Stephen Kershaw, David J. Morgan, James Boyd, David G. Spiller, Gareth Kitchen, Egor Zindy, Mudassar Iqbal, Magnus Rattray, Chris M. Sanderson, Andrew Brass, Claus Jorgensen, Tracy Hussell, Laura C. Matthews, and David W. Ray

Glucocorticoids (GCs) act through the glucocorticoid receptor (GR) to regulate immunity, energy metabolism, and tissue repair. Upon ligand binding, activated GR mediates cellular effects by regulating gene expression, but some GR effects can occur rapidly without new transcription. We show GCs rapidly inhibit cell migration, in response to both GR agonist and antagonist ligand binding. The inhibitory effect on migration is prevented by GR knockdown with siRNA, confirming GR specificity, but not by actinomycin D treatment, suggesting a non-transcriptional mechanism. We identified a rapid onset increase in microtubule polymerisation following glucocorticoid treatment, identifying cytoskeletal stabilisation as the likely mechanism of action. HDAC6 overexpression, but not knockdown of αTAT1, rescued the GC effect, implicating HDAC6 as the GR effector. Consistent with this hypothesis, ligand-dependent cytoplasmic interaction between GR and HDAC6 was demonstrated by quantitative imaging. Taken together, we propose that activated GR inhibits HDAC6 function and thereby increases the stability of the microtubule network to reduce cell motility. We therefore report a novel, non-transcriptional mechanism whereby GCs impair cell motility through inhibition of HDAC6 and rapid reorganization of the cell architecture.

HD Video Player PUP is a potentially unwanted program that in itself is not malicious, but if installed indicates that you most likely have malware or other potentially uwnanted programs installed as well.

This article was published first at Remove the HD Video Player PUP

Attempting to display the contents of an HDF5 file containing fixed-length UTF-8 encoded strings results in an unexpected error in MATLAB.

For example, the following code

  h5disp('myHDF5FileWithFixedLenUTF8Strings.h5')

returns this error:

Error using h5infoc
UTF-8 encoding is only supported for variable length strings.

Error in h5info (line 108)
hinfo = h5infoc(filename,location, useUtf8);

Error in h5disp>display_hdf5 (line 121)
hinfo = h5info(options.Filename,options.Location);

Error in h5disp (line 99)
display_hdf5(options);

President Trump speaks at the White House Friday. He is replacing an official who issued a report that found testing delays and equipment shortages at hospitals.; Credit: Jim Watson/AFP via Getty Images

President Trump is moving to replace the Department of Health and Human Services watchdog whose office found severe shortages of medical supplies in hospitals as COVID-19 cases surged.

In a Friday night announcement, the White House named Jason Weida as its nominee to take the permanent inspector general post currently occupied by Christi Grimm, who's been in that role in an acting capacity since January.

A longtime staffer with Health and Human Services, Grimm was leading the inspector general's office in April when it issued a report chronicling testing delays — up to seven days in some cases — as well as severe shortages of supplies in hospitals amid the COVID-19 pandemic.

"Hospitals reported that they were unable to keep up with COVID-19 testing demands because they lacked complete kits and/or the individual components and supplies needed to complete tests," the survey of 323 hospitals found. "When patient stays were extended while awaiting test results, this strained bed availability, personal protective equipment (PPE) supplies, and staffing."

The report also recalled how one hospital had even resorted to making its own disinfectant.

Trump reacted to the report by calling its findings "wrong," asking to know the name of the inspector general and suggesting the report was politically motivated. He later took to Twitter to castigate Grimm and the report even further.

"Why didn't the I.G., who spent 8 years with the Obama Administration (Did she Report on the failed H1N1 Swine Flu debacle where 17,000 people died?), want to talk to the Admirals, Generals, V.P. & others in charge, before doing her report. Another Fake Dossier!" Trump tweeted in early April.

Grimm is a career official, not a political appointee, and began serving in the Office of the Inspector General in 1999.

The nomination of Weida — currently an assistant U.S. attorney — marks the latest replacement of a high-level watchdog by the president. A month ago, he fired the inspector general who raised concerns that eventually led to his impeachment. Days later, he removed the inspector general charged with overseeing the government's coronavirus response bill.

Sen. Patty Murray, ranking Democrat on the Health, Education, Labor and Pensions Committee, said that Trump's nominee "must not get through the Senate without ironclad commitments" to continue the agency's current investigations without political interference.

"We all know the President hasn't told people the truth about this virus or his Administration's response, and late last night, he moved to silence an independent government official who did," Murray said in a statement released on Saturday. "Anyone who demands less will be complicit in the President's clear pattern of retaliation against those who tell the truth."

