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Seaweed Porphyra yezoensis polysaccharides with different molecular weights inhibit hydroxyapatite damage and osteoblast differentiation of A7R5 cells

Food Funct., 2020, 11,3393-3409
DOI: 10.1039/C9FO01732A, Paper
Ling-Hong Huang, Hong Liu, Jia-Yun Chen, Xin-Yuan Sun, Zhi-hui Yao, Jin Han, Jian-Ming Ouyang
Porphyra yezoensis polysaccharide could effectively reduce the cell damage and osteogenic transformation of vascular smooth muscle cells induced by hydroxyapatite crystals.
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Preparation of theasinensin A and theasinensin B and exploration of their inhibitory mechanism on α-glucosidase

Food Funct., 2020, 11,3527-3538
DOI: 10.1039/C9FO03054A, Paper
Sainan Tao, Guijie Chen, Weiqi Xu, Yujia Peng, Peng Wan, Yi Sun, Xiaoxiong Zeng, Zhonghua Liu
Theasinensin A (TSA) and theasinensin B (TSB), dimers of tea catechins produced during the processing of oolong tea and black tea, had superior inhibitory effects on α-glucosidase.
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Low-dose ethanol intake prevents high-fat diet-induced adverse cardiovascular events in mice

Food Funct., 2020, 11,3549-3562
DOI: 10.1039/C9FO02645B, Paper
Junhui Nie, Linel Darrel Ngokana, Jiayuan Kou, Yuchen Zhao, Jiajie Tu, Heng Ji, Peizhu Tan, Tingting Zhao, Yuwei Cao, Zhaojing Wu, Qi Wang, Shuangfeng Ren, Xiuchen Xuan, Hui Huang, Yanze Li, Huan Liang, Xu Gao, Lingyun Zhou
This study aimed to clarify whether low-dose ethanol intake could prevent high-fat diet-induced adverse effects on cardiomyocytes in mice.
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Oleacein inhibits STAT3, activates the apoptotic machinery, and exerts anti-metastatic effects in the SH-SY5Y human neuroblastoma cells

Food Funct., 2020, 11,3271-3279
DOI: 10.1039/D0FO00089B, Paper
Santa Cirmi, Marilena Celano, Giovanni Enrico Lombardo, Valentina Maggisano, Antonio Procopio, Diego Russo, Michele Navarra
The present findings demonstrate that oleacein, the main secoiridoid of extravirgin olive oil, acts against neuroblastoma cells, by reducing cell adhesion and migration, inducing apoptotic death and modulating STAT3-dependent pathway.
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DHA substitution overcomes high-fat diet-induced disturbance in the circadian rhythm of lipid metabolism

Food Funct., 2020, 11,3621-3631
DOI: 10.1039/C9FO02606A, Paper
Rulong Chen, Zhengyu Zuo, Qi Li, Hualin Wang, Na Li, Hongyu Zhang, Xiaoli Yu, Zhiguo Liu
DHA substitution overcomes high-fat diet-induced disturbance in the circadian rhythm of lipid metabolism via the core gene Clock/Bmal1 controlled circadian nuclear receptor pathway.
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Protocatechuic acid and quercetin glucosides in onions attenuate changes induced by high fat diet in rats

Food Funct., 2020, 11,3585-3597
DOI: 10.1039/C9FO02633A, Paper
Katarzyna Grzelak-Błaszczyk, Joanna Milala, Krzysztof Kołodziejczyk, Michał Sójka, Andrzej Czarnecki, Monika Kosmala, Robert Klewicki, Bartosz Fotschki, Adam Jurgoński, Jerzy Juśkiewicz
Yellow onion waste from industrial peeling was used to obtain three pure preparations: protocatechuic acid (PA), quercetin diglycosides (QD) and quercetin monoglycosides (QM).
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The effect of culinary doses of spices in a high-saturated fat, high-carbohydrate meal on postprandial lipemia and endothelial function: a randomized, controlled, crossover pilot trial

Food Funct., 2020, 11,3191-3200
DOI: 10.1039/C9FO02438G, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Kristina S. Petersen, Connie J. Rogers, Sheila G. West, David N. Proctor, Penny M. Kris-Etherton
Lower doses of spices (2 and 6 g) than previously tested may attenuate postprandial lipemia and impairments in endothelial function caused by a high-saturated fat, high-carbohydrate meal.
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Addition of flavonols and polysaccharides as excipient ingredients into epicatechin rich green tea extract inhibited free radical formation and glucose uptake

