The actress found an important way to get involved.

She's pushing back on the expectations of women over 40.

With the Republican establishment attempting to stop real estate mogul Donald Trump from receiving the GOP nomination, a new anti-Trump ad produced by the Emergency Committee for Israel alleges that Trump supports dictators. But what about Democratic presidential candidate Hillary Clinton’s record on dictators? Earlier this week, Clinton addressed the annual AIPAC conference, seeking to cast herself as a stronger ally to Israel than Donald Trump. We examine her record on Israel and U.S. foreign relations at large with Pulitzer Prize-winning journalist Glenn Greenwald, co-founder of The Intercept. Continue reading →

The internet is reacting to comments made by Donald Trump during a COVID-19-related press briefing held yesterday. Trump claimed that the virus could be treated by bringing "light inside the body" or injecting a disinfectant. Thankfully medical professionals were quick to denounce these claims, and people on the internet have since been creating some excellent memes on the matter. 

This should go without saying, but please don't inject yourself with disinfectant, y'all.

I can tell you--after seeing them in the bathroom mirror this morning--this shortcrust pastry recipe will give you les poignées d'amour. That's French for "love handles." Même pas peur? Not even scared? Good! Read on and discover a truly delicious and versatile pâte brisée. I should know...I've tested 10 of them in the past week--ever since you asked for the recipe! Today's Word: la pâte brisée : shortcrust pastry, a rich dough for making pie crust Audio: Listen to the words pâte brisée in this soundfile En cuisine, la pâte brisée est une pâte servant de base aux tartes salées ou sucrées. La pâte brisée désigne généralement une pâte composée principalement de farine et de matière grasse sans sucre. In cooking, shortcrust pastry is a dough used as a base for savory or sweet pies. Shortcrust pastry generally refers to a dough composed mainly of flour and fat, without sugar. Jérôme's Pâte Brisée: 4-ingredient Shortcrust Pastry (makes one large or two small tarts!) Ingredients... 2 cups flour 2 teaspoons baking powder 1/2 cup white wine 1/2 cup sunflower oil Note: ordinary white wine is all you need. Leftover wine will work as long as it hasn't turned to vinegar. For...

WASHINGTON (April 23, 2020) —  Today, the U.S. Environmental Protection Agency (EPA) announced that it is advising eight technology companies that unscrupulous dealers are using their platforms to sell illegal disinfectant products.

WASHINGTON (29 de abril de 2020) —  Hoy, la Agencia de Protección Ambiental (EPA, por sus siglas en inglés) y los Centros para el Control y la Prevención de Enfermedades (CDC) publicaron una 

Lakers star LeBron James on the prospect of games in empty arenas because of the coronavirus outbreak: "I ain't playing if you don't have the fans."

Turns out a range of charlatans out there are peddling industrial bleach as a cure-all.

Tyler Madden is the newest potential piece of the Kings' future, the biggest prospect they acquired in the trades leading up to the NHL deadline.

The NHL hopes to complete its season after suspending play because of the coronavirus, but playing into the middle of the summer creates complications.

The Ducks weren't expected to be a playoff team in 2019-20 and that's how it's played out. But they've made some personnel moves with the future in mind.

The maker of Lysol and another disinfectant says its products should not be used as an internal treatment for the coronavirus.

Tesla Inc. delivered 95,200 vehicles to customers in the second quarter, outperforming analysts' expectations.

Toshi Reagon and her mother, Sweet Honey in the Rock's Bernice Johnson Reagon, adapt Octavia E. Butler's acclaimed novel "Parable of the Sower."

Especialistas apontam que propagação de vírus pode ter começado antes de 25 de fevereiro, quando primeiro paciente foi diagnosticado com a covid-19.

Colts GM Chris Ballard: Let's slow down on anointing Jacob Eason the 'messiah.'

Eason, a five-star recruit who was a freshman starter at Georgia before transferring to Washington, is used to the weight of expectation

Anthony Leal put individual numbers aside at Bloomington South. The result was a 26-0 record.

Every single one of them is supposed to be exercising oversight of the executive branch.

Elana Medo has dedicated many decades of her life to making mother’s milk available to premature babies. Now a questionable trade secret lawsuit threatens to destroy her life’s work and leave preterm infants without access to life-saving milk. The cost of a Corporation Stealing from an Individual has been the loss of human lives — […]

The post Trade Secrets Claimed by Prolacta to Steal Founders’ Company – Again appeared first on ReadWrite.

Do you want to sell more? Who doesn’t? But you might be missing out on some key conversions because you’re not using the right words to promote your products or services.   Take a new approach to writing with some proven “power” words that increase conversions because they deliver reasons to buy, appeal to our […]

Members Event

Event participants

Anders Fogh Rasmussen, Secretary-General, North Atlantic Treaty Organization (NATO)
Chair: Robin Niblett, Director, Chatham House 

7 November 2019

7 May 2020 , Volume 96, Number 3

Invitation Only Research Event

7 October 2016

MS Brown
Jul 1, 1980; 21:505-517
Reviews

7 May 2020 , Volume 96, Number 3

Expert

Exame poderá detectar a doença na fase inicial. Pesquisadores da Faculdade de Medicina Osteopática da Universidade de Rowan, nos Estados Unidos, afirmam que estão perto de desenvolver um exame de sangue para detectar Alzheimer com precisão, o que dar...

