after Driver jumps from overpass into Trinity River after crash on I-35 in Fort Worth, causing heavy traffic By www.yahoo.com Published On :: 2024-11-12T12:49:59Z Full Article
after U.S. serviceman finally laid to rest, more than 50 years after being killed in Vietnam By www.yahoo.com Published On :: 2024-11-12T00:35:58Z Full Article
after See it: Vehicle falls into North Carolina gorge after driver disregards I-40 closure following Helene By www.yahoo.com Published On :: 2024-11-11T16:39:36Z Full Article
after Man escapes from SUV after driving into Canandaigua Lake from City Pier By www.yahoo.com Published On :: 2024-11-12T22:59:27Z Full Article
after Artsakh Uprooted: Aftermaths of Displacement By www.atour.com Published On :: Mon, 14 Oct 2024 19:10:00 UT Artsakh Uprooted: Aftermaths of Displacement Full Article Armenian Assyrian and Hellenic Genocide News
after CRISPR Immune Cells Not Only Survive, They Thrive After Infusion Into Cancer Patients By scienceblogs.com Published On :: Thu, 06 Feb 2020 19:52:53 +0000 CRISPR Immune Cells Not Only Survive, They Thrive After Infusion Into Cancer Patients In the first-ever (sanctioned) investigational use of multiple edits to the human genome, a study found that cells edited in three specific ways and then removed from patients and brought back into the lab setting were able to kill cancer months after their original manufacturing and infusion. This is the first U.S. clinical trial to test the gene editing approach in humans, and the publication of this new data today follows on the initial report last year that researchers were able to use CRISPR/Cas9 technology to successfully edit three cancer patients' immune cells. The ongoing study is a cooperative between Tmunity Therapeutics, the Parker Institute for Cancer Immunotherapy, and the University of Pennsylvania. Patients on this trial were treated by Edward A. Stadtmauer, MD, section chief of Hematologic Malignancies at Penn, co-lead author on the study. The approach in this study is closely related to CAR T cell therapy, in which patient immune cells are engineered to fight cancer, but it has some key differences. Just like CAR T, researchers in this study began by collecting a patient's T cells from blood. However, instead of arming these cells with a receptor against a protein such as CD19, the team first used CRISPR/Cas9 editing to remove three genes. The first two edits removed a T cell's natural receptors so they can be reprogrammed to express a synthetic T cell receptor, allowing these cells to seek out and destroy tumors. The third edit removed PD-1, a natural checkpoint that sometimes blocks T cells from doing their job. Once the three genes are knocked out, a fourth genetic modification was accomplished using a lentivirus to insert the cancer-specific synthetic T cell receptor, which tells the edited T cells to target an antigen called NY-ESO-1. Previously published data show these cells typically survive for less than a week, but this new analysis shows the edited cells used in this study persisted, with the longest follow up at nine months. Several months after the infusion, researchers drew more blood and isolated the CRISPR-edited cells for study. When brought back into the lab setting, the cells were still able to kill tumors. The CRISPR-edited T cells used in this study are not active on their own like CAR T cells. Instead, they require the cooperation of a molecule known as HLA-A*02:01, which is only expressed in a subset of patients. This means that patients had to be screened ahead of time to make sure they were a match for the approach. Participants who met the requirements received other clinically-indicated therapy as needed while they waited for their cells to be manufactured. Once that process was completed, all three patients received the gene-edited cells in a single infusion after a short course of chemotherapy. Analysis of blood samples revealed that all three participants had the CRISPR-edited T cells take root and thrive in the patients. While none responded to the therapy, there were no treatment-related serious adverse events. CRISPR