Food Funct., 2020, 11,3105-3111
DOI: 10.1039/C9FO03020D, Paper
So-Hee Yoo, Yeong-Eun Lee, Jin-Oh Chung, Chan-Su Rha, Yong-Deog Hong, Mi-Young Park, Soon-Mi Shim
Results from the current study suggested that whole green tea components rich in flavonols and polysaccharides could be potential hypoglycemic excipient ingredients into green tea catechins by enhancing catechin absorption.
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Impact of functional foods and nutraceuticals on high blood pressure with a special focus on meta-analysis: review from a public health perspective

Food Funct., 2020, 11,2792-2804
DOI: 10.1039/D0FO00357C, Review Article
Kamesh Venkatakrishnan, Hui-Fang Chiu, Chin-Kun Wang
In recent times many researchers are expressing immense interest in nutraceuticals and functional foods for combating various diseases or abnormal conditions, especially against hypertension (HT).
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Dietary intake of Lycium ruthenicum Murray ethanol extract inhibits colonic inflammation in dextran sulfate sodium-induced murine experimental colitis

Food Funct., 2020, 11,2924-2937
DOI: 10.1039/D0FO00172D, Paper
Shuai Zong, Liu Yang, Hyun Jin Park, Jinglei Li
Lycium ruthenicum Murray extract protected experimental colitis by inhibiting pro-inflammatory cytokines production, inflammatory cell infiltration, inflammatory mediators activation and oxidative stress, and restored intestinal barrier integrity.
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Study of viability of high pressure extract from pomegranate peel to improve carrot juice characteristics

Food Funct., 2020, 11,3410-3419
DOI: 10.1039/C9FO02922B, Paper
João P. Trigo, Elisabete M. C. Alexandre, Sara Silva, Eduardo Costa, Jorge A. Saraiva, Manuela Pintado
Extracts from fruit processing by-products usually present high amounts of bioactive compounds with several important activities such as antioxidant and antimicrobial capacities.
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Correction: Matrix-mediated distribution of 4-hydroxy-2-hexanal (nonenal) during deep-frying of chicken breast and potato sticks in vegetable oil

Food Funct., 2020, 11,3750-3750
DOI: 10.1039/D0FO90018D, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Lukai Ma, Guoqin Liu, Weiwei Cheng, Xinqi Liu, Huifan Liu, Qin Wang
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Hot-water extract of ripened Pu-erh tea attenuates DSS-induced colitis through modulation of the NF-κB and HIF-1α signaling pathways in mice

Food Funct., 2020, 11,3459-3470
DOI: 10.1039/C9FO02803J, Paper
Yina Huang, Liang Qiu, Xuan Mi, Zhihong Zhang, Di Xu, Xueying Tao, Keyu Xing, Qinglong Wu, Hua Wei
There was lots of information on anti-obesity and reduced risk of cardiovascular disease, to our best knowledge, little was known about the prevention of colitis by RPT. We firstly assessed effects of RPT on phenotypic improvements of DSS-induced colitis in mice.
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Alleviating effects of noni fruit polysaccharide on hepatic oxidative stress and inflammation in rats under a high-fat diet and its possible mechanisms

Food Funct., 2020, 11,2953-2968
DOI: 10.1039/D0FO00178C, Paper
Xiaobing Yang, Wenjing Mo, Chuanjin Zheng, Wenzhi Li, Jian Tang, Xiaoyong Wu
Non-alcoholic fatty liver disease is associated with gut microbiota, oxidative stress, and inflammation.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Ergosterol peroxide from Pleurotus ferulae inhibits gastrointestinal tumor cell growth through induction of apoptosis via reactive oxygen species and endoplasmic reticulum stress

Food Funct., 2020, Advance Article
DOI: 10.1039/C9FO02454A, Paper
Yi Yang, Xiaoyu Luo, Mayila Yasheng, Jun Zhao, Jinyu Li, Jinyao Li
Ergosterol peroxide was purified from Pleurotus ferulae by silica gel chromatography, Sephadex LH-20 chromatography and recrystallization and named as PFEP, which was identified by ESI-MS and NMR.
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Flavonoids isolated from loquat (Eriobotrya japonica) leaves inhibit oxidative stress and inflammation induced by cigarette smoke in COPD mice: the role of TRPV1 signaling pathways

Food Funct., 2020, 11,3516-3526
DOI: 10.1039/C9FO02921D, Paper
Tunyu Jian, Jian Chen, Xiaoqin Ding, Han Lv, Jiawei Li, Yuexian Wu, Bingru Ren, Bei Tong, Yuanyuan Zuo, Kelei Su, Weilin Li
Total flavonoids isolated from loquat leaves inhibit inflammation and oxidative stress by regulating TRPV1 and the related pathway in cigarette smoke-induced COPD mice.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Enzymatic hydrolysis of insect Alphitobius diaperinus towards the development of bioactive peptide hydrolysates

