New workshop in London / remote Link - Enterprise AI workshop – Sep 2018 – in London or remote     AI / Deep Learning applications course/ mentoring program – hands-on experience with limited spaces I am pleased to announce a new course on AI Applications The course combines elements of teaching, coaching and [...]

Apple is about to make losing your luggage far less of a hassle. The Cupertino tech giant is readying the… Continue reading Apple is about to eliminate the stress of losing a suitcase

The post Apple is about to eliminate the stress of losing a suitcase appeared first on ReadWrite.

Roland Bruderer
May 1, 2015; 14:1400-1410
Research

Christian Tagwerker
Apr 1, 2006; 5:737-748
Research

Albrecht Gruhler
Mar 1, 2005; 4:310-327
Research

Yinji Li, Zhiwei Wang and Xiangyu Zhou
Trans. Amer. Math. Soc. 377 (), 5947-5992.
Abstract, references and article information

Ta Cong Son, Tran Manh Cuong, Le Quang Dung and Le Van Dung
Theor. Probability and Math. Statist. 111 (), 153-165.
Abstract, references and article information

On October 24 and 25, SophosAI presents ideas on how to use models large and small—and defend against malignant ones.

Alison B. Ross
Nov 30, 2020; 0:R120.002190v1-mcp.R120.002190
Review

Diana Samodova
Dec 1, 2020; 19:2139-2156
Technological Innovation and Resources

If you have configured more than one SAS Application Server, then SAS Visual Data Builder might unexpectedly use the wrong application server when you preview or schedule queries. This problem occurs even though you h

The SAS 9.4M4 (TS1M4) Hot Fix D7G004 for ODS Templates installs national language support (NLS) content regardless of whether the languages were installed during the initial deployment. Having sparse

Trypsin is the protease of choice in bottom-up proteomics. However, its application can be limited by the amino acid composition of target proteins and the pH of the digestion solution. In this study we characterize ProAlanase, a protease from the fungus Aspergillus niger that cleaves primarily on the C-terminal side of proline and alanine residues. ProAlanase achieves high proteolytic activity and specificity when digestion is carried out at acidic pH (1.5) for relatively short (2 h) time periods. To elucidate the potential of ProAlanase in proteomics applications, we conducted a series of investigations comprising comparative multi-enzymatic profiling of a human cell line proteome, histone PTM analysis, ancient bone protein identification, phosphosite mapping and de novo sequencing of a proline-rich protein and disulfide bond mapping in mAb. The results demonstrate that ProAlanase is highly suitable for proteomics analysis of the arginine- and lysine-rich histones, enabling high sequence coverage of multiple histone family members. It also facilitates an efficient digestion of bone collagen thanks to the cleavage at the C terminus of hydroxyproline which is highly prevalent in collagen. This allows to identify complementary proteins in ProAlanase- and trypsin-digested ancient bone samples, as well as to increase sequence coverage of noncollagenous proteins. Moreover, digestion with ProAlanase improves protein sequence coverage and phosphosite localization for the proline-rich protein Notch3 intracellular domain (N3ICD). Furthermore, we achieve a nearly complete coverage of N3ICD protein by de novo sequencing using the combination of ProAlanase and tryptic peptides. Finally, we demonstrate that ProAlanase is efficient in disulfide bond mapping, showing high coverage of disulfide-containing regions in a nonreduced mAb.

In all cells, proteins are continuously synthesized and degraded in order to maintain protein homeostasis and modify gene expression levels in response to stimuli. Collectively, the processes of protein synthesis and degradation are referred to as protein turnover. At steady state, protein turnover is constant to maintain protein homeostasis, but in dynamic responses, proteins change their rates of synthesis and degradation in order to adjust their proteomes to internal or external stimuli. Thus, probing the kinetics and dynamics of protein turnover lends insight into how cells regulate essential processes such as growth, differentiation, and stress response. Here we outline historical and current approaches to measuring the kinetics of protein turnover on a proteome-wide scale in both steady-state and dynamic systems, with an emphasis on metabolic tracing using stable-isotope-labeled amino acids. We highlight important considerations for designing proteome turnover experiments, key biological findings regarding the conserved principles of proteome turnover regulation, and future perspectives for both technological and biological investigation.

Online Disinformation and Political Discourse: Applying a Human Rights Framework Research paper sysadmin 5 November 2019

Although some digital platforms now have an impact on more people’s lives than does any one state authority, the international community has been slow to hold to account these platforms’ activities by reference to human rights law.

This paper examines how human rights frameworks should guide digital technology.

