peptide (CPP) and heteroduplex oligonucleotide (HDO)-conjugated PROTAC, CPP/HDO-PROTAC, was designed to enhance its intracellular delivery and degradation efficiency.
The content of this RSS Feed (c) The Royal Society of Chemistry




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AIADMK will not form an alliance with BJP in 2026 polls, reiterates Palaniswami

“During the Lok Sabha election, it was said at the party headquarters and in press bytes that the AIADMK will not have alliance with the BJP in the [2026] Assembly election,” he said




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CM Stalin inaugurates 27 new projects at temples across T.N.




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IIT-M students develop robot for O.P. Jindal university’s Constitution Museum

It is trained to respond to questions from visitors in Hindi and English, IIT-M professor says




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Godrej Industries Q2 net profit surges over three fold to ₹288 crore




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Mangaluru Junction - CSMT Superfast Express to get LHB coaches in March 2025

Train No. 12133 Mumbai CSMT-Mangaluru Junction Superfast Express will get an LHB rake from March 1 while its pairing service, Train No. 12134 Mangaluru Junction-Mumbai CSMT Superfast Express, will get an LHB rake from March 2




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Andhra Pradesh government deploys drones to detect ganja palnatations

State collaborates with NCB and Google to map and track cannabis plantations using satellite imagery technology




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117 applications received at Kuppam’s first ‘Praja Darbar’




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Andhra Pradesh govt. reaffirms commitment to ‘irrigating every acre of farmland’ in State through river-interlinking projects




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Jagan dares govt. to arrest him, says will continue to ‘expose failures’




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Varun Hospitality announces eco-friendly mixed-use project to replace The Gateway Hotel in Visakhapatnam




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Supreme Court sets pan-India guidelines against ‘bulldozer justice,’ calls demolitions without due process unconstitutional

The Apex court maintains that these guidelines do not apply in cases of unauthorized public land construction or where demolition is mandated by a court ruling




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Satish Jarkiholi supporter to lead Belagavi DCC bank

Before the election, the three Jarkiholi brothers — Satish (Congress MLA), Ramesh (BJP MLA), and Balachandra (BJP MLA) — met in a private hotel in Belagavi to discuss the names of candidates




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CRICKET | Tanmay’s 15th Ranji Trophy ton powers Hyderabad to position of strength

The opener makes Andhra pay a heavy price for a dropped catch early in his innings; off-spinner Vijay the pick of the bowlers with his three wickets




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Ranji Trophy | Tamil Nadu has Railways under the cosh with dominant show

CRICKET | Skipper Jagadeesan’s decision to field pays off handsomely as Ajith Ram and Gurjapneet take quick wickets; Ahuja, Saif and Merai hold out with half centuries




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Manipur stuns defending champion Punjab




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Swiggy pre-open trade: Shares jump in trading debut after $1.4-billion IPO

The stock listed at ₹420 on India's National Stock Exchange, compared to its issue price of ₹390




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‘Freelance journalist’ held for extortion in Rein Bazaar




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U.T. seeks Centre’s nod to implement Smart Meter Project with post-paid plan option

There is stiff resistance from various quarters for the pre-paid Smart Meter Project. It will be difficult to introduce the prepaid functionality at the beginning stages of the implementation, says Minister for Home A. Namassivayam in his memorandum submitted to Union Minister for Power Manohar Lal Khattar




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BJP leaders to live with people living alongside Musi river




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Punjab Finance Minister bats for cooperative federalism, structural reforms




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Jairam Tiger Mahto stands in the way in tough battle for NDA and INDIA blocs in Jharkhand

Known for raising local issues, the 30-year-old leader hails from Kurmi (Mahtos) community that comprise 22% of the total population, the largest chunk after tribals and plays a decisive role in at least 30 seats




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Barcelona’s Fati sidelined with hamstring injury

Fati is set to miss the club’s Champions League match against French side Brest on November 26, as well as La Liga matches against Celta Vigo, Las Palmas, Mallorca and Real Betis




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Parthiv Patel gets dual responsibility with Gujarat Titans: batting and assistant coach

Parthiv Patel will perform the dual role in the support staff led by head coach Ashish Nehra




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Sindhu movers to pre-quarters, Lakshya bows out of Kumamoto Masters Japan




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Pro Kabaddi League: Gujarat Giants return to winning ways with big win over Bengal Warriorz

In the second match of the night, Haryana Steelers moved to the top of the table and extended their winning run to four games after defeating the Patna Pirates 37-32




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Man arrested for smuggling PDS rice near Jolarpet town




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Donald Trump meets Joe Biden in White House; both pledge smooth transition

In a brief meeting, the two leaders assured the nation of a peaceful transition of power on January 20, 2025.




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Stray dog menace grips Vijayawada

Up to 100 dog bite cases reported in city every day, claims Coporators; shortage of kennels hits street dog sterilisation programme, says VMC official




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HC refuses to restrain police from arresting Omkar Balaji

Justice A.D. Jagadish Chandira simply adjourns his anticipatory bail plea by a week without granting any interim protection




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Rajasthan Assembly bypolls: 65% voter turnout recorded; largely peaceful

Highest voter turnout of 75.27% was recorded in Ramgarh; independent candidate slaps government officer




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Private college lecturer arrested for sexual assault on job aspirant in Coimbatore




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Youth ‘hooked to radical content online’ detained in J&K’s Kulgam

The youth was “misusing social media for radical propaganda aimed at to instigate common people against the Government of India and also glamourising terrorism in J&K”




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Congress has led Karnataka to bankruptcy, alleges Tejasvi Surya in Mumbai

Under the Congress regime, Karnataka is facing extreme financial crisis; the government has been struggling to manage the State’s economy due to its mismanagement of funds, says the BJP MP




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Hindu Makkal Katchi youth wing leader Omkar Balaji arrested in Chennai 




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The impact of Pradhan Mantri Ujjwala Yojana in Jammu and Kashmir

Expanding the network of LPG distribution points in rural areas and extending financial support for refills could further increase clean fuel adoption




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BJP councillor nominated presiding officer for mayoral polls, AAP raises objections

Mayoral elections today; ruling party says L-G should have considered either incumbent Mayor or most senior councillor for role to ensure fairness; AAP in habit of casting aspersions, says BJP




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ED files Prosecution Complaint against Jaffer Sadiq before Additional CBI Court

A release said 20 persons had been arraigned as accused in the case, and Jaffer Sadiq was identified as the mastermind




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Republicans complete power takeover with House majority

After more than a week of vote counting Republicans party had reached the 218 seats needed to retain their majority in the 435-seat lower chamber, having already seized the Senate from the Democrats.




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Teachers should inculcate reading habit among students, says Swami Jithakamananda