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Enantiomeric Copper Based Anticancer Agents Promoting Sequence-Selective Cleavage of G-Quadruplex Telomeric DNA and non-random cleavage of plasmid DNA

Metallomics, 2020, Accepted Manuscript
DOI: 10.1039/D0MT00084A, Paper
Sabiha Parveen, J. A. Cowan, Zhen Yu, Farukh Arjmand
Copper-based binuclear enantiomeric complexes 1S and 1R were synthesized as anticancer chemotherapeutic agents to target G-quadruplex rich region of DNA and thoroughly characterized by various spectroscopic and single X-ray crystal...
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Investigation of the impact of magnesium versus titanium implants on protein composition in osteoblast by label free quantification

Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00028K, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
M. Omidi, N. Ahmad Agha, A. Müller, F. Feyerabend, H. Helmholz, R. Willumeit-Römer, H. Schlüter, B. J. C. Luthringer-Feyerabend
To our knowledge, this is the first report describing and comparing the effects of magnesium and titanium biomaterials on human osteoblast proteome.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Quarantine centres for two ACs set up

Quarantine centres for two ACs set up




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Disqualification case of 7 MLAs : Tribunal reserves judgement

Disqualification case of 7 MLAs : Tribunal reserves judgement




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Speaker inspects quarantine centre

Speaker inspects quarantine centre




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Study quantifies impact of NCI-sponsored trials on clinical cancer care

Nearly half of phase 3 cancer clinical trials carried out by the NCI-sponsored SWOG Cancer Research Network were associated with clinical care guidelines or new drug approvals, a study in JAMA Network Open shows.




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An Shi zhi luan yu Su Dai er chao xin zheng quan jie gou de kai zhan / Lin Weizhou zhu

Lin, Weizhou




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Xi Jin mo nian zhi dong Jin shi qi de "fen xia" zheng zhi : fen quan hua xian xiang xia de chao ting yu zhou zhen / Zhao Lixin zhu

Zhao, Lixin




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Ming dai de yu zheng guan li : guo jia zhi du de si fa quan li yun zuo / Lian Qiyuan zhu

Lian, Qiyuan




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Quan Zuwang zhi shi xue / Zhang Lizhu zhu

Zhang, Lizhu




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Duo chong fu za bei jing xia de Zhongguo jing ji an quan wen ti / Lei Jiasu, Lin Bao, Wang Yilin zhu bian




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Zhong yang qi ye quan mian feng xian guan li jing sui : Zhongguo hai you chuang xin zhi lu / Wu Guangqi, She Lian zhu

Wu, Guangqi, 1957-




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Wo guo ping deng jiu ye ji hui bao zhang yan jiu = Study on equal employment opportunity security in China / Wang Liping zhu

Wang, Liping




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Tai er ji wei cheng nian ren quan yi fa lü bao hu shi wu yan jiu / Song Hongfei, Wu Yongke zhu

Song, Hongfei, author




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Price of inequality : how today's divided society endangers our future. Chinese

Stiglitz, Joseph E




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Science Podcast - Quantum cryptography, salt's role in ecosystems, and a rundown of stories from our daily news site (31 Jan 2014)

Should we worry more about quantum decryption in the future or the past, how salt's role as a micronutrient may effect the global carbon cycle, and a daily news roundup.




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Science Podcast - Evading back-action in a quantum system and a news roundup (16 May 2014)

Measuring minute motions; roundup of daily news with David Grimm.




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Science Podcast - Inequality and health and a news roundup (23 May 2014)

Inequality and health; roundup of daily news with David Grimm.




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Tracking aquatic animals, cochlear implants, and a news roundup

Sara Iverson discusses how telemetry has transformed the study of animal behavior in aquatic ecosystems, and Monita Chatterjee discusses the impact of cochlear implants on the ability to recognize emotion in voices, and David Grimm discusses daily news stories with Sarah Crespi. Hosted by Susanne Bard. [Img: © marinesavers.com]




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How future elites view self-interest and equality and a news roundup

Daniel Markovits discusses the preferences for fairness and equiality among potential future US leaders and David Grimm talks about finding fluorine's origins, persistant lone wolves, and the domestiction of the chicken. Hosted by Sarah Crespi. [Image credit: Philip Pikart/CC BY-SA 4.0]




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Podcast: Patent trolls, the earthquake-volcano link, and obesity in China

Online News Editor Catherine Matacic shares stories on how earthquakes may trigger volcanic eruptions, growing obesity in China’s children, and turning salty water sweet on the cheap.   Lauren Cohen joins host Sarah Crespi to discuss the rise of patent trolls in the United States and a proposal for cutting back on their sizable profits.     [Image: © Alberto Garcia/Corbis]