technology has not previously been tested in humans in the U.S. so the research team had to move through a comprehensive and rigorous series of institutional and federal regulatory approval steps, including approval by the National Institutes of Health's Recombinant DNA Research Advisory Committee and review by the U.S. Food and Drug Administration, as well as Penn's institutional review board and institutional biosafety committee. The entire process required more than two years. Researchers say these new data will open the door to later stage studies to investigate and extend this approach to a broader field beyond cancer, several of which are already planned at Penn. sb admin Thu, 02/06/2020 - 14:52 Categories Life Sciences Full Article
after Cedars-Sinai terminates OB-GYN's hospital privileges after complaint investigation By www.latimes.com Published On :: Sat, 14 Sep 2024 10:00:28 GMT An obstetrician-gynecologist has been barred from practicing at Cedars-Sinai following an investigation into complaints. The doctor has denied wrongdoing. Full Article
after Tooth decay still plagues California kids nearly a decade after Medi-Cal promised change By www.latimes.com Published On :: Tue, 17 Sep 2024 10:00:32 GMT Kids in California struggle with more cavities than kids in most states, despite Medi-Cal efforts to fix dental care administrative hurdles and focus on prevention. Full Article
after Infant mortality in the U.S. worsened after Supreme Court limited abortion access By www.latimes.com Published On :: Mon, 21 Oct 2024 15:00:06 GMT Just months after the Supreme Court limited abortion access, infant mortality rates rose significantly higher, according to a new study. Full Article
after Gas prices could rise after vote by California regulators By www.latimes.com Published On :: Sat, 9 Nov 2024 05:46:28 GMT Gas prices could rise after vote by California regulators Full Article
after US lowers El Salvador travel advisory to Level 2 after caucus protest By www.washingtonexaminer.com Published On :: Tue, 12 Nov 2024 22:31:41 +0000 The United States lowered El Salvador’s travel advisory to Level 2 after protests from the Congressional El Salvador Caucus. The United States had previously refused to lower the country’s travel designation from Level 3, “Reconsider Travel,” the second-highest rating possible, despite the transformation of the country’s crime situation. Over the past decade, the country had […] Full Article World Central America Congress El Salvador Nayib Bukele Travel
after Caps defenseman Mike Green retaliates after attempted slew foot By www.washingtonexaminer.com Published On :: Mon, 13 May 2013 04:00:00 GMT The Capitals were upset with a lot of calls on Sunday in a 1-0 loss to the New York Rangers. Maybe a better way to say it – they were upset about non-calls. New York, the most disciplined team in the NHL this season, wasn’t whistled for a single penalty. Washington took five – two of them obvious, and dumb, retaliation penalties. Full Article
after Bradley Beal crisp in return after six-game absence By www.washingtonexaminer.com Published On :: Mon, 18 Mar 2013 04:00:00 GMT Bradley Beal looked like himself again in his first minutes back on the court in a 127-105 victory over Phoenix on Saturday following six missed games with a sprained left ankle. Full Article
after PGA Tour adds Tiger Woods to policy board after criticism by players over transparency By www.washingtonexaminer.com Published On :: Tue, 01 Aug 2023 17:53:48 GMT The PGA Tour announced it is adding Tiger Woods to its policy board and making changes to its governance after criticism from several players over the lack of transparency in the lead-up to the announced deal between the PGA Tour and the Saudi-backed LIV Golf in June. Full Article
after Randy Travis releases new music with the help of AI after a stroke By www.latimes.com Published On :: Tue, 7 May 2024 17:16:20 GMT Randy Travis has released a new song, "Where That Came From," with the help of artificial intelligence. It's his first single since he had a stroke. Full Article