The post Teste de sangue para detectar Alzheimer está próximo da realidade appeared first on Saúde Próspera.

M. V. Pratsiovytyi and S. P. Ratushniak
Theor. Probability and Math. Statist. 99 (2020), 211-228.
Abstract, references and article information

7 May 2020 , Volume 96, Number 3

Rationale: Fluorescence molecular endoscopy (FME) is an emerging technique that has the potential to improve the 22% colorectal polyp detection miss-rate. We determined the optimal dose-to-imaging interval and safety of FME using EMI-137, a c-Met targeted fluorescent peptide, in a population at high-risk for colorectal cancer. Methods: We performed in vivo FME and quantification of fluorescence by multi-diameter single-fiber reflectance, single-fiber fluorescence spectroscopy in 15 patients with a dysplastic colorectal adenoma. EMI-137 was intravenously administered (0.13mg/kg) at a one-, two- or three-hour dose-to-imaging interval (N = 3 patients per cohort). Two cohorts were expanded to six patients based on target-to-background ratios (TBR). Fluorescence was correlated to histopathology and c-Met expression. EMI-137 binding specificity was assessed by fluorescence microscopy and in vitro experiments. Results: FME using EMI-137 appeared to be safe and well tolerated. All dose-to-imaging intervals showed significantly increased fluorescence in the colorectal lesions compared to surrounding tissue, with a TBR of 1.53, 1.66 and 1.74 respectively (mean intrinsic fluorescence (Q·μ^f_a,x) = 0.035 vs. 0.023mm^-1, P<0.0003; 0.034 vs. 0.021mm^-1, P<0.0001; 0.033 vs. 0.019mm^-1, P<0.0001). Fluorescence correlated to histopathology on a macroscopic and microscopic level, with significant c-Met overexpression in dysplastic mucosa. In vitro, a dose-dependent specific binding was confirmed. Conclusion: FME using EMI-137 appeared to be safe and feasible within a one-to-three hour dose-to-imaging interval. No clinically significant differences were observed between the cohorts, although a one-hour dose-to-imaging interval was preferred from a clinical perspective. Future studies will investigate EMI-137 for improved colorectal polyp detection during screening colonoscopies.

At diagnosis 22% of colorectal cancer (CRC) patients have metastases and 50% later develop metastasis. Peptide receptor radionuclide therapy (PRRT) with lutetium-177 (¹⁷⁷Lu)-PSMA-617 is employed to treat metastatic prostate cancer (PC). ¹⁷⁷Lu-PSMA-617 targets Prostate Specific Membrane Antigen (PSMA) a cell surface protein enriched in PC and the neovasculature of other solid tumors including CRC. We performed gallium-68 (⁶⁸Ga)-PSMA-11 PET-CT imaging of ten metastatic CRC patients to assess metastasis avidity. Eight patients had lesions lacking avidity and two had solitary metastases exhibiting very low avidity. Despite expression of PSMA in CRC neovasculature, none of the patients exhibited tumor avidity sufficient to be considered for ¹⁷⁷Lu-PSMA-617 PRRT.

The purpose of this study was to establish the dose-response relationship of selective internal radiation therapy (SIRT) in patients with metastatic colorectal cancer (mCRC), when informed by radiobiological sensitivity parameters derived from mCRC cell lines exposed to yttrium-90 (⁹⁰Y). Methods: 23 mCRC patients with liver metastases refractory to chemotherapy were included. ⁹⁰Y bremsstrahlung SPECT images were transformed into dose maps assuming the local dose deposition method. Baseline and follow-up CT scans were segmented to derive liver and tumor volumes. Mean, median, and D₇₀ (minimum dose to 70% of tumor volume) values determined from dose maps were correlated with change in tumor volume and vRECIST response using linear and logistic regression, respectively. Radiosensitivity parameters determined by clonogenic assays of mCRC cell lines HT-29 and DLD-1 after exposure to ⁹⁰Y or external beam radiotherapy (EBRT; 6MV photons) were used in biological effective dose (BED) calculations. Results: Mean administered radioactivity was 1469±428 MBq (847-2185 MBq), achieving a mean radiation absorbed tumor dose of 35.5±9.4 Gy and mean normal liver dose of 26.4±6.8 Gy. A 1.0 Gy increase in mean, median, and D₇₀ absorbed dose was associated with reduction in tumor volume of 1.8%, 1.8%, and 1.5%, respectively, and increased probability of vRECIST response (odds ratio: 1.09, 1.09, and 1.10 respectively). Threshold mean, median and D₇₀ doses for response were 48.3, 48.8, and 41.8 Gy respectively. EBRT-equivalent BEDs for ⁹⁰Y are up to 50% smaller than those calculated by applying protraction-corrected radiobiological parameters derived from EBRT alone. Conclusion: Dosimetric studies have assumed equivalence between ⁹⁰Y SIRT and EBRT, leading to inflation of BED for SIRT and possible under-treatment. Radiobiological parameters for ⁹⁰Y were applied to a BED model, providing a calculation method that has the potential to improve assessment of tumor control.