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Podcast: Quantum dots in consumer electronics and a faceoff with the quiz master

Sarah Crespi takes a pop quiz on literal life hacking, spotting poverty from outer space, and the size of the average American vocabulary with Catherine Matacic.   From the magazine You can already buy a quantum dot television, but it’s really just the beginning of the infiltration of quantum dots into our everyday lives. Cherie Kagan is here to talk about her in depth review of the technology published in this week’s issue.   [Image: Public domain; Music: Jeffrey Cook]




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Podcast: Giant virus genetics, human high-altitude adaptations, and quantifying the impact of government-funded science

This week, viruses as remnants of a fourth domain of life, a scan of many Tibetan genomes reveals seven new genes potentially related to high-altitude life, and doubts about dark energy with Online News Editor David Grimm. Danielle Li joins Sarah Crespi to discuss her study quantifying the impact of government funding on innovation by linking patents to U.S. National Institutes of Health grants. Listen to previous podcasts. Download the show transcript. Transcripts courtesy of Scribie.com. [Image: artubo/iStockphoto; Music: Jeffrey Cook]




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Cargo-sorting molecular robots, humans as the ultimate fire starters, and molecular modeling with quantum computers

This week we hear stories on the gut microbiome’s involvement in multiple sclerosis, how wildfires start—hint: It’s almost always people—and a new record in quantum computing with Online News Editor David Grimm. Andrew Wagner talks to Lulu Qian about DNA-based robots that can carry and sort cargo. Sarah Crespi goes behind the scenes with Science’s Photography Managing Editor Bill Douthitt to learn about snapping this week’s cover photo of the world’s smallest neutrino detector. Listen to previous podcasts. [Image: Curtis Perry/Flickr; Music: Jeffrey Cook]




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How Earth’s rotation could predict giant quakes, gene therapy’s new hope, and how carbon monoxide helps deep-diving seals

This week we hear stories on how the sloshing of Earth’s core may spike major earthquakes, carbon monoxide’s role in keeping deep diving elephant seals oxygenated, and a festival celebrating heavily researched yet completely nonsensical theories with Online News Editor David Grimm. Sarah Crespi interviews staff writer Jocelyn Kaiser about the status of gene therapy, including a newly tested gene-delivering virus that may give scientists a new way to treat devastating spinal and brain diseases. Listen to previous podcasts.    [Image: Robert Schwemmer, CINMS, NOAA; Music: Jeffrey Cook]  




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The world’s first dog pictures, and looking at the planet from a quantum perspective

About 8000 years ago, people were drawing dogs with leashes, according to a series of newly described stone carvings from Saudi Arabia. Online News Editor David Grimm talks with Sarah Crespi about reporting on this story and what it says about the history of dog domestication. Sarah also interviews physicist Brad Marston of Brown University on surprising findings that bring together planetary science and quantum physics. It turns out that Earth’s rotation and the presence of oceans and atmosphere on its surface mean it can be described as a “topological insulator”—a term usually reserved for quantum phenomena. Insights from the study of these effects at the quantum level may help us understand weather and currents at the planetary level—including insights into climate change and exoplanets. Listen to previous podcasts.




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Salad-eating sharks, and what happens after quantum computing achieves quantum supremacy

David Grimm—online news editor for Science—talks with Sarah Crespi about two underwater finds: the first sharks shown to survive off of seagrass and what fossilized barnacles reveal about ancient whale migrations. Sarah also interviews Staff Writer Adrian Cho about what happens after quantum computing achieves quantum supremacy—the threshold where a quantum computer’s abilities outstrip nonquantum machines. Just how useful will these machines be and what kinds of scientific problems might they tackle? Listen to previous podcasts.  [Image: Aleria Jensen, NOAA/NMFS/AKFSC; Music: Jeffrey Cook]




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<i>Science</i> and <i>Nature</i> get their social science studies replicated—or not, the mechanisms behind human-induced earthquakes, and the taboo of claiming causality in science

A new project out of the Center for Open Science in Charlottesville, Virginia, found that of all the experimental social science papers published in Science and Nature from 2010–15, 62% successfully replicated, even when larger sample sizes were used. What does this say about peer review? Host Sarah Crespi talks with Staff Writer Kelly Servick about how this project stacks up against similar replication efforts, and whether we can achieve similar results by merely asking people to guess whether a study can be replicated. Podcast producer Meagan Cantwell interviews Emily Brodsky of the University of California, Santa Cruz, about her research report examining why earthquakes occur as far as 10 kilometers from wastewater injection and fracking sites. Emily discusses why the well-established mechanism for human-induced earthquakes doesn’t explain this distance, and how these findings may influence where we place injection wells in the future. In this month’s book podcast, Jen Golbeck interviews Judea Pearl and Dana McKenzie, authors of The Book of Why: The New Science of Cause and Effect. They propose that researchers have for too long shied away from claiming causality and provide a road map for bringing cause and effect back into science. This week’s episode was edited by Podigy. Download a transcript of this episode (PDF) Listen to previous podcasts. About the Science Podcast [Image: Jens Lambert, Shutterstock; Music: Jeffrey Cook]