Food Funct., 2020, 11,3539-3548
DOI: 10.1039/D0FO00188K, Paper
Pedro Sousa, Sandra Borges, Manuela Pintado
Edible insects are a promising protein source for the future generation, due to their nutritional composition, sustainability and low environmental impact.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Antihypertensive effects of Trichiurus lepturus myosin hydrolysate in spontaneously hypertensive rats

Food Funct., 2020, 11,3645-3656
DOI: 10.1039/C9FO02687H, Paper
Weiqing Fu, Peixin Wang, Hongqiang Wu, Zhigang Zhang, Hongliang Zeng, Yi Zhang, Baodong Zheng, Jiamiao Hu
In this study, the blood pressure-lowering effects of Trichiurus lepturus myosin hydrolysate (TMH) and its possible mechanism were investigated in spontaneously hypertensive rats (SHRs).
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A lupine (Lupinus angustifolious L.) peptide prevents non-alcoholic fatty liver disease in high-fat-diet-induced obese mice

Food Funct., 2020, 11,2943-2952
DOI: 10.1039/D0FO00206B, Paper
Open Access
Ana Lemus-Conejo, Elena Grao-Cruces, Rocio Toscano, Lourdes M. Varela, Carmen Claro, Justo Pedroche, Francisco Millan, Maria C. Millan-Linares, Sergio Montserrat-de la Paz
A lupine (Lupinus angustifolious L.) peptide prevents non-alcoholic fatty liver disease in high-fat-diet-induced obese mice.
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Kaempferol modulates TCDD- and t-BHQ-induced drug-metabolizing enzymes and luteolin enhances this effect

Food Funct., 2020, 11,3668-3680
DOI: 10.1039/C9FO02951F, Paper
Tomoya Kitakaze, Atsushi Makiyama, Rika Nakai, Yuki Kimura, Hitoshi Ashida
Co-treatment with kaempferol and luteolin inhibits AhR- and Nrf2-induced expression of drug-metabolizing enzymes.
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The purification, structural characterization and antidiabetic activity of a polysaccharide from Anoectochilus roxburghii

Food Funct., 2020, 11,3730-3740
DOI: 10.1039/C9FO00860H, Paper
Yuntao Liu, Tingting Tang, Songqi Duan, Cheng Li, Qinlu Lin, Hejun Wu, Aiping Liu, Bin Hu, Dingtao Wu, Suqing Li, Li Shen, Wenjuan Wu
Anoectochilus roxburghii, a traditional Chinese medicinal herb, has been widely used for treating numerous chronic diseases.
The content of this RSS Feed (c) The Royal Society of Chemistry




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tert-Butyl-p-benzoquinone induces autophagy by inhibiting the Akt/mTOR signaling pathway in RAW 264.7 cells

Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00281J, Paper
Xianghe Meng, Chaosheng Xia, Qin Ye, Xiaohua Nie
Autophagy mediate by p53/Akt/mTOR signaling was linked to overproduction of ROS by tert-butyl-p-benzoquinone.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Usage of supercritical fluid techniques to obtain bioactive alkaloid-rich extracts from cherimoya peel and leaves: extract profiles and their correlation with antioxidant properties and acetylcholinesterase and α-glucosidase inhibitory activities

Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00342E, Paper
Oscar Galarce-Bustos, Mª Teresa Fernández-Ponce, Antonio Montes, Clara Pereyra, Lourdes Casas, Casimiro Mantell, Mario Aranda
The wastes generated by cherimoya cultivation and processing industries should be contemplated as a valuable source of bioactive alkaloids, with potential in pharmaceutical applications for the treatment or prevention of chronic diseases.
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Bergaptol from blossoms of Citrus aurantium L. var. amara Engl inhibits LPS-induced inflammatory responses and ox-LDL-induced lipid deposition

Food Funct., 2020, Accepted Manuscript
DOI: 10.1039/C9FO00255C, Paper
Chun-Yan Shen, Tian-Xing Wang, Jian-Guo Jiang, Chun-Ling Huang, Wei Zhu
Aberrant activation of inflammation and excess accumulation of lipids play pivotal roles in atherosclerosis (AS) progression. Constituents from Citrus aurantium Linn variant amara Engl (CAVA) were effectively investigated for their...
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Red ginseng protects against cisplatin-induced intestinal toxicity by inhibiting apoptosis and autophagy via the PI3K/AKT and MAPK signaling pathways

Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00469C, Paper
Jun-jie Zhang, Jian-qiang Wang, Xing-yue Xu, Jia-yu Yang, Zi Wang, Shuang Jiang, Ying-ping Wang, Jing Zhang, Rui Zhang, Wei Li
Although growing evidence has shown that ginseng (Panax ginseng C.A. Meyer.) exerts strong protective and preventive effects on cisplatin-induced side effects, the ameliorative effects of ginseng on intestinal damage caused by cisplatin are unknown to date.
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Production of GABA-enriched idli with ACE inhibitory and antioxidant properties using Aspergillus oryzae: the antihypertensive effects in spontaneously hypertensive rats

Food Funct., 2020, Advance Article
DOI: 10.1039/C9FO02854D, Paper
Mohsen Zareian, Ehsan Oskoueian, Marjan Majdinasab, Bita Forghani
The present study aimed to develop a fermented food (idli) with enhanced γ-aminobutyric acid (GABA) and angiotensin I-converting enzyme (ACE) inhibitory properties using a GABA-producing fungus.
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Jiaogulan tea (Gpostemma pentaphyllum) potentiates the antidiabetic effect of white tea via the AMPK and PI3K pathways in C57BL/6 mice

Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00395F, Paper
Xiaoyan Xia, Jing Xu, Xude Wang, Hua Wang, Zhenchuan Lin, Keping Shao, LinLin Fang, Chenning Zhang, Yuqing Zhao
The use of plant-based beverages to interfere with the onset of diabetes may be a promising approach towards type 2 diabetes mellitus (T2DM).
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Cerebral effect of optimized Allium sativum oil-loaded chitosan nanorods: GC-MS analysis and in-vitro/in-vivo evaluation

Food Funct., 2020, Accepted Manuscript
DOI: 10.1039/C9FO02911G, Paper
Rabab Kamel, Abeer Salama, Nesma Mohammed, Nermine Shaffie
The chemical constituents of Allium sativum (Garlic) oil were investigated using GC/Ms technique after silylation, and revealed the presence of several fatty acids and their esters. The most dominant was...
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Kinetic profile and urinary excretion of phenyl-γ-valerolactones upon consumption of cranberry: a dose-response relationship

Food Funct., 2020, Accepted Manuscript
DOI: 10.1039/D0FO00806K, Paper
Claudia Favari, Pedro Mena, Claudio Curti, Geoffrey Istas, Christian Heiss , Daniele Del Rio, Ana Rodriguez-Mateos
Cranberries are a rich source of poly(phenols), mainly monomeric and oligomeric flavan-3-ols. However, information on the appearance of their main circulating microbial metabolites, namely phenyl-γ-valerolactones and phenylvaleric acid, is lacking...
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Unveiling the bioactivity potential of Allium triquetrum L. lipophilic fraction: chemical characterization and in vitro antibacterial activity against methicillin-resistant Staphylococcus aureus

Food Funct., 2020, Accepted Manuscript
DOI: 10.1039/D0FO00769B, Paper
Samia Rabah, Kahina Kouachi, Patricia Ramos, Ana T. P. C. Gomes, Adelaide Almeida, Hayate Haddadi-Guemghar, Khodir Madani, Armando Silvestre, Sónia A. O. Santos
The lipophilic composition of Allium triquetrum L. bulbs, flowers and leaves was studied for the first time, by GC-MS. Sixty-two compounds were firstly identified in A. triquetrum L. Fatty acids...
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Effects of compound K, a metabolite of ginsenosides, on memory and cognitive dysfunction in db/db mice involve the inhibition of ER stress and the NLRP3 inflammasome pathway

Food Funct., 2020, Advance Article
DOI: 10.1039/C9FO02602A, Paper
Chu-Wen Li, Min-Zhen Deng, Zhi-Jie Gao, Yuan-Ye Dang, Guo-Dong Zheng, Xiu-Juan Yang, Ying-Xin Chao, Ye-Feng Cai, Xiao-Li Wu
The metabolite of ginsenosides, compound K improves memory and cognitive dysfunction in diabetes mellitus mice.
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Mechanisms for Lactobacillus rhamnosus treatment of intestinal infection by drug-resistant Escherichia coli

Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00128G, Paper
Na Li, Bing Pang, Junjun Li, Guanwen Liu, Xiaoguang Xu, Dongyan Shao, Chunmei Jiang, Baowei Yang, Junling Shi
Reducing the viability of pathogens may also play an important role for the therapeutic effects of Lactobacillus rhamnosus SHA113 against multiple-drug-resistant E. coli, as well as influencing on the intestinal integrity and functions of animals.
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Supplementation of Bacillus amyloliquefaciens AS385 culture broth powder containing 1-deoxynojirimycin in a high-fat diet altered the gene expressions related to lipid metabolism and insulin signaling in mice epididymal white adipose tissue

Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00271B, Paper
Isabella Supardi Parida, Soo Takasu, Junya Ito, Ryoichi Ikeda, Kenji Yamagishi, Toshiyuki Kimura, Takahiro Eitsuka, Kiyotaka Nakagawa
Supplementation of Bacillus amyloliquefaciens AS385 culture broth powder in high-fat diet restored adiposity, glucose tolerance and insulin sensitivity in mice.
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Unsaturated alginate oligosaccharides attenuated obesity-related metabolic abnormalities by modulating gut microbiota in high-fat-diet mice

Food Funct., 2020, Accepted Manuscript
DOI: 10.1039/C9FO02857A, Paper
Shangyong Li, Linna Wang, Bo Liu, Ningning He
Gut microbiota plays an important role in the high-fat diet (HFD)-induced obesity and related metabolic syndrome (MetS). Our previous study has demonstrated that unsaturated alginate oligosaccharides (UAOS) degraded by alginate...
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Covid-19: Quality PMS portfolios will help weather this downturn better

Investors who are over-allocated to the mid- and small-cap category need to switch to large- and multi-cap-oriented schemes




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Oxygen kits to help you self-treat your breathing ailment at home or work

The devices come in handly if you have respiratory issues like COPD, asthma or sleep apnea. But if it is Covid-19, go straight to an authorised hospital




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Avoid banks and NBFCs with high proportion of unsecured and SME loans

Longer-term investors with a three-five-year horizon have an opportunity to pick quality stocks, which in calmer times tend to trade at exorbitant valuations




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Dealing with Covid-19: Keep your vehicle in good shape during lockdown

Fill fresh engine oil and coolant before you store it away




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Apple Reports Record Third Quarter Results

Apple has announced financial results for its fiscal 2015 third quarter ended June 27. The company posted quarterly revenue of $49.6 billion and quarterly net profit of $10.7 billion, or $1.85 per diluted share. These results compare to revenue of $37.4 billion and net profit of $7.7 billion, or $1.28 per diluted share, in the year-ago quarter. Gross margin was 39.7 percent compared to 39.4 percent in the year-ago quarter. International sales accounted for 64 percent of the quarter’s revenue. The growth was fueled by record third-quarter sales of iPhone and Mac, all-time record revenue from services, and the successful launch of Apple Watch. “We had an amazing quarter, with iPhone revenue up 59 percent over last year, strong sales of Mac, all-time record revenue from services, driven by the App Store, and a great start for Apple Watch,” said Tim Cook, Apple’s CEO. “The excitement for Apple Music has been incredible, and we’re looking forward to releasing iOS 9, OS X El Capitan, and watchOS 2 to customers in the fall.”




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Apple Names Jeff Williams Chief Operating Officer

Apple has announced that Jeff Williams has been named chief operating officer and Johny Srouji is joining Apple’s executive team as senior vice president for Hardware Technologies. Phil Schiller, senior vice president of Worldwide Marketing, will expand his role to include leadership of the App Store across all Apple platforms. Apple also announced that Tor Myhren will join Apple in the first calendar quarter of 2016 as vice president of Marketing Communications, reporting to CEO Tim Cook. “We are fortunate to have incredible depth and breadth of talent across Apple’s executive team. As we come to the end of the year, we’re recognizing the contributions already being made by two key executives,” said Cook. “Jeff is hands-down the best operations executive I’ve ever worked with, and Johny’s team delivers world-class silicon designs which enable new innovations in our products year after year.”






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Trailer: WAR is high on action and drama

The face-off between Hrithik Roshan and Tiger Shroff may give you goosebumps, feels Karan Sanjay Shah.






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Trailer: Good Newwz is high on fun and entertainment

Directed by newcomer Raj Mehta, this Dharma Production venture is a comedy with loads of dhamakedaar one-liners and fine performances.




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What did *you* think about Pagalpanti?

We give you *your* space to tell us just what you thought of Pagalpanti.




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Yeh Saali Aashiqui Review

'Yeh Saali Aashiqui held my attention purely for audacity,' says Sukanya Verma.




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Chhapaak Trailer: Deepika's screams are spine-chilling

The Chhapaak trailer could have been a dark and depressing tale of a girl disfigured by a vicious attack but fortunately, it isn't, feels Moumita Bhattacharjee.