Colorectal cancer (CRC) arises as the consequence of progressive changes from normal epithelial cells through polyp to tumor, and thus is an useful model for studying metabolic shift. In the present study, we studied the metabolomic profiles using high analyte specific gas chromatography/mass spectrometry (GC/MS) and liquid chromatography tandem mass spectrometry (LC/MS/MS) to attain a systems-level view of the shift in metabolism in cells progressing along the path to CRC. Colonic tissues including tumor, polyps and adjacent matched normal mucosa from 26 patients with sporadic CRC from freshly isolated resections were used for this study. The metabolic profiles were obtained using GC/MS and LC/MS/MS. Our data suggest there was a distinct profile change of a wide range of metabolites from mucosa to tumor tissues. Various amino acids and lipids in the polyps and tumors were elevated, suggesting higher energy needs for increased cellular proliferation. In contrast, significant depletion of glucose and inositol in polyps revealed that glycolysis may be critical in early tumorigenesis. In addition, the accumulation of hypoxanthine and xanthine, and the decrease of uric acid concentration, suggest that the purine biosynthesis pathway could have been substituted by the salvage pathway in CRC. Further, there was a step-wise reduction of deoxycholic acid concentration from mucosa to tumors. It appears that to gain a growth advantage, cancer cells may adopt alternate metabolic pathways in tumorigenesis and this flexibility allows them to adapt and thrive in harsh environment.

7 May 2020 , Volume 96, Number 3

11 December 2019

Milk production may involve a transient development of insulin resistance in non-mammary tissues to support redistribution of maternal macronutrients to match the requirements of the lactating mammary gland. In the present study, adipose and liver metabolic responses were measured in the fasting state and during a 2-step (10 and 20 mU/m²/min) hyperinsulinemic-euglycemic clamp with stable isotopes, in 6-week postpartum women who were lactating (n=12) or formula-feeding (n=6) their infants and who were closely matched for baseline characteristics (e.g., parity, body composition, intrahepatic lipid). When controlling for the low insulin concentrations of both groups, the lactating women exhibited a fasting rate of endogenous glucose production (EGP) that was 2.6-fold greater, and a lipolysis rate that was 2.3-fold greater than the formula-feeding group. During the clamp, the groups exhibited similar suppression rates of EGP and lipolysis. In the lactating women only, higher prolactin concentrations were associated with greater suppression rates of lipolysis, lower intrahepatic lipid and plasma triacylglycerol concentrations. These data suggest that whole-body alterations in glucose transport may be organ specific and facilitate nutrient partitioning during lactation. Recapitulating a shift toward noninsulin-mediated glucose uptake could be an early postpartum strategy to enhance lactation success in women at risk for delayed onset of milk production.

Adipose tissue macrophages (ATMs) are involved in the development of insulin resistance in obesity. We have recently shown that myeloid cell–specific reduction of HMG-CoA reductase (Hmgcr^m–/m–), which is the rate-limiting enzyme in cholesterol biosynthesis, protects against atherosclerosis by inhibiting macrophage migration in mice. We hypothesized that ATMs are harder to accumulate in Hmgcr^m–/m– mice than in control Hmgcr^fl/fl mice in the setting of obesity. To test this hypothesis, we fed Hmgcr^m–/m– and Hmgcr^fl/fl mice a high-fat diet (HFD) for 24 weeks and compared plasma glucose metabolism as well as insulin signaling and histology between the two groups. Myeloid cell–specific reduction of Hmgcr improved glucose tolerance and insulin sensitivity without altering body weight in the HFD-induced obese mice. The improvement was due to a decrease in the number of ATMs. The ATMs were reduced by decreased recruitment of macrophages as a result of their impaired chemotactic activity. These changes were associated with decreased expression of proinflammatory cytokines in adipose tissues. Myeloid cell–specific reduction of Hmgcr also attenuated hepatic steatosis. In conclusion, reducing myeloid HMGCR may be a promising strategy to improve insulin resistance and hepatic steatosis in obesity.

The increase in life expectancy in England has almost “ground to a halt” since 2010 and austerity measures are likely to be a significant contributor. In this podcast Michael Marmot, director at University College London’s Institute of Health Equity, joins us to discuss what might be causing that drop off, and why a decrease in early life chances...

Members Event Webinar

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Professor Matthew Goodwin, Visiting Senior Fellow, Europe Programme, Chatham House
Professor David Cutts, Associate Fellow, Europe Programme, Chatham House

Interview with Ari Nieh, with commentary from Yvonne Lai Like many of us, I began teaching online this Spring. Unlike many of us, I began doing so at the start of the semester. I am co-teaching a class at Michigan … Continue reading →