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Will a radical open-access proposal catch on, and quantifying the most deadly period of the Holocaust

Plan S, an initiative that requires participating research funders to immediately publish research in an open-access journal or repository, was announced in September 2018 by Science Europe with 11 participating agencies. Several others have signed on since the launch, but other funders and journal publishers have reservations. Host Meagan Cantwell speaks with Contributing Correspondent Tania Rabesandratana about those reservations and how Plan S is trying to change publishing practices and research culture at large. Some 1.7 million Jewish people were murdered by the Nazis in the 22 months of Operation Reinhard (1942–43) which aimed to eliminate all Jews in occupied Poland. But until now, the speed and totality of these murders were poorly understood. It turns out that about one-quarter of all Jews killed during the Holocaust were murdered in the autumn of 1942, during this operation. Meagan talks with Lewi Stone, a professor of biomathematics at Tel Aviv University in Israel and mathematical science at RMIT University in Melbourne, Australia, about this shocking kill rate, and why researchers are taking a quantitative approach to characterizing genocides. This week’s episode was edited by Podigy. Download the transcript (PDF) Listen to previous podcasts. About the Science Podcast [Image: Michael Beckwith; Music: Jeffrey Cook]




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Measuring earthquake damage with cellphone sensors and determining the height of the ancient Tibetan Plateau

In the wake of a devastating earthquake, assessing the extent of damage to infrastructure is time consuming—now, a cheap sensor system based on the accelerometers in cellphones could expedite this process. Host Sarah Crespi talks with Contributing Correspondent Lizzie Wade about how these sensor systems work and how they might assist communities after an earthquake. In another Earth-shaking study, scientists have downgraded the height of the ancient Tibetan Plateau. Most reconstructions estimate that the “rooftop of the world” reached its current height of 4500 meters about 40 million years ago, but a new study suggests it was a mere 3000 meters high during this period. Host Meagan Cantwell speaks with Svetlana Botsyun, a postdoctoral researcher at Tübingen University in Germany, about her team’s new approach to studying paleoelevation, and how a shorter Tibetan Plateau would have impacted the surrounding area’s climate. This week’s episode was edited by Podigy. Download the transcript (PDF) Listen to previous podcasts. About the Science Podcast [Image: Martin Luff/Flickr; Music: Jeffrey Cook]




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Earthquakes caused by too much water extraction, and a dog cancer that has lived for millennia

After two mysterious earthquake swarms occurred under the Sea of Galilee, researchers found a relationship between these small quakes and the excessive extraction of groundwater. Science journalist Michael Price talks with host Sarah Crespi about making this connection and what it means for water-deprived fault areas like the Sea of Galilee and the state of California. Also this week, Sarah talks with graduate student Adrian Baez-Ortega from the University of Cambridge in the United Kingdom’s Transmissible Cancer Group about the genome of a canine venereal cancer that has been leaping from dog to dog for about 8000 years. By comparing the genomes of this cancer from dogs around the globe, the researchers were able to learn more about its origins and spread around the world. They also discuss how such a long-lived cancer might help them better understand and treat human cancers. This week’s episode was edited by Podigy. Ads on this week’s show: Science Sessions podcast from the Proceedings of the National Academy of Sciences Download the transcript (PDF) Listen to previous podcasts. About the Science Podcast




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From nose to toes—how coronavirus affects the body, and a quantum microscope that unlocks the magnetic secrets of very old rocks

Coronavirus affects far more than just the lungs, and doctors and researchers in the midst of the pandemic are trying to catalog—and understand—the virus’ impact on our bodies. Staff Writer Meredith Wadman joins host Sarah Crespi to discuss what we know about how COVID-19 kills. See all of our News coverage of the pandemic here, and all of our Research and Editorials here. Also this week, Staff Writer Paul Voosen talks with Sarah about quantum diamond microscopes. These new devices are able to detect minute traces of magnetism, giving insight into the earliest movements of Earth’s tectonic plates and even ancient paleomagnetic events in space. This week’s episode was produced with help from Podigy. Listen to previous podcasts. About the Science Podcast Download a transcript (PDF).