Summary

• Online political campaigning techniques are distorting our democratic political processes. These techniques include the creation of disinformation and divisive content; exploiting digital platforms’ algorithms, and using bots, cyborgs and fake accounts to distribute this content; maximizing influence through harnessing emotional responses such as anger and disgust; and micro-targeting on the basis of collated personal data and sophisticated psychological profiling techniques. Some state authorities distort political debate by restricting, filtering, shutting down or censoring online networks.
• Such techniques have outpaced regulatory initiatives and, save in egregious cases such as shutdown of networks, there is no international consensus on how they should be tackled. Digital platforms, driven by their commercial impetus to encourage users to spend as long as possible on them and to attract advertisers, may provide an environment conducive to manipulative techniques.
• International human rights law, with its careful calibrations designed to protect individuals from abuse of power by authority, provides a normative framework that should underpin responses to online disinformation and distortion of political debate. Contrary to popular view, it does not entail that there should be no control of the online environment; rather, controls should balance the interests at stake appropriately.
• The rights to freedom of thought and opinion are critical to delimiting the appropriate boundary between legitimate influence and illegitimate manipulation. When digital platforms exploit decision-making biases in prioritizing bad news and divisive, emotion-arousing information, they may be breaching these rights. States and digital platforms should consider structural changes to digital platforms to ensure that methods of online political discourse respect personal agency and prevent the use of sophisticated manipulative techniques.
• The right to privacy includes a right to choose not to divulge your personal information, and a right to opt out of trading in and profiling on the basis of your personal data. Current practices in collecting, trading and using extensive personal data to ‘micro-target’ voters without their knowledge are not consistent with this right. Significant changes are needed.
• Data protection laws should be implemented robustly, and should not legitimate extensive harvesting of personal data on the basis of either notional ‘consent’ or the data handler’s commercial interests. The right to privacy should be embedded in technological design (such as by allowing the user to access all information held on them at the click of a button); and political parties should be transparent in their collection and use of personal data, and in their targeting of messages. Arguably, the value of personal data should be shared with the individuals from whom it derives.
• The rules on the boundaries of permissible content online should be set by states, and should be consistent with the right to freedom of expression. Digital platforms have had to rapidly develop policies on retention or removal of content, but those policies do not necessarily reflect the right to freedom of expression, and platforms are currently not well placed to take account of the public interest. Platforms should be far more transparent in their content regulation policies and decision-making, and should develop frameworks enabling efficient, fair, consistent internal complaints and content monitoring processes. Expertise on international human rights law should be integral to their systems.
• The right to participate in public affairs and to vote includes the right to engage in public debate. States and digital platforms should ensure an environment in which all can participate in debate online and are not discouraged from standing for election, from participating or from voting by online threats or abuse.

What can be achieved using applications such as AI/ML, Deep Learning, and Big Data Analytics has been revolutionized by Magnum IO GPUDirect Storage’s capabilities. Agencies have invested in these solutions […]

The post Accelerating GPU Based Applications with NVIDIA Validated Magnum IO GPUDirect Storage and Pavilion appeared first on HPCwire.

LONDON, Nov. 1, 2024 — Quantum Motion, a UK-based quantum computing scale-up founded by Professor John Morton, University College London (UCL), and Professor Simon Benjamin, University of Oxford, has worked […]

The post Quantum Motion and Goldman Sachs Identify Quantum Applications in Financial Services Project appeared first on HPCwire.

Sept. 23, 2024 — Altera, an Intel Company, today unveiled an array of FPGA hardware, software and development tools that make its programmable solutions more accessible across a broader range of […]

The post Intel’s Altera Unveils New FPGA Tools and Kits to Boost AI and Edge Applications appeared first on HPCwire.

Chip-maker Nvidia on Friday briefly became the world's most valuable company after surpassing Apple in total market value, but Apple regained its top position by the close of trading.

The demand for substitute teacher positions is outpacing the supply, and the quality of those applying is a concern in many places.

The pilot, which was initially one of the most buzzed about pieces of ESSA, allows states to try out new forms of testing in a handful of districts, with the goal of eventually taking them statewide.

An audit of the early-childhood education offerings in Minnesota finds complexity and fragmentation as well as a lack of data about program effectiveness.

Estimating the direction of functional connectivity (FC) can help further elucidate complex brain function. However, the estimation of directed FC at the voxel level in fMRI data, and evaluating its performance, has yet to be done. We therefore developed a novel directed seed-based connectivity analysis (SCA) method based on normalized pairwise Granger causality that provides greater detail and accuracy over ROI-based methods. We evaluated its performance against 145 cortical retrograde tracer injections in male and female marmosets that were used as ground truth cellular connectivity on a voxel-by-voxel basis. The receiver operating characteristic (ROC) curve was calculated for each injection, and we achieved area under the ROC curve of 0.95 for undirected and 0.942 for directed SCA in the case of high cell count threshold. This indicates that SCA can reliably estimate the strong cellular connections between voxels in fMRI data. We then used our directed SCA method to analyze the human default mode network (DMN) and found that dlPFC (dorsolateral prefrontal cortex) and temporal lobe were separated from other DMN regions, forming part of the language-network that works together with the core DMN regions. We also found that the cerebellum (Crus I-II) was strongly targeted by the posterior parietal cortices and dlPFC, but reciprocal connections were not observed. Thus, the cerebellum may not be a part of, but instead a target of, the DMN and language-network. Summarily, our novel directed SCA method, visualized with a new functional flat mapping technique, opens a new paradigm for whole-brain functional analysis.