Health and Human Services did not comment to NPR on Grimm's future role, but said in statement that the agency had been preparing "to assist a new Inspector General appointee over a year ago, when the previous presidentially-appointed and senate-confirmed Inspector General first announced his intention to retire from government service. We will continue to work conscientiously to support a smooth leadership transition."

This content is from Southern California Public Radio. View the original story at SCPR.org.

Rick Bright filed a complaint this week with the Office of Special Counsel, a government agency responsible for whistleblower complaints.; Credit: /Public Health Emergency via AP

Attorneys for Rick Bright, the government scientist who said he had been reassigned and subsequently filed a whistleblower complaint, say a government watchdog agrees that he should be reinstated to his post.

Bright was serving as director of the Biomedical Advanced Research and Development Authority, which is working on a vaccine to combat the coronavirus.

He said he was ousted from the position last month because he wanted to spend money on safe and vetted treatments for COVID-19 — not on ones without "scientific merit," such as hydroxychloroquine, the anti-malarial drug that President Trump and others had been touting.

Trump on Wednesday called Bright "a disgruntled employee who's trying to help the Democrats win an election."

Bright's attorneys say that the Office of Special Counsel, which hears whistleblower cases, determined there were "reasonable grounds" to believe that his removal was retaliatory and therefore prohibited.

Bright's attorneys say OSC plans to contact the Department of Health and Human Services to request that it put Bright's removal on hold for 45 days so the office can complete its investigation into the allegations.

The OSC said it "cannot comment on or confirm the status of open investigations."

In a statement to NPR, Caitlin Oakley, a spokesperson for HHS, said: "This is a personnel matter that is currently under review. However, HHS strongly disagrees with the allegations and characterizations in the complaint from Dr. Bright."

This content is from Southern California Public Radio. View the original story at SCPR.org.

Rick Bright filed a complaint this week with the Office of Special Counsel, a government agency responsible for whistleblower complaints.; Credit: /Public Health Emergency via AP

Attorneys for Rick Bright, the government scientist who said he had been reassigned and subsequently filed a whistleblower complaint, say a government watchdog agrees that he should be reinstated to his post.

Bright was serving as director of the Biomedical Advanced Research and Development Authority, which is working on a vaccine to combat the coronavirus.

He said he was ousted from the position last month because he wanted to spend money on safe and vetted treatments for COVID-19 — not on ones without "scientific merit," such as hydroxychloroquine, the anti-malarial drug that President Trump and others had been touting.

Trump on Wednesday called Bright "a disgruntled employee who's trying to help the Democrats win an election."

Bright's attorneys say that the Office of Special Counsel, which hears whistleblower cases, determined there were "reasonable grounds" to believe that his removal was retaliatory and therefore prohibited.

Bright's attorneys say OSC plans to contact the Department of Health and Human Services to request that it put Bright's removal on hold for 45 days so the office can complete its investigation into the allegations.

The OSC said it "cannot comment on or confirm the status of open investigations."

In a statement to NPR, Caitlin Oakley, a spokesperson for HHS, said: "This is a personnel matter that is currently under review. However, HHS strongly disagrees with the allegations and characterizations in the complaint from Dr. Bright."

This content is from Southern California Public Radio. View the original story at SCPR.org.

A bug is making it so users are unable to enable HDR video streaming after upgrading to Windows 10 1903 or later if they previously disabled the setting. [...]

The first project is to develop an automated real-time email-communication solution for customer queries and reduce turn-around time on redressal.

Just in time for the conservationist president's birthday, the U.S. unveils a plan to freeze uranium mining near one of his favorite places: the Grand Canyon.

New study advises women to eat fish while pregnant, but hold the mercury. Researchers evaluated 600 mothers and children and found that children who are exposed

The boy who eats lunch alone in the school office everyday because no one will sit with him now has more than 1.2 million likes on his Facebook birthday page.

Mom posts open invite on Facebook and receives a 'Reddit hug' from the online community.

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Boy asks his friends to celebrate his birthday by volunteering at an animal shelter.

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The Arctic repository is making the unprecedented move to assist researchers sidelined by Syria’s Civil War.

Stephanie Ogden will move from Lloyd’s after just over a year and has ten years’ experience of working at Allianz.

With the inclusion of free or price-reduced TiVo-powered DVRs (digital video recorders), the benefits of DIRECTV have become so much greater.

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The Democrats have taken over Capitol Hill, and have a mandate to withdraw American forces from Iraq ASAP. It is likely that in the medium to long term, this move would have great impact on Israel

A respected voice in his community, Dr. Serwatka's career fights for the equality of many

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Koincable shares what happens inside their factory during the quality control process to make sure that all products meet the required specifications.