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Migration and Inequality


 

In a world of increasingly heated political debates on migration, relentlessly caught up in questions of security, humanitarian crisis, and cultural “problems,” this book radically shifts the focus to address migration through the lens of inequality.
 
Taking an innovative approach, Mirna Safi offers a fresh perspective on how migration is embedded in the elementary mechanisms that shape the landscape of inequality. She sketches out three distinct



Read More...




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Migration and Inequality


 

In a world of increasingly heated political debates on migration, relentlessly caught up in questions of security, humanitarian crisis, and cultural “problems,” this book radically shifts the focus to address migration through the lens of inequality.
 
Taking an innovative approach, Mirna Safi offers a fresh perspective on how migration is embedded in the elementary mechanisms that shape the landscape of inequality. She sketches out three distinct



Read More...




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A membraneless gas-trapping device for cyanide detection and quantification

Anal. Methods, 2020, 12,2009-2015
DOI: 10.1039/D0AY00245C, Paper
Chatipat Lorpaiboon, Wanutcha Lorpaiboon, Manchuta Dangkulwanich
A novel device for trapping gaseous compounds was invented and employed to create a user-friendly cyanide test kit for aqueous solutions.
The content of this RSS Feed (c) The Royal Society of Chemistry




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The development and validation of a GC-MS method for the quantification of glycolaldehyde formed from carbohydrate fragmentation processes

Anal. Methods, 2020, 12,1975-1987
DOI: 10.1039/C9AY02639H, Paper
Samin Fathalinejad, Esben Taarning, Peter Christensen, Jan H. Christensen
Glycolaldehyde is a small sugar-like molecule that is readily formed by the thermochemical fragmentation of carbohydrates and it has similar physico-chemical properties to sugars.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Recent advance in the analysis methodologies for microplastics in aquatic organisms: Current knowledge and research challenges

Anal. Methods, 2020, Accepted Manuscript
DOI: 10.1039/D0AY00143K, Minireview
Jingkun Zhu, Can Wang
The widespread occurrence and high bioavailability of microplastics have increasingly attracted wide attention to society. Because of the presence of microplastics in aquatic organisms, it is necessary to investigate their...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Quantification of reduced and oxidized coenzyme Q10 in supplements and medicines by HPLC-UV

Anal. Methods, 2020, Accepted Manuscript
DOI: 10.1039/D0AY00683A, Paper
Žane Temova Rakuša, Albin Kristl, Robert Roškar
Coenzyme Q10 (CoQ10) supplements are widely used because of its antioxidant and anti-inflammatory effects, especially in the management of cardiovascular diseases. The latest pharmaceutical approach to increase CoQ10 bioavailability and...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Rapid detection of quality of Japanese fermented soy sauce using near-infrared spectroscopy

Anal. Methods, 2020, Advance Article
DOI: 10.1039/D0AY00521E, Paper
Shuo Wang, Takehiro Tamura, Nobuyuki Kyouno, Xiaofang Liu, Han Zhang, Yoshinobu Akiyama, Jie Yu Chen
The application of NIR spectroscopy has great potential as an alternative quality control method, which provides a robust model for routinely estimating the final quality of soy sauce production rapidly and economically.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Quantitative analysis of the effect of reabsorption on the Raman spectroscopy of distinct (n, m) carbon nanotubes

Anal. Methods, 2020, Advance Article
DOI: 10.1039/D0AY00356E, Paper
Shilong Li, Xiaojun Wei, Linhai Li, Jiaming Cui, Dehua Yang, Yanchun Wang, Weiya Zhou, Sishen Xie, Atsushi Hirano, Takeshi Tanaka, Hiromichi Kataura, Huaping Liu
Quantitatively analyzing the effect of reabsorption on the Raman spectroscopy of SWCNTs and clarifying the influence mechanism by experiments.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Versatile additively manufactured (3D printed) wall-jet flow cell for high performance liquid chromatography-amperometric analysis: application to the detection and quantification of new psychoactive substances (NBOMes)

Anal. Methods, 2020, 12,2152-2165
DOI: 10.1039/D0AY00500B, Paper
Open Access
Hadil M. Elbardisy, Eduardo M. Richter, Robert D. Crapnell, Michael P. Down, Peter G. Gough, Tarek S. Belal, Wael Talaat, Hoda G. Daabees, Craig E. Banks
Additive manufacturing is an emerging technology of vast applicability, receiving significant interest in a plethora of industrial and research domains as it allows the translation of designs produced via computer software, into 3D printed objects.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Quality by Design (QbD) approach for the development of a rapid UHPLC method for simultaneous determination of aglycone and glycoside forms of isoflavones in dietary supplements