FAO Director-General José Graziano da Silva today praised UN Secretary-General Ban Ki Moon for his support in the fight against hunger at a meeting with FAO member countries, the Committee [...]

Put your hands together for our host, Eric Schulze, as he dives into history to answer your questions.

The Pinecrest Queensway and Somerset West health centres are aiming to get a slice of $370 million of provincial funding to operate centres focused on addictions recovery and links to supportive housing.

R&D ‘Sandbox’ Previews Some Potential Capabilities for 3D CAD Software

Real-time Integration of 2D Schematics and 3D Models Allows Mechanical and Electrical Teams to Better Collaborate and Deliver More Accurate Designs

New Conceptual, Instinctive, Social, Connected Design Application Introduced at SOLIDWORKS World 2014

Reduces Time to Create Regulatory Reports While Increasing Data Accuracy

The long-rumored Apple Ring continues to generate buzz as industry insiders speculate on its potential to reshape health tech, despite uncertainty around its release.

Wearable technology has evolved rapidly, with smartwatches and fitness trackers leading the charge. Both Samsung and Apple are now delving into more discrete, ring-style wearables, which offer a more subtle and comfortable way to gather health data compared to traditional wrist-worn devices.

Samsung may release its Galaxy Ring 2 soon, while Apple explores not just rings but also band and glasses-based wearables.


Rumor Score: ???? Possible


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Apple is set to streamline its retail displays, making way for new Mac models by downgrading the Apple Vision Pro demo experience.

Starting November 8, Apple will pilot a revised store layout in select retail locations, merging the Vision Pro demo and display tables. The shift will make space for the latest Mac products, including the M4 models.

The new format will reduce the two separate Vision Pro tables — a layout for demo and display units — into a single, multifunctional table. Along with accommodating new Mac displays, Apple's move will address low Vision Pro sales.


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Apple now has an official password manager, but importing your old passwords from other apps into Apple Passwords can be a bit of a pain.

The introduction of iOS 18 and macOS Seqouia has seen the old iCloud Keychain be rolled into the new Apple Passwords app, alongside a few other Apple password management features. If you already use a password manager outside of iCloud Keychain, you'll probably want to import your passwords if you intend on using Apple Passwords.

Do note that Apple's new Passwords app is really built for storing login passwords. It does not, as yet, store the items like credit card numbers, software serial numbers, or secure documents, that other password managers too.


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The first reviews of the New Mac mini, iMac, and MacBook Pro, are in — and surprisingly range from delight to strange cynicism. Plus there are yet more rumors of the next Apple Vision Pro, but you need not hold your breath.

Typical. You wait ages for a new Mac and three of them turn up — to mixed reviews. That's not mixed as in some reviews are critical while others are not, it's that some are fulsome while others are begrudging.



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Maybe there isn't one giant improvement in the iPhone 16 Pro Max from its predecessor, but there are many improvements worth the steep price of admission.

The iPhone 16 Pro Max is a curious device. While it has a fractionally larger screen than last time, so does the iPhone 16 Pro.

And while it has a new Camera Control button, so does every model in the iPhone 16 range.


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Apple is likely to launch a refreshed Apple Vision Pro headset before a cheaper version of the product arrives, according to a new report.

Apple is believed to be working on "several ideas" for its overall Apple Vision product line and its future intentions. Currently, it is expected that an updated Apple Vision Pro will be the first, ahead of a rumored cheaper "Apple Vision" headset.

The next Apple Vision Pro would likely sport an M5 processor and other internal changes, but would otherwise be very similar to the existing model. It's expected to arrive in late 2025, reports Bloomberg, or the spring of 2026.


Rumor Score: ???? Possible


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Repair parts for the iPhone 16 lineup are now available to order in the US and other countries, including for those wanting to fix their iPhone for themselves.

Following the release of the repair manuals for the iPhone 16 in September, it's now possible to acquire replacement parts for repairs from Apple directly. This is a continuation of a move starting in 2022 towards more user repairability of its products.

Batteries, one of the most common replacement parts, sell for $99 for the iPhone 16 and iPhone 16 Plus, or $119 for the iPhone 16 Pro or Pro Max. Likewise, replacement camera assemblies cost $169 or $249, depending on the model.