after Trump plans to raise money in California in the aftermath of felony conviction By www.latimes.com Published On :: Fri, 31 May 2024 16:51:37 GMT Former President Trump is scheduled to headline fundraisers in San Francisco, Beverly Hills and Newport Beach next week after his felony convictions. Full Article
after After a glitchy start, Trump encounters a sympathetic interviewer in Elon Musk By www.latimes.com Published On :: Mon, 12 Aug 2024 22:19:20 GMT Former President Trump returned to X, formerly Twitter, posting multiple videos as he seeks to rebuild momentum for his flagging campaign. Full Article
after Online fraudster on the loose after bilking investors out of millions with fake inventions, websites By www.latimes.com Published On :: Thu, 5 Sep 2024 18:53:21 GMT Santa Clara County fraudster Dennis Fountaine fled sentencing last month. Fountaine was convicted of three felony counts of grand theft by fraud. He also admitted to the aggravated white-collar enhancement for defrauding four victims of over $350,000. Full Article
after Sonos tries to get its groove back after upsetting loyal customers By www.latimes.com Published On :: Fri, 4 Oct 2024 10:00:37 GMT Sonos, known for its wireless speakers, has a plan to earn back trust from its customers after the botched launch of a new app angered its fans as competition with Google, Apple and other companies heats up. Full Article
after After year of adversity, Stallworth glad to be back By www.washingtonexaminer.com Published On :: Tue, 11 Jun 2013 04:00:00 GMT When Donte Stallworth signed with New England last offseason, Redskins coach Mike Shanahan told him he’d made a mistake. Shanahan was smiling when he said that today. But Shanahan admitted he did not want to lose Stallworth a year ago. Full Article
after New Jersey politician refuses to resign after alleged hit-and-run By www.washingtonexaminer.com Published On :: Thu, 18 Aug 2022 18:47:20 GMT A Jersey City councilwoman refused to step down from office Wednesday night amid outcry over an alleged hit-and-run last month. Full Article
after Alaska Airlines flight makes emergency return to Portland after losing window By www.washingtonexaminer.com Published On :: Sat, 06 Jan 2024 03:51:27 GMT An Alaska Airlines flight was forced to return to Portland, Oregon, on Friday, after a window on the Boeing blew off midflight. Full Article
after WATCH: Chicago Bears player dramatically flops after shove By www.washingtonexaminer.com Published On :: Fri, 14 Oct 2022 01:40:44 GMT Chicago Bears offensive lineman Sam Mustipher fell backwards in a dramatic fashion after an apparent light shove by Washington Commanders defensive tackle Daron Payne during a game Thursday night. Full Article
after After more than a decade of litigation, the EPA has released a plan to reduce carcinogenic chemicals in the Spokane River By www.inlander.com Published On :: Thu, 07 Nov 2024 01:30:00 -0800 Nearly half a century ago, the Environmental Protection Agency used the Toxic Substances Control Act to ban the use and production of polychlorinated biphenyls, or PCBs… Full Article Local News
after The Rocky Horror Picture Show still draws crowds of superfans and virgins alike nearly five decades after its initial release By www.inlander.com Published On :: Thu, 24 Oct 2024 01:30:00 -0700 The Rocky Horror Picture Show is unlike anything else… Full Article Arts & Culture
after Sherman, Wash: Tucked amid rolling fields is the well-kept remnant of a town that began to decline shortly after its founding in the 1880s By www.inlander.com Published On :: Thu, 31 Oct 2024 01:30:00 -0700 It's a sunny Monday as I drive out to Sherman, one of Lincoln County's few ghost towns… Full Article Arts & Culture
after After being eliminated from the city’s budget over a decade ago, Mayor Lisa Brown wants Spokane Arts back in the city By www.inlander.com Published On :: Wed, 06 Nov 2024 12:06:26 -0800 Art and community have gone hand in hand for millennia… Full Article Arts & Culture
after After nearly 50 years, Jerry Quinn Sr.'s work to preserve the Northwest's railroad legacy keeps rolling By www.inlander.com Published On :: Mon, 06 Dec 2021 04:00:00 -0800 On the face of it, the legacy of Jerry Quinn Sr. is simple… Full Article Health & Home/Home