Anal. Methods, 2020, 12,2082-2092
DOI: 10.1039/C9AY02778E, Paper
Kornelija Lasić, Ana Mornar, Biljana Nigović
Systematic development of a UHPLC method by QbD approach as performed for simultaneous determination of aglycone (genistein, daidzein, biochanin A and formononetin) and glycoside (genistin, daidzin, sissotrin, ononin) forms of isoflavones.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Correction: Towards simultaneous quantification of protease inhibitors and inflammatory biomarkers in serum for people living with HIV

Anal. Methods, 2020, 12,2196-2196
DOI: 10.1039/D0AY90050H, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Pengyi Wang, Charles S. Venuto, Raymond Cha, Benjamin L. Miller
The content of this RSS Feed (c) The Royal Society of Chemistry




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Portable and benchtop Raman spectrometers coupled to cluster analysis to identify quinine sulfate polymorphs in solid dosage forms and antimalarial drug quantification in solution by AuNPs-SERS with MCR-ALS

Anal. Methods, 2020, Advance Article
DOI: 10.1039/D0AY00693A, Paper
Sarmento J. Mazivila, Helena I. S. Nogueira, Ricardo N. M. J. Páscoa, David S. M. Ribeiro, João L. M. Santos, João M. M. Leitão, Joaquim C. G. Esteves da Silva
Raman spectrometers coupled to cluster analysis were able to identify two polymorphs of quinine sulfate in solid dosage forms. Gold nanoparticles-surface-enhanced Raman scattering with MCR-ALS was used to antimalarial drug quantification in solution.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Quantification of Anthracene after dermal absorption test via APCI-Tandem Mass Spectrometry

Anal. Methods, 2020, Accepted Manuscript
DOI: 10.1039/D0AY00486C, Paper
Xinyi Sui, Julio E Teran, Chengcheng Feng, Killian Wustrow, Caroline J. Smith , Nelson R Vinueza
An analytical method for the detection and quantification of anthracene from dermal samples was developed by using Atmospheric Pressure Chemical Ionization-Tandem Mass Spectrometry (APCI-MS/MS). The anthracene samples were obtained from...
The content of this RSS Feed (c) The Royal Society of Chemistry




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A simple paper-based approach for arsenic determination in water using hydride generation coupled with mercaptosuccinic-acid capped CdTe quantum dots

Anal. Methods, 2020, Accepted Manuscript
DOI: 10.1039/D0AY00273A, Paper
Oraphan Thepmanee, Kanlaya Prapainop Katewongsa, Obnithi Nooppha, Nuanlaor Ratanawimarnwong, Weena Siangproh, Orawon Chailapakul, Kriangsak Songsrirote
This research aims to develop a simple paper-based device for arsenic detection in water samples where a hydride generation technique coupled with mercaptosuccinic acid-capped CdTe quantum dots (MSA-CdTe QDs) as...
The content of this RSS Feed (c) The Royal Society of Chemistry




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ELISA as an effective tool to determine spatial and seasonal occurrence of emerging contaminants in the aquatic environment

Anal. Methods, 2020, Advance Article
DOI: 10.1039/D0AY00426J, Paper
Carla Patrícia Silva, Tânia Carvalho, Rudolf J. Schneider, Valdemar I. Esteves, Diana L. D. Lima
Monitoring emerging contaminants is essential as they represent a risk to the aquatic environment. ELISA is a promising method for their quantification mostly because it allows controlling their concentration levels through large screening campaigns.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Fabrication of an electrochemical sensor based on metal-organic framework ZIF-8 for quantitation of silver ion: optimizing experimental conditions by central composite design (CCD)

Anal. Methods, 2020, Accepted Manuscript
DOI: 10.1039/D0AY00843E, Paper
Farzaneh Hashemi , Ali Reza Zanganeh, Farid Naeimi , Maryam Tayebani
The ZIF-8 was synthesized and carbon paste electrode (CPE) modified with this metal-organic framework utilized for quantitation of silver(Ι) by differential pulse anodic stripping voltammetry (DPASV) technique. The prepared ZIF-8...
The content of this RSS Feed (c) The Royal Society of Chemistry




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GDP will contract in the first quarter: KV Subramanian, CEA

Unlike '08, economic impact now is tied to the pandemic and health, so it is far harder to estimate damage.




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Stochastic Processes and Applications [electronic resource] : Diffusion Processes, the Fokker-Planck and Langevin Equations / by Grigorios A. Pavliotis

New York, NY : Springer New York : Imprint: Springer, 2014