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It's been more than a year since Apple Watch Ultra 2 launched, and we've had the wearable that's only gotten better on our wrist the whole time.

I do these extended long-term reviews often on Apple products, often by the time a new model has launched. I see how my opinions have changed with extended use and whether or not it was and is worth buying now.

If this was like any other year, I'd probably have the Apple Watch Ultra 2 on one wrist and the Apple Watch Ultra 3 on the other - but not this time.


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A US order to TSMC to cut AI chip supplies to China over Huawei sanctions won't cause problems for Apple. However, Taiwan's prohibition of TSMC producing 2-nanometer chips elsewhere could make an impact.

U.S. sanctions against Huawei has caused problems for TSMC over attempts by intermediaries to order certain AI-based chip designs on Huawei's behalf. From Monday, TSMC is suspending shipments of the AI-focused chips to China, on the orders of the United States.

The Department of Commerce imposed export restrictions of select chip designs that were intended to be shipped to China, an unnamed source of Reuters claims. The shipment ban, which kicks in from Monday, affects certain types of chips made with 7-nanometer processes or advanced designs, intended for AI or graphics processing.


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On this episode of the HomeKit Insider Podcast we talk about Apple's new betas, discuss the major Matter 1.4 release which adds new categories and other improvements, and more!

Before jumping into Matter, we got several new beta updates from Apple. For example, tvOS 18.2 added behind the scenes code to soon enable the new slate of wallpapers.

On Vision Pro, visionOS 2.2 added new ultra-wide mirroring options for the Mac. Finally, macOS Sequoia 15.2 adds new control for mirroring where the user can display a single window/app, extend the display, or duplicate your whole display.


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Proposed tariffs under the Trump administration could trigger considerable price increases for consumer electronics in the United States, though Apple may be able to weather the storm.

During his first time in office, President Donald Trump's trade war with China resulted in price increases. While there were threats that Apple's products would be dinged by tariffs, Tim Cook's regular Trump talks helped Apple avoid being hurt by the import charges.

For Trump's second term in office, it seems that a similar situation could happen again, with Chinese imports being hit with high tariffs. However, this time Apple is in a much better position.


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Apple's 2024 Mac mini stashes the power button underneath, a bold move that executives say aligns with user habits, even if it's left some fans scratching their heads.

The company's latest Mac mini is significantly downsized — about half the size of its predecessor. The overhaul makes it more compact and gave Apple's designers challenges in laying out external features.

Apple's Vice Presidents, Greg Joswiak, Apple's Senior Vice President of Worldwide Marketing, and John Ternus, Senior Vice President of Hardware Engineering, explained to IThome. They emphasized that the compact form factor still makes it easy to access the button by tucking a finger underneath to press it.


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Apple has released new firmware for the AirPods Pro 2 and AirPods 4, another software update for its personal audio devices.

Apple has been uncharacteristically frequent with its firmware updates for its AirPods product lines. The relatively high tempo of updates has continued with yet another AirPods firmware update.

Rolled out on Monday, the latest firmware updates are for the AirPods Pro 2 with both Lightning and USB-C charging cases, as well as both of the AirPods 4 models.


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Apple Musicis turning its "100 Best Albums" list into a luxurious collectible book, bringing iconic records from the screen to your shelf.

Earlier in 2024, Apple launched its "100 Best Albums" list directly in the Apple Music app, sparking plenty of lively debates among fans. Now, the company is releasing the list in a different medium.

The Apple Music: 100 Best Albums book is a heavyweight in more ways than one. It weighs 8 pounds and has luxurious touches like a linen cover, gold page edges, and an acrylic slipcase. Each copy is hand-numbered, making it a unique piece of music history.


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The third developer beta of iOS 18.2 is now available for all compatible iPhone models, as Apple Intelligence testing continues. Here's everything you need to know about the update.

On Monday, Apple released iOS 18.2 developer beta 3, with build number 22C5131e, up from the previous 22C5125e. While the update is compatible with devices as old as the iPhone XS and iPhone XR, the software includes a variety of Apple Intelligence features that only work on iPhone 15 Pro, iPhone 15 Pro Max, and the iPhone 16 range.

The iOS 18.2 update introduces support for Image Playground, Genmoji, Visual Intelligence, and ChatGPT integration via Siri. There's also a new FindMy feature that helps users locate lost luggage or AirTags.


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A newly-discovered iPhone 14 Pro prototype features one of the earliest known incarnations of Apple's scrapped haptic button project.

Back in July of 2024, AppleInsider published exclusive imagery of a prototype iPhone 15 Pro Max equipped with Apple's long-rumored haptic buttons. Developed under the codename Project Bongo, the haptic buttons were supposed to make their debut in 2023 but never ended up on mass-production units.




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