after 10 observations and overreactions after Gonzaga's opening night win over Baylor By www.inlander.com Published On :: Fri, 08 Nov 2024 14:56:02 -0800 There's starting off on the right foot, and then there's whatever happened Monday night inside Spokane Arena. The Gonzaga men's basketball team loudly announced itself as a national title contender late on college basketball's opening night with a dominating 101-63 win against Baylor… Full Article Culture/Sports
after Clear the table after a meal and enjoy the camaraderie of a crafty evening By www.inlander.com Published On :: Sat, 09 Nov 2024 01:30:00 -0800 There's no doubt it's fun to get together with friends and family and catch up on one another's lives during the holidays… Full Article Health & Home/Lifestyle
after After more than two decades, acclaimed artist Ben Joyce is getting his first proper gallery exhibition By www.inlander.com Published On :: Thu, 19 Sep 2024 01:30:00 -0700 "There's a million things I want to do," says Ben Joyce… Full Article Fall Arts
after The Spokane-centric musical festival Volume returns after five-year hiatus By www.inlander.com Published On :: Thu, 12 Sep 2024 01:30:00 -0700 "It was always absolute madness."… Full Article Music News
after The Indigo Girls enjoy renewed interest after music featured in three recent films, including their own documentary By www.inlander.com Published On :: Thu, 26 Sep 2024 01:30:00 -0700 Last year, summer belonged to "Barbenheimer," the simultaneous theatrical release of Greta Gerwig's Barbie and Christopher Nolan's Oppenheimer… Full Article Music News
after After an Inlander article about her links to conspiracy theory websites, Rep. Jenny Graham responds with profanity, threats and another conspiracy website By www.inlander.com Published On :: Mon, 14 Sep 2020 13:40:49 -0700 State Rep. Jenny Graham (R-Spokane) called me on my cellphone the day the Inlander published my story about her unwittingly linking to conspiracy theory posts on Facebook. I called her back immediately — while she was still leaving a voicemail — and was greeted with two blasts of profanity. "You cocksucker!… Full Article News/Local News
after Haven't been to this intimate of a show in a long time... So great to see @rgenauer and the @assemblyofdust after #agreatlongwhile. Saw #Strangefolk a ton of times in the early 2000s between Chicago and Vermont By www.flickr.com Published On :: Thu, 08 Sep 2016 19:09:54 -0700 marusin posted a photo: via Instagram ift.tt/2c3to8E Full Article
after Janet Mock Rants Against Hollywood at 'Pose' Premiere After Only Getting Paid $40,000 Per Episode By www.aceshowbiz.com Published On :: Sat, 01 May 2021 08:00:01 +0000 During her speech, the producer and director of the show also apologizes to boyfriend Angel Bismark Curiel as she admits to having cheated on him during the show's production. Full Article tv Pose Janet Mock
after 'American Idol': Viewers Are Enraged After Fan-Favorite Is Eliminated Following a Twist By www.aceshowbiz.com Published On :: Mon, 03 May 2021 10:08:07 +0000 On the Disney Night, the Top 10 of the current season 19 hit the stage to sing Disney classics with host Ryan Seacrest announcing Arthur Gunn, the runner-up of season 18, as the Comeback winner. Full Article tv American Idol
after Tom Cavanagh and Carlos Valdes Bid Farewell to 'The Flash' After Seven Seasons By www.aceshowbiz.com Published On :: Wed, 05 May 2021 03:46:47 +0000 The original stars of The CW series will not be returning for an eighth season while fellow castmates Candice Patton and Danielle Panabaker are negotiating new deals. Full Article tv The Flash Tom Cavanagh;Carlos Valdes
after Morgan Wallen Excluded From Billboard Music Awards Despite 6 Nods After N-Word Scandal By www.aceshowbiz.com Published On :: Fri, 30 Apr 2021 07:51:07 +0000 According to Dick Clark Productions, the 'Whiskey Glasses' singer will not be 'performing, presenting or accepting' any possible trophies at the 2021 music awards show. Full Article music Morgan Wallen
after Grammys Announces Several Changes After The Weeknd Drama By www.aceshowbiz.com Published On :: Sat, 01 May 2021 03:39:50 +0000 The new changes arrive after The Weeknd publicly called out the organization for snubbing him as her received zero nominations at this year's ceremony over his successful hit 'Blinding Lights'. Full Article music The Weeknd
after Lucinda Williams Hopes to Make Live Concert Return in the Summer After Secret 2020 Stroke By www.aceshowbiz.com Published On :: Tue, 04 May 2021 06:04:05 +0000 The 'Can't Let Go' singer reveals that she spent a week in intensive care and a month of therapy at a Nashville hospital after struggling to maintain her balance in the bathroom of her home. Full Article music Lucinda Williams
after Jesy Nelson Feels Huge Wave of Relief After Little Mix Exit, Thanks Liam Payne for Reaching Out By www.aceshowbiz.com Published On :: Wed, 05 May 2021 03:00:01 +0000 The former Little Mix member gets candid about her decision to leave the girl group, claiming she felt 'enormous pressure' for being constantly compared to her bandmates. Full Article music Jesy Nelson Little Mix;Liam Payne
after Tristan Thompson's Alleged Fling to Move 'Forward With the Truth' After Receiving Cease and Desist By www.aceshowbiz.com Published On :: Thu, 06 May 2021 02:52:41 +0000 Sydney Chase admits she has received the legal notice after it was initially sent to an email address she no longer uses, but she refuses to comply with the letter. Full Article celebrity Tristan Thompson Sydney Chase
after Pastor Carl Lentz's Wife Shares Reflective Post Six Months After He's Fired From Hillsong Church By www.aceshowbiz.com Published On :: Thu, 06 May 2021 03:43:32 +0000 Explaining the reason why she had been absent from social media, Lauren Lentz admits to having 'blocked and deleted more people and comments than I can count' in the wake of her husband's cheating scandal. Full Article celebrity Carl Lentz
after Ben Affleck Plans on 'Hanging Out Again' With Jennifer Lopez After Amid Reconciliation Rumors By www.aceshowbiz.com Published On :: Thu, 06 May 2021 05:24:26 +0000 The 'Zack Snyder's Justice League' actor and his former fiancee are reported to 'have lots to talk about' following her split from MLB star Alex Rodriguez. Full Article celebrity Ben Affleck Jennifer Lopez
after Diddy Asks People To Take His New Middle Name Seriously After Legally Changing It to Love By www.aceshowbiz.com Published On :: Tue, 04 May 2021 06:37:57 +0000 The 'I'll Be Missing You' hitmaker announces that he finally changed his middle name legally by proudly showing off his new driver's license and a legal document from the court. Full Article celebrity Diddy
after Quando Rondo Hints at Betrayal After Being Shot at in Georgia By www.aceshowbiz.com Published On :: Tue, 04 May 2021 07:35:00 +0000 The 'I Remember' rapper posts a cryptic message on his Instagram Story after he and his entourage were reportedly rained with bullets in a parking lot near a highway. Full Article celebrity Quando Rondo
after See Mark Wahlberg's Shocking Transformation After Gaining 20 Lbs. in 3 Weeks for 'Father Stu' Role By www.aceshowbiz.com Published On :: Tue, 04 May 2021 08:34:04 +0000 The 'Transformers: The Last Knight' actor shares a before and after picture to compare his previously ripped physique to his now fuller figure after vowing to indulge in his favorite food. Full Article movie Father Stu Mark Wahlberg
after Gwyneth Paltrow Sparks Backlash After Skipping Line at Santa Monica DMV By www.aceshowbiz.com Published On :: Tue, 04 May 2021 14:00:01 +0000 The 'Shakespeare in Love' actress is caught on camera sneaking in through the backdoor while 50 people are patiently waiting for their turn outside of the building. Full Article celebrity Gwyneth Paltrow
after Justin Theroux Recalls Suffering From Memory Loss After Being Hit by Van By www.aceshowbiz.com Published On :: Tue, 04 May 2021 18:49:20 +0000 The 'Leftovers' actor struggled to remember his name and was mistakenly told that he needed a brain surgery following a serious accident in New York City. Full Article celebrity Justin Theroux